Citation Impact
Citing Papers
Diterpenes from European Euphorbia Species Serving as Prototypes for Natural‐Product‐Based Drug Discovery
2012
Whole plant cannabis extracts in the treatment of spasticity in multiple sclerosis: a systematic review
2009
A cell-free platform for the prenylation of natural products and application to cannabinoid production
2019 StandoutNobel
In vivo protective effect of protocatechuic acid on tert-butyl hydroperoxide-induced rat hepatotoxicity
2002
The re-emergence of natural products for drug discovery in the genomics era
2015 Standout
Resiniferatoxin for Pain Treatment: An Interventional Approach to Personalized Pain Medicine
2013
The Structural Basis for 14-3-3:Phosphopeptide Binding Specificity
1997 Standout
Modulation of anxiety through blockade of anandamide hydrolysis
2002 Standout
Sense and specificity: a molecular identity for nociceptors
1999 StandoutNobel
Metabolic fingerprinting of Cannabis sativa L., cannabinoids and terpenoids for chemotaxonomic and drug standardization purposes
2010
Adverse Health Effects of Marijuana Use
2014 Standout
Dynamic Covalent Chemistry
2002 StandoutNobel
The capsaicin receptor: a heat-activated ion channel in the pain pathway
1997 StandoutNatureNobel
Analgesic and antiinflammatory activity of constituents ofCannabis sativa L.
1988
Differential effects of cannabis extracts and pure plant cannabinoids on hippocampal neurones and glia
2006
ThermoTRP channels and beyond: mechanisms of temperature sensation
2003 StandoutNobel
Protein Kinase Inhibitor H7 Blocks the Induction of Immediate-Early Genes zif268 and c-fosby a Mechanism Unrelated to Inhibition of Protein Kinase C but Possibly Related to Inhibition of Phosphorylation of RNA Polymerase II
1999
From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes
2013
A capsaicin-receptor homologue with a high threshold for noxious heat
1999 StandoutNatureNobel
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Inhibitors of protein kinase C
1994
Anandamide – the other side of the coin
2000 StandoutNobel
Inflammatory bowel disease: clinical aspects and established and evolving therapies
2007 Standout
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
1989 Standout
Taming THC: potential cannabis synergy and phytocannabinoid‐terpenoid entourage effects
2011 Standout
Activation of the PKC‐isotypes α, β1, γ, δ, and ε by phorbol esters of different biological activities
1991
The vanilloid (capsaicin) receptor: Receptor types and species differences
1994
The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli
1998 StandoutNobel
Similarities and differences in the action of resiniferatoxin and capsaicin on central and peripheral endings of primary sensory neurons
1990
New 19-acetoxyingol diterpenes from the latex of Euphorbia poisonii (Euphorbiaceae)
1996
Diffuse large B-cell lymphoma outcome prediction by gene-expression profiling and supervised machine learning
2002 Standout
Interpretation of BMP signaling in early Xenopus development
2007 StandoutNobel
Molecular Mechanisms of Depression: Perspectives on New Treatment Strategies
2013 Standout
Involvement of CB1 cannabinoid receptors in emotional behaviour
2002
Isolation and Characterization of New Cannabis Constituents from a High Potency Variety
2008
Synergy research: Approaching a new generation of phytopharmaceuticals
2009
Unsaturated Long-Chain N-Acyl-vanillyl-amides (N-AVAMs): Vanilloid Receptor Ligands That Inhibit Anandamide-Facilitated Transport and Bind to CB1 Cannabinoid Receptors
1999 StandoutNobel
Conformational studies on resiniferatoxin (RTX), an ultrapotent vanilloid agonist
1998
Characterization of resiniferatoxin binding sites on sensory neurons: Co-regulation of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia
1993
Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin
1990
Natural Product Hybrids as New Leads for Drug Discovery
2003 Standout
A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain
2008
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release
1998 StandoutNobel
Production and physiological actions of anandamide in the vasculature of the rat kidney.
1997
Boron trifluoride etherate on silica-A modified lewis acid reagent (VII). Antitumor activity of cannabigerol against human oral epitheloid carcinoma cells
1998
Complexities of the Protein Kinase C Pathway
1991
A genetically engineered cell-based biosensor for functional classification of agents
2001 StandoutNobel
Antidepressant‐like effects of cannabidiol in mice: possible involvement of 5‐HT1Areceptors
2009
The molecular logic of endocannabinoid signalling
2003 Standout
Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers
2002 StandoutNobel
Nabilone for the Treatment of Pain in Fibromyalgia
2007
Duration of desensitization and ultrastructural changes in dorsal root ganglia in rats treated with resiniferatoxin, an ultrapotent capsaicin analog
1989
The biopsychosocial approach to chronic pain: Scientific advances and future directions.
2007 Standout
Post-translationally modified 14-3-3 isoforms and inhibition of protein kinase C
1995
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
2004 StandoutNatureNobel
Synergy and other interactions in phytomedicines
2001 Standout
Cystic Fibrosis Transmembrane Conductance Regulator Mediates the Cyclic Adenosine Monophosphate–Induced Fluid Secretion But Not the Inhibition of Resorption in Mouse Gallbladder Epithelium
1997 StandoutNobel
Interferon β-1a in ulcerative colitis: a placebo controlled, randomised, dose escalating study
2003
A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating
2008 StandoutNobel
Thermoregulatory effects of resiniferatoxin in the mouse: Comparison with capsaicin
1989
Pharmacological enhancement of cannabinoid CB1 receptor activity elicits an antidepressant-like response in the rat forced swim test
2005
Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia
2000 StandoutNature
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor
1990
Is there a role for the endocannabinoid system in the etiology and treatment of melancholic depression?
2005
Src-dependent Tyrosine Phosphorylation Regulates Dynamin Self-assembly and Ligand-induced Endocytosis of the Epidermal Growth Factor Receptor
2002 StandoutNobel
Trends in the Development of New Antidepressants. Is there a Light at the End of the Tunnel?
2004
Nutzen einer Add-On-Therapie mit dem synthetischen Cannabinomimetikum Nabilone bei Patienten mit chronischen Schmerzzuständen – eine randomisierte kontrollierte Studie
2006
Distinct Effects of Δ9-Tetrahydrocannabinol and Cannabidiol on Neural Activation During Emotional Processing
2009
Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology
2005
Tigliane diterpenes from the latex of Euphorbia obtusifolia with inhibitory activity on the mammalian mitochondrial respiratory chain
2003
Cannabidivarin‐rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor‐independent mechanism
2013
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976
1993 Standout
NK CELL RECOGNITION
2004 Standout
Similarities and Differences in the Structure−Activity Relationships of Capsaicin and Resiniferatoxin Analogues
1996
Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed
2012 Standout
Diterpenes from Euphorbia segetalis
1998
Insect Diversity in the Fossil Record
1993 StandoutScience
"Inordinate Fondness" Explained: Why Are There So Many Beetles?
1998 StandoutScience
Irritant plants in the spurge family (Euphorbiaceae)
1986
Inhibition of the Spontaneous Rate of Contraction of Neonatal Cardiac Myocytes by Protein Kinase C Isozymes
1995
Jatrophane and lathyrane diterpenoid esters from north american leafy spurge seed
1992
Dynamin I is a Ca(2+)-sensitive phospholipid-binding protein with very high affinity for protein kinase C.
1994 StandoutNobel
Medicinal cannabis: is Δ9–tetrahydrocannabinol necessary for all its effects?
2003
Characterization of a Novel Membrane Glycoprotein Involved in Platelet Activation
1989
Impaired Nociception and Pain Sensation in Mice Lacking the Capsaicin Receptor
2000 StandoutScienceNobel
Vanilloid (Capsaicin) Receptors and Mechanisms
1999 Standout
Five ingol esters and a 17-hydroxyingenol ester from the latex of . Assignment of esters using 13C.N.M.R. methods.
1984
β-Adrenergic Receptor Subtype-Specific Signaling in Cardiac Myocytes from β1 and β2 Adrenoceptor Knockout Mice
2001 StandoutNobel
Antigen Receptor-Induced Signal Transduction Imbalances Associated with the Negative Selection of Immature B Cells
1999
Selectively Cytotoxic Diterpenes from Euphorbia poisonii
1996
Chemical and Pharmacological Research of the Plants in Genus Euphorbia
2008 Standout
Synthesis and Evaluation of Phorboid 20-Homovanillates: Discovery of a Class of Ligands Binding to the Vanilloid (Capsaicin) Receptor with Different Degrees of Cooperativity
1996
The Vanilloid Receptor: A Molecular Gateway to the Pain Pathway
2001 StandoutNobel
Regulation of cAMP-activated apical membrane chloride conductance in gallbladder epithelium.
1994
Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons.
1996
Der Stand der Totalsynthese zu Beginn des 21. Jahrhunderts
2000
Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal
2014 Standout
Cannabinoids for Medical Use
2015 Standout
Cannabis sativa: volatile compounds from pollen and entire male and female plants of two variants, Northern Lights and Hawaian Indica
2005
Focal Lysolecithin-Induced Demyelination of Peripheral Afferents Results in Neuropathic Pain Behavior That Is Attenuated by Cannabinoids
2003
Natural Products as Sources of New Drugs from 1981 to 2014
2016 Standout
Escalation of Plant Defense: Do Latex and Resin Canals Spur Plant Diversification?
1991
Euphorbia Diterpenes: Isolation, Structure, Biological Activity, and Synthesis (2008–2012)
2014 Standout
Thiourea analogues of resiniferatoxin as ligands for the vanilloid receptor
1995
Preparative Isolation of Cannabinoids from Cannabis sativa by Centrifugal Partition Chromatography
2004
Free Radicals in the Physiological Control of Cell Function
2002 Standout
Differential stimulation of protein kinase C activity by phorbol ester or calcium/phosphatidylserine in vitro and in intact synaptosomes.
1992
Ingenane and lathyrane diterpenes from the latex of Euphorbia canariensis
1997
Neurogenic component of phorbol ester-induced mouse skin inflammation.
1989
Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients
2004
Ingenane and lathyrane diterpenes from the latex of euphorbia acrurensis
1998
8-methoxyingol esters from the latex of Euphorbia hermentiana
1983
Works of Fred J. Evans being referenced
The Medicinal Chemistry of Cannabis: O'Shaughnessy's Legacy
1997
Natural products as probes for new drug target identification
1991
Role of protein kinase C in induction of gene expression and inhibition of cell proliferation by interferon α
1992
Tumour-promoting and hyperplastic effects of phorbol and daphnane esters in CD-1 mouse skin and a synergistic effect of calcium ionophore with the non-promoting activator of protein kinase C, sapintoxin A
1989
Phorbol esters showing selective activation of PKS isozymes in vitro regulate thyroid function and insulin-like growth factor binding protein secretion
1994
Cannabinoids: The Separation of Central from Peripheral Effects on a Structural Basis
1991
Cannabinoids in Clinical Practice
2000
12-Deoxyphorbol-13-O-phenylacetate-20-acetate is not protein kinase C-β isozyme-selective in vivo
1994
Two minor diterpenes from Euphorbia latex
1978
Inhibition of Erythema Induced by Pro‐inflammatory Esters of 12‐Deoxyphorbol
1981
New Phorbol and Deoxyphorbol Esters: Isolation and Relative Potencies in Inducing Platelet Aggregation and Erythema of Skin
1983
Actions of cannabis constituents on enzymes of arachidonate metabolism: anti-inflammatory potential
1987
Ingenol esters from the pro-inflammatory fraction of Euphorbia kamerunica
1982
The irritant toxins of Blue Euphorbia (Euphorbia coerulescens Haw.)
1978
A Tri-Ester of Ingol From the Latex of Euphorbia kamerunica
1982
a new aromatic ester diterpene from Euphorbia poisonii
1976
Skin irritants of the sun spurge (Euphorbia helioscopia L)
1980
Two new toxins from the latex of Euphorbia poisonii
1976
Macrocyclic diterpene esters of the cytotoxic fraction from Euphorbia kamerunica
1981
Investigations into the skin-irritant properties of resiniferonol ortho esters
1979
An assay procedure for the comparative irritancy testing of esters in the tigliane and daphnane series
1979
Studies on the mechanism of action of 12-deoxyphorbolphenylacetate, a potent platelet aggregating tigliane ester
1981
Skin irritant effects of esters of phorbol and related polyols
1980
The effects of phorbol esters with different biological activities on protein kinase C
1987
The potent irritancy of the daphnane orthoester, resiniferatoxin, exhibits features of a mixed aetiology
1992
Plants and Plant Products that Induce Contact Dermatitis
1980
Phorbol ester activation of the isotypes of protein kinase C from bovine and rat brain
1991
Activity correlations in the phorbol ester series
1987
Properties of a Resiniferatoxin-stimulated, Calcium Inhibited but Phosphatidylserine-dependent Kinase, which is Distinct from Protein Kinase C Isotypes α, β1γ, δ, ε and η
1995
Inhibition of the cataleptic effect of tetrahydrocannabinol by other constituents of Cannabis sativa L.
1988