Citation Impact
Citing Papers
Sir2-Dependent Activation of Acetyl-CoA Synthetase by Deacetylation of Active Lysine
2002 Science
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.
1996
Amyloid β Protein Precursor Is Possibly a Heparan Sulfate Proteoglycan Core Protein
1988 Science
Complex Genetic Disease: Can Genetic Strategies in Alzheimer's Disease and New Genetic Mechanisms Be Applied to Epilepsy?
1994
Advances in the Cellular and Molecular Biology of the Beta-Amyloid Protein in Alzheimer 's Disease
2002
Fibril formation by primate, rodent, and Dutch-hemorrhagic analogs of Alzheimer amyloid .beta.-protein
1992
Activation of Store-Operated Ca2+ Current in Xenopus Oocytes Requires SNAP-25 but Not a Diffusible Messenger
1999 StandoutNobel
β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity
1995
Cellular and molecular biology of neuropeptide processing and packaging
1989
Nicastrin Functions as a γ-Secretase-Substrate Receptor
2005 StandoutNobel
Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome
1995
Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths
1994
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
Cerebrovascular transport of Alzheimer's amyloidβ and apolipoproteins J and E: Possible anti-amyloidogenic role of the blood-brain barrier
1996
Soluble multimeric Alzheimer β(1–40) pre-amyloid complexes in dilute solution
1995
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Amyloid β-Protein Inhibits Ubiquitin-dependent Protein Degradation in Vitro
1995
Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)
1994 Standout
A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid
1992 Standout
Cell biology of protein misfolding: The examples of Alzheimer's and Parkinson's diseases
2004
Store-Operated Ca2+ Entry
1999
Eomesodermin, a Key Early Gene in Xenopus Mesoderm Differentiation
1996 StandoutNobel
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
2007 Standout
Plasma Levels of amyloid β proteins Aβ1–40 and Aβ1–42(43) are elevated in Down's syndrome
1997
Rapid induction of Alzheimer A beta amyloid formation by zinc
1994 Science
Amyloids and Are Generated Intracellularly in Cultured Human Neurons and Their Secretion Increases with Maturation
1996
Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene
1991 Nature
Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity
1994
Secretion of β-amyloid precursor protein cleaved at the amino terminus of the β-amyloid peptide
1993 Nature
Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons
2000
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
2002
Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-γ and PTEN
2006 StandoutNatureNobel
Synaptic transmission: A bidirectional and self-modifiable form of cell-cell communication
1993 StandoutNobel
The Hallmarks of Cancer
2000 Standout
Ectodomain Phosphorylation of β-Amyloid Precursor Protein at Two Distinct Cellular Locations
1997
Antimicrobial peptides of vertebrates
1998
Genetics and molecular advances in Alzheimer's disease
1993
Aggregation of Secreted Amyloid β-Protein into Sodium Dodecyl Sulfate-stable Oligomers in Cell Culture
1995
Alzheimer's Disease: The Amyloid Cascade Hypothesis
1992 StandoutScience
Neuronal differentiation factors/cytokines and synaptic plasticity
1993
Extracellular Matrix Molecules and their Receptors: Functions in Neural Development
1991
Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease
1992
Enzymes Required for Yeast Prohormone Processing
1988
In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity
1991
Expression of APP in the early stage of brain damage
1991
Intragonadal Regulation of Follicular Maturation
1989
Rho GTPases and signaling networks
1997 Standout
Structural and kinetic features of amyloid β-protein fibrillogenesis
1998
Activin A and follistatin expression in developing targets of ciliary ganglion neurons suggests a role in regulating neurotransmitter phenotype
1995
Arrest of -Amyloid Fibril Formation by a Pentapeptide Ligand
1996
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
Interactions of Alzheimer amyloid‐β peptides with glycosaminoglycans
1999
Amyloidogenic Processing of Human Amyloid Precursor Protein in Hippocampal Neurons Devoid of Cathepsin D
1996
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: β4
1989
Transmembrane Pickets Connect Cyto- and Pericellular Skeletons Forming Barriers to Receptor Engagement
2018 StandoutNobel
Evidence for intracellular cleavage of the Alzheimer's amyloid precursor in PC12 cells
1992
Presenile dementia and cerebral haemorrhage linked to a mutation at codon 692 of the β–amyloid precursor protein gene
1992
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
APP Processing and Synaptic Function
2003
The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
1993 Standout
Animal models of cerebral β-amyloid angiopathy
1997
Reconstitution of SEC gene product-dependent intercompartmental protein transport
1988 StandoutNobel
Interactions between activin and follicle-stimulating hormone-suppressing protein and their mechanisms of action on cultured rat granulosa cells
1991
Calcium-destabilizing and neurodegenerative effects of aggregated β-amyloid peptide are attenuated by basic FGF
1993
Synaptic structure and development: The neuromuscular junction
1993
Expression and characterization of recombinant human acyloxyacyl hydrolase, a leukocyte enzyme that deacylates bacterial lipopolysaccharides
1991
Amyloid-associated proteins α1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer β-protein into filaments
1994 Nature
Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
2005 Standout
Enhanced Production and Oligomerization of the 42-residue Amyloid β-Protein by Chinese Hamster Ovary Cells Stably Expressing Mutant Presenilins
1997
Amyloid β-Protein Fibrillogenesis
1997
Expression of APP in transgenic mice: a Comparison of neuron-specific promoters
1996
Receptor-Mediated Transport of Human Amyloid β-Protein 1–40 and 1–42 at the Blood–Brain Barrier
1999
Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease
1996
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Clearance of Alzheimer’s amyloid-β1-40 peptide from brain by LDL receptor–related protein-1 at the blood-brain barrier
2000
Rapid Communication: Characterization of β‐Amyloid Peptide from Human Cerebrospinal Fluid
1993
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Organizing the cell cortex: the role of ERM proteins
2010 Standout
Chaperoning Alzheimer's amyloids
1994
Mutagenesis Identifies New Signals for β-Amyloid Precursor Protein Endocytosis, Turnover, and the Generation of Secreted Fragments, Including Aβ42
1999
Amyloid β-peptide is produced by cultured cells during normal metabolism
1992 StandoutNature
Formation of stable complexes between two Alzheimer's disease gene products: Presenilin-2 and β-amyloid precursor protein
1997
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments
1992 Nature
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway
1995
Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
1993 Standout
Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria
1994 StandoutNatureNobel
The molecular pathology of Alzheimer's disease
1991 Standout
Translating cell biology into therapeutic advances in Alzheimer's disease
1999 Nature
High tissue content of soluble beta 1-40 is linked to cerebral amyloid angiopathy.
1994
Identification of a stable fragment of the Alzheimer amyloid precursor containing the beta-protein in brain microvessels.
1992
Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein Precursor
1993 Science
Identification of a tyrosine residue at a nucleotide binding site in the beta subunit of the mitochondrial ATPase with p-fluorosulfonyl[14C]-benzoyl-5'-adenosine.
1978
The beta-amyloid precursor protein of Alzheimer's disease enhances neuron viability and modulates neuronal polarity.
1997
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
1992 StandoutNature
Framing β–amyloid
1992
Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices.
1993
The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis
1987 StandoutNobel
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
1994
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Expression of activin subunits, activin receptors and follistatin in postimplantation mouse embryos suggests specific developmental functions for different activins
1994
Polarized secretion of beta-amyloid precursor proteinand amyloid beta-peptide in MDCK cells.
1994
Alzheimer's disease: a re-examination of the amyloid hypothesis
1998
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS
1998
A Century of Alzheimer's Disease
2006 StandoutScience
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease.
1991
Lack of Neurodegeneration in Transgenic Mice Overexpressing Mutant Amyloid Precursor Protein Is Associated with Increased Levels of Transthyretin and the Activation of Cell Survival Pathways
2002
Inactivation of a Serotonin-Gated Ion Channel by a Polypeptide Toxin from Marine Snails
1998 StandoutScienceNobel
Diffusible, nonfibrillar ligands derived from Aβ 1–42 are potent central nervous system neurotoxins
1998 Standout
Primary structure of the human follistatin precursor and its genomic organization.
1988 Nobel
Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner
1995
Generation and reproductive phenotypes of mice lacking estrogen receptor β
1998 StandoutNobel
Regulation of Plasma Cholesterol by Lipoprotein Receptors
1981 StandoutScienceNobel
Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives
1992 Science
Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.
1993
Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities
1996
Mechanism of the cleavage specificity of Alzheimer’s disease γ-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein
1999
Activin-Binding Protein from Rat Ovary Is Follistatin
1990 Science
Alzheimer's Disease: Genes, Proteins, and Therapy
2001 Standout
The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex
1993
Beta-amyloid precursor protein cleavage by a membrane-bound protease.
1992
Somatostatin
1983
Rho GTPases and the Actin Cytoskeleton
1998 StandoutScience
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease.
1993
Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
2002
Selective ectodomain phosphorylation and regulated cleavage of beta-amyloid precursor protein.
1994
Yeast KEX1 gene encodes a putative protease with a carboxypeptidase B-like function involved in killer toxin and α-factor precursor processing
1987
Alzheimer's Disease: Molecular Understanding Predicts Amyloid-Based Therapeutics
2003
Reduction of β‐amyloid peptide42 in the cerebrospinal fluid of patients with Alzheimer's disease
1995
Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
1981 StandoutNobel
Posttranslational processing of the LDL receptor and its genetic disruption in familial hypercholesterolemia
1982 StandoutNobel
Clathrin: A Role in the Intracellular Retention of a Golgi Membrane Protein
1989 StandoutScienceNobel
Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers.
1996
Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system
1993
beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.
1993
Pituitary FSH is released by a heterodimer of the β-subunits from the two forms of inhibin
1986 NatureNobel
Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models
1999
Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals.
1995
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.
1992
Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin
1999 StandoutNobel
Alzheimer Amyloid Protein Precursor in the Rat Hippocampus: Transport and Processing through the Perforant Path
1998
Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition
1991 Science
beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.
1993
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
2000 Standout
Evidence that production and release of amyloid beta-protein involves the endocytic pathway
1994
Osteopontin
2000 Standout
Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity
2000
The β-Amyloid Precursor Protein of Alzheimer’s Disease Enhances Neuron Viability and Modulates Neuronal Polarity
1997
Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor
1992 Science
Mutations associated with a locus for familial Alzheimer's disease result in alternative processing of amyloid beta-protein precursor
1994
Chloroquine inhibits intracellular degradation but not secretion of Alzheimer beta/A4 amyloid precursor protein.
1992
Domain map of the LDL receptor: Sequence homology with the epidermal growth factor precursor
1984 StandoutNobel
Apolipoprotein J and Alzheimer's amyloid β solubility
1996
Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing
1992 StandoutScience
Expression of inhibin subunits and follistatin during postimplantation mouse development: decidual expression of activin and expression of follistatin in primitive streak, somites and hindbrain
1994
MODELS OF AMYLOID SEEDING IN ALZHEIMER'S DISEASE AND SCRAPIE: Mechanistic Truths and Physiological Consequences of the Time-Dependent Solubility of Amyloid Proteins
1997
Conserved quaternary structure of ligand-gated ion channels: the postsynaptic glycine receptor is a pentamer.
1988
Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.
1987 Nobel
Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
1993 Standout
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Partial purification and characterization of the low density lipoprotein receptor from bovine adrenal cortex.
1980
Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71.
1981
Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.
1992
Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins
1998
Trafficking of cell surface beta-amyloid precursor protein: retrograde and transcytotic transport in cultured neurons.
1995
Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.
1993
Alzheimer beta/A4 amyloid precursor protein in human brain: aging-associated increases in holoprotein and in a proteolytic fragment.
1991
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.
1994
Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
2001
Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state
1993
beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity
1992
Works of Fred Esch being referenced
.alpha.1.beta.1 Integrin heterodimer functions as a dual laminin/collagen receptor in neural cells
1990
Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids
1992 Nature
Exact cleavage site of Alzheimer amyloid precursor in neuronal PC-12 cells
1991
Cloning, expression during development, and evidence for release of a trophic factor for ciliary ganglion neurons
1992
Follistatin specifically inhibits pituitary follicle stimulating hormone release invitro
1987 Nobel
Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing
1988
Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the β-amyloid precursor protein
1993
The Isolation and Characterization of a Novel Corticostatin/Defensin-like Peptide from the Kidney
1996
Purification of a Multipotent Antideath Activity from Bovine Liver and Its Identification as Arginase: Nitric Oxide-Independent Inhibition of Neuronal Apoptosis
1998
A procedure for the synthesis of p-fluorosulfonyl[14C]-benzoyl-5′-adenosine with [14C] in the benzoyl moiety
1978
Rho- and Rac-dependent Assembly of Focal Adhesion Complexes and Actin Filaments in Permeabilized Fibroblasts: An Essential Role for Ezrin/Radixin/Moesin Proteins
1997
Identification of a lysine residue at a nucleotide binding site in the firefly luciferase with p-fluorosulfonyl[14C]benzoyl-5'-adenosine
1981
Polypeptide microsequence analysis with the commercially available gas-phase sequencer
1984
Physiological roles of somatocrinin and somatostatin in the regulation of growth hormone secretion
1982 Nobel
Cleavage of Amyloid β Peptide During Constitutive Processing of Its Precursor
1990 Science
Cloning and sequence analysis of cDNA for bovine carboxypeptidase E
1986 Nature
Coding of Two Sphingolipid Activator Proteins (SAP-1 and SAP-2) by Same Genetic Locus
1988 Science
Neuronal nicotinic acetylcholine receptor β‐subunit is coded for by the cDNA clone α4
1987