Standout Papers
- Conformational Transformations in Peptides Containing Two Putative α-Helices of the Prion Protein (1995)
- Proposed three-dimensional structure for the cellular prion protein. (1994)
- Separation of Scrapie Prion Infectivity from PrP Amyloid Polymers (1996)
- Selective Neuronal Targeting in Prion Disease (1997)
Citation Impact
Citing Papers
Structural studies of the scrapie prion protein by electron crystallography
2002 Nobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Structure, function, and evolution of transient and obligate protein–protein interactions
2005
A 7-kDa Prion Protein (PrP) Fragment, an Integral Component of the PrP Region Required for Infectivity, Is the Major Amyloid Protein in Gerstmann-Sträussler-Scheinker Disease A117V
2001
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Molecular biology and genetics of prion diseases
1994 StandoutNobel
The Crystal Structure of the Globular Domain of Sheep Prion Protein
2004
Folding and intrinsic stability of deletion variants of PrP(121–231), the folded C-terminal domain of the prion protein
2002
Pathway Complexity of Prion Protein Assembly into Amyloid
2002 Nobel
Improved molecular replacement by density- and energy-guided protein structure optimization
2011 StandoutNatureNobel
NMR structure of the mouse prion protein domain PrP(121–231)
1996 StandoutNatureNobel
Dominant forces in protein folding
1990 Standout
Copper Binding to the Octarepeats of the Prion Protein
2003
Context-dependent secondary structure formation of a designed protein sequence
1996 Nature
Mapping Cu(II) Binding Sites in Prion Proteins by Diethyl Pyrocarbonate Modification and Matrix-assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) Mass Spectrometric Footprinting
2002
Identification of small RNA pathway genes using patterns of phylogenetic conservation and divergence
2012 StandoutNatureNobel
Toxicity of novel C‐terminal prion protein fragments and peptides harbouring disease‐related C‐terminal mutations
2001
pH-dependent Stability and Conformation of the Recombinant Human Prion Protein PrP(90–231)
1997
Copper and zinc cause delivery of the prion protein from the plasma membrane to a subset of early endosomes and the Golgi
2003
Metal ions and prion diseases
2002
Principles for designing ideal protein structures
2012 StandoutNatureNobel
3D solution structure of copper and silver‐substituted yeast metallothioneins
1996
Modeller: Generation and Refinement of Homology-Based Protein Structure Models
2003
Prion Protein Binds Copper within the Physiological Concentration Range
2001
Molecular properties of complexes formed between the prion protein and synthetic peptides
1997 StandoutNobel
Studies on peptide fragments of prion proteins
2001
Antioxidant activity related to copper binding of native prion protein
2001
Recombinant full‐length murine prion protein, mPrP(23–231): purification and spectroscopic characterization
1997 StandoutNobel
Prion Protein Isoforms, a Convergence of Biological and Structural Investigations
1995 StandoutNobel
Modeling of loops in protein structures
2000 Standout
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Autonomous and Reversible Folding of a Soluble Amino-terminally Truncated Segment of the Mouse Prion Protein
1996
Prediction of protein side-chain conformation by packing optimization
1991
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
CD and NMR Studies of Prion Protein (PrP) Helix 1
2003
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Sites for Gα Binding on the G Protein β Subunit Overlap with Sites for Regulation of Phospholipase Cβ and Adenylyl Cyclase
1998 Nobel
A de Novo Designed Template for Generating Conformation-specific Antibodies That Recognize α-Helices in Proteins
2002
Molecular Evolution of the Mammalian Prion Protein
2003
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
The Structure of Amyloid Fibrils by Electron Microscopy and X-Ray Diffraction
1997
Evidence that the 127–164 Region of Prion Proteins Has Two Equi-Energetic Conformations with β or α Features
2001
Molecular dynamics simulation of human prion protein including both N-linked oligosaccharides and the GPI anchor
2000
Copper(II) complexes of peptide fragments of the prion protein. Conformation changes induced by copper(II) and the binding motif in C-terminal protein region
2003
TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action
2016 StandoutNatureNobel
Probing Copper2+ Binding to the Prion Protein Using Diamagnetic Nickel2+ and 1H NMR: The Unstructured N terminus Facilitates the Coordination of Six Copper2+ Ions at Physiological Concentrations
2005
NMR characterization of the full‐length recombinant murine prion protein, mPrP(23–231)
1997 StandoutNobel
De novo design of bioactive protein switches
2019 StandoutNatureNobel
Ionic Strength and Transition Metals Control PrPSc Protease Resistance and Conversion-inducing Activity
2004
A conformational transition at the N terminus of the prion protein features in formation of the scrapie isoform 1 1Edited by M. Yaniv
1997 StandoutNobel
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Oxidation of methionine residues in the prion protein by hydrogen peroxide
2004 Nobel
Heterotrimeric G protein activation by G-protein-coupled receptors
2007
Seven-transmembrane-spanning receptors and heart function
2002 StandoutNatureNobel
Copper Chelation Delays the Onset of Prion Disease
2003
Aberrant metal binding by prion protein in human prion disease
2001
Cyclic coordinate descent: A robotics algorithm for protein loop closure
2003
Insoluble wild–type and protease–resistant mutant prion protein in brains of patients with inherited prion disease
1996 StandoutNobel
Physical‐chemical determinants of turn conformations in globular proteins
2007
Coupling backbone flexibility and amino acid sequence selection in protein design
1997
Solution structures of micelle-bound amyloid β-(1-40) and β-(1-42) peptides of Alzheimer’s disease 1 1Edited by P. E. Wright
1999
Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein
1995 StandoutNobel
Accurate prediction of the stability and activity effects of site-directed mutagenesis on a protein core
1991 StandoutNatureNobel
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Structural Biology of Prions
2000
Design of protein conformational switches
2006
Prion (PrPSc)-specific epitope defined by a monoclonal antibody
1997 StandoutNatureNobel
Molecular biology and pathogenesis of prion diseases
1996
Preferential Cu2+ Coordination by His96 and His111 Induces β-Sheet Formation in the Unstructured Amyloidogenic Region of the Prion Protein
2004
The dimeric and tetrameric octarepeat fragments of prion protein behave differently to its monomeric unit
2004
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Identification of a prion protein epitope modulating transmission of bovine spongiform encephalopathy prions to transgenic mice
1997 StandoutNobel
A segment of cold shock protein directs the folding of a combinatorial protein
2005 StandoutNobel
Copper(II) Inhibits in Vitro Conversion of Prion Protein into Amyloid Fibrils
2005
Prion-inducing domain 2–114 of yeast Sup35 protein transforms in vitro into amyloid-like filaments
1997 StandoutNobel
Evolution of Proteins and Proteomes: A Phylogenetics Approach
2005
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Ab Initio Protein Structure Prediction: Progress and Prospects
2001 StandoutNobel
Prion protein NMR structure and familial human spongiform encephalopathies
1998 StandoutNobel
NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106–126
2003
Chemical chaperones interfere with the formation of scrapie prion protein.
1996 StandoutNobel
Location and properties of metal-binding sites on the human prion protein
2001
Ablation of the metal ion-induced endocytosis of the prion protein by disease-associated mutation of the octarepeat region
2001
Evidence for protein X binding to a discontinuous epitope on the cellular prion protein during scrapie prion propagation
1997 StandoutNobel
Structure-function analysis of human interleukin-2. Identification of amino acid residues required for biological activity.
1987
Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.
1993 Standout
Automated structure-based prediction of functional sites in proteins: applications to assessing the validity of inheriting protein function from homology in genome annotation and to protein docking
2001
Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein
2002
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Copper-catalyzed oxidation of the recombinant SHa(29–231) prion protein
2001 Nobel
Structural Aspects of Ligand Binding to and Electron Transfer in Bacterial and Fungal P450s
2004
Prion protein (PrP) synthetic peptides induce cellular PrP to acquire properties of the scrapie isoform.
1995 StandoutNobel
Importance of disulfide linkage for constructing the biologically active human interleukin-2
1987
Identification of the Cu2+Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy
2000 Nobel
Fragmentation and dimerization of copper-loaded prion protein by copper-catalysed oxidation
2005
Resiniferatoxin Binds to the Capsaicin Receptor (TRPV1) near the Extracellular Side of the S4 Transmembrane Domain
2004
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
1996 StandoutScienceNobel
Prion Diseases and the BSE Crisis
1997 StandoutScienceNobel
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Prions
1998 StandoutNobel
Progress in Modeling of Protein Structures and Interactions
2005 StandoutScienceNobel
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Protein Structure Prediction and Structural Genomics
2001 StandoutScienceNobel
G PROTEIN βγ SUBUNITS
1997
Solution structure of a 142-residue recombinant prion protein corresponding to the infectious fragment of the scrapie isoform
1997 StandoutNobel
Structure of the recombinant full-length hamster prion protein PrP(29–231): The N terminus is highly flexible
1997 StandoutNobel
Copper Binding in the Prion Protein
2004
Three-Dimensional Structure of Interleukin-2
1987 Science
Copper Coordination in the Full-Length, Recombinant Prion Protein
2003 Nobel
Evidence for the role of PrP C helix 1 in the hydrophilic seeding of prion aggregates
1999
Copper induces increased beta-sheet content in the scrapie-susceptible ovine prion protein PrPVRQ compared with the resistant allelic variant PrPARR
2004
Coupled prediction of protein secondary and tertiary structure
2003 StandoutNobel
Crystal Structure of the Catalytic Domains of Adenylyl Cyclase in a Complex with G sα ·GTPγS
1997 ScienceNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Etiology and pathogenesis of prion diseases.
1995 StandoutNobel
Molecular Basis for Interactions of G Protein βγ Subunits with Effectors
1998 StandoutScienceNobel
Evolution of proteins and proteomes: a phylogenetics approach.
2007
Crystal Structure of the Adenylyl Cyclase Activator G s α
1997 ScienceNobel
Recombinant scrapie-like prion protein of 106 amino acids is soluble
1996 StandoutNobel
Hints of Nonhierarchical Folding of Acidic Fibroblast Growth Factor
2002
The Octarepeat Domain of the Prion Protein Binds Cu(II) with Three Distinct Coordination Modes at pH 7.4
2005
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
2008 Standout
Comparative Protein Structure Modeling Using Modeller
2006 Standout
Acidic pH and Detergents Enhance in Vitro Conversion of Human Brain PrPC to a PrPSc-like Form
2002
Structure and Chemistry of Cytochrome P450
2005 Standout
Interleukin-2: Inception, Impact, and Implications
1988 StandoutScience
Works of Fred E. Cohen being referenced
Conformational Transformations in Peptides Containing Two Putative α-Helices of the Prion Protein
1995 StandoutNobel
Identification of functional surfaces of the zinc binding domains of intracellular receptors
1997
X-ray Diffraction of Scrapie Prion Rods and PrP Peptides
1995
Separation of Scrapie Prion Infectivity from PrP Amyloid Polymers
1996 StandoutNobel
Taxonomy and conformational analysis of loops in proteins
1992
MacMatch: a tool for pattern-based protein secondary structure prediction
1993
Scrapie prions: a three-dimensional model of an infectious fragment
1996
Prion Protein Peptides Induce .alpha.-Helix to .beta.-Sheet Conformational Transitions
1995
Copper binding to octarepeat peptides of the prion protein monitored by mass spectrometry
2000
Hydrogen bonds involving sulfur atoms in proteins
1991
Heritable disorder resembling neuronal storage disease in mice expressing prion protein with deletion of an α-helix
1997
Selective Neuronal Targeting in Prion Disease
1997 StandoutNobel
Conformational switching in designed peptides: the helix/sheet transition
1996
Pairwise sequence alignment below the twilight zone11Edited by B. Honig
2001
Protein misfolding and prion diseases
1999
Co-evolution of proteins with their interaction partners 1 1Edited by B. Honig
2000
Strain‐specified relative conformational stability of the scrapie prion protein
2001 Nobel
The prion folding problem
1997
Evolutionarily conserved Galphabetagamma binding surfaces support a model of the G protein-receptor complex.
1996
Proposed three-dimensional structure for the cellular prion protein.
1994 StandoutNobel
Topological distribution of four-alpha-helix bundles.
1989
Structure-Activity Studies of Interleukin-2
1986 Science
Origins of structural diversity within sequentially identical hexapeptides
1993