Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Programmable RNA recognition using a CRISPR-associated Argonaute
2018 StandoutNobel
Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Na v 1.7)
2012
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
GPCR activation mechanisms across classes and macro/microscales
2021
Flexibility of human cytochrome P450 enzymes: Molecular dynamics and spectroscopy reveal important function-related variations
2010
Asymmetric Counteranion‐Directed Catalysis: Concept, Definition, and Applications
2012 StandoutNobel
Asymmetric Counteranion‐Directed Transition‐Metal Catalysis: Enantioselective Epoxidation of Alkenes with Manganese(III) Salen Phosphate Complexes
2009 StandoutNobel
5-HT2 receptors modulate excitatory neurotransmission to cardiac vagal neurons within the nucleus ambiguus evoked during and after hypoxia
2009 StandoutNobel
Adaptations for the Oxidation of Polycyclic Aromatic Hydrocarbons Exhibited by the Structure of Human P450 1A2
2007
Rethinking amide bond synthesis
2011 StandoutNature
Functional study of rat 5‐HT2A receptors using antisense oligonucleotides
2003
Vascularized and functional human liver from an iPSC-derived organ bud transplant
2013 StandoutNature
The influence of 5‐HT2and 5‐HT4receptor antagonists to modify drug induced disinhibitory effects in the mouse light/dark test
1997
Activation of 5-HT 2B Receptors in the Medial Amygdala causes Anxiolysis in the Social Interaction Test in the Rat
1997
Roof and Floor of the Muscarinic Binding Pocket: Variations in the Binding Modes of Orthosteric Ligands
2007
Loading of Vesicles into Soft Amphiphilic Nanotubes using Osmosis
2015 StandoutNobel
Structure Modeling of All Identified G Protein–Coupled Receptors in the Human Genome
2006
The 7 TM G‐Protein‐Coupled Receptor Target Family
2006
The Catalytic Asymmetric Knoevenagel Condensation
2011 StandoutNobel
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Primary‐Amine‐Catalyzed Enantioselective Intramolecular Aldolizations
2008 StandoutNobel
Physiology and Pathophysiology of Sodium Channel Inactivation
2016
The Serotonin Syndrome
2005 Standout
Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2
2007
A-to-I RNA Editing and Human Disease
2006
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Organocatalytic Asymmetric Hydrolysis of Epoxides
2014 StandoutNobel
Functional Characterization of 17 CYP2D6 Allelic Variants (CYP2D6.2, 10, 14A–B, 18, 27, 36, 39, 47–51, 53–55, and 57)
2008
Direct Asymmetric α Benzoyloxylation of Cyclic Ketones
2011 StandoutNobel
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2
2009
Analysis and Separation of Residues Important for the Chemoattractant and Antimicrobial Activities of β-Defensin 3
2008 StandoutNobel
Courtship and Other Behaviors Affected by a Heat-Sensitive, Molecularly Novel Mutation in the cacophony Calcium-Channel Gene of Drosophila
2002 StandoutNobel
A review of central 5-HT receptors and their function
1999 Standout
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Catalytic Asymmetric Hydroperoxidation of α,β‐Unsaturated Ketones: An Approach to Enantiopure Peroxyhemiketals, Epoxides, and Aldols
2008 StandoutNobel
RS-102221: A Novel High Affinity and Selective, 5-HT 2C Receptor Antagonist
1997
6-[2-(4-Aryl-1-piperazinyl)ethyl]-2H-1,4-benzoxazin-3(4H)-ones: Dual-acting 5-HT1 receptor antagonists and serotonin reuptake inhibitors
2008
Evidence for expression of the 5-hydroxytryptamine-2B receptor protein in the rat central nervous system
1997
Polymorphic Cytochrome P450 2D6: Humanized Mouse Model and Endogenous Substrates
2004
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
2017 Standout
Effects of 8‐OHDPAT and 5‐HT1A antagonists WAY100135 and WAY100635, on guinea‐pig behaviour and dorsal raphe 5‐HT neurone firing
1996
Structure and dynamics of the M3 muscarinic acetylcholine receptor
2012 StandoutNatureNobel
Orai1 is an essential pore subunit of the CRAC channel
2006 StandoutNature
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation
2013 Standout
In vitroandin vivoprofile of SB 206553, a potent 5‐HT2C/5‐HT2Breceptor antagonist with anxiolytic‐like properties
1996
PREDICT modeling and in‐silico screening for G‐protein coupled receptors
2004
Mutagenic Mapping Suggests a Novel Binding Mode for Selective Agonists of M1 Muscarinic Acetylcholine Receptors
2008
Effects of the 5‐HT2B receptor agonist, BW 723C86, on three rat models of anxiety
1996
GPCRdb: an information system for G protein-coupled receptors
2015
Conformational Plasticity and Structure/Function Relationships in Cytochromes P450
2010
Toward high-resolution prediction and design of transmembrane helical protein structures
2007 StandoutNobel
The Unexpected Importance of the Primary Structure of the Hydrophobic Part of One-Component Ionizable Amphiphilic Janus Dendrimers in Targeted mRNA Delivery Activity
2022 StandoutNobel
3d Transition Metals for C–H Activation
2018 Standout
Enantioselective α-heterofunctionalisation of carbonyl compounds: organocatalysis is the simplest approach
2006
Activation of H2O2 by Chiral Confined Brønsted Acids: A Highly Enantioselective Catalytic Sulfoxidation
2012 StandoutNobel
Permeation and Selectivity in Calcium Channels
2003
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Novel Aza-analogous Ergoline Derived Scaffolds as Potent Serotonin 5-HT6 and Dopamine D2 Receptor Ligands.
2014
Bioisosterism: A Rational Approach in Drug Design
1996
Catalytic Asymmetric Epoxidation of Cyclic Enones
2008 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Organocatalysis by N-Heterocyclic Carbenes
2007 Standout
The Medicinal Chemist’s Toolbox: An Analysis of Reactions Used in the Pursuit of Drug Candidates
2011 Standout
Dendron-Mediated Self-Assembly, Disassembly, and Self-Organization of Complex Systems
2009
Predictive Models for Cytochrome P450 Isozymes Based on Quantitative High Throughput Screening Data
2011
Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes
2009
Fluorine in Pharmaceuticals: Looking Beyond Intuition
2007 StandoutScience
Cu(II) Catalyzed Imine C–H Functionalization Leading to Synthesis of 2,5-Substituted 1,3,4-Oxadiazoles
2011
Generation of a Set of Simple, Interpretable ADMET Rules of Thumb
2008
Computational Modeling Approaches to Structure−Function Analysis of G Protein-Coupled Receptors
2005
Synthesis of 5-Substituted Indole Derivatives. Part 4: Naratriptan from α-Anilinoacetaldehyde Dimethylacetal by TiCl4-Mediated Cyclisation
2003
The Cinchona Primary Amine-Catalyzed Asymmetric Epoxidation and Hydroperoxidation of α,β-Unsaturated Carbonyl Compounds with Hydrogen Peroxide
2013 StandoutNobel
Targeted Delivery of mRNA with One-Component Ionizable Amphiphilic Janus Dendrimers
2021 StandoutNobel
Prediction of membrane protein structures with complex topologies using limited constraints
2009 StandoutNobel
A Heck–Matsuda Process for the Synthesis of β‐Arylethenesulfonyl Fluorides: Selectively Addressable Bis‐electrophiles for SuFEx Click Chemistry
2016 StandoutNobel
Pharmacology of the Na v 1.1 domain IV voltage sensor reveals coupling between inactivation gating processes
2017 StandoutNobel
Catalytic Asymmetric Epoxidation of α-Branched Enals
2010 StandoutNobel
Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions
2016 Standout
Functional analysis of fruitless gene expression by transgenic manipulations of Drosophila courtship
2005 StandoutNobel
Complete Field Guide to Asymmetric BINOL-Phosphate Derived Brønsted Acid and Metal Catalysis: History and Classification by Mode of Activation; Brønsted Acidity, Hydrogen Bonding, Ion Pairing, and Metal Phosphates
2014 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
Update 1 of: Computational Modeling Approaches to Structure–Function Analysis of G Protein-Coupled Receptors
2011
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
5-HT2AReceptor-Mediated Regulation of Brain-Derived Neurotrophic Factor mRNA in the Hippocampus and the Neocortex
1997
Asymmetric Enamine Catalysis
2007 StandoutNobel
Enzyme-Controlled Nitrogen-Atom Transfer Enables Regiodivergent C–H Amination
2014 StandoutNobel
Cytochrome P450 and Chemical Toxicology
2007
Structural Adaptability Facilitates Histidine Heme Ligation in a Cytochrome P450
2015 StandoutNobel
Works of Frank E. Blaney being referenced
Structural Determinants of Drugs Acting on the Nav1.8 Channel
2009
Modeling the pore structure of voltage-gated sodium channels in closed, open, and fast-inactivated conformation reveals details of site 1 toxin and local anesthetic binding
2006
Comparison of azabicyclic esters and oxadiazoles as ligands for the muscarinic receptor
1991
A molecular mechanism for toxin block in N-type calcium channels
1998
Unifying Family A GPCR Theories of Activation
2014
Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling
2000
Modeling GPCR active state conformations: The β2‐adrenergic receptor
2011
3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors
2006
Crystal Structure of Human Cytochrome P450 2D6
2005
Novel 5-HT1A/1B/1D receptors antagonists with potent 5-HT reuptake inhibitory activity
2008
5-HT2 receptor subtypes: A family re-united?
1995
Models of ion pores in N-type voltage-gated calcium channels
1995
6-Chloro-5-methyl-1-[[2-[(2-methyl-3- pyridyl)oxy]-5-pyridyl]carbamoyl]indoline (SB-242084): The First Selective and Brain Penetrant 5-HT2C Receptor Antagonist
1997
Synthesis, Biological Activity, and Molecular Modeling Studies of Selective 5-HT2C/2B Receptor Antagonists
1996
Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure−Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines
1998
Stepwise Modulation of Neurokinin-3 and Neurokinin-2 Receptor Affinity and Selectivity in Quinoline Tachykinin Receptor Antagonists
2001
Definition of the G Protein-Coupled Receptor Transmembrane Bundle Binding Pocket and Calculation of Receptor Similarities for Drug Design
2009
Evidence for the Proximity of the Extreme N-Terminus of the Neurokinin-2 (NK2) Tachykinin Receptor to Cys167 in the Putative Fourth Transmembrane Helix
2004
Unified Route to the Palmarumycin and Preussomerin Natural Products. Enantioselective Synthesis of (−)-Preussomerin G
2002
CCR2: Characterization of the Antagonist Binding Site from a Combined Receptor Modeling/Mutagenesis Approach
2003