Standout Papers
Citation Impact
Citing Papers
A Prokaryotic Voltage-Gated Sodium Channel
2001 Science
Gating the Selectivity Filter in ClC Chloride Channels
2003 StandoutScienceNobel
Lack of an effect of dairy protein (casein) and soy protein on plasma cholesterol of strict vegetarians. An experiment and a critical review.
1983
The open pore conformation of potassium channels
2002 StandoutNatureNobel
Structure of a mammalian ryanodine receptor
2014 StandoutNatureNobel
Matters of life and death: programmed cell death at Cold Spring Harbor
1998
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
Electrostatic interactions of S4 voltage sensor in shaker K+ channel
1995
Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron–principal neuron synapse
2005
Hypocholesterolemic effect of vegetable protein in a hypocaloric diet
1989
Intake of 25 g of Soybean Protein with or without Soybean Fiber Alters Plasma Lipids in Men with Elevated Cholesterol Concentrations
1994
Probing the outer vestibule of a sodium channel voltage sensor
1997
Discoveries in structure and physiology of mechanically activated ion channels
2020 StandoutNatureNobel
Mutations in an S4 segment of the adult skeletal muscle sodium channel cause paramyotonia congenita
1992
Multiple subunits of a voltage-dependent potassium channel contribute to the binding site for tetraethylammonium
1992
Molecular mechanisms of nociception
2001 StandoutNatureNobel
TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells
2018
Voltage-Sensing Residues in the S2 and S4 Segments of the Shaker K+ Channel
1996
Calcium-activated potassium channels expressed from cloned complementary DNAs
1992 StandoutNobel
Heteromultimeric channels formed by rat brain potassium-channel proteins
1990 StandoutNatureNobel
Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel
1996
Effects of soy protein and casein in low cholesterol diets on plasma lipoproteins in normolipidemic subjects
1988
X-ray structure of a voltage-dependent K+ channel
2003 StandoutNatureNobel
Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women
1994
Crystal structure and mechanism of a calcium-gated potassium channel
2002 StandoutNatureNobel
Ion Permeation through a Voltage- Sensitive Gating Pore in Brain Sodium Channels Having Voltage Sensor Mutations
2005
Diversity and ubiquity of K channels
1988
Pores Formed by Single Subunits in Mixed Dimers of Different CLC Chloride Channels
2001
Temperature-sensitive mutations in the III–IV cytoplasmic loop region of the skeletal muscle sodium channel gene in paramyotonia congenita
1992
Rapid gating and anion permeability of an intracellular aquaporin
1999 StandoutNatureNobel
Projection structure of a ClC-type chloride channel at 6.5 Å resolution
2001 Nature
Recombinant G-protein βγ-subunits activate the muscarinic-gated atrial potassium channel
1994 StandoutNatureNobel
Evidence for voltage-dependent S4 movement in sodium channels
1995
Soybean protein diet increases low density lipoprotein receptor activity in mononuclear cells from hypercholesterolemic patients.
1987
Chemistry of ion coordination and hydration revealed by a K+ channel–Fab complex at 2.0 Å resolution
2001 StandoutNatureNobel
Identification of a mutation in the gene causing hyperkalemic periodic paralysis
1991
Primary structure and functional expression from complementary DNA of a brain calcium channel
1991 Nature
Piezo proteins are pore-forming subunits of mechanically activated channels
2012 StandoutNatureNobel
Contribution of the S4 Segment to Gating Charge in the Shaker K+ Channel
1996 StandoutNobel
Dynamics of rat entorhinal cortex layer II and III cells: characteristics of membrane potential resonance at rest predict oscillation properties near threshold
2004
Evidence for cooperative interactions in potassium channel gating
1992 Nature
Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in shaker K+ channels
1991
Molecular Basis of Charge Movement in Voltage-Gated Sodium Channels
1996
Bcl-2-family proteins: the role of the BH3 domain in apoptosis
1998
Effects of a soy-protein beverage on plasma lipoproteins in children with familial hypercholesterolemia
1991
Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge
1992
Cloning and expression of an inwardly rectifying ATP-regulated potassium channel
1993 Nature
Depression of plasma cholesterol in men by consumption of baked products containing soy protein
1993
Bcl-2 Undergoes Phosphorylation by c-Jun N-terminal Kinase/Stress-activated Protein Kinases in the Presence of the Constitutively Active GTP-binding Protein Rac1
1997
Molecular mechanism of cyclic-nucleotide-gated channel activation
1994 Nature
Bax in Murine Thymus Is a Soluble Monomeric Protein That Displays Differential Detergent-induced Conformations
1998
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
1994 StandoutNatureNobel
Pore loops: An emerging theme in ion channel structure
1995 StandoutNobel
Toward the molecular structure of the mitochondrial channel, VDAC
1992
Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology
2010
Changes in densities and kinetics of delayed rectifier potassium channels during neuronal differentiation
1988
Role of Bcl‐2 family proteins in apoptosis: apoptosomes or mitochondria?
1998
The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis
2004
Effect of soy protein diet versus standard low fat, low cholesterol diet on lipid and lipoprotein levels in children with familial or polygenic hypercholesterolemia
1993
Novel potassium channels encoded by the Shaker locus in drosophila photoreceptors
1991
The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
2004 StandoutNobel
Structural determinants of ion selectivity in brain calcium channel
1993
The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
1999
Structure and function of voltage‐gated sodium channels at atomic resolution
2013
The Mitochondrial F0F1-ATPase Proton Pump Is Required for Function of the Proapoptotic Protein Bax in Yeast and Mammalian Cells
1998
Primary structure and functional expression of a mouse inward rectifier potassium channel
1993 Nature
Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
1998
Gating charge differences between two voltagegated K+ channels are due to the specific charge content of their respective S4 regions
1993
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily
2005
Voltage gating of ion channels
1994
Atomic scale structure and functional models of voltage-gated potassium channels
1992
From Ionic Currents to Molecular Mechanisms
2000 Standout
Metal Ions, pH, and Cholesterol Regulate the Interactions of Alzheimer's Disease Amyloid-β Peptide with Membrane Lipid
2003
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Differential contribution by conserved glutamate residues to an ion‐selectivity site in the L‐type Ca2+ channel pore
1993
Regulation of apoptosis by BH3 domains in a cell-free system
1997
Bax Inhibitor-1, a Mammalian Apoptosis Suppressor Identified by Functional Screening in Yeast
1998
Voltage-gated sodium channels expressed in the human cerebellar medulloblastoma cell line TE671
1990
Three Transmembrane Conformations and Sequence-Dependent Displacement of the S4 Domain in Shaker K + Channel Gating
1998
A dual-Ca2+-sensor model for neurotransmitter release in a central synapse
2007 StandoutNatureNobel
Transmembrane Movement of the Shaker K+ Channel S4
1996
Charge displacements in a single potassium ion channel macromolecule during gating
1994
The principle of gating charge movement in a voltage-dependent K+ channel
2003 StandoutNatureNobel
A Met-to-Val mutation in the skeletal muscle Na+ channel α-subunit in hyperkalaemic periodic paralysis
1991 Nature
Interaction of hydrophobic anions with the rat skeletal muscle chloride channel ClC‐1: effects on permeation and gating
2001
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence
1991 Nature
The role of Drosophila Piezo in mechanical nociception
2012 StandoutNatureNobel
Dietary treatment for familial hypercholesterolemia—differential effects of dietary soy protein according to the apolipoprotein E phenotypes
1991
Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids
1995 Standout
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion
1995 Nature
Determination of the subunit stoichiometry of a voltage-activated potassium channel
1991 StandoutNatureNobel
The internal quaternary ammonium receptor site of Shaker potassium channels
1993
X-ray structure of a ClC chloride channel at 3.0 Å reveals the molecular basis of anion selectivity
2002 StandoutNatureNobel
Structure and Function of the Voltage Sensor of Sodium Channels Probed by a β-Scorpion Toxin
2006
Voltage-sensing residues in the S4 region of a mammalian K+ channel
1991 Nature
Mtd, a Novel Bcl-2 Family Member Activates Apoptosis in the Absence of Heterodimerization with Bcl-2 and Bcl-XL
1998
Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC
1999 StandoutNature
Role of H5 domain in determining pore diameter and ion permeation through cyclic nucleotide-gated channels
1993 Nature
Calcium channel characteristics conferred on the sodium channel by single mutations
1992 Nature
SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome
1995 Standout
Cloning and expression localization of cDNA for rat homolog of TRP protein, a possible store-operated calcium (Ca2+) channel
1996
Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
1998
Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons
1992 StandoutNobel
Activation of the cloned muscarinic potassium channel by G protein βγ subunits
1994 StandoutNatureNobel
An emerging pharmacology of peptide toxins targeted against potassium channels
1988
Relaxation and fluctuations of membrane currents that flow through drug-operated channels
1977
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
Inward current channels activated by intracellular Ca in cultured cardiac cells
1981 StandoutNatureNobel
Single transient K channels in mammalian sensory neurons
1986
Potassium channels in cultured bovine adrenal chromaffin cells.
1985 StandoutNobel
Soybean protein independently lowers plasma cholesterol levels in primary hypercholesterolemia
1982
Soy protein and casein in cholesterol-enriched diets: effects on plasma lipoproteins in normolipidemic subjects
1989
Single channel recordings of Ca2+-activated K+ currents in rat muscle cell culture
1981 Nature
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation
1990 Science
A role for hydrophobic residues in the voltage-dependent gating of Shaker K+ channels.
1991
Pressure-sensitive ion channel in Escherichia coli.
1987
A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.
1990
Cholesterol-Lowering and HDL-Raising Properties of Lecithinated Soy Proteins in Type II Hyperlipidemic Patients
1985
Sodium channel mutations in paramyotonia congenita exhibit similar biophysical phenotypes in vitro.
1994
Single Na+ channel currents observed in cultured rat muscle cells
1980 StandoutNatureNobel
Acetylcholine activation of single muscarinic K+ channels in isolated pacemaker cells of the mammalian heart
1983 Nature
Fluctuations in the microsecond time range of the current through single acetylcholine receptor ion channels
1981 StandoutNatureNobel
Comparison of the effect of dietary meat versus dietary soybean protein on plasma lipids of hyperlipidemic individuals
1980
Hematopoietic Malignancies Demonstrate Loss-of-Function Mutations ofBAX
1998
A quantitative description of membrane currents in rabbit myelinated nerve.
1979
Interaction between tetraethylammonium and amino acid residues in the pore of cloned voltage-dependent potassium channels.
1991
Primary Structure And Functional Expression of the 5HT 3 Receptor, A Serotonin-gated Ion Channel
1991 StandoutScienceNobel
Activation of Shaker Potassium Channels
1998
Mechanism by which cyanine dyes measure membrane potential in red blood cells and phosphatidylcholine vesicles
1974
Selectivity Changes in Site-Directed Mutants of the VDAC Ion Channel: Structural Implications
1990 Science
Bax and Adenine Nucleotide Translocator Cooperate in the Mitochondrial Control of Apoptosis
1998 Science
Exchange of Conduction Pathways Between Two Related K + Channels
1991 Science
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
1985 StandoutNobel
Constancy of fasting serum cholesterol of healthy young women upon substitution of soy protein isolate for meat and dairy protein in medium and low fat diets
1986
Molecular Basis of Gating Charge Immobilization in Shaker Potassium Channels
1991 Science
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Single channel Ca2+ currents inHelix pomatia neurons
1981
A single point mutation confers tetrodotoxin and saxitoxin insensitivity on the sodium channel II
1989
Molecular Structure and Physiological Function of Chloride Channels
2002
Hypercholesterolaemia treated by soybean protein diet.
1987
Sodium Channel Activation Gating Is Affected by Substitutions of Voltage Sensor Positive Charges in All Four Domains
1997
The structure of ion channels in membranes of excitable cells
1989
Hippocampus-independent phase precession in entorhinal grid cells
2008 StandoutNatureNobel
Measurement of Ca2+ concentrations in living cells
1982
A Mutant of TTX-Resistant Cardiac Sodium Channels with TTX-Sensitive Properties
1992 Science
Ion permeation and selectivity in ClC-type chloride channels
2001
Electrostatics and the Gating Pore of Shaker Potassium Channels
2001
Molecular anatomy and molecular design of channel proteins
1990
Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions.
1983
Gating Current Noise Produced by Elementary Transitions in Shaker Potassium Channels
1994 Science
The Structure of the Potassium Channel: Molecular Basis of K + Conduction and Selectivity
1998 StandoutScienceNobel
Direct Physical Measure of Conformational Rearrangement Underlying Potassium Channel Gating
1996 Science
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
1989 StandoutNobel
Single channel activity associated with the calcium dependent outward current inHelix pomatia
1981 StandoutNobel
The Permeability Transition Pore Complex: A Target for Apoptosis Regulation by Caspases and Bcl-2–related Proteins
1998
Shaker potassium channel gating. III: Evaluation of kinetic models for activation.
1994
Bax directly induces release of cytochrome c from isolated mitochondria
1998
Soybean protein diets in the management of type II hyperlipoproteinaemia
1985
The Voltage Sensor in Voltage-Dependent Ion Channels
2000
Intermediate Conductances during Deactivation of Heteromultimeric Shaker Potassium Channels
1998
Cooperative interactions among subunits of a voltage-dependent potassium channel. Evidence from expression of concatenated cDNAs.
1992
K + Current Diversity Is Produced by an Extended Gene Family Conserved in Drosophila and Mouse
1990 Science
A Decade of CLC Chloride Channels: Structure, Mechanism, and Many Unsettled Questions
2000
MULTICENTRE STUDY OF SOYBEAN PROTEIN DIET FOR OUTPATIENT HYPERCHOLESTEROLÆMIC PATIENTS
1980
A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.
1992
A Functional Connection Between the Pores of Distantly Related Ion Channels as Revealed by Mutant K + Channels
1992 StandoutScienceNobel
Comparison of actions of soy protein and casein on metabolism of plasma lipoproteins and cholesterol in humans
1983
A non-disruptive technique for loading calcium buffers and indicators into cells
1981 StandoutNatureNobel
Conduction and selectivity in potassium channels
1983
A comparison of the effect of diets containing beef protein and plant proteins on blood lipids of healthy young men
1984
Synaptotagmin: a Calcium Sensor on the Synaptic Vesicle Surface
1992 StandoutScienceNobel
Mitochondria and Apoptosis
1998 StandoutScience
Gating of the Bacterial Sodium Channel, NaChBac
2004
Shaker potassium channel gating. II: Transitions in the activation pathway.
1994
A MOLECULAR DESCRIPTION OF NERVE TERMINAL FUNCTION
1983
The Size of Gating Charge in Wild-Type and Mutant Shaker Potassium Channels
1992 Science
Review of clinical studies on cholesterol-lowering response to soy protein
1991
Turnover of very low-density lipoprotein-apoprotein B is increased by substitution of soybean protein for meat and dairy protein in the diets of hypercholesterolemic men
1984
Atrial G protein-activated K+ channel: expression cloning and molecular properties.
1993
Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.
1992
MOLECULAR PROPERTIES OF VOLTAGE-SENSITIVE SODIUM CHANNELS
1986
Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells.
1988
Fecal cholesterol excretion studies in type II hypercholesterolemic patients treated with the soybean protein diet
1982
Bax interacts with the permeability transition pore to induce permeability transition and cytochromecrelease in isolated mitochondria
1998
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
2002 StandoutScienceNobel
Different Fast-Gate Regulation by External Cl− and H+ of the Muscle-Type Clc Chloride Channels
2001
Hypocholesterolemic effect of substituting soybean protein for animal protein in the diet of healthy young women
1978
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones
1982 StandoutNatureNobel
Gating currents and charge movements in excitable membranes
2006
Determinants of hypocholesterolemic response to soy and animal protein-based diets
1981
Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
1997
K+ Channels Gated by Voltage and Ions
1984
Molecular Localization of an Ion-Binding Site Within the Pore of Mammalian Sodium Channels
1992 Science
PGE2 modulates the tetrodotoxin‐resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP‐protein kinase A cascade.
1996
Effects of casein versus soy protein diets on serum cholesterol and lipoproteins in young healthy volunteers
1981
Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions
1998
Structural basis for gating charge movement in the voltage sensor of a sodium channel
2011 StandoutNobel
Influence of diets containing casein, soy isolate, and soy concentrate on serum cholesterol and lipoproteins in middle-aged volunteers
1982
A Component of Calcium-activated Potassium Channels Encoded by the Drosophila slo Locus
1991 Science
Shaker potassium channel gating. I: Transitions near the open state.
1994
Works of Franco Conti being referenced
Calcium dependent shifts of Na + channel activation correlated with the state dependence of calcium-binding to the pore
1998
Pursuing the structure and function of voltage-gated channels
1990
Single point mutations of the sodium channel drastically reduce the pore permeability without preventing its gating
1991
Quantal charge redistributions accompanying the structural transitions of sodium channels
1989
Structural parts involved in activation and inactivation of the sodium channel
1989 Nature
Mapping the site of block by tetrodotoxin and saxitoxin of sodium channel II
1991
Clinical experience with the soybean protein diet in the treatment of hypercholesterolemia
1979
Measurement of the conductance of the sodium channel from current fluctuations at the node of Ranvier.
1976
Channel noise in nerve membranes and lipid bilayers
1975
Subthreshold Behavior and Phenomenological Impedance of the Squid Giant Axon
1970
Conductance fluctuations from the inactivation process of sodium channels in myelinated nerve fibres*
1980
Non‐stationary fluctuations of the potassium conductance at the node of ranvier of the frog.
1984
The Muscle Chloride Channel ClC-1 Has a Double-Barreled Appearance that Is Differentially Affected in Dominant and Recessive Myotonia
1999
Potassium and sodium ion current noise in the membrane of the squid giant axon.
1975
Pressure dependence of the potassium currents of squid giant axon
1982
Gating currents of inactivating and non-inactivating potassium channels expressed in Xenopus oocytes
1991
SOYBEAN-PROTEIN DIET IN THE TREATMENT OF TYPE-II HYPERLIPOPROTEINÆMIA
1977
Fluorescence signals in ANS-stained squid giant axons during voltage-clamp
1971
The Steady-State Properties of an Ion Exchange Membrane with Mobile Sites
1966
Pressure dependence of sodium gating currents in the squid giant axon
1984
Inhibition of Bax Channel-Forming Activity by Bcl-2
1997 Science
Conductance of the sodium channel in myelinated nerve fibres with modified sodium inactivation.
1976
[7] Nonstationary noise analysis and application to patch clamp recordings
1992
Single channel recordings of K+ currents in squid axons
1980 StandoutNatureNobel