Standout Papers

Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device 2001 2026 2009 2017 1.6k
  1. Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device (2001)
    Todd Thorsen, Richard W. Roberts et al. Physical Review Letters
  2. Protein stability promotes evolvability (2006)
    Jesse D. Bloom, Christopher R. Otey et al. Proceedings of the National Academy of Sciences
  3. Exploring protein fitness landscapes by directed evolution (2009)
    Philip A. Romero, Frances H. Arnold Nature Reviews Molecular Cell Biology
  4. A synthetic multicellular system for programmed pattern formation (2005)
    Subhayu Basu, Yoram Gerchman et al. Nature
  5. Directed Evolution: Bringing New Chemistry to Life (2017)
    Frances H. Arnold Angewandte Chemie International Edition
  6. Engineering microbial consortia: a new frontier in synthetic biology (2008)
    Katie Brenner, Lingchong You et al. Trends in biotechnology
  7. Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes (2012)
    Pedro S. Coelho, Eric M. Brustad et al. Science
  8. A microfabricated fluorescence-activated cell sorter (1999)
    Charles Spence, Axel Scherer et al. Nature Biotechnology
  9. Why highly expressed proteins evolve slowly (2005)
    D. Allan Drummond, Jesse D. Bloom et al. Proceedings of the National Academy of Sciences
  10. Engineering new catalytic activities in enzymes (2020)
    Kai Chen, Frances H. Arnold Nature Catalysis
  11. Molecular evolution by staggered extension process (StEP) in vitro recombination (1998)
    Lori Giver, Zhixin Shao et al. Nature Biotechnology
  12. Programmed population control by cell–cell communication and regulated killing (2004)
    Lingchong You, Robert Sidney Cox et al. Nature
  13. Design by Directed Evolution (1998)
    Frances H. Arnold Accounts of Chemical Research
  14. Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life (2016)
    S. B. Jennifer Kan, Russell D. Lewis et al. Science
  15. Long-Term Monitoring of Bacteria Undergoing Programmed Population Control in a Microchemostat (2005)
    Frederick Balagadde, Lingchong You et al. Science
  16. Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution (2015)
    Hans Renata, Z. Jane Wang et al. Angewandte Chemie International Edition
  17. Tuning the activity of an enzyme for unusual environments: sequential random mutagenesis of subtilisin E for catalysis in dimethylformamide. (1993)
    Kun Chen, Frances H. Arnold Proceedings of the National Academy of Sciences
  18. Directed evolution of a thermostable esterase (1998)
    Lori Giver, Anne Gershenson et al. Proceedings of the National Academy of Sciences
  19. Metal-Affinity Separations: A New Dimension in Protein Processing (1991)
    Frances H. Arnold Nature Biotechnology
  20. Machine learning-assisted directed protein evolution with combinatorial libraries (2019)
    Zachary Wu, S. B. Jennifer Kan et al. Proceedings of the National Academy of Sciences
  21. An Integrated Microfabricated Cell Sorter (2002)
    Hou-Pu Chou, Charles Spence et al. Analytical Chemistry
  22. A synthetic Escherichia coli predator–prey ecosystem (2008)
    Frederick Balagadde, Hao Song et al. Molecular Systems Biology
  23. In the light of directed evolution: Pathways of adaptive protein evolution (2009)
    Jesse D. Bloom, Frances H. Arnold Proceedings of the National Academy of Sciences
  24. Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase (2002)
    Anton Glieder, Edgardo T. Farinas et al. Nature Biotechnology
  25. Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation (1999)
    Hyun Joo, Zhanglin Lin et al. Nature
  26. Directed evolution of a para-nitrobenzyl esterase for aqueous-organic solvents (1996)
    Jeffrey C. Moore, Frances H. Arnold Nature Biotechnology
  27. Directed evolution of a genetic circuit (2002)
    Yohei Yokobayashi, Ron Weiss et al. Proceedings of the National Academy of Sciences
  28. Enzymatic functionalization of carbon–hydrogen bonds (2010)
    Jared C. Lewis, Pedro S. Coelho et al. Chemical Society Reviews
  29. Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme (2017)
    Christopher K. Prier, Ruijie K. Zhang et al. Nature Chemistry
  30. Atmospheric sulphuric acid and aerosol formation: implications from atmospheric measurements for nucleation and early growth mechanisms (2006)
    S.‐L. Sihto, Markku Kulmala et al. Atmospheric chemistry and physics
  31. Innovation by Evolution: Bringing New Chemistry to Life (Nobel Lecture) (2019)
    Frances H. Arnold Angewandte Chemie International Edition
  32. A serine-substituted P450 catalyzes highly efficient carbene transfer to olefins in vivo (2013)
    Pedro S. Coelho, Z. Jane Wang et al. Nature Chemical Biology
  33. Exploiting and engineering hemoproteins for abiological carbene and nitrene transfer reactions (2017)
    Oliver F. Brandenberg, Rudi Fasan et al. Current Opinion in Biotechnology
  34. Cytochrome P450: taming a wild type enzyme (2011)
    Sang Taek Jung, Ryan Lauchli et al. Current Opinion in Biotechnology
  35. Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization (2018)
    Ruijie K. Zhang, Kai Chen et al. Nature
  36. Enantioselective Intramolecular CH Amination Catalyzed by Engineered Cytochrome P450 Enzymes In Vitro and In Vivo (2013)
    John A. McIntosh, Pedro S. Coelho et al. Angewandte Chemie International Edition
  37. Genetically programmed chiral organoborane synthesis (2017)
    S. B. Jennifer Kan, Xiongyi Huang et al. Nature
  38. Navigating the protein fitness landscape with Gaussian processes (2012)
    Philip A. Romero, Andreas Krause et al. Proceedings of the National Academy of Sciences
  39. Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry (2014)
    Fei Sun, Wenbin Zhang et al. Proceedings of the National Academy of Sciences
  40. Navigating the Unnatural Reaction Space: Directed Evolution of Heme Proteins for Selective Carbene and Nitrene Transfer (2021)
    Yang Yang, Frances H. Arnold Accounts of Chemical Research
  41. Learned protein embeddings for machine learning (2018)
    Kevin Yang, Zachary Wu et al. Bioinformatics
  42. Enzymatic construction of highly strained carbocycles (2018)
    Kai Chen, Xiongyi Huang et al. Science
  43. Improved Cyclopropanation Activity of Histidine‐Ligated Cytochrome P450 Enables the Enantioselective Formal Synthesis of Levomilnacipran (2014)
    Z. Jane Wang, Hans Renata et al. Angewandte Chemie International Edition
  44. Combining chemistry and protein engineering for new-to-nature biocatalysis (2022)
    David C. Miller, Soumitra V. Athavale et al. Nature Synthesis
  45. Opportunities and Challenges for Machine Learning-Assisted Enzyme Engineering (2024)
    Jason Yang, Frances H. Arnold et al. ACS Central Science
  46. Active learning-assisted directed evolution (2025)
    Jason Yang, Sukhvinder Kaur et al. Nature Communications

Immediate Impact

44 by Nobel laureates 73 from Science/Nature 92 standout
Sub-graph 1 of 17

Citing Papers

Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
De novo design of modular protein hydrogels with programmable intra- and extracellular viscoelasticity
2024 StandoutNobel
38 intermediate papers

Works of Frances H. Arnold being referenced

The nature of chemical innovation: new enzymes by evolution
2015
Synthesis of bioactive protein hydrogels by genetically encoded SpyTag-SpyCatcher chemistry
2014 Standout
and 62 more

Author Peers

Author Last Decade Papers Cites
Frances H. Arnold 29192 5362 8139 8959 590 50.7k
William L. Jorgensen 46135 2674 18403 12400 465 102.7k
Erik Lindahl 39790 968 7183 7279 185 69.0k
David van der Spoel 31219 1176 6802 7110 162 60.0k
Michele Parrinello 32747 5556 10256 11013 668 110.8k
Peter A. Kollman 67883 1323 16781 7367 455 114.2k
Lee G. Pedersen 28653 759 5566 5079 222 49.3k
Wilfred F. van Gunsteren 39801 1257 7532 6733 528 68.8k
Jeffry D. Madura 23787 1397 4468 5380 118 42.4k
Jayaraman Chandrasekhar 21558 1423 8997 4376 178 46.3k
Kevin M. Smith 14322 913 3625 3765 975 35.0k

All Works

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2026