Standout Papers
Citation Impact
Citing Papers
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
The Protein-Folding Problem, 50 Years On
2012 Science
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
A designed heme-[4Fe-4S] metalloenzyme catalyzes sulfite reduction like the native enzyme
2018 Science
De novo design of picomolar SARS-CoV-2 miniprotein inhibitors
2020 StandoutScienceNobel
Generative models for graph-based protein design
2019
De novo design of modular and tunable protein biosensors
2021 StandoutNatureNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Ensemble-based enzyme design can recapitulate the effects of laboratory directed evolution in silico
2020
De Novo Design of a Highly Stable Ovoid TIM Barrel: Unlocking Pocket Shape towards Functional Design
2022
Platinum-catalyzed hydrofunctionalization of unactivated alkenes with carbon, nitrogen and oxygen nucleophiles
2007
Computational design of protein-small molecule interfaces
2013
Evolution of a designed retro-aldolase leads to complete active site remodeling
2013 StandoutNobel
Human Carbonic Anhydrase II as a host for piano-stool complexes bearing a sulfonamide anchor
2011
Beyond directed evolution—semi-rational protein engineering and design
2010
Increased Diels-Alderase activity through backbone remodeling guided by Foldit players
2012 StandoutNobel
Robust design and optimization of retroaldol enzymes
2012 StandoutNobel
Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
2012 StandoutNobel
Structural Analyses of Covalent Enzyme–Substrate Analog Complexes Reveal Strengths and Limitations of De Novo Enzyme Design
2011 StandoutNobel
Computational Enzyme Design
2013 StandoutNobel
Installing hydrolytic activity into a completely de novo protein framework
2016
Artificial Metalloenzymes as Catalysts in Stereoselective Diels–Alder Reactions
2012
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Intramolecular Hydroamination/Cyclisation of Aminoallenes Mediated by a Neutral Zirconocene Catalyst: A Computational Mechanistic Study
2007
Synthetic, Switchable Enzymes
2017
Role of the Biomolecular Energy Gap in Protein Design, Structure, and Evolution
2012 StandoutNobel
De novo design of luciferases using deep learning
2023 StandoutNatureNobel
Palladium(II)‐Catalyzed CH Activation/CC Cross‐Coupling Reactions: Versatility and Practicality
2009 Standout
Principles for designing ideal protein structures
2012 StandoutNatureNobel
An exciting but challenging road ahead for computational enzyme design
2010 StandoutNobel
Protein stability: computation, sequence statistics, and new experimental methods
2015
New Generation of Biocatalysts for Organic Synthesis
2014
Protein folding and de novo protein design for biotechnological applications
2013
Design and evolution of an enzyme with a non-canonical organocatalytic mechanism
2019 Nature
Gold(i)-catalyzed intramolecular hydroamination of unactivated alkenes with carboxamides
2006
Rational design of α-helical tandem repeat proteins with closed architectures
2015 StandoutNatureNobel
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Efficient Lewis acid catalysis of an abiological reaction in a de novo protein scaffold
2021
The coming of age of de novo protein design
2016 StandoutNatureNobel
Design of biologically active binary protein 2D materials
2021 StandoutNatureNobel
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
De Novo Proteins with Life-Sustaining Functions Are Structurally Dynamic
2015
Engineering an efficient and enantioselective enzyme for the Morita–Baylis–Hillman reaction
2021 StandoutNobel
A Promiscuous De Novo Retro‐Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates
2015
A designer enzyme for hydrazone and oxime formation featuring an unnatural catalytic aniline residue
2018
Improved protein structure prediction using potentials from deep learning
2020 StandoutNatureNobel
Evaluation and ranking of enzyme designs
2010 StandoutNobel
Enantioselective Enzymes by Computational Design and In Silico Screening
2015 StandoutNobel
De novo design of a fluorescence-activating β-barrel
2018 StandoutNatureNobel
Recent progress in industrial biocatalysis
2010
Mechanism‐Inspired Engineering of Phenylalanine Aminomutase for Enhanced β‐Regioselective Asymmetric Amination of Cinnamates
2011 StandoutNobel
Status of protein engineering for biocatalysts: how to design an industrially useful biocatalyst
2010
Catalytic alkene cyclohydroamination via an imido mechanism
2008
A new homogeneous zinc complex with increased reactivity for the intramolecular hydroamination of alkenes
2006
De Novo Enzyme Design Using Rosetta3
2011 StandoutNobel
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
De novo enzymes by computational design
2013
Exploring the repeat protein universe through computational protein design
2015 StandoutNatureNobel
Expanding P450 catalytic reaction space through evolution and engineering
2014 StandoutNobel
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Protein sequence design with a learned potential
2022
Multistate approaches in computational protein design
2012
Computational design of an endo-1,4- -xylanase ligand binding site
2011
Optimizing non-natural protein function with directed evolution
2010 StandoutNobel
An accurate binding interaction model in de novo computational protein design of interactions: If you build it, they will bind
2013
De novo protein design by deep network hallucination
2021 StandoutNatureNobel
Engineering the third wave of biocatalysis
2012 StandoutNature
De novo protein design by inversion of the AlphaFold structure prediction network
2023
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
BiCl3‐Catalyzed Hydroamination of Norbornene with Aromatic Amines
2007
Computational Design of an α-Gliadin Peptidase
2012 StandoutNobel
Computation-Guided Backbone Grafting of a Discontinuous Motif onto a Protein Scaffold
2011 StandoutScienceNobel
Fundamental Challenges in Mechanistic Enzymology: Progress toward Understanding the Rate Enhancements of Enzymes
2013
Hydroamination: Direct Addition of Amines to Alkenes and Alkynes
2008 Standout
Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors
2013 StandoutScienceNobel
Manufacturing Molecules Through Metabolic Engineering
2010 Science
P450BM3‐Axial Mutations: A Gateway to Non‐Natural Reactivity
2014 StandoutNobel
Addition of N−H and O−H Bonds of Amines and Alcohols to Electron-Deficient Olefins Catalyzed by Monomeric Copper(I) Systems: Reaction Scope, Mechanistic Details, and Comparison of Catalyst Efficiency
2007
Mild, Rhodium-Catalyzed Intramolecular Hydroamination of Unactivated Terminal and Internal Alkenes with Primary and Secondary Amines
2008
Design of Protein Catalysts
2013
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
De novo design of protein homo-oligomers with modular hydrogen-bond network–mediated specificity
2016 StandoutScienceNobel
New Tricks for Old Proteins: Single Mutations in a Nonenzymatic Protein Give Rise to Various Enzymatic Activities
2015
Protein design: Past, present, and future
2015
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Synthesis, Characterization, and Reactivity of Terminal Titanium Imido Complexes Incorporating Constrained-Geometry Carboranyl Ligands
2005
Gold‐Catalyzed Hydroamination of C–C Multiple Bonds
2006
Radical catalysis
2007 StandoutNatureNobel
Discovery and Protein Engineering of Biocatalysts for Organic Synthesis
2011
Directed Evolution of Protein Catalysts
2018
A computational method for design of connected catalytic networks in proteins
2019 StandoutNobel
Room Temperature Hydroamination ofN-Alkenyl Ureas Catalyzed by a Gold(I)N-Heterocyclic Carbene Complex
2006
A Pentagonal Pyramidal Zirconium Imido Complex for Catalytic Hydroamination of Unactivated Alkenes
2006
Highly Active Au(I) Catalyst for the Intramolecularexo-Hydrofunctionalization of Allenes with Carbon, Nitrogen, and Oxygen Nucleophiles
2006
Recent advances in metal free- and late transition metal-catalysed hydroamination of unactivated alkenes
2015
Iterative approach to computational enzyme design
2012
Biocatalysis in Organic Chemistry and Biotechnology: Past, Present, and Future
2013
Intermolecular Hydroamination of Methylenecyclopropane Catalyzed by Group IV Metal Complexes
2007
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design
2017 StandoutNobel
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Design of a hyperstable 60-subunit protein icosahedron
2016 StandoutNatureNobel
Catalysis by a De Novo Zinc-Mediated Protein Interface: Implications for Natural Enzyme Evolution and Rational Enzyme Engineering
2012
A Promiscuous De Novo Retro‐Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base Intermediates
2015
Activation of olefins via asymmetric Brønsted acid catalysis
2018 StandoutScienceNobel
Energy Functions in De Novo Protein Design: Current Challenges and Future Prospects
2013
Some Typical Advances in the Synthetic Applications of Allenes
2005 Standout
Combined Covalent-Electrostatic Model of Hydrogen Bonding Improves Structure Prediction with Rosetta
2015 StandoutNobel
Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
2014 StandoutNobel
Neutral and Cationic Alkyl Tantalum Imido Complexes: Synthesis and Migratory Insertion Reactions
2006
RosettaRemodel: A Generalized Framework for Flexible Backbone Protein Design
2011 StandoutNobel
Asymmetric Transition-Metal-Catalyzed Allylic Alkylations: Applications in Total Synthesis
2003 Standout
Bioinspired Catalyst Design and Artificial Metalloenzymes
2011
Works of Forrest E. Michael being referenced
Computational Design of an Enzyme Catalyst for a Stereoselective Bimolecular Diels-Alder Reaction
2010 StandoutScienceNobel
Computational Design of Enone-Binding Proteins with Catalytic Activity for the Morita–Baylis–Hillman Reaction
2013 StandoutNobel
Stereoselective synthesis of 2,5-disubstituted morpholines using a palladium-catalyzed hydroamination reaction
2013
Palladium(II)‐Catalyzed Intramolecular Hydroamination of 1,3‐Dienes to Give Homoallylic Amines
2013
C−H Bond Activation of Hydrocarbons by an Imidozirconocene Complex
2004
Room Temperature Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes
2006
Application of Chiral Mixed Phosphorus/Sulfur Ligands to Palladium-Catalyzed Allylic Substitutions
2000
Mechanisms of Allene Stereoinversion by Imidozirconium Complexes
2003
Rearrangements and Stereomutations of Metallacycles Derived from Allenes and Imidozirconium Complexes
2005
Application of Chiral Mixed Phosphorus/Sulfur Ligands to Enantioselective Rhodium-Catalyzed Dehydroamino Acid Hydrogenation and Ketone Hydrosilylation Processes
2003
Mechanistic Studies of a Palladium-Catalyzed Intramolecular Hydroamination of Unactivated Alkenes: Protonolysis of a Stable Palladium Alkyl Complex Is the Turnover-Limiting Step
2008