Standout Papers
Citation Impact
Citing Papers
A Tlr7 translocation accelerates systemic autoimmunity in murine lupus
2006
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
2009 StandoutNobel
Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
2004 StandoutScience
A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis
2021 StandoutScienceNobel
Yellow fever vaccine YF-17D activates multiple dendritic cell subsets via TLR2, 7, 8, and 9 to stimulate polyvalent immunity
2006
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
2012
Essential role of IPS-1 in innate immune responses against RNA viruses
2006
A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells
2005
Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses
2008
Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7
2005
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction
2005 Nature
IRF-7 is the master regulator of type-I interferon-dependent immune responses
2005 StandoutNature
IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
2006
The sweetness of the DNA backbone drives Toll-like receptor 9
2008
The Forward Genetic Dissection of Afferent Innate Immunity
2008 StandoutNobel
Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
2005 Nature
Regulation of the type I IFN induction: a current view
2005
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
2009
Extracellular miRNA: A Collision of Two Paradigms
2016
Type I Interferons in Host Defense
2006
mRNA-based therapeutics — developing a new class of drugs
2014 StandoutNobel
Genetic analysis of resistance to viral infection
2007 StandoutNobel
Lipid nanoparticle chemistry determines how nucleoside base modifications alter mRNA delivery
2021 StandoutNobel
Cell Type-Specific Involvement of RIG-I in Antiviral Response
2005
Toll-like receptor control of the adaptive immune responses
2004 Standout
Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines
2004
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Saturated Fatty Acid Activates but Polyunsaturated Fatty Acid Inhibits Toll-like Receptor 2 Dimerized with Toll-like Receptor 6 or 1
2004 Standout
Bacterial RNA is recognized by different sets of immunoreceptors
2009
mRNA
2013
Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells
2009
The Specific and Essential Role of MAVS in Antiviral Innate Immune Responses
2006
The roles of TLRs, RLRs and NLRs in pathogen recognition
2009
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
2004
The interface between innate and adaptive immunity
2004 StandoutNobel
Toll-like receptors in systemic autoimmune disease
2006
Toll-like receptors in innate immunity
2004 Standout
Intracellular Toll-like Receptors
2010 StandoutNobel
Distinct Poly(I-C) and Virus-activated Signaling Pathways Leading to Interferon-β Production in Hepatocytes
2005
Recognition of Double-stranded RNA by Human Toll-like Receptor 3 and Downstream Receptor Signaling Requires Multimerization and an Acidic pH
2005
The transmembrane domain directs TLR9 to intracellular compartments that contain TLR3
2006
Toll-like receptor signalling
2004 Standout
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study
2020 Standout
Regulatory T cells and cancer
2007
Nucleic acid agonists for Toll‐like receptor 7 are defined by the presence of uridine ribonucleotides
2006
The DNA Sugar Backbone 2′ Deoxyribose Determines Toll-like Receptor 9 Activation
2008
IκB kinase-α is critical for interferon-α production induced by Toll-like receptors 7 and 9
2006 Nature
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
2005 Standout
Ligand-induced conformational changes allosterically activate Toll-like receptor 9
2007
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses
2004 Standout
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9
2008
Innate immune recognition of viral infection
2006 Standout
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
2008
TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function
2004
The Functional Effects of Physical Interactions among Toll-like Receptors 7, 8, and 9
2006
Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response
2005 Nature
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
2004
Therapeutics targeting the innate immune system
2004
TLR signaling
2006 Standout
Viral recognition by Toll-like receptors
2007
Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA
2005
TLR3 and TLR7 Are Targeted to the Same Intracellular Compartments by Distinct Regulatory Elements
2005
The Interferon Regulatory Factor, IRF5, Is a Central Mediator of Toll-like Receptor 7 Signaling
2005
TLR3 in antiviral immunity: key player or bystander?
2005
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
2005 StandoutNobel
In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle
2013
Developing mRNA-vaccine technologies
2012
Innate immune recognition of nucleic acids: Beyond toll-like receptors
2005
Prophylactic mRNA vaccination against allergy
2010
T Cell-Independent and Toll-like Receptor-Dependent Antigen-Driven Activation of Autoreactive B Cells
2008
Functional Proteomics Reveals the Biochemical Niche of C. elegans DCR-1 in Multiple Small-RNA-Mediated Pathways
2006 StandoutNobel
The Unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7 and 9
2006 StandoutNobel
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
Plasmacytoid dendritic cells in immunity
2004
Toll-like receptors and innate immunity
2009
Porcine TLR8 and TLR7 are both activated by a selective TLR7 ligand, imiquimod
2008
Dendritic cells respond to influenza virus through TLR7‐ and PKR‐independent pathways
2004
TMEM41B Is a Pan-flavivirus Host Factor
2020 StandoutNobel
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
Pathogen Recognition and Innate Immunity
2006 Standout
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
2008 StandoutNobel
Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway
2007 StandoutNobel
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
The science of adjuvants
2007
Slc15a4, AP-3, and Hermansky-Pudlak syndrome proteins are required for Toll-like receptor signaling in plasmacytoid dendritic cells
2010 StandoutNobel
Sex-Based Differences in Susceptibility to Severe Acute Respiratory Syndrome Coronavirus Infection
2017
The Roles of Two IκB Kinase-related Kinases in Lipopolysaccharide and Double Stranded RNA Signaling and Viral Infection
2004
Identification of an N-Terminal Recognition Site in TLR9 That Contributes to CpG-DNA-Mediated Receptor Activation
2009
Differential Requirement for TANK-binding Kinase-1 in Type I Interferon Responses to Toll-like Receptor Activation and Viral Infection
2004
Replication-Dependent Potent IFN-α Induction in Human Plasmacytoid Dendritic Cells by a Single-Stranded RNA Virus
2004
Autoantibodies make a U-turn
2005
Recognition of single-stranded RNA viruses by Toll-like receptor 7
2004
Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function
2009 StandoutNobel
Expression of an anti‐RNA autoantibody in a mouse model of SLE increases neutrophil and monocyte numbers as well as IFN ‐I expression
2013
Immunologically Active Autoantigens: The Role of Toll-Like Receptors in the Development of Chronic Inflammatory Disease
2007
Cutting Edge: Innate Immune System Discriminates between RNA Containing Bacterial versus Eukaryotic Structural Features That Prime for High-Level IL-12 Secretion by Dendritic Cells
2004 StandoutNobel
Structure and Function of Toll Receptors and Their Ligands
2007
IFN Regulatory Factor 3-Dependent Induction of Type I IFNs by Intracellular Bacteria Is Mediated by a TLR- and Nod2-Independent Mechanism
2004
TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN
2009
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Naturally occurring nucleoside modifications suppress the immunostimulatory activity of RNA: implication for therapeutic RNA development.
2007 StandoutNobel
Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems
2014 StandoutNobel
Particle size and activation threshold: a new dimension of danger signaling
2010
Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires' disease
2005 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
2011 StandoutNobel
TYPE I INTERFERONS (α/β) IN IMMUNITY AND AUTOIMMUNITY
2004 StandoutNobel
TLR-Independent Induction of Dendritic Cell Maturation and Adaptive Immunity by Negative-Strand RNA Viruses
2004
Myeloid Differentiation Factor-88 Plays a Crucial Role in the Pathogenesis of Coxsackievirus B3–Induced Myocarditis and Influences Type I Interferon Production
2005
CpG RNA: Identification of Novel Single-Stranded RNA That Stimulates Human CD14+CD11c+ Monocytes
2005
Tools for translation: non-viral materials for therapeutic mRNA delivery
2017
Foxp3+natural regulatory T cells preferentially form aggregates on dendritic cellsin vitroand actively inhibit their maturation
2008 StandoutNobel
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
2008 StandoutNobel
IPC: Professional Type 1 Interferon-Producing Cells and Plasmacytoid Dendritic Cell Precursors
2004
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
2005
TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA
2008
Silencing or Stimulation? siRNA Delivery and the Immune System
2011
Differential Role for TLR3 in Respiratory Syncytial Virus-Induced Chemokine Expression
2005
Flavivirus Activation of Plasmacytoid Dendritic Cells Delineates Key Elements of TLR7 Signaling beyond Endosomal Recognition
2006
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
2007
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006 StandoutNobel
Toll-like receptor 8-mediated activation of murine plasmacytoid dendritic cells by vaccinia viral DNA
2010
Endosomal Translocation of Vertebrate DNA Activates Dendritic Cells via TLR9-Dependent and -Independent Pathways
2005
Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response
2006
In vivo hematopoietic stem cell modification by mRNA delivery
2023 StandoutScienceNobel
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-α induction
2005
Autophagy-Dependent Viral Recognition by Plasmacytoid Dendritic Cells
2007 Science
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
Toll-like Receptor 9–Dependent and –Independent Dendritic Cell Activation by Chromatin–Immunoglobulin G Complexes
2004
Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines
2023 StandoutNobel
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
2005
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
The interaction between the ER membrane protein UNC93B and TLR3, 7, and 9 is crucial for TLR signaling
2007 StandoutNobel
The microbial mimic poly IC induces durable and protective CD4+T cell immunity together with a dendritic cell targeted vaccine
2008 StandoutNobel
A Point Mutation in the Amino Terminus of TLR7 Abolishes Signaling without Affecting Ligand Binding
2011 StandoutNobel
Cutting Edge: Activation of Murine TLR8 by a Combination of Imidazoquinoline Immune Response Modifiers and PolyT Oligodeoxynucleotides
2006
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
2020 StandoutNobel
Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus
2005
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Florian Heil being referenced
Species-Specific Recognition of Single-Stranded RNA via Toll-like Receptor 7 and 8
2004 StandoutScience
The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
2003