Standout Papers
Citation Impact
Citing Papers
Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution
2009 StandoutScienceNobel
Schizosacharomyces pombe RNA polymerase II at 3.6-Å resolution
2009 Nobel
RNA polymerase II trigger loop residues stabilize and position the incoming nucleotide triphosphate in transcription
2010 StandoutNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Identification of a Small Interface between the Methyltransferase and RNA Polymerase of NS5 that is Essential for Zika Virus Replication
2018 StandoutNobel
Self-assembly of metal–organic polyhedra into supramolecular polymers with intrinsic microporosity
2018 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Uridine Depletion and Chemical Modification Increase Cas9 mRNA Activity and Reduce Immunogenicity without HPLC Purification
2018
A structure‐based benchmark for protein–protein binding affinity
2011
Engineering precision nanoparticles for drug delivery
2020 Standout
Establishing, maintaining and modifying DNA methylation patterns in plants and animals
2010 Standout
Tetraspanins at a glance
2014
Structural Basis of Transcription
2004 StandoutNobel
The ϕ29 DNA polymerase:protein‐primer structure suggests a model for the initiation to elongation transition
2006 StandoutNobel
Structural Basis of Transcription: Role of the Trigger Loop in Substrate Specificity and Catalysis
2006 StandoutNobel
Regulation of cell signalling by uPAR
2009
Structures of Complete RNA Polymerase II and Its Subcomplex, Rpb4/7
2005
Integrins in cancer: biological implications and therapeutic opportunities
2009 Standout
Structural basis for substrate loading in bacterial RNA polymerase
2007 Nature
Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment
2012 Standout
Visualizing polynucleotide polymerase machines at work
2006 StandoutNobel
Structure of transcribing mammalian RNA polymerase II
2016 Nature
Roles of RNA polymerase IV in gene silencing
2008
Post-transcriptional gene regulation by mRNA modifications
2016 Standout
Origins and Mechanisms of miRNAs and siRNAs
2009 Standout
Survey of the year 2004 commercial optical biosensor literature
2005
Structural visualization of key steps in human transcription initiation
2013 Nature
EMDataBank unified data resource for 3DEM
2015
The RNA Polymerase II Machinery
2002
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates
2014
Whither Ribosome Structure and Dynamics Research? (A Perspective)
2016 StandoutNobel
RNA polymerase II–TFIIB structure and mechanism of transcription initiation
2009 Nature
Recruitment of RNA polymerase III to its target promoters
2002
mRNA vaccines for infectious diseases: principles, delivery and clinical translation
2021 StandoutNobel
Unified two-metal mechanism of RNA synthesis and degradation by RNA polymerase
2003
Shedding light on the cell biology of extracellular vesicles
2018 Standout
Tetraspanins: push and pull in suppressing and promoting metastasis
2008
Structure of the Yeast RNA Polymerase II Holoenzyme
2002 StandoutNobel
Structure of Yeast RNA Polymerase II in Solution
2002
Complete RNA Polymerase II Elongation Complex Structure and Its Interactions with NTP and TFIIS
2004
Remodelling the extracellular matrix in development and disease
2014 Standout
RNA Polymerase II/TFIIF Structure and Conserved Organization of the Initiation Complex
2003 StandoutNobel
Structure of the Ultra-High-Affinity Colicin E2 DNase–Im2 Complex
2012 StandoutNobel
Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening
2012
SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs
2008 StandoutNobel
multifunctional enzymes in cancer
2006
Subunit Compositions of the RNA-Silencing Enzymes Pol IV and Pol V Reveal Their Origins as Specialized Forms of RNA Polymerase II
2008
Choosing an effective protein bioconjugation strategy
2011
Microenvironmental regulation of metastasis
2008 Standout
Survey of the year 2003 commercial optical biosensor literature
2004
Head Module Control of Mediator Interactions
2006 StandoutNobel
Site-specific chemical protein conjugation using genetically encoded aldehyde tags
2012 StandoutNobel
Glycosylation of the laminin receptor (α3β1) regulates its association with tetraspanin CD151: Impact on cell spreading, motility, degradation and invasion of basement membrane by tumor cells
2014
Targeting of tetraspanin proteins — potential benefits and strategies
2008
Reading, writing and erasing mRNA methylation
2019 Standout
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing
2005
Glycosylation in cancer: mechanisms and clinical implications
2015 Standout
Metal A and Metal B Sites of Nuclear RNA Polymerases Pol IV and Pol V Are Required for siRNA-Dependent DNA Methylation and Gene Silencing
2008
Identification of microRNAs of the herpesvirus family
2005 StandoutNobel
An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP
2002
Extracellular vesicles: Exosomes, microvesicles, and friends
2013 Standout
Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
2013 StandoutScienceNobel
Search and sequence analysis tools services from EMBL-EBI in 2022
2022 Standout
Diffusion of nucleoside triphosphates and role of the entry site to the RNA polymerase II active center
2004 StandoutNobel
Organic Photoredox Catalysis
2016 Standout
The Hitchhiker’s Guide to Flow Chemistry
2017 Standout
Quantitative Connection between Ensemble Thermodynamics and Single-Molecule Kinetics: A Case Study Using Cryogenic Electron Microscopy and Single-Molecule Fluorescence Resonance Energy Transfer Investigations of the Ribosome
2015 StandoutNobel
Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II
2004 StandoutScienceNobel
Structural insights into ribosome translocation
2016
Degradable Controlled-Release Polymers and Polymeric Nanoparticles: Mechanisms of Controlling Drug Release
2016 Standout
Architecture of initiation-competent 12-subunit RNA polymerase II
2003
A Pictet-Spengler ligation for protein chemical modification
2012 StandoutNobel
Contributions of Amino Acid Side Chains to the Kinetics and Thermodynamics of the Bivalent Binding of Protein L to Ig κ Light Chain
2004 StandoutNobel
Structural Basis for Transcription Regulation by Alarmone ppGpp
2004
Matrix Proteases in Health and Disease
2012
Structural Perspective on Mutations Affecting the Function of Multisubunit RNA Polymerases
2006
Metal‐Free Photocatalytic Aerobic Oxidation of Thiols to Disulfides in Batch and Continuous‐Flow
2015
Rotational Control of a Dirhodium-Centered Supramolecular Four-Gear System by Ligand Exchange
2016
A systematic dissection of determinants and consequences of snoRNA-guided pseudouridylation of human mRNA
2022 StandoutNobel
Structure of Eukaryotic RNA Polymerases
2008
Activatable Photosensitizers for Imaging and Therapy
2010 Standout
Complete, 12-subunit RNA polymerase II at 4.1-Å resolution: Implications for the initiation of transcription
2003 StandoutNobel
Surface Plasmon Resonance Sensors for Detection of Chemical and Biological Species
2008 Standout
Distinct Mechanisms of Transcription Initiation by RNA Polymerases I and II
2018
The translation elongation cycle—capturing multiple states by cryo-electron microscopy
2017 StandoutNobel
The A14–A43 heterodimer subunit in yeast RNA pol I and their relationship to Rpb4–Rpb7 pol II subunits
2002
Structural Basis of Transcription: An RNA Polymerase II-TFIIB Cocrystal at 4.5 Angstroms
2004 StandoutScienceNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Story in a sample—the potential (and limitations) of cryo‐electron microscopy applied to molecular machines
2013 StandoutNobel
Works of Finn Werner being referenced
The Initiation Factor TFE and the Elongation Factor Spt4/5 Compete for the RNAP Clamp during Transcription Initiation and Elongation
2011
Making connections — strategies for single molecule fluorescence biophysics
2013
Regulation of Urokinase Receptor Proteolytic Function by the Tetraspanin CD82
2005
Formation and Abundance of 5‐Hydroxymethylcytosine in RNA
2015
Tissue Plasminogen Activator Binds to Human Vascular Smooth Muscle Cells by a Novel Mechanism
1999
Archaeal RNA polymerase subunits F and P are bona fide homologs of eukaryotic RPB4 and RPB12
2000
Functional Regulation of Tissue Plasminogen Activator on the Surface of Vascular Smooth Muscle Cells by the Type-II Transmembrane Protein p63 (CKAP4)
2003
A Recombinant RNA Polymerase II-like Enzyme Capable of Promoter-Specific Transcription
2002
Characterization of low-glycosylated forms of soluble human urokinase receptor expressed in Drosophila Schneider 2 cells after deletion of glycosylation-sites
2004
Structure of an Archaeal Homolog of the Eukaryotic RNA Polymerase II RPB4/RPB7 Complex
2001
Spt4/5 stimulates transcription elongation through the RNA polymerase clamp coiled-coil motif
2010
Structure and function of archaeal RNA polymerases
2007
Evolution of multisubunit RNA polymerases in the three domains of life
2011
Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis
2011
Molecular Machines in Biology
2011 StandoutNobel
Assembly of Urokinase Receptor-Mediated Plasminogen Activation Complexes Involves Direct, Non-Active-Site Interactions between Urokinase and Plasminogen
1998
Direct Modulation of RNA Polymerase Core Functions by Basal Transcription Factors
2005