Standout Papers
Citation Impact
Citing Papers
Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors
2002 StandoutScienceNobel
New Murine Homeoboxes: Structure, Chromosomal Assignment, and Differential Expression in Adult Erythropoiesis
1987
The cultural mouse
2001 StandoutNobel
Evolution of a regulatory gene family: HOM/HOX genes
1993
A homeodomain substitution changes the regulatory specificity of the Deformed protein in drosophila embryos
1989
Organization of the Fugu rubripes Hox clusters: evidence for continuing evolution of vertebrate Hox complexes
1997 StandoutNobel
Maintenance of functional equivalence during paralogous Hox gene evolution
2000 StandoutNatureNobel
Mouse Hox-2.2 specifies thoracic segmental identity in Drosophila embryos and larvae
1990
A newantennapedia-class gene from the zebrafish
1991
extradenticle, a regulator of homeotic gene activity, is a homolog of the homeobox-containing human proto-oncogene pbx1
1993 StandoutNobel
Segmental expression of Hox-2 homoeobox-containing genes in the developing mouse hindbrain
1989 Nature
Homeotic transformations in the mouse induced by overexpression of a human Hox3.3 transgene
1992
A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
1993
Cloning of ascidian homeobox genes provides evidence for a primordial chordate cluster
1995
PCR-survey of hox-genes of the zebrafish: New sequence information and evolutionary implications
1996
Analysis of LacZ reporter genes in transgenic embryos suggests the presence of several cis‐acting regulatory elements in the murine Hoxb‐6 gene
1993
The Hox-1.3 homeo box protein is a sequence-specific DNA-binding phosphoprotein.
1989
Altering the boundaries of Hox3.1 expression: Evidence for antipodal gene regulation
1992
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
1993 StandoutNobel
Cloning and analysis of three new homeobox genes from the nematodeCaenorhabditis elegans
1990
Evolution of Antennapedia-Class Homeobox Genes
1996
The vertebrate limb: A model system to study the Hox/hom gene network during development and evolution
1992
Evolution of the vertebrate Hox homeobox genes
1992
Forty years with homologous recombination
2001 StandoutNobel
Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene
1992
Colinearity in the Xenopus laevis Hox-2 complex
1993
Autoregulation of a drosophila homeotic selector gene
1988
The murine and Drosophila homeobox gene complexes have common features of organization and expression
1989
The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
1988 Standout
Archetypal organization of the amphioxus Hox gene cluster
1994 Nature
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
1991 StandoutNobel
Homeobox genes and axial patterning
1992 Standout
Expression of Hox-2.4 homeobox gene directed by proviral insertion in a myeloid leukemia
1989
The sequence specificity of homeodomain-DNA interaction
1988
Translational activation of the lck proto-oncogene
1988 StandoutNatureNobel
A cloned octamer transcription factor stimulates transcription from lymphoid–specific promoters in non–B cells
1988 Nature
The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
1988 Nature
Deformed autoregulatory element from Drosophila functions in a conserved manner in transgenic mice
1992 Nature
Hox genes in vertebrate development
1994 Standout
Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium
1990
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
1991 Nature
Evidence for Four Hox Clusters in the KillifishFundulus heteroclitus(Teleostei)
1996
Microinjection of synthetic Xhox-1A homeobox mRNA disrupts somite formation in developing Xenopus embryos
1988
HoxGroup 3 Paralogs Regulate the Development and Migration of the Thymus, Thyroid, and Parathyroid Glands
1998 StandoutNobel
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
1997 Standout
Organization of four mouse lambda light chain immunoglobulin genes.
1981 StandoutNobel
Human Hepatocellular Carcinoma Cell Lines Secrete the Major Plasma Proteins and Hepatitis B Surface Antigen
1980 StandoutScience
Purification and characterization of proteins that bind to yeast ARSs.
1988
Molecular cloning and cell cycle-specific regulation of a functional human thymidine kinase gene.
1983
Sequences 5′ of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development
1993
The molecular control of spatial patterning in amphioxus
1994
Somatic generation of antibody diversity.
1976 StandoutNobel
NMR structure determination reveals that the homeodomain is connected through a flexible linker to the main body in the Drosophila Antennapedia protein.
1992 StandoutNobel
The human T-cell receptor α-chain gene maps to chromosome 14
1985 StandoutNatureNobel
An autoregulatory element of the murine Hox-4.2 gene.
1992
Genetic Dissection of Neural Properties using Somatic Cell Hybrids
1972
A chicken caudal homologue, CHox-cad, is expressed in the epiblast with posterior localization and in the early endodermal lineage
1991
An appraisal of the application of recombinant DNA techniques to chromosome defects
1985
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
1990 Standout
Regulation of thymidylate synthetase in mouse leukemia cells (L1210).
1980
Introduction and expression of a fetal human globin gene in mouse fibroblasts.
1982 StandoutNobel
Specification of axial identity in the mouse: role of the Hoxa-5 (Hox1.3) gene.
1993
MAPPING OF A HUMAN GENETIC REGULATOR ELEMENT BY SOMATIC CELL GENETIC ANALYSIS
1970
Dramatic growth of mice that develop from eggs microinjected with metallothionein–growth hormone fusion genes
1982 Nature
Human gene mapping using an X/autosome translocation
1976
An amphioxus homeobox gene: sequence conservation, spatial expression during development and insights into vertebrate evolution
1992
Microinjection of a rabbit beta-globin gene into zygotes and its subsequent expression in adult mice and their offspring.
1981
Green Fluorescent Protein as a Marker for Gene Expression
1994 StandoutScienceNobel
Analysis of the murine Hox-2.7 gene: conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions.
1992
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
1979 StandoutNobel
The T cell receptor β chain genes are located on chromosome 6 in mice and chromosome 7 in humans
1984
Structure and activity of regulatory elements involved in the activation of the Hoxd-11 gene during late gastrulation.
1993
Cotransfer of circular and linear prokaryotic and eukaryotic DNA sequences into mouse cells.
1980
Control of thymidine kinase mRNA during the cell cycle.
1987
Regulation of Adenosine 3′,5′-Cyclic Monophosphate Metabolism in Cultured Neuroblastoma Cells
1971 StandoutNatureNobel
Lipofection: a highly efficient, lipid-mediated DNA-transfection procedure.
1987 Standout
Zebrafish hox genes: genomic organization and modified colinear expression patterns in the trunk
1998
Murine Developmental Control Genes
1990 Science
Homeobox genes in the ribbonwormLineus sanguineus: Evolutionary implications
1998
Cell cycle regulated synthesis of stable mouse thymidine kinase mRNA is mediated by a sequence within the cDNA
1987
Expression of c-kit gene products in known cellular targets of W mutations in normal and W mutant mice--evidence for an impaired c-kit kinase in mutant mice.
1989
The mouse Hox-1.3 gene is functionally equivalent to the Drosophila Sex combs reduced gene.
1993
Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene.
1988
Introduction of a rabbit β-globin gene into the mouse germ line
1981 Nature
Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression.
1991
Expression of a Microinjected Porcine Class I Major Histocompatibility Complex Gene in Transgenic Mice
1985 StandoutScienceNobel
Homeobox genes in normal hematopoiesis and leukemia
1992
New procedure for DNA transfection with polycation and dimethyl sulfoxide.
1984
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).
1988
Isolation of a recombinant copy of the gene encoding C/EBP.
1988
Identification of a third type of lambda light chain in mouse immunoglobulins.
1981
Structure, organization, and somatic rearrangement of T cell gamma genes
1985
Separate elements cause lineage restriction and specify boundaries of Hox-1·1 expression
1991
Conservation of synteny between the genome of the pufferfish (Fugu rubripes) and the region on human chromosome 14 (14q24.3) associated with familial Alzheimer disease (AD3 locus)
1996 StandoutNobel
A murine even-skipped homologue, Evx 1, is expressed during early embryogenesis and neurogenesis in a biphasic manner.
1990
Gain of function mutations for paralogous Hox genes: implications for the evolution of Hox gene function.
1995
Zebrafish hox Clusters and Vertebrate Genome Evolution
1998 StandoutScience
Chromosomal Locations of the Murine T-Cell Receptor Alpha-Chain Gene and the T-Cell Gamma Gene
1985 StandoutScienceNobel
Expression of the T-cell-specific γ gene is unnecessary in T cells recognizing class II MHC determinants
1985 StandoutNatureNobel
Isolation of functional cDNA clones for human thymidylate synthase.
1984
Distribution of ribosomal gene length variants among mouse chromosomes.
1982
DNA rearrangement of a homeobox gene in myeloid leukaemic cells.
1988
Fate of teratocarcinoma cells injected into early mouse embryos
1975 StandoutNatureNobel
Enzymatic Amplification of β-Globin Genomic Sequences and Restriction Site Analysis for Diagnosis of Sickle Cell Anemia
1985 StandoutScienceNobel
Clusters of Master Control Genes Regulate the Development of Higher Organisms
1992 StandoutNobel
Cotransfer of two linked human genes into cultured mouse cells.
1976
Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity
1996
Control of Thymidylate Synthase mRNA Content and Gene Transcription in an Overproducing Mouse Cell Line
1985
New Procedure for DNA Transfection with Polycation and Dimethyl Sulfoxide
1984
Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs
1981
Physical linkage of the constant region genes for immunoglobulins lambda I and lambda III.
1981
Regulation of Axon Formation by Clonal Lines of a Neural Tumor
1970 StandoutNobel
Genetic analysis of the dominant white-spotting (W) region on mouse chromosome 5: identification of cloned DNA markers near W.
1988
Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis
1993 StandoutNobel
Chromosome assignment of some human enzyme loci: mitochondrial malate dehydrogenase to 7, mannosephosphate isomerase and pyruvate kinase to 15 and probably, esterase D to 13
1975
High efficiency transformation by direct microinjection of DNA into cultured mammalian cells
1980 StandoutNobel
Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts.
1980
Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice
1993
Expression of homeo box genes during mouse development: a review.
1988
Amino acid substitution matrices from an information theoretic perspective
1991
HLA membrane antigens: sequencing by intrinsic radioactivity.
1976 StandoutNobel
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
1986 StandoutNobel
Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins.
1989
A mouse gene homologous to the Drosophila gene caudal is expressed in epithelial cells from the embryonic intestine.
1988
Murine genes related to the Drosophila AbdB homeotic genes are sequentially expressed during development of the posterior part of the body.
1991
Rescue and regulation of proboscipedia: a homeotic gene of the Antennapedia Complex
1991
Rearrangement and transcription of a T-cell receptor beta-chain gene in different T-cell subsets.
1985
Expression of Genes for Metabolism of Cyclic Adenosine 3′:5′-Monophosphate in Somatic Cells
1973 StandoutNobel
Reversion of Malignancy and Normalized Differentiation of Teratocarcinoma Cells in Chimeric Mice
1978
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Developmental and spatial patterns of expression of the mouse homeobox gene,Hox2.1
1987
Microfilaments in Cellular and Developmental Processes
1971 StandoutScience
Coordinate modulation of transfected HSV thymidine kinase and human globin genes
1983 StandoutNobel
Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction
1992 StandoutScience
Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.
1987
Ribosomal DNA spacer-length polymorphisms in barley: mendelian inheritance, chromosomal location, and population dynamics.
1984 Standout
Conservation of autosomal gene synteny groups in mouse and man
1978 Nature
Identification of a retinoic acid response element upstream of the murine Hox-4.2 gene.
1993
Transformation of murine LMTK? cells with purified HLA class I genes
1983
Unusual association of V, J and C regions in a mouse immunoglobulin λ chain
1982 Nature
Xenogeneic gene expression in chimeric mice derived from rat--mouse hybrid cells.
1979
Role in translation of a triple tandemly repeated sequence in the 5′-untranslated region of human thymidylate synthase mRNA
1987 StandoutNobel
Identification and purification of a factor that binds to the Mlu I cell cycle box of yeast DNA replication genes.
1991 StandoutNobel
Genes for Neuronal Properties Expressed in Neuroblastoma × L Cell Hybrids
1971
High-affinity binding sites for the Deformed protein are required for the function of an autoregulatory enhancer of the Deformed gene.
1991
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes.
1982 StandoutNobel
Molecular bases of dominant negative and loss of function mutations at the murine c-kit/white spotting locus: W37, Wv, W41 and W.
1990
The zebrafish homeobox gene hox-2.2: transcription unit, potential regulatory regions and in situ localization of transcripts.
1990
Mouse immune interferon (IFN-?) gene is on chromosome 10
1984
Efficient gene transfer in C.elegans: extrachromosomal maintenance and integration of transforming sequences.
1991 StandoutNobel
A yeast artificial chromosome containing the mouse homeobox cluster Hox-2.
1990
Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines
1984 StandoutNatureNobel
Insertion of DNA sequences into the human chromosomal β-globin locus by homologous recombination
1985 StandoutNatureNobel
Somatic generation of antibody diversity
1983 StandoutNatureNobel
Promoter specificity and modulation of RNA polymerase II transcription
1989
Differential utilization of the same reading frame in a Xenopus homeobox gene encodes two related proteins sharing the same DNA-binding specificity.
1988
Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia.
1992
Cell cycle-dependent regulation of thymidine kinase activity introduced into mouse LMTK- cells by DNA and chromatin-mediated gene transfer.
1981
Embryonic-fetal erythroid characteristics of a human leukemic cell line.
1980
The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain.
1988
Modulation of transfected gene expression mediated by changes in chromatin structure
1982
Genetic Transformation of Drosophila with Transposable Element Vectors
1982 StandoutScience
Restricted association of V and J-C gene segments for mouse lambda chains.
1984 StandoutNobel
Expression of Genes for Metabolism of Cyclic Adenosine 3′:5′-Monophosphate in Somatic Cells
1973 StandoutNobel
Nucleosomes in metaphase chromosomes
1976 StandoutNobel
Human and mouse cellularmyc protooncogenes reside on chromosomes involved in numerical and structural aberrations in cancer 1
1983
In situ detection of sequence-specific DNA binding activity specified by a recombinant bacteriophage.
1988
Works of F.H. Ruddle being referenced
Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains.
1980
Phylogenetic reconstruction of vertebrate Hox cluster duplications
1997
Microcell-mediated transfer of murine chromosomes into mouse, Chinese hamster, and human somatic cells.
1977
Repression of the beta-amyloid gene in a Hox-3.1-producing cell line.
1992
Cotransfer of thymidine kinase and galactokinase genes by chromosome-mediated gene transfer.
1978
? 2-Microglobulin locus on human chromosome 15
1976 StandoutNobel
Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chains.
1981 Nobel
Genetic transformation of mouse embryos by microinjection of purified DNA.
1980
Mammalian Homeo Box Genes
1985
Detection of homeobox genes in development and evolution.
1991
Linkage Relationships of Seventeen Human Gene Loci as determined by Man-Mouse Somatic Cell Hybrids
1971
Structural analysis of the Hox-3.1 transcription unit and the Hox-3.2--Hox-3.1 intergenic region.
1990
Transfer of the human gene for hypoxanthine-guanine phosphoribosyltransferase via isolated human metaphase chromosomes into mouse L-cells.
1975
Localization of the casein gene family to a single mouse chromosome.
1982
Assignment of the genes for malate oxidoreductase decarboxylating to chromosome 6 and peptidase B and lactate dehydrogenase B to chromosome 12 in man.
1973
Assignment of the gene for galactokinase to human chromosome 17 and its regional localisation to band q21-22
1974 Nature
Chromosome-mediated gene transfer results in two classes of unstable transformants.
1980
Starch gel electrophoretic phenotypes of mouse×human somatic cell hybrids and mouse isozyme polymorphisms
1971
The genes coding for the muscle contractile proteins, myosin heavy chain, myosin light chain 2, and skeletal muscle actin are located on three different mouse chromosomes.
1982
Chromosomal assignment of the mouse kappa light chain genes.
1979
Function of the lactate dehydrogenase B gene in mouse erythrocytes: evidence for control by a regulatory gene.
1968
Homeobox genes in mouse development.
1991
Regulation of thymidylate synthetase activity in cultured mammalian cells
1972
Chromosomal assignment of gene encoding the largest subunit of RNA polymerase II in the mouse
1986
Molecular analysis of chromosome-mediated gene transfer.
1979
Partial purification and characterization of DNA from the human X chromosome.
1979
THE LINKAGE OF GENES FOR THE HUMAN INTERFERON-INDUCED ANTIVIRAL PROTEIN AND INDOPHENOL OXIDASE-B TRAITS TO CHROMOSOME G-21
1973
The evolution of the vertebrate Dlx gene family.
1996
Human nucleolus organizers on nonhomologous chromosomes can share the same ribosomal gene variants.
1981
Partial purification and characterization of the mRNA for human thymidine kinase and hypoxanthine/guanine phosphoribosyltransferase.
1982
Use of a protein-blotting procedure and a specific DNA probe to identify nuclear proteins that recognize the promoter region of the transferrin receptor gene.
1985
Mammalian homeobox-containing genes: genome organization, structure, expression and evolution.
1988
Duplication of large genomic regions during the evolution of vertebrate homeobox genes.
1989
Expression of paternal glucose phosphate isomerase-1 (Gpi-1) in preimplantation stages of mouse embryos
1971
Tay-Sachs' and Sandhoff's diseases: the assignment of genes for hexosaminidase A and B to individual human chromosomes.
1975
Phenotype stabilisation and integration of transferred material in chromosome-mediated gene transfer
1979 Nature
Location of genes coding for 18S and 28S ribosomal RNA within the genome of Mus musculus
1975
Evidence for positive and negative regulation of the Hox-3.1 gene.
1990
Linkage of isozyme loci in the mouse: Phosphoglucomutase-2 (Pgm-2), mitochondrial NADP malate dehydrogenase (Mod-2), and dipeptidase-1 (Dip-1)
1971
Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.
1986
Murine T cell receptor beta chain is encoded on chromosome 6.
1984
Mechanisms of DNA uptake by mammalian cells: fate of exogenously added DNA monitored by the use of fluorescent dyes.
1982
DNA sequence associated with chromosome translocations in mouse plasmacytomas.
1982
The homeo domain of a murine protein binds 5' to its own homeo box.
1986
Molecular cloning and structural analysis of murine thymidine kinase genomic and cDNA sequences.
1985
Structure and expression of Hox-2.2, a murine homeobox-containing gene.
1988
Genomic cloning and preliminary characterization of the human thymidine kinase gene.
1983
Expansion of the Hox gene family and the evolution of chordates.
1993
Identification of human genomic clones coding the major histocompatibility antigens HLA-a2 and HLA-B7 by DNA-mediated gene transfer.
1982
Deoxyribonucleic acid-mediated gene transfer in mammalian cells: molecular analysis of unstable transformants and their progression to stability.
1981
A new electrophoretic technique for mouse, human, and Chinese hamster galactokinase
1974
Human mitochondrial thymidine kinase is coded for by a gene on chromosome 16 of the nucleus
1977
Assignment of the genes for thymidine kinase and galactokinase toMus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids
1977
DNA-mediated gene transfer of a circular plasmid into murine cells.
1979
Assignment of the genes for human peptidase A to chromosome 18 and cytoplasmic glutamic oxaloacetate transaminase to chromosome 10 using somatic-cell hybrids
1973
Expression of liver phenotypes in cultured mouse hepatoma cells: Synthesis and secretion of serum albumin
1973
Chromosomal assignment of a family of human oncogenes.
1983
Report of the committee on the genetic constitution of autosomes other than chromosomes 1, 2, and 6
1976
Two steps in the evolution of Antennapedia-class vertebrate homeobox genes.
1989
Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus.
1988
Human c-fos oncogene mapped within chromosomal region 14q21----q31.
1984
Isolation of Microtubule Protein from Cultured Mouse Neuroblastoma Cells
1970