Standout Papers
Citation Impact
Citing Papers
CTLA-4 Control over Foxp3 + Regulatory T Cell Function
2008 StandoutScienceNobel
T cell metabolism drives immunity
2015
Immunomodulatory agents lenalidomide and pomalidomide co‐stimulate T cells by inducing degradation of T cell repressors I karos and A iolos via modulation of the E 3 ubiquitin ligase complex CRL 4 CRBN
2013
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
CD8+ T Cells Specific for Tumor Antigens Can Be Rendered Dysfunctional by the Tumor Microenvironment through Upregulation of the Inhibitory Receptors BTLA and PD-1
2011
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
2013 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance
2009
Foxp3 depends on Ikaros for control of regulatory T cell gene expression and function
2024
Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses
2020
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
2018
Strategies for late phase preclinical and early clinical trials of senolytics
2021
Confusing signals: Recent progress in CTLA-4 biology
2015
Aiolos promotes TH17 differentiation by directly silencing Il2 expression
2012
Physiological functions of the HECT family of ubiquitin ligases
2009
Correlation of Transcriptional Repression by p21SNFTwith Changes in DNA·NF-AT Complex Interactions
2002
Autophagy as a promoter of longevity: insights from model organisms
2018
Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections
2005 StandoutNatureNobel
Signals from the lysosome: a control centre for cellular clearance and energy metabolism
2013 Standout
Diet-derived advanced glycation end products or lipofuscin disrupts proteostasis and reduces life span in Drosophila melanogaster
2013
Autophagy in infection, inflammation and immunity
2013 Standout
The coming of age of chaperone-mediated autophagy
2018
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
2007
Chaperone-mediated autophagy sustains haematopoietic stem-cell function
2021 Nature
Autoregulation of NFATc1/A Expression Facilitates Effector T Cells to Escape from Rapid Apoptosis
2002
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
2007 Standout
Regulation of the Th2 Cytokine Locus by a Locus Control Region
2003
Autophagy and Cellular Immune Responses
2013
T cell exhaustion
2011 Standout
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
The lineage decisions of helper T cells
2002
Hallmarks of aging: An expanding universe
2023 Standout
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Egr-2 and Egr-3 are negative regulators of T cell activation
2005
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Transcriptional regulation by calcium, calcineurin, and NFAT
2003 Standout
Phagocytosis of apoptotic cells in homeostasis
2015
The role of NFAT transcription factors in integrin-mediated carcinoma invasion
2002 Standout
NFAT Regulation in Smooth Muscle
2003
Biological Functions of Autophagy Genes: A Disease Perspective
2019 Standout
rVistafor Comparative Sequence-Based Discovery of Functional Transcription Factor Binding Sites
2002
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
2013
Modulation of T Cell Cytokine Production by Interferon Regulatory Factor-4
2002
Deconvoluting the context-dependent role for autophagy in cancer
2012
Autophagy inhibition in cancer therapy: metabolic considerations for antitumor immunity
2012
Autophagy and human disease: emerging themes
2014
Autophagy and cancer therapy
2011
Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity
2000
An Slfn2 mutation causes lymphoid and myeloid immunodeficiency due to loss of immune cell quiescence
2010 StandoutNobel
Harnessing the plasticity of CD4+ T cells to treat immune-mediated disease
2016
Identifying the MAGUK Protein Carma-1 as a Central Regulator of Humoral Immune Responses and Atopy by Genome-Wide Mouse Mutagenesis
2003
Essential Role of the E3 Ubiquitin Ligase Cbl-b in T Cell Anergy Induction
2004
Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal
2009
NFAT1 and NFAT2 are positive regulators of IL-4 gene transcription
2002
Structure of NFAT1 bound as a dimer to the HIV-1 LTR κB element
2003
Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process
2003
Peptide-MHC potency governs dynamic interactions between T cells and dendritic cells in lymph nodes
2007
Induction of T cell anergy: integration of environmental cues and infectious tolerance
2010
Hallmarks of T cell aging
2021
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Receptor-mediated selective autophagy degrades the endoplasmic reticulum and the nucleus
2015 StandoutNatureNobel
Targeting autophagy in cancer
2017 Standout
Chaperone-mediated autophagy: a unique way to enter the lysosome world
2012
Instruction of Distinct CD4 T Helper Cell Fates by Different Notch Ligands on Antigen-Presenting Cells
2004 StandoutNobel
Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity
2024 StandoutNobel
Mechanisms maintaining peripheral tolerance
2009
An epigenetic view of helper T cell differentiation
2003
E3 ubiquitin ligases as T cell anergy factors
2004
Large Scale Gene Expression Analysis of Osteoclastogenesisin Vitro and Elucidation of NFAT2 as a Key Regulator
2002
Ikaros in immune receptor signaling, lymphocyte differentiation, and function
2010
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Induction and Activation of the Transcription Factor NFATc1 (NFAT2) Integrate RANKL Signaling in Terminal Differentiation of Osteoclasts
2002 Standout
Molecular damage in aging
2021
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
A guide to cancer immunotherapy: from T cell basic science to clinical practice
2020 Standout
Alternative activation of macrophages
2003 Standout
GRAIL
2003
Inferences, questions and possibilities in Toll-like receptor signalling
2004 StandoutNatureNobel
FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT
2006
NFATc2-Mediated Repression of Cyclin-Dependent Kinase 4 Expression
2002
Autophagy and Cancer Therapy
2014
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
2015
Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation
2014
Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1α (HIF-1α) for Lysosomal Degradation
2013 StandoutNobel
Inhibitory effect of dietary lipids on chaperone-mediated autophagy
2012
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo
2012
CD4+CD25−LAG3+regulatory T cells controlled by the transcription factor Egr-2
2009 StandoutNobel
Peptidic degron for IMiD-induced degradation of heterologous proteins
2019 StandoutNobel
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Constitutive Cytokine mRNAs Mark Natural Killer (NK) and NK T Cells Poised for Rapid Effector Function
2003
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Costimulation via OX40L Expressed by B Cells Is Sufficient to Determine the Extent of Primary CD4 Cell Expansion and Th2 Cytokine Secretion In Vivo
2003
New Insights into the Molecular Basis of T Cell Anergy: Anergy Factors, Avoidance Sensors, and Epigenetic Imprinting
2009
Early Growth Response Gene-2, a Zinc-Finger Transcription Factor, Is Required for Full Induction of Clonal Anergy in CD4+ T Cells
2004
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
2006
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
Activation and Deactivation of Gene Expression by Ca2+/Calcineurin-NFAT-mediated Signaling
2004
The bullseye synapse formed between CD4+ T‐cell and staphylococcal enterotoxin B‐pulsed dendritic cell is a suppressive synapse in T‐cell response
2014
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
T Cell Anergy
2003
PD-L1 and PD-L2 are differentially regulated by Th1 and Th2 cells
2003 StandoutNobel
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
The future of immune checkpoint therapy
2015 StandoutScienceNobel
Recent progress in autophagic lysosome reformation
2017
Autophagy pathway: Cellular and molecular mechanisms
2017 Standout
Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
2002
Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation
2013
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+regulatory T cells, evoking antitumor immune responses in humans
2013 StandoutNobel
PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
2010 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase
2010 StandoutNobel
Mitophagy confers resistance to siderophore-mediated killing by Pseudomonas aeruginosa
2015 StandoutNobel
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
Bridging the NFAT and NF-κB Families
2001
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Kinetic analysis of genomewide gene expression reveals molecule circuitries that control T cell activation and Th1/2 differentiation
2004
De novo design of protein logic gates
2020 StandoutScienceNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses
2012 StandoutNobel
Differential control of human Treg and effector T cells in tumor immunity by Fc-engineered anti–CTLA-4 antibody
2018 StandoutNobel
FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression
2007
Works of Fernando Macián being referenced
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance
2009
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis
2011
Autophagy in T Cell Function and Aging
2019
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
2004
An asymmetric NFAT1 dimer on a pseudo-palindromic κB-like DNA site
2003
Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun
2000
Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation
2014
T-cell anergy
2004
The lipid kinase PI4KIIIβ preserves lysosomal identity
2012
IL-2 signaling prevents T cell anergy by inhibiting the expression of anergy-inducing genes
2008
Partners in transcription: NFAT and AP-1
2001 Standout
A photoconvertible fluorescent reporter to track chaperone-mediated autophagy
2011
Autophagy and the immune function in aging
2014
Selective autophagy in the maintenance of cellular homeostasis in aging organisms
2011
NFAT proteins: key regulators of T-cell development and function
2005
Transcriptional Mechanisms Underlying Lymphocyte Tolerance
2002
TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
2002
Targeted Cleavage of Signaling Proteins by Caspase 3 Inhibits T Cell Receptor Signaling in Anergic T Cells
2008
Regulatory T cells suppress CD 4 + T cells through NFAT ‐dependent transcriptional mechanisms
2014
Silencing of the I l2 gene transcription is regulated by epigenetic changes in anergic T cells
2012
Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells
2006
Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity
2017
Age-associated changes in human CD4+ T cells point to mitochondrial dysfunction consequent to impaired autophagy
2019
Chaperone-Mediated Autophagy Is Required for Tumor Growth
2011
Reciprocal Modulatory Interaction between Human Immunodeficiency Virus Type 1 Tat and Transcription Factor NFAT1
1999
Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation
2010