Standout Papers
- Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency. (2000)
Citation Impact
Citing Papers
Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
2008 StandoutScienceNobel
Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice
2017 Science
Three pathways to mature macrophages in the early mouse yolk sac
2005
A key role for ATF3 in regulating mast cell survival and mediator release
2010
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
2012 StandoutScience
Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
2005
Sequential Binding of Cytosolic Phox Complex to Phagosomes through Regulated Adaptor Proteins: Evaluation Using the Novel Monomeric Kusabira-Green System and Live Imaging of Phagocytosis
2008
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
The stem cell niches in bone
2006
Rac GTPase Isoform-specific Regulation of NADPH Oxidase and Chemotaxis in Murine Neutrophils in Vivo
2004
Hematopoietic stem cell repopulating ability can be maintained in vitro by some primary endothelial cells
2004
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
2005
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Rac1 and Rac2 GTPases in haematopoiesis
2004
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
2010 StandoutNature
Oncogenic kinase signalling
2001 StandoutNature
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
2003 StandoutNature
Tumorigenic Cells Are Common in Mouse MPNSTs but Their Frequency Depends upon Tumor Genotype and Assay Conditions
2012
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
2014 StandoutNature
Influence of tumour micro-environment heterogeneity on therapeutic response
2013 StandoutNature
Genotoxicity of Retroviral Integration In Hematopoietic Cells
2006
The changing landscape of atherosclerosis
2021 StandoutNature
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
2014 StandoutNature
Effects of extracellular matrix viscoelasticity on cellular behaviour
2020 StandoutNature
Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
2010 StandoutNobel
The role of chemokine activation of Rac GTPases in hematopoietic stem cell marrow homing, retention, and peripheral mobilization
2006
Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia
2008
Cell type-specific functions of Rho GTPases revealed by gene targeting in mice
2006
The bone marrow niche for haematopoietic stem cells
2014 StandoutNature
Evolving synergistic combinations of targeted immunotherapies to combat cancer
2015
Short-term memory of danger signals and environmental stimuli in immune cells
2013
Putting tumours in context
2001 Standout
The effect of time-dependent deformation of viscoelastic hydrogels on myogenic induction and Rac1 activity in mesenchymal stem cells
2013
Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia
2006
RNA hyperediting and alternative splicing of hematopoietic cell phosphatase (PTPN6) gene in acute myeloid leukemia
2000
A role of PIEZO1 in iron metabolism in mice and humans
2021 StandoutNobel
Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life
2008
Mammalian Rho GTPases: new insights into their functions from in vivo studies
2008 Standout
The development of allergic inflammation
2008 StandoutNature
TWEAK, a New Secreted Ligand in the Tumor Necrosis Factor Family That Weakly Induces Apoptosis
1997
Rac2 Specificity in Macrophage Integrin Signaling
2003
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
2014 StandoutNature
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
2013 Standout
Orderly hematopoietic development of induced pluripotent stem cells via Flk‐1+ hemoangiogenic progenitors
2009 StandoutNobel
NF1 Tumor Suppressor Gene Function
2001
GTP‐binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo
2007
Regional Localization within the Bone Marrow Influences the Functional Capacity of Human HSCs
2013
Regulation of neutrophil function by Rac GTPases
2003
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
2010 Nature
Erythro-myeloid progenitors: “Definitive” hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells
2013
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
Hematopoietic Dysfunction in a Mouse Model for Fanconi Anemia Group D1
2006
Regulation of mast-cell and basophil function and survival by IgE
2002
Metastatic colonization by circulating tumour cells
2016 StandoutNature
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
2007 StandoutNature
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
2010
Rho GTPases and Regulation of Hematopoietic Stem Cell Localization
2008
Gene regulation by long non-coding RNAs and its biological functions
2020 Standout
Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development
2003
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
A prudent path forward for genomic engineering and germline gene modification
2015 StandoutScienceNobel
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic Protein 1 in lymphopoiesis and innate immunity
2008 StandoutNobel
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
Rac2 Regulates Neutrophil Chemotaxis, Superoxide Production, and Myeloid Colony Formation through Multiple Distinct Effector Pathways
2005
Vav1 and Rac Control Chemokine-promoted T Lymphocyte Adhesion Mediated by the Integrin α4β1
2005
Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring
1999 StandoutScience
Expression and Function of Leptin Receptor Isoforms in Myeloid Leukemia and Myelodysplastic Syndromes: Proliferative and Anti-Apoptotic Activities
1999
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Rac1-deficient macrophages exhibit defects in cell spreading and membrane ruffling but not migration
2004
Chemoattractant-Stimulated Rac Activation in Wild-Type and Rac2-Deficient Murine Neutrophils: Preferential Activation of Rac2 and Rac2 Gene Dosage Effect on Neutrophil Functions
2002
RhoH, a hematopoietic-specific Rho GTPase, regulates proliferation, survival, migration, and engraftment of hematopoietic progenitor cells
2004
Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
2008 StandoutScienceNobel
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells
2007
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
RhoG Regulates the Neutrophil NADPH Oxidase
2006
Ontogeny of the Hematopoietic System
2007
Generation and Characterization of Rac3 Knockout Mice
2005
Death Receptors: Signaling and Modulation
1998 StandoutScience
An essential role for Rac1 in endothelial cell function and vascular development
2008
Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases
2003 Science
Calcium mobilization and Rac1 activation are required for VCAM-1 (vascular cell adhesion molecule-1) stimulation of NADPH oxidase activity
2004
Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling
2007 StandoutNobel
Ubiquitous Transgenic Expression of the IL-23 Subunit p19 Induces Multiorgan Inflammation, Runting, Infertility, and Premature Death
2001
Biology and targeting of the Jumonji-domain histone demethylase family in childhood neoplasia: a preclinical overview
2019
Rac2 Is an Essential Regulator of Neutrophil Nicotinamide Adenine Dinucleotide Phosphate Oxidase Activation in Response to Specific Signaling Pathways
2001
Rho GTPase CDC42 regulates directionality and random movement via distinct MAPK pathways in neutrophils
2006
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Precision glycocalyx editing as a strategy for cancer immunotherapy
2016 StandoutNobel
Rac1 and Rac2 regulate macrophage morphology but are not essential for migration
2006
Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation
2020 StandoutNobel
Deficiency of Small Gtpase Rac2 Affects T Cell Activation
2001
Critical Roles for Rac1 and Rac2 GTPases in B Cell Development and Signaling
2003 Science
Rac2-Deficient Murine Macrophages Have Selective Defects in Superoxide Production and Phagocytosis of Opsonized Particles
2004
Neutrophils from p40phox−/− mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
2006
Active Demethylation of the Foxp3 Locus Leads to the Generation of Stable Regulatory T Cells within the Thymus
2013
Compact Biocompatible Quantum Dots Functionalized for Cellular Imaging
2008 StandoutNobel
Growth Factors, Matrices, and Forces Combine and Control Stem Cells
2009 StandoutScience
Rac2 is critical for neutrophil primary granule exocytosis
2004
Functional requirements of AID’s higher order structures and their interaction with RNA-binding proteins
2016 StandoutNobel
Rac1 Deletion in Mouse Neutrophils Has Selective Effects on Neutrophil Functions
2003
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton
2006
Works of Feng‐Chun Yang being referenced
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
2019
Nf1+/− mast cells induce neurofibroma like phenotypes through secreted TGF-β signaling
2006
CD27/CD70 interaction directly drives B cell IgG and IgM synthesis
1995
CD27/CD70 interaction directly induces natural killer cell killing activity
1996
Biochemical and Biological Characterization of a Human Rac2 GTPase Mutant Associated with Phagocytic Immunodeficiency
2001
Rac2 Stimulates Akt Activation Affecting BAD/Bcl-XL Expression while Mediating Survival and Actin Function in Primary Mast Cells
2000
Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia
2018
Nf1-Dependent Tumors Require a Microenvironment Containing Nf1+/−- and c-kit-Dependent Bone Marrow
2008
Dominant negative mutation of the hematopoietic-specific Rho GTPase, Rac2, is associated with a human phagocyte immunodeficiency.
2000 StandoutNobel
Mast cells and the neurofibroma microenvironment
2010
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization
2001
Differential Effects of Human Granulocyte Colony-Stimulating Factor (hG-CSF) and Thrombopoietin on Megakaryopoiesis and Platelet Function in hG-CSF Receptor-Transgenic Mice
1999
The Rac2 Guanosine Triphosphatase Regulates B Lymphocyte Antigen Receptor Responses and Chemotaxis and Is Required for Establishment of B-1a and Marginal Zone B Lymphocytes
2002
Rac2-Deficient Hematopoietic Stem Cells Show Defective Interaction with the Hematopoietic Microenvironment and Long-Term Engraftment Failure
2005
Leptin Stimulates the Proliferation of Murine Myelocytic and Primitive Hematopoietic Progenitor Cells
1997
Rac2‐deficient mice display perturbed T‐cell distribution and chemotaxis, but only minor abnormalities in TH1 responses
2002
Stimulation of Mouse and Human Primitive Hematopoiesis by Murine Embryonic Aorta-Gonad-Mesonephros–Derived Stromal Cell Lines
1998
Ex vivo culture of Fancc-/- stem/progenitor cells predisposes cells to undergo apoptosis, and surviving stem/progenitor cells display cytogenetic abnormalities and an increased risk of malignancy
2005
Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies
2011
Evidence for the presence of murine primitive megakarycytopoiesis in the early yolk sac
2001
Genetic and Biochemical Evidence That Haploinsufficiency of the Nf1 Tumor Suppressor Gene Modulates Melanocyte and Mast Cell Fates in Vivo
2000
Stimulation of Mouse and Human Primitive Hematopoiesis by Murine Embryonic Aorta-Gonad-Mesonephros–Derived Stromal Cell Lines
1998