Standout Papers
Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Hypoxia Induces Trimethylated H3 Lysine 4 by Inhibition of JARID1A Demethylase
2010
JMJD6 Is a Histone Arginine Demethylase
2007 Science
The RNA Polymerase II Kinase Ctk1 Regulates Positioning of a 5′ Histone Methylation Boundary along Genes
2006
Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers
2011 Nobel
The Noncoding RNA MALAT1 Is a Critical Regulator of the Metastasis Phenotype of Lung Cancer Cells
2012
Vernalization-Mediated Epigenetic Silencing by a Long Intronic Noncoding RNA
2010 Science
The genomic binding sites of a noncoding RNA
2011
Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells
2009 Science
( R )-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
2013 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
2017
Regulation of BRCA2 Gene Expression by the SLUG Repressor Protein in Human Breast Cells
2005
FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
2012
Cancer and Altered Metabolism: Potential Importance of Hypoxia-Inducible Factor and 2-Oxoglutarate-Dependent Dioxygenases
2011 StandoutNobel
Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation
2015
Direct conversion of fibroblasts to functional neurons by defined factors
2010 StandoutNatureNobel
Nanog Is the Gateway to the Pluripotent Ground State
2009 StandoutNobel
Hierarchical Mechanisms for Direct Reprogramming of Fibroblasts to Neurons
2013 StandoutNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The sequence, structure and evolutionary features of HOTAIR in mammals
2011
Human colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus
2014
An integrated encyclopedia of DNA elements in the human genome
2012 StandoutNature
Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
2014
Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?
2010
lincRNAs: Genomics, Evolution, and Mechanisms
2013 Standout
Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia
2014
Control of somatic tissue differentiation by the long non-coding RNA TINCR
2012 StandoutNature
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Non-coding RNAs as regulators of embryogenesis
2011
Control of the Embryonic Stem Cell State
2011
No-Nonsense Functions for Long Noncoding RNAs
2011
Understanding the language of Lys36 methylation at histone H3
2012
Physiological and biochemical aspects of hydroxylations and demethylations catalyzed by human 2-oxoglutarate oxygenases
2010
RBP2 Belongs to a Family of Demethylases, Specific for Tri-and Dimethylated Lysine 4 on Histone 3
2007
Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines
2010
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Cell-Type-Specific Control of Enhancer Activity by H3K9 Trimethylation
2012
Chromatin Modifications and Their Function
2007 Standout
A model for transmission of the H3K27me3 epigenetic mark
2008
Modular regulatory principles of large non-coding RNAs
2012 StandoutNature
Metabolic Regulation of Epigenetics
2012
Chromatin Connections to Pluripotency and Cellular Reprogramming
2011
Structural architecture of the human long non-coding RNA, steroid receptor RNA activator
2012
Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease
2008
The role of long non-coding RNAs in genome formatting and expression
2015
Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis
2007 Nature
Physical and Functional Association of a Trimethyl H3K4 Demethylase and Ring6a/MBLR, a Polycomb-like Protein
2007
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
2005
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36
2006 Nature
Understanding the transcriptome through RNA structure
2011
Identification and functional analysis of 9p24 amplified genes in human breast cancer
2011
Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells
2009
UTX mediates demethylation of H3K27me3 at muscle-specific genes during myogenesis
2010
In Vivo Residue-specific Histone Methylation Dynamics
2009
The emerging role of lncRNAs in cancer
2015 Standout
Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Epigenetic Regulation of the Hypoxic Response via Hypoxia-Inducible Factor and Histone Modifying Enzymes
2011
Structural and Functional Differences in the Long Non-Coding RNA Hotair in Mouse and Human
2011
Single-Nucleosome Mapping of Histone Modifications in S. cerevisiae
2005
Phosphorylation of the PRC2 component Ezh2 is cell cycle-regulated and up-regulates its binding to ncRNA
2010
A global transcriptional analysis of Plasmodium falciparum malaria reveals a novel family of telomere-associated lncRNAs
2011
Inheritance of Silent rDNA Chromatin Is Mediated by PARP1 via Noncoding RNA
2012
The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E‐cadherin and vitamin D receptor in human colon carcinomas
2006
Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases
2018
Structural Insights into Histone Demethylation by JMJD2 Family Members
2006
Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression
2006
Diversity within the JMJD2 histone demethylase family
2006
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
2007
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells
2006
H3K27 Demethylases, at Long Last
2007
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36
2011
Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation
2013 Nature
The Tissue-Specific lncRNA Fendrr Is an Essential Regulator of Heart and Body Wall Development in the Mouse
2013
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants
2009 StandoutNatureNobel
Genomic amplification and oncogenic properties of the GASC1 histone demethylase gene in breast cancer
2009
Dynamic Regulation of Histone Lysine Methylation by Demethylases
2007
Reversing histone methylation
2005 Nature
To repress or not to repress: This is the guardian's question
2011
Transcriptional regulation of cadherins during development and carcinogenesis
2004
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation
2005 Nature
JmjC-domain-containing proteins and histone demethylation
2006
The complex language of chromatin regulation during transcription
2007 StandoutNature
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
The key to development: interpreting the histone code?
2005
LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
2005 Nature
The Long Noncoding RNAs NEAT1 and MALAT1 Bind Active Chromatin Sites
2014
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells
2007
Targeted RNA sequencing reveals the deep complexity of the human transcriptome
2011
Expanding chemical biology of 2-oxoglutarate oxygenases
2008
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation
2008
Histone demethylation by a family of JmjC domain-containing proteins
2005 StandoutNature
Large non-coding RNAs: missing links in cancer?
2010
KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints
2009 Nature
Intrinsic Immunity Shapes Viral Resistance of Stem Cells
2017 StandoutNobel
Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation
2014
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Stem Cells, the Molecular Circuitry of Pluripotency and Nuclear Reprogramming
2008
Lineage-Specific Polycomb Targets and De Novo DNA Methylation Define Restriction and Potential of Neuronal Progenitors
2008
Molecular Mechanisms of Long Noncoding RNAs
2011 Standout
Dogma Derailed: The Many Influences of RNA on the Genome
2013
Pioneer transcription factors: establishing competence for gene expression
2011
Long non-coding RNAs and chromatin modifiers
2013
The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions
2008 StandoutNobel
JHDM2A, a JmjC-Containing H3K9 Demethylase, Facilitates Transcription Activation by Androgen Receptor
2006
Regeneration, repair and remembering identity: the three Rs of Hox gene expression
2009
Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin
2005
Enhancer decommissioning by LSD1 during embryonic stem cell differentiation
2012 Nature
A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations
2010 Standout
The diverse functions of histone lysine methylation
2005 Standout
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
2007 Standout
Promiscuous RNA binding by Polycomb repressive complex 2
2013 Nobel
Suppression of inflammation by a synthetic histone mimic
2010 StandoutNatureNobel
Increased mitochondrial function downstream from KDM5A histone demethylase rescues differentiation in pRB-deficient cells
2015
Intronic RNAs mediate EZH2 regulation of epigenetic targets
2012
Non-coding RNAs in human disease
2011 Standout
Junk DNA and the long non-coding RNA twist in cancer genetics
2015
Long non-coding RNA HOTAIR in carcinogenesis and metastasis
2013
ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs
2011
Structural and Functional Analysis of JMJD2D Reveals Molecular Basis for Site-Specific Demethylation among JMJD2 Demethylases
2012
Braveheart, a Long Noncoding RNA Required for Cardiovascular Lineage Commitment
2013
Repression of the Long Noncoding RNA-LET by Histone Deacetylase 3 Contributes to Hypoxia-Mediated Metastasis
2013
The lncRNA Malat1 Is Dispensable for Mouse Development but Its Transcription Plays a cis-Regulatory Role in the Adult
2012
Acetylation by p300 Regulates Nuclear Localization and Function of the Transcriptional Corepressor CtBP2
2005
The hallmarks of cancer
2012 Standout
A Crack in Histone Lysine Methylation
2004
Modification of Enhancer Chromatin: What, How, and Why?
2013
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
Charting histone modifications and the functional organization of mammalian genomes
2010
Long noncoding RNAs and human disease
2011 Standout
RNA templating the epigenome
2011
Physiological roles of long noncoding RNAs: insight from knockout mice
2014
Loss of the abundant nuclear non-coding RNAMALAT1is compatible with life and development
2012
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Long noncoding RNAs in C. elegans
2012
Subnuclear segregation of genes and core promoter factors in myogenesis
2011 StandoutNobel
The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones
2014 Standout
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
2006
Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin
2005
Genomic Maps of Long Noncoding RNA Occupancy Reveal Principles of RNA-Chromatin Interactions
2011
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Reading, writing and erasing mRNA methylation
2019 Standout
Structural basis for histone H3 Lys 27 demethylation by UTX/KDM6A
2011
SUMOylation promotes de novo targeting of HP1α to pericentric heterochromatin
2011
Flowering time control: another window to the connection between antisense RNA and chromatin
2012
Computational Identification and Functional Predictions of Long Noncoding RNA in Zea mays
2012
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage
2013
Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression
2011
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Noncoding RNA and Polycomb recruitment
2013
Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
2013
The JMJD2 members of histone demethylase revisited
2007
Multivalent engagement of chromatin modifications by linked binding modules
2007
Roles of jumonji and jumonji family genes in chromatin regulation and development
2006
lincRNAs act in the circuitry controlling pluripotency and differentiation
2011 StandoutNature
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3
2006 Nature
Taking LSD1 to a New High
2005
Jarid2/Jumonji Coordinates Control of PRC2 Enzymatic Activity and Target Gene Occupancy in Pluripotent Cells
2009
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
2013 Standout
Enhancer function: new insights into the regulation of tissue-specific gene expression
2011
Structural studies on human 2-oxoglutarate dependent oxygenases
2010
The Polycomb complex PRC2 and its mark in life
2011 StandoutNature
NONCODE 2016: an informative and valuable data source of long non-coding RNAs
2015
lncRNA-dependent mechanisms of androgen-receptor-regulated gene activation programs
2013 Nature
Organoid single-cell genomic atlas uncovers human-specific features of brain development
2019 StandoutNatureNobel
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Targeted Disruption of Hotair Leads to Homeotic Transformation and Gene Derepression
2013
Hypoxia induces a novel signature of chromatin modifications and global repression of transcription
2008
Histone lysine demethylases: emerging roles in development, physiology and disease
2007
LncRNA: A link between RNA and cancer
2014
Nuclear Speckle-Associated Protein Pnn/DRS Binds to the Transcriptional Corepressor CtBP and Relieves CtBP- Mediated Repression of the E-Cadherin Gene
2004
Nuclear Reprogramming in Cells
2008 StandoutScienceNobel
Vernalization: Winter and the Timing of Flowering in Plants
2009
Genome Regulation by Long Noncoding RNAs
2012 Standout
RNA–protein analysis using a conditional CRISPR nuclease
2013 StandoutNobel
Long noncoding RNAs regulate adipogenesis
2013
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Aire
2009
Methylation: lost in hydroxylation?
2005
Genome-Wide Analysis Uncovers Regulation of Long Intergenic Noncoding RNAs in Arabidopsis
2012
Epigenetic Regulation by Histone Demethylases in Hypoxia
2015
NONCODING RNAS IN THE MAMMALIAN CENTRAL NERVOUS SYSTEM
2006
Chromatin and oxygen sensing in the context of JmjC histone demethylases
2014
PintlincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2
2013
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Regulation of mammalian cell differentiation by long non‐coding RNAs
2012
Lanthanum Chloride Inhibits LPS Mediated Expressions of Pro-Inflammatory Cytokines and Adhesion Molecules in HUVECs: Involvement of NF-κB-Jmjd3 Signaling
2017 Standout
Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability
2010
Chromatin Modifications by Methylation and Ubiquitination: Implications in the Regulation of Gene Expression
2006
The Histone Demethylase KDM5b/JARID1b Plays a Role in Cell Fate Decisions by Blocking Terminal Differentiation
2008
Structural Insight into the Recognition of the H3K4me3 Mark by the TFIID Subunit TAF3
2008
Hypoxic Stress Induces Dimethylated Histone H3 Lysine 9 through Histone Methyltransferase G9a in Mammalian Cells
2006
RNA meets chromatin
2005
Integrative analysis of HIF binding and transactivation reveals its role in maintaining histone methylation homeostasis
2009
WormBook
2008
Long Intergenic Noncoding RNAs: New Links in Cancer Progression
2011
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
2012 StandoutNobel
Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α
2008 StandoutNobel
Genome-Wide Views of Chromatin Structure
2009
Systematic identification of long noncoding RNAs expressed during zebrafish embryogenesis
2011
Long noncoding RNAs as a novel component of the Myc transcriptional network
2015
Snail Mediates E-Cadherin Repression by the Recruitment of the Sin3A/Histone Deacetylase 1 (HDAC1)/HDAC2 Complex
2003
Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression
2007
Ubp10/Dot4p Regulates the Persistence of Ubiquitinated Histone H2B: Distinct Roles in Telomeric Silencing and General Chromatin
2005
Methods for comprehensive experimental identification of RNA-protein interactions
2014
RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation
2011 Science
Tag SNPs in long non-coding RNA H19 contribute to susceptibility to gastric cancer in the Chinese Han population
2015
DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression
2008 Science
The emerging functions of histone demethylases
2008
Works of Fei Lan being referenced
Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes
2010 StandoutScience
Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors
2005
Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation
2010
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal
2018
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
2004 Standout
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development
2010 Nature
Epigenetic regulation: methylation of histone and non-histone proteins
2009
The X-Linked Mental Retardation Gene SMCX/JARID1C Defines a Family of Histone H3 Lysine 4 Demethylases
2007
S. pombe LSD1 Homologs Regulate Heterochromatin Propagation and Euchromatic Gene Transcription
2007
KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs
2013
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
2018
Coordinated histone modifications mediated by a CtBP co-repressor complex
2003 Nature
Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases
2006
Mechanisms involved in the regulation of histone lysine demethylases
2008
A histone H3 lysine 27 demethylase regulates animal posterior development
2007 Nature
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression
2007 Nature
Structural basis of the recognition of a methylated histone tail by JMJD2A
2007