Citation Impact
Citing Papers
Global phosphorylation analysis of β-arrestin–mediated signaling downstream of a seven transmembrane receptor (7TMR)
2010 StandoutNobel
A Sulfilimine Bond Identified in Collagen IV
2009 StandoutScienceNobel
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
Gene expression profiling of multiple histone deacetylase (HDAC) inhibitors: defining a common gene set produced by HDAC inhibition in T24 and MDA carcinoma cell lines.
2003
Tyrosine Phosphorylation Mapping of the Epidermal Growth Factor Receptor Signaling Pathway
2002
A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
2000
A stomatin-like protein necessary for mechanosensation in C. elegans
1995 StandoutNatureNobel
Agonist-stimulated synthesis of phosphatidylinositol(3,4,5)-trisphosphate
1993
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Insulin Stimulates the Phosphorylation of the 66- and 52-Kilodalton Shc Isoforms by Distinct Pathways1
1997
Retinoic acid receptors: From molecular mechanisms to cancer therapy
2014
Stem cells, cancer, and cancer stem cells
2001 StandoutNature
Signalling scaffolds and local organization of cellular behaviour
2015
Molecular mechanisms of nociception
2001 StandoutNatureNobel
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Epigenetics in human disease and prospects for epigenetic therapy
2004 StandoutNature
Oxidative stress and gene regulation
2000
Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses
1994
Twenty-Five Years of the Nucleosome, Fundamental Particle of the Eukaryote Chromosome
1999 StandoutNobel
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans
1996 StandoutNatureNobel
SH2 and SH3 domains
1993
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
2001
Histone deacetylases: a common molecular target for differentiation treatment of acute myeloid leukemias?
2001
The Hallmarks of Cancer
2000 Standout
Mitochondrial longevity pathways
2010
Recognition and specificity in protein tyrosine kinase-mediated signalling
1995
Tyrosine Phosphorylation of the β-Amyloid Precursor Protein Cytoplasmic Tail Promotes Interaction with Shc
2002
Acquisition of Oncogenic Potential by RAR Chimeras in Acute Promyelocytic Leukemia through Formation of Homodimers
2000
APL, a model disease for cancer therapies?
2001
Molecular genetics of acute promyelocytic leukemia
1999
Central nervous system control of food intake
2000 StandoutNature
Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
2004
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation
1999
Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3' enhancer
1998
T cell antigen CD28 binds to the GRB‐2/SOS complex, regulators of p21ras
1995
Impairment of p53 acetylation, stability and function by an oncogenic transcription factor
2004
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
2001 StandoutNatureNobel
The Metastasis-associated Proteins 1 and 2 Form Distinct Protein Complexes with Histone Deacetylase Activity
2003
Oligomerization of RAR and AML1 Transcription Factors as a Novel Mechanism of Oncogenic Activation
2000
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
HDAC inhibitors enhance the apoptosis-inducing potential of TRAIL in breast carcinoma
2005
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
NURD, a Novel Complex with Both ATP-Dependent Chromatin-Remodeling and Histone Deacetylase Activities
1998
Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer
1998 StandoutNature
Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells
2001 Standout
CED-1 Is a Transmembrane Receptor that Mediates Cell Corpse Engulfment in C. elegans
2001 StandoutNobel
Efficacy of Pamidronate in Reducing Skeletal Complications in Patients with Breast Cancer and Lytic Bone Metastases
1996 Standout
Global, In Vivo, and Site-Specific Phosphorylation Dynamics in Signaling Networks
2006 Standout
The Hallmarks of Aging
2013 Standout
Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
2006 Standout
The Dermatomyositis-Specific Autoantigen Mi2 Is a Component of a Complex Containing Histone Deacetylase and Nucleosome Remodeling Activities
1998
MEP-1 and a Homolog of the NURD Complex Component Mi-2 Act Together to Maintain Germline-Soma Distinctions in C. elegans
2002 StandoutNobel
Insulin Action and the Insulin Signaling Network*
1995
NURD-complex genes antagonise Ras-induced vulval development in Caenorhabditis elegans
2000
Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells
1998
Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor
1993
c-Src-mediated Phosphorylation of the Epidermal Growth Factor Receptor on Tyr845 and Tyr1101 Is Associated with Modulation of Receptor Function
1999
Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib
2004 Standout
Insulin-like Growth Factor-I Receptor Internalization Regulates Signaling via the Shc/Mitogen-activated Protein Kinase Pathway, but Not the Insulin Receptor Substrate-1 Pathway
1998
Endocytosis of Functional Epidermal Growth Factor Receptor-Green Fluorescent Protein Chimera
1998
Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage
2008
The p66shc adaptor protein controls oxidative stress response and life span in mammals
1999 StandoutNature
Collagen Hydroxylases and the Protein Disulfide Isomerase Subunit of Prolyl 4‐Hydroxylases
1998
Insulin stimulates tyrosine phosphorylation of the proto-oncogene product of c-Cbl in 3T3-L1 adipocytes
1997
The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein
1996
Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation
2000 StandoutNobel
Role of the Src Homology 2 (SH2) Domain and C-Terminus Tyrosine Phosphorylation Sites of SH2-Containing Inositol Phosphatase (SHIP) in the Regulation of Insulin-Induced Mitogenesis1
1999
Discovery of (Aryloxopropenyl)pyrrolyl Hydroxyamides as Selective Inhibitors of Class IIa Histone Deacetylase Homologue HD1-A
2003
Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription
2000 StandoutNobel
The signaling pathway coupling epidermal growth factor receptors to activation of p21ras.
1994
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.
1994
The role of p21ras in receptor tyrosine kinase signaling
1995
Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
1995 StandoutNatureNobel
β-Arrestin-Dependent Formation of β 2 Adrenergic Receptor-Src Protein Kinase Complexes
1999 StandoutScienceNobel
Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein
1997 StandoutNobel
Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene.
1996 StandoutNobel
Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras.
1994 StandoutNobel
Thyrotropin-releasing hormone stimulates MAP kinase activity in GH3 cells by divergent pathways. Evidence of a role for early tyrosine phosphorylation.
1994
Activation and differentiation requirements of primary T cells in vitro.
1993 StandoutNobel
Mass spectrometry-based proteomics
2003 StandoutNature
G protein beta gamma subunits stimulate phosphorylation of Shc adapter protein.
1995 StandoutNobel
Altered Myeloid Development and Acute Leukemia in Transgenic Mice Expressing PML-RARα Under Control of Cathepsin G Regulatory Sequences
1997
Physiological and Molecular Basis of Thyroid Hormone Action
2001 Standout
Binding of F-spondin to amyloid-β precursor protein: A candidate amyloid-β precursor protein ligand that modulates amyloid-β precursor protein cleavage
2004 StandoutNobel
Shc is the predominant signaling molecule coupling insulin receptors to activation of guanine nucleotide releasing factor and p21ras-GTP formation.
1994
Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells
2012 StandoutNobel
High-efficiency gene transfer and selection of human hematopoietic progenitor cells with a hybrid EBV/retroviral vector expressing the green fluorescence protein.
1998
Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.
1994
Cytoplasmic Sequestration of the Polyomavirus Enhancer Binding Protein 2 (PEBP2)/Core Binding Factor α (CBFα) Subunit by the Leukemia-Related PEBP2/CBFβ-SMMHC Fusion Protein Inhibits PEBP2/CBF-Mediated Transactivation
1998
Bcl-2 Cooperates with Promyelocytic Leukemia Retinoic Acid Receptor α Chimeric Protein (Pmlrarα) to Block Neutrophil Differentiation and Initiate Acute Leukemia
2001 Nobel
Neurite outgrowth of PC12 cells is suppressed by wortmannin, a specific inhibitor of phosphatidylinositol 3-kinase.
1994
Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
2000
Nuclear Receptor Coregulators: Cellular and Molecular Biology*
1999 Standout
Repeated pulses of serotonin required for long-term facilitation activate mitogen-activated protein kinase in sensory neurons of Aplysia
1998 StandoutNobel
APMLRARα transgene initiates murine acute promyelocytic leukemia
1997 Nobel
Human naive and memory T cells
1988
Inhibition by cAMP of Ras-Dependent Activation of Raf
1993 Science
Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.
1996
Endothelin induces tyrosine phosphorylation and GRB2 association of Shc in astrocytes.
1994
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases.
1992
Analysis of receptor signaling pathways by mass spectrometry: Identification of Vav-2 as a substrate of the epidermal and platelet-derived growth factor receptors
2000
Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor
2002 Science
Function of PI3Kγ in Thymocyte Development, T Cell Activation, and Neutrophil Migration
2000 StandoutScienceNobel
Evidence for a functional role of Shc proteins in mitogenic signaling induced by insulin, insulin-like growth factor-1, and epidermal growth factor.
1994
Phase I trial of the histone deacetylase inhibitor, depsipeptide (FR901228, NSC 630176), in patients with refractory neoplasms.
2002
A role for Mints in transmitter release: Mint 1 knockout mice exhibit impaired GABAergic synaptic transmission
2003 StandoutNobel
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Histone deacetylase inhibitors induce remission in transgenic models of therapy-resistant acute promyelocytic leukemia
2001
The mouse waved-2 phenotype results from a point mutation in the EGF receptor tyrosine kinase.
1994
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors
2000 StandoutNobel
Works of Fausto Grignani being referenced
Frequency of RAS and p53 Mutations in Acute Promyelocytic Leukemias
1993
Formation of PML/RARα high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML/RARα-mediated retinoic acid response
1999
Analysis of p53 gene mutations in acute myeloid leukemia
1994
The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
1993
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
1992
The acute promyelocytic leukemia-specific PML/RAR alpha fusion protein reduces the frequency of commitment to apoptosis upon growth factor deprivation of GM-CSF-dependent myeloid cells.
1995
Vindesine and mitomycin c in chemotherapy refractory advanced breast cancer
1986
Phenotypic dissection of cord blood immunoregulatory T-cell subsets by using a two-color immunofluorescence study
1986
Opposite Effects of the Acute Promyelocytic Leukemia PML-Retinoic Acid Receptor α (RARα) and PLZF-RARα Fusion Proteins on Retinoic Acid Signalling
1997
Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukaemia
1998 Nature