Citation Impact
Citing Papers
Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
2006 StandoutNobel
Complete Replication of Hepatitis C Virus in Cell Culture
2005 StandoutScienceNobel
Characterization of a canine homolog of hepatitis C virus
2011 StandoutNobel
Keeping G Proteins at Bay: A Complex Between G Protein-Coupled Receptor Kinase 2 and Gßγ
2003 StandoutScienceNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy
2004 StandoutScience
Evidence for a functional RNA element in the hepatitis C virus core gene
2007 StandoutNobel
An enzymatic toolkit for selective proteolysis, detection, and visualization of mucin-domain glycoproteins
2020 StandoutNobel
Three conformational snapshots of the hepatitis C virus NS3 helicase reveal a ratchet translocation mechanism
2009 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Characterization of the Structure and Function of a New Mitogen-activated Protein Kinase (p38β)
1996
SEC14L2 enables pan-genotype HCV replication in cell culture
2015 StandoutNatureNobel
Crystal Structure of p38 Mitogen-activated Protein Kinase
1996
The structural basis for the specificity of pyridinylimidazole inhibitors of p38 MAP kinase
1997
Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
2019
Congenital leptin deficiency is associated with severe early-onset obesity in humans
1997 StandoutNature
Oxidative stress and gene regulation
2000
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
ERK3 Is a Constitutively Nuclear Protein Kinase
1996
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication
1999
Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK
1998
Progressive Cyclic Nucleotide-induced Conformational Changes in the cGMP-dependent Protein Kinase Studied by Small Angle X-ray Scattering in Solution
1997
Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines
1995
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility
1997
Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK
1994 StandoutNobel
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
How MAP Kinases Are Regulated
1995 Standout
Protein kinase regulation: insights from crystal structure analysis
1994
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
1998
Structural Analysis of the MAP Kinase ERK2 and Studies of MAP Kinase Regulatory Pathways
1996
Identification of Substrates and Regulators of the Mitogen-activated Protein Kinase ERK5 Using Chimeric Protein Kinases
1998
Substrate Recognition Domains within Extracellular Signal-regulated Kinase Mediate Binding and Catalytic Activation of Mitogen-activated Protein Kinase Phosphatase-3
2000
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
1994 StandoutNature
A conserved docking motif in MAP kinases common to substrates, activators and regulators
2000
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
A method to predict residues conferring functional differences between related proteins: Application to MAP kinase pathways
2000
Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation
1997
Structural Basis for the Autoinhibition of Calcium/Calmodulin-Dependent Protein Kinase I
1996
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
A highly specific inhibitor of human p38 MAP kinase binds in the ATP pocket
1997
MAP kinase pathways
1999
RNA Polymerase Activity and Specific RNA Structure Are Required for Efficient HCV Replication in Cultured Cells
2010
Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
1999
Active and Inactive Protein Kinases: Structural Basis for Regulation
1996
Mechanism of CDK activation revealed by the structure of a cyclinA-CDK2 complex
1995 Nature
Oxidants, oxidative stress and the biology of ageing
2000 StandoutNature
Dimerization in MAP-kinase signaling
2000
A light-entrainment mechanism for the Drosophila circadian clock
1996 StandoutNatureNobel
The Conformational Plasticity of Protein Kinases
2002
Nucleoside triphosphate-binding proteins: different scaffolds to achieve phosphoryl transfer
1999
Characterization of a Protein Kinase that Phosphorylates Serine 189 of the Mitogen-activated Protein Kinase Homolog ERK3
1996
CASK Functions as a Mg2+-Independent Neurexin Kinase
2008 StandoutNobel
The biology of leptin: a review.
1998
Structural basis of inhibitor selectivity in MAP kinases
1998
Crystal structure of the tyrosine kinase domain of the human insulin receptor
1994 Nature
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
New Insights into the Control of MAP Kinase Pathways
1999
Contributions of the Mitogen-activated Protein (MAP) Kinase Backbone and Phosphorylation Loop to MEK Specificity
1996
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
1994 StandoutScience
A single amino acid substitution makes ERK2 susceptible to pyridinyl imidazole inhibitors of p38 MAP kinase
1998
The Evolution of the MAP Kinase Pathways: Coduplication of Interacting Proteins Leads to New Signaling Cascades
1999
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
2010 Nature
Activity of the MAP kinase ERK2 is controlled by a flexible surface loop
1995
Phosphorylation of MAP Kinases by MAP/ERK Involves Multiple Regions of MAP Kinases
1999
Phosphorylation of the MAP Kinase ERK2 Promotes Its Homodimerization and Nuclear Translocation
1998
Novel Insights into Hepatitis C Virus Replication and Persistence
2004
A constitutively active and nuclear form of the MAP kinase ERK2 is sufficient for neurite outgrowth and cell transformation
1998
Regulation of Protein Kinases
2004
Purification of a 12,020-Dalton Protein That Enhances the Activation of Mitogen-activated Protein (MAP) Kinase by MAP Kinase Kinase
1995
Activation of Stress-activated Protein Kinases/c-Jun N-terminal Protein Kinases (SAPKs/JNKs) by a Novel Mitogen-activated Protein Kinase Kinase (MKK7)
1997
Trends in peptide drug discovery
2021
Replication of hepatitis C virus
2007 StandoutNobel
Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP
2010 StandoutNobel
Quantitative Analysis of the Hepatitis C Virus Replication Complex
2005
Catalytic Reaction Pathway for the Mitogen-Activated Protein Kinase ERK2
2000
Quantitative exploration of the molecular origin of the activation of GTPase
2013 StandoutNobel
Mutation of Position 52 in ERK2 Creates a Nonproductive Binding Mode for Adenosine 5‘-Triphosphate,
1996
Initiation of viral RNA-dependent RNA polymerization
2004
Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
1998 StandoutScienceNobel
Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
1997 Standout
The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae
2000 StandoutNobel
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
2001 Standout
ERK5 Is a Novel Type of Mitogen-Activated Protein Kinase Containing a Transcriptional Activation Domain
2000
A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs
1996
Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero
1998 StandoutNobel
Occurrence, Biogenesis, and Synthesis of Biologically Active Carbazole Alkaloids
2012 Standout
A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1
1996
Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR
2020
The structure of mitogen-activated protein kinase p38 at 2.1-Å resolution
1997
A General Mechanism for Network-Dosage Compensation in Gene Circuits
2010 StandoutScienceNobel
Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability
2009 StandoutNobel
cis -Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome
2004
Studying Hepatitis C Virus: Making the Best of a Bad Virus
2007 StandoutNobel
Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes
1998
Hepatitis C Virus RNA Synthesis in a Cell-Free System Isolated from Replicon-Containing Hepatoma Cells
2003 StandoutNobel
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase).
1994
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein.
1995
The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans
1995 StandoutNobel
Identification of MAP Kinase Domains by Redirecting Stress Signals into Growth Factor Responses
1996 Science
Fission yeast orb 6, a ser/thr protein kinase related to mammalian rho kinase and myotonic dystrophy kinase, is required for maintenance of cell polarity and coordinates cell morphogenesis with the cell cycle
1998 StandoutNobel
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1997 StandoutScienceNobel
Neuroscience: Breaking Down Scientific Barriers to the Study of Brain and Mind
2000 StandoutScienceNobel
Kinetic and Catalytic Mechanisms of Protein Kinases
2001
Protein-Protein Interactions between Hepatitis C Virus Nonstructural Proteins
2003
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
The Caenorhabditis elegans gene mek-2 is required for vulval induction and encodes a protein similar to the protein kinase MEK.
1995 StandoutNobel
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.
1996
Signal Transduction through MAP Kinase Cascades
1998 Standout
Mitogen-activated protein kinase/extracellular signal-regulated kinase 2 regulates cytoskeletal organization and chemotaxis via catalytic and microtubule-specific interactions.
1997 Nobel
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.
1994
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase.
1995
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of Faming Zhang being referenced
Step-up fecal microbiota transplantation strategy: a pilot study for steroid-dependent ulcerative colitis
2015
Crystal structure of the obese protein Ieptin-E100
1997 Nature
Preparation of novel aza-1,7-annulated indoles and their conversion to potent indolocarbazole kinase inhibitors
2004
Insulin structure and function
2007
Crystallization and Preliminary X-ray Studies of Extracellular Signal-regulated Kinase-2/MAP Kinase with an Incorporated His-tag
1993
Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
2003
Atomic structure of the MAP kinase ERK2 at 2.3 Å resolution
1994 Nature
Oligomerization and Cooperative RNA Synthesis Activity of Hepatitis C Virus RNA-Dependent RNA Polymerase
2002
Synthesis and Activity of New Aryl- and Heteroaryl-Substituted Pyrazole Inhibitors of the Transforming Growth Factor-β Type I Receptor Kinase Domain
2003
Identification of a C-Terminal Regulatory Motif in Hepatitis C Virus RNA-Dependent RNA Polymerase: Structural and Biochemical Analysis
2003