Standout Papers
Citation Impact
Citing Papers
Genomic Variation in Seven Khoe-San Groups Reveals Adaptation and Complex African History
2012 Science
Sorting of GPI-anchored proteins into ER exit sites by p24 proteins is dependent on remodeled GPI
2011
Selective export of human GPI-anchored proteins from the endoplasmic reticulum
2010
Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation
2013 StandoutScience
Identification of the haematopoietic stem cell niche and control of the niche size
2003 StandoutNature
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth
2011
Groucho proteins: transcriptional corepressors for specific subsets of DNA-binding transcription factors in vertebrates and invertebrates
1998
Cargo Selection in Vesicular Transport: The Making and Breaking of a Coat
2002
The complexities of skeletal biology
2003 StandoutNature
Transcriptional mechanisms in osteoblast differentiation and bone formation
2003
Stromal fibroblasts in cancer initiation and progression
2004 StandoutNature
Sox9 Modulates Proliferation and Expression of Osteogenic Markers of Adipose-Derived Stem Cells (ASC)
2013 Standout
Transcription factors in bone: developmental and pathological aspects
2002
Mechanisms of TGF-β Signaling from Cell Membrane to the Nucleus
2003 Standout
Structural basis for triplet repeat disorders: a computational analysis
1999 StandoutNobel
Differential regulation of Cbfa1/Runx2 and osteocalcin gene expression by vitamin‐D3, dexamethasone, and local growth factors in primary human osteoblasts
2002
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
A Pro250Arg substitution in mouse Fgfr1 causes increased expression of Cbfa1 and premature fusion of calvarial sutures
2000
Multiple Cargo Binding Sites on the COPII Subunit Sec24p Ensure Capture of Diverse Membrane Proteins into Transport Vesicles
2003 StandoutNobel
Association of a RUNX2 Promoter Polymorphism with Bone Mineral Density in Postmenopausal Korean Women
2009
Interaction and functional cooperation of the leukemia-associated factors AML1 and p300 in myeloid cell differentiation
1998
TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
2001
Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
2007 StandoutNatureNobel
Runx2 and Runx3 are essential for chondrocyte maturation, and Runx2 regulates limb growth through induction of Indian hedgehog
2004
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Reaching a Genetic and Molecular Understanding of Skeletal Development
2002 Standout
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The genetic transformation of bone biology
1999
Toll-like receptors and cancer
2008
Lectins and traffic in the secretory pathway
2000
Hierarchy revealed in the specification of three skeletal fates by Sox9 and Runx2
2004
The Hedgehog and Wnt signalling pathways in cancer
2001 StandoutNature
A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21
2003
BONE CELLS AND MATRICES IN ORTHOPEDIC TISSUE ENGINEERING
2000
Interaction of FGF, Ihh/Pthlh, and BMP Signaling Integrates Chondrocyte Proliferation and Hypertrophic Differentiation
2002
Cbfa1 Contributes to the Osteoblast-specific Expression of type I collagen Genes
2001
Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
2001
Promoter 2 -1025 T/C Polymorphism in the RUNX2 Gene Is Associated with Femoral Neck BMD in Spanish Postmenopausal Women
2007
Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation
1997 Standout
Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
2001
Limb malformations and the human HOX genes
2002
FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
2002 Standout
Cooperative Interactions between Activating Transcription Factor 4 and Runx2/Cbfa1 Stimulate Osteoblast-specific Osteocalcin Gene Expression
2005
Developmental regulation of the growth plate
2003 StandoutNature
Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
1999 Standout
Growth Regulatory Factors and Bone
2001
Smad and AML Proteins Synergistically Confer Transforming Growth Factor β1 Responsiveness to Human Germ-line IgA Genes
2000
Identification of Putative Target Genes of the Transcription Factor RUNX2
2013 StandoutNobel
Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development
2004
The Novel Zinc Finger-Containing Transcription Factor Osterix Is Required for Osteoblast Differentiation and Bone Formation
2002 Standout
The Missing Bone
1997
Immunity, Inflammation, and Cancer
2010 Standout
Interaction and Functional Cooperation of PEBP2/CBF with Smads
1999
Endocrine Regulation of Energy Metabolism by the Skeleton
2007 Standout
Building strong bones: molecular regulation of the osteoblast lineage
2011
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
2010 StandoutNature
Cleidocranial dysplasia: oral features and genetic analysis of 11 patients
2011
Osteoclast differentiation and activation
2003 StandoutNature
Bone stem cells
1998
Maturational disturbance of chondrocytes inCbfa1-deficient mice
1999
Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone
2014 StandoutNature
CBFA1 Mutation Analysis and Functional Correlation with Phenotypic Variability in Cleidocranial Dysplasia
1999
Genetics of craniofacial development and malformation
2001
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic development
1999
Functional haploinsufficiency of the human homeobox gene MSX2 causes defects in skull ossification
2000
Regulation of the osteoblast‐specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
2003
AP-1 and Cbfa/Runt Physically Interact and Regulate Parathyroid Hormone-dependent MMP13 Expression in Osteoblasts through a New Osteoblast-specific Element 2/AP-1 Composite Element
2001
Parathyroid Hormone Regulation of the Rat Collagenase-3 Promoter by Protein Kinase A-dependent Transactivation of Core Binding Factor α1
2000
Dysregulation of Chondrogenesis in Human Cleidocranial Dysplasia
2005
Mechanisms of Bone Metastasis
2004 Standout
How cells read TGF-β signals
2000 Standout
Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis
2004
Tyrosine phosphorylation controls Runx2‐mediated subnuclear targeting of YAP to repress transcription
2004
Osteogenesis and Bone-Marrow-Derived Cells
2001
Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking
2006 StandoutNobel
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
KDEL-Cargo Regulates Interactions between Proteins Involved in COPI Vesicle Traffic
2001 StandoutNobel
COPII and the regulation of protein sorting in mammals
2011 StandoutNobel
Missense mutations abolishing DNA binding of the osteoblast-specific transcription factor OSF2/CBFA1 in cleidocranial dysplasia
1997
Genetic control of skeletal development
2001
The control of chondrogenesis
2005
Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development
2002
Genomic structure and isoform expression of the mouse, rat and human Cbfa1/Osf2 transcription factor
1998
Parathyroid hormone-dependent signaling pathways regulating genes in bone cells
2002
Genomic Promoter Occupancy of Runt-related Transcription Factor RUNX2 in Osteosarcoma Cells Identifies Genes Involved in Cell Adhesion and Motility
2011
Cell Signaling by Receptor Tyrosine Kinases
2000 Standout
Ectopic Expression of SOX9 in Osteoblasts Alters Bone Mechanical Properties
2011
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
The Osteoblast: A Sophisticated Fibroblast under Central Surveillance
2000 Science
Cleidocranial dysplasia: clinical and molecular genetics
1999
Serum response factor regulates bone formation via IGF-1 and Runx2 signals
2012
Differential Expression Patterns of Runx2 Isoforms in Cranial Suture Morphogenesis
2001
The p24 proteins are not essential for vesicular transport in Saccharomyces cerevisiae
2000 StandoutNobel
Gene Regulatory Networks and the Evolution of Animal Body Plans
2006 StandoutScience
Cbfa1 isoform overexpression upregulates osteocalcin gene expression in non-osteoblastic and pre-osteoblastic cells
1999
Bone Resorption by Osteoclasts
2000 StandoutScience
Regulation of Osteoblast Differentiation Mediated by Bone Morphogenetic Proteins, Hedgehogs, and Cbfa1
2000
Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte–specific expression in vivo
2003
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Dominance of SOX9 function over RUNX2 during skeletogenesis
2006
Fast structural responses of gap junction membrane domains to AB5 toxins
2013 StandoutNobel
Bone Development
2000
Tissue Engineering--Current Challenges and Expanding Opportunities
2002 StandoutScience
Collagenase 3 Is a Target of Cbfa1, a Transcription Factor of the runt Gene Family Involved in Bone Formation
1999
Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations
2018 StandoutScienceNobel
Overexpression of Cbfa1 in osteoblasts inhibits osteoblast maturation and causes osteopenia with multiple fractures
2001
Intracellular Functions of N-Linked Glycans
2001 StandoutScience
Two Domains Unique to Osteoblast-Specific Transcription Factor Osf2/Cbfa1 Contribute to Its Transactivation Function and Its Inability To Heterodimerize with Cbfβ
1998
Signal Transduction by the TGF-β Superfamily
2002 StandoutScience
The high mobility group transcription factor Sox8 is a negative regulator of osteoblast differentiation
2005
Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane
2007
Regulation of human cranial osteoblast phenotype by FGF-2, FGFR-2 and BMP-2 signaling.
2002
Differential Roles for Bone Morphogenetic Protein (BMP) Receptor Type IB and IA in Differentiation and Specification of Mesenchymal Precursor Cells to Osteoblast and Adipocyte Lineages
1998
Wnt5aandWnt5bexhibit distinct activities in coordinating chondrocyte proliferation and differentiation
2003
Dexamethasone Enhances In Vitro Vascular Calcification by Promoting Osteoblastic Differentiation of Vascular Smooth Muscle Cells
1999
BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation
2001
Vascular Calcification
2006 Standout
Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors
2005
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
2016 StandoutNobel
COPII and COPI Traffic at the ER-Golgi Interface
2011
Skeletal Malformations Caused by Overexpression of Cbfa1 or Its Dominant Negative Form in Chondrocytes
2001
Runx2 Is a Common Target of Transforming Growth Factor β1 and Bone Morphogenetic Protein 2, and Cooperation between Runx2 and Smad5 Induces Osteoblast-Specific Gene Expression in the Pluripotent Mesenchymal Precursor Cell Line C2C12
2000
Smooth Muscle Cell Phenotypic Transition Associated With Calcification
2001 Standout
Works of F Otto being referenced
Mutation Analysis of Core Binding Factor A1 in Patients with Cleidocranial Dysplasia
1999
Mutations Involving the Transcription Factor CBFA1 Cause Cleidocranial Dysplasia
1997 Standout
Phase II trial of intravenous endotoxin in patients with colorectal and non-small cell lung cancer
1996
Regulation of chondrocyte differentiation by Cbfa1
1999
The p24 family member p23 is required for early embryonic development
2000