Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
An enumerative algorithm for de novo design of proteins with diverse pocket structures
2020 StandoutNobel
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
2016 StandoutScienceNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage
2022 StandoutNobel
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2
2019 StandoutNobel
Computational design of soluble and functional membrane protein analogues
2024 StandoutNatureNobel
Retargeting CD19 Chimeric Antigen Receptor T Cells via Engineered CD19-Fusion Proteins
2019
Metascape provides a biologist-oriented resource for the analysis of systems-level datasets
2019 Standout
Tuning the Transcriptional Response to Hypoxia by Inhibiting Hypoxia-inducible Factor (HIF) Prolyl and Asparaginyl Hydroxylases
2016 StandoutNobel
The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy
2015 StandoutNobel
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Abiotic Stress Signaling and Responses in Plants
2016 Standout
Physicochemical Determinants of Chaperone Requirements
2010
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Species‐specific detection of the antiviral small‐molecule compound CMA by STING
2013
Inference of Macromolecular Assemblies from Crystalline State
2007 Standout
Microscale Fluorescent Thermal Stability Assay for Membrane Proteins
2008
Structural and Biochemical Analysis of Nuclease Domain of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated Protein 3 (Cas3)
2011
Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity
2015 Standout
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Genome-wide RNAi screen identifies human host factors crucial for influenza virus replication
2010 Nature
Evolutionarily Conserved Roles of the Dicer Helicase Domain in Regulating RNA Interference Processing
2014 StandoutNobel
Recent insights into the complexity of Tank‐binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1
2013
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Structures of parasitic CDPK domains point to a common mechanism of activation
2010
A Helical RGD Motif Promoting Cell Adhesion: Crystal Structures of the Helicobacter pylori Type IV Secretion System Pilus Protein CagL
2013
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
mTOR Signaling in Growth, Metabolism, and Disease
2017 Standout
A Broad-Spectrum Inhibitor of CRISPR-Cas9
2017 StandoutNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
Enhancements to the Rosetta Energy Function Enable Improved Identification of Small Molecules that Inhibit Protein-Protein Interactions
2015
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
Facilities for macromolecular crystallography at the Helmholtz-Zentrum Berlin
2012
Specific CLK Inhibitors from a Novel Chemotype for Regulation of Alternative Splicing
2011
Primary, Adaptive, and Acquired Resistance to Cancer Immunotherapy
2017 Standout
Structures of membrane proteins
2010 StandoutNobel
Structural Basis of Inhibition of the Human NAD+-Dependent Deacetylase SIRT5 by Suramin
2007
Mechanism of Foreign DNA Selection in a Bacterial Adaptive Immune System
2012 StandoutNobel
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
2011 Nature
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
The unfolded protein response signals through high-order assembly of Ire1
2008 Nature
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Filling out the structural map of the NTF2-like superfamily
2013
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Cryo-EM structure of a type IV secretion system
2022 StandoutNatureNobel
Thermofluor-based optimization strategy for the stabilization and crystallization of Campylobacter jejuni desulforubrerythrin
2011
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Progress in the Discovery of Small-Molecule Inhibitors of Bromodomain–Histone Interactions
2011
Structural basis of recognition of interferon-α receptor by tyrosine kinase 2
2014
Engineering a minimal G protein to facilitate crystallisation of G protein-coupled receptors in their active conformation
2016
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Copper is required for oncogenic BRAF signalling and tumorigenesis
2014 Nature
Computational design of a synthetic PD-1 agonist
2021 StandoutNobel
Design and Synthesis of Nonequilibrium Systems
2015 StandoutNobel
Structure of a dimeric crenarchaeal Cas6 enzyme with an atypical active site for CRISPR RNA processing
2013
Structure of the STRA6 receptor for retinol uptake
2016 StandoutScienceNobel
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response
2011
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation
2011 StandoutScience
Tandem Facial Amphiphiles for Membrane Protein Stabilization
2010 StandoutNobel
Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING
2015
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
2015 Science
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
B cell–intrinsic TBK1 is essential for germinal center formation during infection and vaccination in mice
2021 StandoutNobel
The Halogen Bond
2016 Standout
Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO)
2013
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Structural diversity of calmodulin binding to its target sites
2013
Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells
2015
Accurate proteome-wide missense variant effect prediction with AlphaMissense
2023 StandoutScienceNobel
Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids
2014
Works of F. Niesen being referenced
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
2006
A catalog of human cDNA expression clones and its application to structural genomics
2004
Structure of the CaMKIIδ/Calmodulin Complex Reveals the Molecular Mechanism of CaMKII Kinase Activation
2010
Kinase Domain Insertions Define Distinct Roles of CLK Kinases in SR Protein Phosphorylation
2009
Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites
2008
A prominent -hairpin structure in the winged-helix domain of RECQ1 is required for DNA unwinding and oligomer formation
2010
X-ray structure of engineered human Aortic Preferentially Expressed Protein-1 (APEG-1)
2005
The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability
2007 Standout