Standout Papers
Citation Impact
Citing Papers
IMF-κB and Rel: Participants in a Multiform Transcriptional Regulatory System
1993
Cleavage of 5′ splice site and lariat formation are independent of 3′ splice site in yeast mRNA splicing
1985 StandoutNatureNobel
Completion of the entire hepatitis C virus life cycle in genetically humanized mice
2013 StandoutNatureNobel
Selection and evolution of enzymes from a partially randomized non-catalytic scaffold
2007 StandoutNatureNobel
Ribozyme-catalysed amino-acid transfer reactions
1996 StandoutNatureNobel
Functional proteins from a random-sequence library
2001 StandoutNatureNobel
The bicoid protein is a positive regulator of hunchback transcription in the early Drosophila embryo
1989 StandoutNatureNobel
Long-Term sensitization training in Aplysia leads to an increase in calreticulin, a major presynaptic calcium-binding protein
1992 StandoutNobel
GAL4 activates gene expression in mammalian cells
1988
The U1 snRNP protein U1C recognizes the 5′ splice site in the absence of base pairing
2002 StandoutNatureNobel
A mediator required for activation of RNA polymerase II transcription in vitro
1991 StandoutNatureNobel
Three-dimensional structure of Escherichia coli RNA polymerase holoenzyme determined by electron crystallography
1989 StandoutNatureNobel
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences
1989 StandoutNatureNobel
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
The allosteric transition of glycogen phosphorylase
1989 Nature
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
1989 StandoutNatureNobel
Regulation by HIV Rev depends upon recognition of splice sites
1989 StandoutNobel
Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen
1989 StandoutNatureNobel
Primary structure and genomic organization of the histidine-rich protein of the malaria parasite Plasmodium lophurae
1984 StandoutNatureNobel
The LDL Receptor Gene: A Mosaic of Exons Shared with Different Proteins
1985 StandoutScienceNobel
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells
1983
Multiple factors including the small nuclear ribonucleoproteins U1 and U2 are necessary for Pre-mRNA splicing in vitro
1985
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA
1986
Trans splicing of mrna precursors in vitro
1985 StandoutNobel
Normal and mutant human β-globin pre-mRNAs are faithfully and efficiently spliced in vitro
1984
The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro
1983
Expression and function of transplantation antigens with altered or deleted cytoplasmic domains
1983
Specific and stable intron-factor interactions are established early during in vitro pre-mRNA splicing
1985
Altering Genotype and Phenotype by DNA-Mediated Gene Transfer
1980 StandoutScienceNobel
Dephosphorylation of the Inhibitor Component of Troponin by Phosphorylase Phosphatase
1972 StandoutNobel
Architecture and anatomy of the chromosomal locus in human chromosome 21 encoding the Cu/Zn superoxide dismutase.
1985
The primary structure of the duck alpha D-globin gene: an unusual 5′ splice junction sequence.
1983
The role of small nuclear ribonucleoprotein particles in pre-mRNA splicing
1987 Nature
Specific transcription and RNA splicing defects in five cloned β-thalassaemia genes
1983 Nature
Novel cysteine-rich motif and homeodomain in the product of the Caenorhabditis elegans cell lineage gene lin-II
1990 StandoutNatureNobel
Evidence against a scanning model of RNA splicing.
1983
A minimal intron length but no specific internal sequence is required for splicing the large rabbit β-globin intron
1984
Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2
1985 StandoutNatureNobel
The structure of one of the eight or more distinct chromosomal genes for human interferon-α
1980 Nature
Evidence for an intron-contained sequence required for the splicing of yeast RNA polymerase II transcripts
1983
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Diversity of murine gamma genes and expression in fetal and adult T lymphocytes
1986 StandoutNatureNobel
Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences
1985 StandoutNatureNobel
Lariat structures are in vivo intermediates in yeast pre-mRNA splicing
1984
Compartmentation of G Protein-Coupled Signaling Pathways in Cardiac Myocytes
2001
Fission yeast Schizosaccharomyces pombe correctly excises a mammalian RNA transcript intervening sequence
1985 StandoutNatureNobel
Targeted disruption of IRF-1 or IRF-2 results in abnormal type I IFN gene induction and aberrant lymphocyte development
1993
Comparison of Intron-Dependent and Intron-Independent Gene Expression
1988 Nobel
THE MUTATION AND POLYMORPHISM OF THE HUMAN β-GLOBIN GENE AND ITS SURROUNDING DNA
1984
Novel Proteinaceous Infectious Particles Cause Scrapie
1982 StandoutScienceNobel
The Chemistry of Self-Splicing RNA and RNA Enzymes
1987 StandoutScienceNobel
Long-term sensitization training in Aplysia leads to an increase in the expression of BiP, the major protein chaperon of the ER.
1992 StandoutNobel
A multicomponent complex is involved in the splicing of messenger RNA precursors
1985 StandoutNobel
Randomization of genes by PCR mutagenesis.
1992
Expression of a Bacterial Gene in Mammalian Cells
1980 StandoutScienceNobel
Functionally homologous cell cycle control genes in budding and fission yeast
1982 StandoutNatureNobel
Functional analysis and regulation of nuclear import of dorsal during the immune response in Drosophila.
1995 StandoutNobel
The Tetrahymena ribozyme acts like an RNA restriction endonuclease
1986 StandoutNatureNobel
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Synthesis of rabbit β-globin in cultured monkey kidney cells following infection with a SV40 β-globin recombinant genome
1979 StandoutNatureNobel
Roles of two DNA-binding factors in replication, segregation and transcriptional repression mediated by a yeast silencer.
1988 StandoutNobel
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.
1995
15N nuclear magnetic resonance of living cells
1975 StandoutNatureNobel
Tissue specificity of Drosophila P element transposition is regulated at the level of mRNA splicing
1986
Cloning and sequence analysis of the mouse genomic locus encoding the largest subunit of RNA polymerase II.
1987
A point mutation in the conserved hexanucleotide at a yeast 5′ splice junction uncouples recognition, cleavage, and ligation
1985
IN VITRO SYNTHESIS OF PARTICULATE GLYCOGEN
1965 StandoutNobel
Transcriptional Regulation in Mammalian Cells by Sequence-Specific DNA Binding Proteins
1989 StandoutScience
Structural comparison of two serine proteinase-protein inhibitor complexes: Eglin-C-subtilisin Carlsberg and CI-2-subtilisin Novo
1988 Standout
Cryptic branch point activation allows accurate in vitro splicing of human β-globin intron mutants
1985
Mutation in LDL Receptor: Alu-Alu Recombination Deletes Exons Encoding Transmembrane and Cytoplasmic Domains
1985 StandoutScienceNobel
Differential Responses to IFN-α Subtypes in Human T Cells and Dendritic Cells
2003
A compensatory base change in U1 snRNA suppresses a 5′ splice site mutation
1986
A role for branchpoints in splicing in vivo
1985 Nature
A novel mechanism of alternative RNA splicing for the developmentally regulated generation of troponin T isoforms from a single gene
1984
Cognate DNA Binding Specificity Retained After Leucine Zipper Exchange Between GCN4 and C/EBP
1989 StandoutScienceNobel
[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors
1983
A family of unusually spliced biologically active transcripts encoded by a Drosophila clock gene
1987 StandoutNatureNobel
Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
1988 StandoutNatureNobel
The receptor for transepithelial transport of IgA and IgM contains multiple immunoglobulin-like domains
1984 StandoutNatureNobel
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
RNA splicing and intron turnover are greatly diminished by a mutant yeast branch point.
1986 StandoutNobel
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro
1984
Observation of tissue metabolites using 31P nuclear magnetic resonance
1974 Nature
Localization of calmodulin in rat tissues.
1980
The role of protein phosphorylation in neural and hormonal control of cellular activity
1982 Nature
Electrophoresis of ribonucleoproteins reveals an ordered assembly pathway of yeast splicing complexes
1986 StandoutNatureNobel
5′ cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5′ splice region, not by the conserved 5′ GU
1987
Molecular consequences of specific intron mutations on yeast mRNA splicing in vivo and in vitro
1985
Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
2006 StandoutNatureNobel
Works of F Meyer being referenced
Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes
1990
Control of Phosphorylase Activity in a Muscle Glycogen Particle
1970 StandoutNobel
Control of Phosphorylase Activity in a Muscle Glycogen Particle
1970 StandoutNobel
A large fragment approach to DNA synthesis: total synthesis of a gene for the protease inhibitor eglin c from the leechHirudo medicinalisand its expression inE. coli
1984
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit β-globin gene
1983 Nature
Site-directed mutagenesis in DNA: Generation of point mutations in cloned β globin complementary DNA at the positions corresponding to amino acids 121 to 123
1978
Reversible silencing of enhancers by sequences derived from the human IFN-α promoter
1987
[The state of glycogen in the liver of rats].
1958
Control of Phosphorylase Activity in a Muscle Glycogen Particle
1970 StandoutNobel