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Citing Papers
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Structure and Biosynthesis of the Mannan Component of the Yeast Cell Envelope
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Regulated import and degradation of a cytosolic protein in the yeast vacuole
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The multicatalytic proteinase complex, a major extralysosomal proteolytic system
1990
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Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
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LMP2+ proteasomes are required for the presentation of specific antigens to cytotoxic T lymphocytes
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Expression of functional Thermoplasma acidophilum proteasomes in Escherichia coli
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The Active Sites of the Eukaryotic 20 S Proteasome and Their Involvement in Subunit Precursor Processing
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A Model for the Quaternary Structure of the Proteasome Activator PA28
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Proteasome Activation by REG Molecules Lacking Homolog-specific Inserts
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Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei
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Enzymatic changes of the bovine pituitary multicatalytic proteinase complex, induced by magnesium ions
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Inferring the historical patterns of biological evolution
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1997
Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants
1998 Nobel
The ubiquitin-proteasome proteolytic pathway
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Binding of Amyloid β Protein to the 20 S Proteasome
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Active Site-directed Inhibitors of Rhodococcus 20 S Proteasome
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Autocatalytic Subunit Processing Couples Active Site Formation in the 20S Proteasome to Completion of Assembly
1996
The 20S proteasome mediates the degradation of mouse and yeast ornithine decarboxylase in yeast cells
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Dissecting the assembly pathway of the 20S proteasome
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Evidence indicating that the multicatalytic proteinase of rabbit reticulocytes is not incorporated as a core enzyme into a 26 S proteinase complex
1992
The Human α-Type Proteasomal Subunit HsC8 Forms a Double Ringlike Structure, but Does Not Assemble into Proteasome-like Particles with the β-Type Subunits HsDelta or HsBPROS26
1997
Cloning and sequencing of the gene encoding the large (α‐) subunit of the proteasome from Thermoplasma acidophilum
1991
Membrane fusion and the cell cycle: Cdc48p participates in the fusion of ER membranes
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Biochemical properties of the proteasome from Thermoplasma acidophilum
1992
The proteasome from Thermoplasma acidophilum is neither a cysteine nor a serine protease
1995
Homology in Structural Organization BetweenE. coliClpAP Protease and the Eukaryotic 26 S Proteasome
1995
Cell cycle-dependent change of proteasome distribution during embryonic development of the ascidian Halocynthia roretzi
1992
Eubacterial proteasomes
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Inhibition of the chymotrypsin-like activity of the pituitary multicatalytic proteinase complex
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Possible mechanism of nuclear translocation of proteasomes
1990
26S Proteasome Structure Revealed by Three-dimensional Electron Microscopy
1998
An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes
1999
Lactacystin and clasto-Lactacystin β-Lactone Modify Multiple Proteasome β-Subunits and Inhibit Intracellular Protein Degradation and Major Histocompatibility Complex Class I Antigen Presentation
1997
Incorporation of major histocompatibility complex – encoded subunits LMP2 and LMP7 changes the quality of the 20S proteasome polypeptide processing products independent of interferon‐γ
1995
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
1998
20 S proteasomes are assembled via distinct precursor complexes processing of LMP2 and LMP7 proproteins takes place in 13–16 S preproteasome complexes
1994
Ubiquitin found in the archaebacterium Thermoplasma acidophilum
1993
The 26S proteasome of the yeast Saccharomyces cerevisiae
1994 StandoutNobel
The Proteasome Subunit, C2, Contains an Important Site for Binding of the PA28 (11S) Activator
1996
cDNA Cloning, Expression, and Functional Characterization of PI31, a Proline-rich Inhibitor of the Proteasome
2000
The 1.9 Å Structure of a Proteasome-11S Activator Complex and Implications for Proteasome-PAN/PA700 Interactions
2005
Subunit topology of the Rhodococcus proteasome
1997
Structural features of archaebacterial and eukaryotic proteasomes
1995
Structural and functional effects of PA700 and modulator protein on proteasomes 1 1Edited by W. Baumeister
1997
The three‐dimensional structure of proteasomes from Thermoplasma acidophilum as determined by electron microscopy using random conical tilting
1991
Ubiquitin C-Terminal Hydrolase Is an Immediate-Early Gene Essential for Long-Term Facilitation in Aplysia
1997 StandoutNobel
Processive Degradation of Proteins and Other Catalytic Properties of the Proteasome from Thermoplasma acidophilum
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Critical elements in proteasome assembly
1994
A 200‐amino acid ATPase module in search of a basic function
1995
[24] Multicatalytic endopeptidase complex: Proteasome
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Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolis
1998
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
Duplicated Proteasome Subunit Genes in Drosophila melanogaster Encoding Testes-Specific Isoforms
1996
Maturation of mammalian 20 S proteasome: purification and characterization of 13 S and 16 S proteasome precursor complexes
1997
Proteinase yscE of yeast shows homology with the 20 S cylinder particles of Xenopus laevis
1988
THE UBIQUITIN-CONJUGATION SYSTEM
1992
Dissociation and reconstitution of the Thermoplasma proteasome
1994
Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death
1995
Proteasome: from structure to function
1996
Structure of 20S proteasome from yeast at 2.4Å resolution
1997 StandoutNatureNobel
The human proteasomal subunit HsC8 induces ring formation of other α-type subunits 1 1Edited by R. Huber
1998
The proteasome
1997
Existence of a molecular ruler in proteasomes suggested by analysis of degradation products
1994
The prosomal protein of 27 kDa and a nuclear 38 kDa protein are immunologically related
1990
Proteasomes: protein degradation machines of the cell
1994
The proteasome/multicatalytic—multifunctional proteinase In vivo function in the ubiquitin‐dependent N‐end rule pathway of protein degradation in eukaryotes
1992
Autocatalytic processing of the 20S proteasome
1996 Nature
Self-compartmentalizing proteases
1997
Proteolysis, proteasomes and antigen presentation
1992 Nature
Molecular Mechanism of Protein Folding in the Cell
2011 StandoutNobel
Global quantification of mammalian gene expression control
2011 StandoutNature
The first characterization of a eubacterial proteasome: the 20S complex of Rhodococcus
1995
A Proteasome from the Methanogenic Archaeon Methanosarcina thermophila
1995
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Proteasome function is dispensable under normal but not under heat shock conditions in Thermoplasma acidophilum
1998
Degradation of oxidized insulin B chain by the multiproteinase complex macropain (proteasome)
1991
Conformational constraints in protein degradation by the 20S proteasome
1995
Proteasomes and other self-compartmentalizing proteases in prokaryotes
1999
Inhibition of Proteasome Activities and Subunit-Specific Amino-Terminal Threonine Modification by Lactacystin
1995 ScienceNobel
Mts4, a Non-ATPase Subunit of the 26 S Protease in Fission Yeast Is Essential for Mitosis and Interacts Directly with the ATPase Subunit Mts2
1997
The proteasome activator 11 S REG (PA28) and Class I antigen presentation
1999
Subcellular distribution of yeast invertase isoenzymes
1975
The Regulatory Complex of Drosophila melanogaster 26s Proteasomes
2000
Localization of acid phosphatase in Saccharomyces cerevisiae: a clue to cell wall formation
1977
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
The multicatalytic and 26 S proteases.
1993
Purification and characterization of a multiprotein component of the Drosophila 26 S (1500 kDa) proteolytic complex.
1993
Degradation of Proteins with Acetylated Amino Termini by the Ubiquitin System
1989 StandoutScienceNobel
Localized deposition of chitin on the yeast cell surface in response to mating pheromone
1979 StandoutNobel
Proteasome regulation of activation-induced T cell death
1997 StandoutNobel
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Purification and Characterization of a Proteasome from the Hyperthermophilic Archaeon Pyrococcus furiosus
1997
Skeletal muscle proteasome can degrade proteins in an ATP-dependent process that does not require ubiquitin.
1989
Gold Nanoparticles: Assembly, Supramolecular Chemistry, Quantum-Size-Related Properties, and Applications toward Biology, Catalysis, and Nanotechnology
2003 Standout
Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis.
1996 Nobel
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
A polypeptide bound by the chaperonin groEL is localized within a central cavity.
1993
The proteasome (multicatalytic protease) is a component of the 1500-kDa proteolytic complex which degrades ubiquitin-conjugated proteins.
1990
Localized secretion of acid phosphatase reflects the pattern of cell surface growth in saccharomyces cerevisiae
1980 StandoutNobel
Localization of acid phosphatase in protoplasts from Saccharomyces cerevisiae
1975
Proteasomes: destruction as a programme
1996
Evidence for the presence of five distinct proteolytic components in the pituitary multicatalytic proteinase complex. Properties of two components cleaving bonds on the carboxyl side of branched chain and small neutral amino acids
1993
Biosynthesis of cell walls of fungi
1979
ATG Systems from the Protein Structural Point of View
2009 StandoutNobel
Biochemical and Physical Properties of theMethanococcus jannaschii20S Proteasome and PAN, a Homolog of the ATPase (Rpt) Subunits of the Eucaryal 26S Proteasome
2000
Crystal Structure of the 20 S Proteasome from the Archaeon T. acidophilum at 3.4 Å Resolution
1995 ScienceNobel
The formation of glycosidic bonds in yeast glycoproteins
1977
Purification of an 11 S regulator of the multicatalytic protease.
1992
Covalent modification of the active site threonine of proteasomal β subunits and theEscherichia colihomolog HslV by a new class of inhibitors
1997
Site of catabolite inactivation
1994 StandoutNatureNobel
Early stages in the yeast secretory pathway are required for transport of carboxypeptidase Y to the vacuole
1982 StandoutNobel
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins.
1996 StandoutNobel
Chaperonin-mediated protein folding: GroES binds to one end of the GroEL cylinder, which accommodates the protein substrate within its central cavity.
1992
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu.
1994 StandoutNobel
Accurate protein structure modeling using sparse NMR data and homologous structure information
2012 StandoutNobel
Proteasomes in the archaea: from structure to function
2000
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.
1994
Subunit stoichiometry and three-dimensional arrangement in proteasomes from Thermoplasma acidophilum.
1992
Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme
1997
Proteasomes (multi-protease complexes) as 20 S ring-shaped particles in a variety of eukaryotic cells.
1988
The 20S Proteasome of Streptomyces coelicolor
1998
Activation of the multicatalytic protease. The 11 S regulator and 20 S ATPase complexes contain distinct 30-kilodalton subunits
1994
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway.
1995 StandoutNobel
Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes
1998
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Molecular interaction of the proteasome (multicatalytic proteinase). Evidence that the proteasome is not a constituent of the ‘26 S’ multienzyme complex
1991
Roles of Ubiquitinylation in Proteolysis and Cellular Regulation
1995
Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1
1998 Nobel
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin.
1989 StandoutNobel
Single-particle selection and alignment with heavy atom cluster-antibody conjugates
1998 StandoutNobel
Multiple forms of the 20 S multicatalytic and the 26 S ubiquitin/ATP-dependent proteases from rabbit reticulocyte lysate.
1992
PA700, an ATP-dependent activator of the 20 S proteasome, is an ATPase containing multiple members of a nucleotide-binding protein family.
1994
An abundant and ubiquitous homo-oligomeric ring-shaped ATPase particle related to the putative vesicle fusion proteins Sec18p and NSF.
1990
The PRE4 gene codes for a subunit of the yeast proteasome necessary for peptidylglutamyl-peptide-hydrolyzing activity. Mutations link the proteasome to stress- and ubiquitin-dependent proteolysis.
1993
THE PROTEASOME
1999 Nobel
Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway
1980 StandoutNobel
Biochemical Characterization of the 20S Proteasome from the Methanoarchaeon Methanosarcina thermophila
1998
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
In vivo function of the proteasome in the ubiquitin pathway.
1992
Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival.
1991
Structural insight into TRPV5 channel function and modulation
2019 StandoutNobel
Proteasomes are essential for yeast proliferation. cDNA cloning and gene disruption of two major subunits.
1990
Isolation of glucose-containing high-mannose glycoprotein core oligosaccharides.
1984 StandoutNobel
Molecular cloning and functional analysis of three subunits of yeast proteasome.
1991
Review
1997
Nuclear localization signals of human and Thermoplasma proteasomal alpha subunits are functional in vitro.
1995
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue
2016 StandoutNobel
Involvement of the proteasome in various degradative processes in mammalian cells.
1989
Changes in intracellular localization of proteasomes in immortalized ovarian granulosa cells during mitosis associated with a role in cell cycle control.
1993
Archaea and the prokaryote-to-eukaryote transition
1997
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Inhibitors of the proteasome pathway interfere with induction of nitric oxide synthase in macrophages by blocking activation of transcription factor NF-kappa B.
1996 StandoutNobel
Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy
2015 StandoutNobel
Structural flexibility of the Gαs α-helical domain in the β 2 -adrenoceptor Gs complex
2011 StandoutNobel
Purification of two high molecular weight proteases from rabbit reticulocyte lysate.
1987
Compartmentalized assembly of oligosaccharides on exported glycoproteins in yeast
1981 StandoutNobel
Proteasomes: multicatalytic proteinase complexes
1993
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase.
1995 StandoutNobel
Secretion and cell-surface growth are blocked in a temperature-sensitive mutant of Saccharomyces cerevisiae
1979 StandoutNobel
Works of F. Köpp being referenced
In vitro Activation of the 20S Proteasome
1993
The human proteasome subunit HsN3 is located inthe inner rings of the complex dimer
1995
The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria
1989
Electron microscopy and image analysis of the multicatalytic proteinase
1988
Localization of subunits in proteasomes from Thermoplasma acidophilum by immunoelectron microscopy
1991
Electron microscopy and image analysis reveal common principles of organization in two large protein complexes: groEL-Type proteins and proteasomes
1990
Effect of the multicatalytic proteinase (prosome) on translational activity in rabbit reticulocyte lysates
1990
Drosophila small cytoplasmic 19S ribonucleoprotein is homologous to the rat multicatalytic proteinase
1988 Nature
Identical Subunit Topographies of Human and Yeast 20S Proteasomes
1999
Chapter 2 Electron Microscopy of Yeasts
1975
The multicatalytic proteinase (prosome, proteasome): comparison of the eukaryotic and archaebacterial enzyme.
1991
Intracellular localization of mannan synthetase activity in budding baker's yeast
1973
Subunit arrangement in the human 20S proteasome
1997
Evidence Indicating that the Human Proteasome is a Complex Dimer
1993
Size and shape of the multicatalytic proteinase from rat skeletal muscle
1986