Standout Papers
Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Generation of ordered protein assemblies using rigid three-body fusion
2021 StandoutNobel
Asymmetrical Distribution of the Second Messenger c-di-GMP upon Bacterial Cell Division
2010 Science
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy
2012 StandoutScienceNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
Protein structure determination using metagenome sequence data
2017 StandoutScienceNobel
Structure of a 16-nm Cage Designed by Using Protein Oligomers
2012 Science
A post‐translational, c‐di‐GMP‐dependent mechanism regulating flagellar motility
2010
Methylation of Gibberellins by Arabidopsis GAMT1 and GAMT2
2007
Influenza virus pleiomorphy characterized by cryoelectron tomography
2006
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition
2016
Four-component protein nanocages designed by programmed symmetry breaking
2024 StandoutNatureNobel
Hierarchical design of pseudosymmetric protein nanocages
2024 StandoutNatureNobel
Selective Exo-Enzymatic Labeling Detects Increased Cell Surface Sialoglycoprotein Expression upon Megakaryocytic Differentiation
2016
The ϕPA3 phage nucleus is enclosed by a self-assembling 2D crystalline lattice
2023 StandoutNobel
Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa
2012
Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification
2019 StandoutNobel
Cell-based glycan arrays for probing glycan–glycan binding protein interactions
2018
Solution Structure of the PilZ Domain Protein PA4608 Complex with Cyclic di-GMP Identifies Charge Clustering as Molecular Readout
2011
Synthesis and Biological Evaluation of Isosteric Analogues of FK866, an Inhibitor of NAD Salvage
2008
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
2013 StandoutNature
Crystallographic snapshot of cellulose synthesis and membrane translocation
2012 Nature
Metal-chelating non-canonical amino acids in metalloprotein engineering and design
2018
A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa
2011
Structural Basis for the Discriminative Recognition of N6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins
2015
Structural characterization reveals that a PilZ domain protein undergoes substantial conformational change upon binding to cyclic dimeric guanosine monophosphate
2010
The role of PilZ domain proteins in the virulence of Xanthomonas campestris pv. campestris
2008
Engineered Glycocalyx Regulates Stem Cell Proliferation in Murine Crypt Organoids
2018
A Novel Tetrameric PilZ Domain Structure from Xanthomonads
2011
The cAMP Receptor-Like Protein CLP Is a Novel c-di-GMP Receptor Linking Cell–Cell Signaling to Virulence Gene Expression in Xanthomonas campestris
2009
The structure of CCT–Hsc70NBD suggests a mechanism for Hsp70 delivery of substrates to the chaperonin
2008
Sensing the messenger: The diverse ways that bacteria signal through c‐di‐GMP
2012
N6-methyladenosine Modulates Messenger RNA Translation Efficiency
2015 Standout
Coordinated Cyclic-Di-GMP Repression of Salmonella Motility through YcgR and Cellulose
2012
Structure of the Type VI Secretion System Contractile Sheath
2015 StandoutNobel
An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
2011 StandoutNature
Polypeptide and peptide toxins, magnifying lenses for binding sites in nicotinic acetylcholine receptors
2009
Should we stay or should we go: mechanisms and ecological consequences for biofilm dispersal
2011
c-di-GMP can form remarkably stable G-quadruplexes at physiological conditions in the presence of some planar intercalators
2011
Base ionization and ligand binding: how small ribozymes and riboswitches gain a foothold in a protein world
2011
Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
2022 Standout
Structure and mechanism of a bacterial light-regulated cyclic nucleotide phosphodiesterase
2009 Nature
You’ve come a long way: c-di-GMP signaling
2012
Accurate design of co-assembling multi-component protein nanomaterials
2014 StandoutNatureNobel
The structure and inhibition of a GGDEF diguanylate cyclase complexed with (c-di-GMP)2at the active site
2011
Glycyl radical activating enzymes: Structure, mechanism, and substrate interactions
2014
Inhibition of shoot branching by new terpenoid plant hormones
2008 StandoutNature
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
c-di-GMP Turn-Over in Clostridium difficile Is Controlled by a Plethora of Diguanylate Cyclases and Phosphodiesterases
2011
Bacterial nucleotide-based second messengers
2009
Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme
2017
A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain
2010 StandoutNobel
The Dimerization of an α/β-Knotted Protein Is Essential for Structure and Function
2007
Construction of molecular assemblies via docking: Modeling of tetramers with D2 symmetry
2003
Cyclic di-GMP Sensing via the Innate Immune Signaling Protein STING
2012
Evidence for Cyclic Di-GMP-Mediated Signaling in Bacillus subtilis
2012
Systemic signaling during plant defense
2013
Dynamic RNA Modifications in Gene Expression Regulation
2017 Standout
Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli
2008
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
MrkH, a Novel c-di-GMP-Dependent Transcriptional Activator, Controls Klebsiella pneumoniae Biofilm Formation by Regulating Type 3 Fimbriae Expression
2011
Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP
2012
Expanding and reprogramming the genetic code
2017 Nature
Identification and molecular characterization of a cyclic-di-GMP effector protein, PlzA (BB0733): additional evidence for the existence of a functional cyclic-di-GMP regulatory network in the Lyme disease spirochete,Borrelia burgdorferi
2009
XC1028 from Xanthomonas campestris adopts a PilZ domain‐like structure without a c‐di‐GMP switch
2008
Cyclic di‐GMP, an established secondary messenger still speeding up
2011
The bacterial second messenger c-di-GMP: mechanisms of signalling
2011
Metallopeptide catalysts and artificial metalloenzymes containing unnatural amino acids
2014
When the PilZ don’t work: effectors for cyclic di-GMP action in bacteria
2012
The Protein Structure Initiative: achievements and visions for the future
2012
Structural Basis for c-di-GMP-Mediated Inside-Out Signaling Controlling Periplasmic Proteolysis
2011
Structure of PP4397 Reveals the Molecular Basis for Different c-di-GMP Binding Modes by Pilz Domain Proteins
2010
Rational design of photosynthetic reaction center protein maquettes
2022
The c-di-GMP Binding Protein YcgR Controls Flagellar Motor Direction and Speed to Affect Chemotaxis by a “Backstop Brake” Mechanism
2010
The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum
2007
Phenylpropanoid Biosynthesis
2009 Standout
Structural and mechanistic determinants of c-di-GMP signalling
2009
Principles of c-di-GMP signalling in bacteria
2009
Structural diversity in the AdoMet radical enzyme superfamily
2012
Allosteric activation of exopolysaccharide synthesis through cyclic di‐GMP‐stimulated protein–protein interaction
2012
Design and Synthesis ofbis-carbamate Analogs of Cyclicbis-(3′-5′)-Diguanylic Acid (c-di-GMP) and the Acyclic Dimer PGPG
2008
pKNOT: the protein KNOT web server
2007
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Structural basis of ligand binding by a c-di-GMP riboswitch
2009
Spermidine/Spermine N1-Acetyltransferase-1 Binds to Hypoxia-inducible Factor-1α (HIF-1α) and RACK1 and Promotes Ubiquitination and Degradation of HIF-1α
2007 StandoutNobel
Structural Insight into the Mechanism of c-di-GMP Hydrolysis by EAL Domain Phosphodiesterases
2010
Cyclic diguanylate turnover mediated by the sole GGDEF/EAL response regulator in Pseudomonas putida : its role in the rhizosphere and an analysis of its target processes
2011
Mechanisms of Protein Import and Routing in Chloroplasts
2004
PILZ Protein Structure and Interactions with PILB and the FIMX EAL Domain: Implications for Control of Type IV Pilus Biogenesis
2009
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Accurate design of megadalton-scale two-component icosahedral protein complexes
2016 StandoutScienceNobel
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Biocatalysis with Unnatural Amino Acids: Enzymology Meets Xenobiology
2017
Oligomer Formation of the Bacterial Second Messenger c-di-GMP: Reaction Rates and Equilibrium Constants Indicate a Monomeric State at Physiological Concentrations
2011
Prediction of the structure of symmetrical protein assemblies
2007 StandoutNobel
Salicylic Acid, a Multifaceted Hormone to Combat Disease
2009 Standout
Visualizing the Perturbation of Cellular Cyclic di-GMP Levels in Bacterial Cells
2013
Computational design of a homotrimeric metalloprotein with a trisbipyridyl core
2016 StandoutNobel
RadicalS-Adenosylmethionine Enzymes
2014
Rapid screening of sugar-nucleotide donor specificities of putative glycosyltransferases
2016
Artificial Metalloenzymes for Asymmetric Catalysis by Creation of Novel Active Sites in Protein and DNA Scaffolds
2014
B4GAT1 is the priming enzyme for the LARGE-dependent functional glycosylation of α-dystroglycan
2014
Playing with the Molecules of Life
2018
Engineered Biosynthesis of β‐Alkyl Tryptophan Analogues
2018 StandoutNobel
Engineering enzymes for noncanonical amino acid synthesis
2018 StandoutNobel
Supramolecular Assembly of Artificial Metalloenzymes Based on the Dimeric Protein LmrR as Promiscuous Scaffold
2015
Cyclic di-GMP Signaling Regulates Invasion by Ehrlichia chaffeensis of Human Monocytes
2010
Bright Side of Lignin Depolymerization: Toward New Platform Chemicals
2018 Standout
Pyrolytic Depolymerization of Polyolefins Catalysed by Zirconium‐based UiO‐66 Metal–Organic Frameworks
2024 StandoutNobel
Remote C–H bond functionalization reveals the distance-dependent isotope effect
2008
Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
2011 Standout
Structures of wild-type and mutant human spermidine/spermine N 1 -acetyltransferase, a potential therapeutic drug target
2006
Molecular basis for the recognition of methylated adenines in RNA by the eukaryotic YTH domain
2014
Heme Enzyme Structure and Function
2014
Diverse Bacterial Microcompartment Organelles
2014
Cyclic di-GMP: the First 25 Years of a Universal Bacterial Second Messenger
2013 Standout
De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures
2017 StandoutNobel
Artificial Metalloenzymes: Reaction Scope and Optimization Strategies
2017
Engineering Orthogonal Polypeptide GalNAc-Transferase and UDP-Sugar Pairs
2019 StandoutNobel
Cyclic Diguanylate Signaling Proteins Control Intracellular Growth of Legionella pneumophila
2011
Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions
2016 Standout
Probing the CMP‐Sialic Acid Donor Specificity of Two Human β‐d ‐Galactoside Sialyltransferases (ST3Gal I and ST6Gal I) Selectively Acting on O‐ and N‐Glycosylproteins
2017
Protein Design: Toward Functional Metalloenzymes
2014
Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion
2012
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Mechanical Bonds and Topological Effects in Radical Dimer Stabilization
2014 StandoutNobel
T cell exclusion, immune privilege, and the tumor microenvironment
2015 StandoutScience
The ONIOM method: its foundation and applications to metalloenzymes and photobiology
2011
The Mononuclear Molybdenum Enzymes
2014 Standout
Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators
2011
Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design
2015 StandoutNobel
Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli
2009
Vibrio parahaemolyticusScrC Modulates Cyclic Dimeric GMP Regulation of Gene Expression Relevant to Growth on Surfaces
2007
The Anabaena sp. Strain PCC 7120 Gene all2874 Encodes a Diguanylate Cyclase and Is Required for Normal Heterocyst Development under High-Light Growth Conditions
2008
Prevailing Concepts of c-di-GMP Signaling
2009
Structure and Flexibility of Nanoscale Protein Cages Designed by Symmetric Self-Assembly
2013
C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products
2018
Chemistry and Biology Of Multicomponent Reactions
2012 Standout
Alternate Heme Ligation Steers Activity and Selectivity in Engineered Cytochrome P450-Catalyzed Carbene-Transfer Reactions
2018 StandoutNobel
Biokatalyse mit nicht‐natürlichen Aminosäuren: Enzymologie trifft Xenobiologie
2017
A Novel Potent Nicotinamide Phosphoribosyltransferase Inhibitor Synthesized via Click Chemistry
2009
The response threshold of S almonellaPilZ GMP
2012
Top-down design of protein architectures with reinforcement learning
2023 StandoutScienceNobel
Design of Heme Enzymes with a Tunable Substrate Binding Pocket Adjacent to an Open Metal Coordination Site
2023 StandoutNobel
Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions
2010 Standout
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids
2014
Works of F. Forouhar being referenced
Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
2005
Enzymatic Basis for N-Glycan Sialylation
2013
Structural Conservation of the Myoviridae Phage Tail Sheath Protein Fold
2011
The structural basis of cyclic diguanylate signal transduction by PilZ domains
2007
Crystal structure of pea Toc34, a novel GTPase of the chloroplast protein translocon
2001
Functional insights from structural genomics
2007
Two poplar methyl salicylate esterases display comparable biochemical properties but divergent expression patterns
2009
The Crystal Structure of the Influenza Matrix Protein M1 at Neutral pH: M1–M1 Protein Interfaces Can Rotate in the Oligomeric Structures of M1
2001
Structural Basis of Membrane-induced Cardiotoxin A3 Oligomerization
2003
Functional assignment based on structural analysis: Crystal structure of the yggJ protein (HI0303) of Haemophilus influenzae reveals an RNA methyltransferase with a deep trefoil knot
2003
Identification of Eukaryotic and Prokaryotic Methylthiotransferase for Biosynthesis of 2-Methylthio-N6-threonylcarbamoyladenosine in tRNA
2010
Computational Design of an Unnatural Amino Acid Dependent Metalloprotein with Atomic Level Accuracy
2013 StandoutNobel
Nicotinamide adenine dinucleotide metabolism as an attractive target for drug discovery
2007
Characterization of a patient-derived variant of GPX4 for precision therapy
2021
Crystal Structure of the C-terminal 10-kDa Subdomain of Hsc70
2003
Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases
2013
Structural genomics reveals EVE as a new ASCH/PUA‐related domain
2008
Crystal structure of VC0702 at 2.0 Å: Conserved hypothetical protein from Vibrio cholerae
2006
Structural and Functional Evidence for Bacillus subtilis PaiA as a Novel N1-Spermidine/Spermine Acetyltransferase
2005
Post-translational Modification of Ribosomal Proteins
2009
Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase
2006