F. Bichât

The re-emergence of natural products for drug discovery in the genomics era

Assembly of non-natural electron transfer conduits in the cytochrome P450 system: A critical assessment and update of artificial redox constructs amenable to exploitation in biotechnological areas

mTOR Signaling in Growth Control and Disease

Regulation of cell death: the calcium–apoptosis link

Cytochrome P450: taming a wild type enzyme

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice

Discovery of a regioselectivity switch in nitrating P450s guided by molecular dynamics simulations and Markov models

Caspases: pharmacological manipulation of cell death

The Bcl2 family: regulators of the cellular life-or-death switch

Caspase-2 Induces Apoptosis by Releasing Proapoptotic Proteins from Mitochondria

DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis

Molecular and Genetic Properties of Tumors Associated with Local Immune Cytolytic Activity

Vital functions for lethal caspases

The Endocannabinoid System as an Emerging Target of Pharmacotherapy

Requirement for Aspartate-cleaved Bid in Apoptosis Signaling by DNA-damaging Anti-cancer Regimens

Apop-1, a Novel Protein Inducing Cyclophilin D-dependent but Bax/Bak-related Channel-independent Apoptosis

Caspase-2 Can Trigger Cytochrome c Release and Apoptosis from the Nucleus

Targeting cannabinoid receptors to treat leukemia: Role of cross-talk between extrinsic and intrinsic pathways in Δ9-tetrahydrocannabinol (THC)-induced apoptosis of Jurkat cells

Caspase Functions in Cell Death and Disease

mTOR: from growth signal integration to cancer, diabetes and ageing

Mitochondrial Membrane Permeabilization in Cell Death

Activation of apoptosis signalling pathways by reactive oxygen species

Caspase-2 Acts Upstream of Mitochondria to Promote Cytochromec Release during Etoposide-induced Apoptosis

Caspase Family Proteases and Apoptosis

Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9

Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy

Effect of Conformational Dynamics on Substrate Recognition and Specificity as Probed by the Introduction of a de Novo Disulfide Bond into Cytochrome P450 2B1

CK2 controls TRAIL and Fas sensitivity by regulating FLIP levels in endometrial carcinoma cells

Granulocyte-macrophage colony-stimulating factor (GM-CSF) induces antiapoptotic and proapoptotic signals in acute myeloid leukemia

Sudemycins, Novel Small Molecule Analogues of FR901464, Induce Alternative Gene Splicing

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells

Flavonoids in Cancer and Apoptosis

Modulation of apoptosis by procaspase-2 short isoform: selective inhibition of chromatin condensation, apoptotic body formation and phosphatidylserine externalization

Improvement of Cyclophosphamide Activation by CYP2B6 Mutants: From in Silico to ex Vivo

Involvement of caspase-2 long isoform in Fas-mediated cell death of human leukemic cells