Standout Papers
- Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice (2002)
- Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels (1999)
- Gene targeting — homing in on α2-adrenoceptor-subtype function (1997)
- Gene targeting — homing in on α2-adrenoceptor-subtype function (1997)
- Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist (1997)
Citation Impact
Citing Papers
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
A Meta-Analysis of Cytokines in Major Depression
2009 Standout
Cascading effects of stressors and inflammatory immune system activation: implications for major depressive disorder
2009
Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice
1999 StandoutNobel
Adrenergic α2C-Receptors Modulate the Acoustic Startle Reflex, Prepulse Inhibition, and Aggression in Mice
1998 StandoutNobel
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
A Neurotrophic Model for Stress-Related Mood Disorders
2006 Standout
Guanfacine, But Not Clonidine, Improves Planning and Working Memory Performance in Humans
1999
Role of α2C‐adrenoceptor subtype in spatial working memory as revealed by mice with targeted disruption of the α2C‐adrenoceptor gene
1999
Mechanisms and Functional Implications of Adult Neurogenesis
2008 Standout
Brain-derived neurotrophic factor in the ventral midbrain–nucleus accumbens pathway: a role in depression
2003
Forebrain-specific trkB-receptor knockout mice: behaviorally more hyperactive than “depressive”
2003
Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine
1991
The Neuropeptide VGF Produces Antidepressant-Like Behavioral Effects and Enhances Proliferation in the Hippocampus
2007
The effects of dexmedetomidine, an alpha2 agonist, on learning and memory, assessed using passive avoidance and water maze tasks in rats
1992
Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice
2006
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox
2003 StandoutNobel
Localization ofα2c-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system
1998
Cell-type Specific Targeting of the α2c-Adrenoceptor
2000 StandoutNobel
Receptor subtype and dose dependence of dexmedetomidine-induced accumulation of [14C]glutamine in astrocytes suggests glial involvement in its hypnotic-sedative and anesthetic-sparing effects
2000
Antinociceptive Response to Nitrous Oxide Is Mediated by Supraspinal Opiate and Spinal α2Adrenergic Receptors in the Rat
1996
Neurotrophic factors and regulation of mood: Role of exercise, diet and metabolism
2005
Association of distinct α 2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders
2004
Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat.
1996
Alpha2C-adrenoceptor overexpression disrupts execution of spatial and non-spatial search patterns
1999 StandoutNobel
Neurotrophin levels in postmortem brains of suicide victims and the effects of antemortem diagnosis and psychotropic drugs
2005
Selective Loss of Brain-Derived Neurotrophic Factor in the Dentate Gyrus Attenuates Antidepressant Efficacy
2007
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
2006
The effects of prefrontal intracortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats
1996
Abnormal Regulation of the Sympathetic Nervous System in α2A-Adrenergic Receptor Knockout Mice
1999 StandoutNobel
Insulin and phorbol ester stimulate phosphorylation of acetyl‐CoA carboxylase at similar sites in isolated adipocytes
1988
Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice
2004
Assessing antidepressant activity in rodents: recent developments and future needs
2002
Hippocampal neurogenesis: Opposing effects of stress and antidepressant treatment
2006
Brain-Derived Neurotrophic Factor and Antidepressant Drugs Have Different But Coordinated Effects on Neuronal Turnover, Proliferation, and Survival in the Adult Dentate Gyrus
2005
Genetic Regulation of Behavioral and Neuronal Responses to Fluoxetine
2007
Role of Neurotrophic Factors in the Etiology and Treatment of Mood Disorders
2004
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses
2011 StandoutNature
Atipamezole, an α2 antagonist, stabilizes age-related high-voltage spindle and passive avoidance defects
1992
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
1989 StandoutNature
A Four Amino Acid Deletion Polymorphism in the Third Intracellular Loop of the Human α2C-Adrenergic Receptor Confers Impaired Coupling to Multiple Effectors
2000
Exercise builds brain health: key roles of growth factor cascades and inflammation
2007 Standout
BDNF Variation and Mood Disorders: A Novel Functional Promoter Polymorphism and Val66Met are Associated with Anxiety but Have Opposing Effects
2005
Two functionally distinct α2-adrenergic receptors regulate sympathetic neurotransmission
1999 StandoutNatureNobel
Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways
2017 StandoutNobel
Stress, Depression, and Neuroplasticity: A Convergence of Mechanisms
2007
Brain-Derived Neurotrophic Factor Conditional Knockouts Show Gender Differences in Depression-Related Behaviors
2006
α2C-Adrenoceptor-Overexpressing Mice Are Impaired in Executing Nonspatial and Spatial Escape Strategies
1998 StandoutNobel
Activation of α-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos
1992
Is it time to reassess the BDNF hypothesis of depression?
2007
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
2014 StandoutNobel
Mice with reduced brain-derived neurotrophic factor expression show decreased choline acetyltransferase activity, but regular brain monoamine levels and unaltered emotional behavior
2004
The effects of α2-adrenoceptor stimulation on neocortical EEG activity in control and 6-hydroxydopamine dorsal noradrenergic bundle-lesioned rats
1993
Structure of the αβ tubulin dimer by electron crystallography
1998 StandoutNature
Major Depressive Disorder
2008 Standout
Inositol trisphosphate and calcium signalling
1993 StandoutNature
Dose- and parameter-dependent effects of atipamezole, an α2-antagonist, on the performance of rats in a five-choice serial reaction time task
1993
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild‐type and D79N α2A‐adrenoceptor transgenic mice
1999
Differential targeting and function of α2A and α2C adrenergic receptor subtypes in cultured sympathetic neurons
2006 StandoutNobel
Acute administration of ketamine induces antidepressant-like effects in the forced swimming test and increases BDNF levels in the rat hippocampus
2007
Role of neurotrophic factors in depression
2006
KYNURENINE METABOLITES AND INFLAMMATION MARKERS IN DEPRESSED PATIENTS TREATED WITH FLUOXETINE OR COUNSELLING
2008
Assessment of the role of α2‐adrenoceptor subtypes in the antinociceptive, sedative and hypothermic action of dexmedetomidine in transgenic mice
1997
d-amphetamine and l-5-hydroxytryptophan-induced behaviours in mice with genetically-altered expression of the α2C-adrenergic receptor subtype
1998 StandoutNobel
Effects of medetomidine, an α-2 adrenoceptor agonist, and atipamezole, an α-2 antagonist, on spatial memory performance in adult and aged rats
1992
New insights into BDNF function in depression and anxiety
2007
The molecular neurobiology of depression
2008 StandoutNature
Synergistic interactions between two α 2-adrenoceptor agonists, dexmedetomidine and ST-91, in two substrains of Sprague–Dawley rats
2000
The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
2007
Depression: a case of neuronal life and death?
2004
Is mood chemistry?
2005
In Vivo Gene Modification Elucidates Subtype-Specific Functions of α2-Adrenergic Receptors
2000
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins.
1987 StandoutNobel
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.
1990 StandoutNobel
Guanylate cyclase from bovine lung. Evidence that enzyme activation by phenylhydrazine is mediated by iron-phenyl hemoprotein complexes.
1984 StandoutNobel
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
2006 StandoutScience
Receptor Subtype-Induced Targeting and Subtype-Specific Internalization of Human α2-Adrenoceptors in PC12 Cells
1999
Inactivation of catalase by phenylhydrazine. Formation of a stable aryl-iron heme complex.
1983
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins.
1986 StandoutNobel
G Proteins and Regulation of Adenylyl Cyclase
1989 StandoutNobel
The free energy for hydrolysis of a microtubule-bound nucleotide triphosphate is near zero: all of the free energy for hydrolysis is stored in the microtubule lattice [published erratum appears in J Cell Biol 1995 Apr;129(2):549]
1994
Expression of Gsα in Escherichia coli
1989 StandoutNobel
Myocyte Adrenoceptor Signaling Pathways
2003 StandoutScienceNobel
Heterozygous α 2A -adrenergic receptor mice unveil unique therapeutic benefits of partial agonists
2002 StandoutNobel
Assembly of tubulin with nucleotide analogs.
1981
Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
1996 StandoutScienceNobel
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
The α2A-Adrenergic Receptor Plays a Protective Role in Mouse Behavioral Models of Depression and Anxiety
2001
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go.
1987 StandoutNobel
Tubulin GTP hydrolysis influences the structure, mechanical properties, and kinesin-driven transport of microtubules.
1994
Mutation of the α2A-Adrenoceptor Impairs Working Memory Performance and Annuls Cognitive Enhancement by Guanfacine
2002 StandoutNobel
Lipid modifications of G protein subunits.
1991 StandoutNobel
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.
1987 StandoutNobel
Antithetic regulation by β-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway β-agonist paradox
2003 StandoutNobel
Antinociceptive Action of Nitrous Oxide Is Mediated by Stimulation of Noradrenergic Neurons in the Brainstem and Activation of α2BAdrenoceptors
2000 StandoutNobel
Role of GTP hydrolysis in microtubule dynamics: information from a slowly hydrolyzable analogue, GMPCPP.
1992
19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-
1991 StandoutNobel
Overexpression of Alpha2C-adrenoceptors impairs water maze navigation
1999
In vivo gene modification elucidates subtype-specific functions of alpha(2)-adrenergic receptors.
2000
Dynamic instability of microtubule growth
1984 StandoutNature
Alpha1-adrenergic receptors: new insights and directions.
2001
The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.
2001
Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
2003 StandoutScience
Studies on the Influence of Enriched-Environment Housing Combined With Systemic Administration of an α2-Adrenergic Antagonist on Spatial Learning and Hyperactivity After Global Ischemia in Rats
1997
INSIGHTS FROM IN VIVO MODIFICATION OF ADRENERGIC RECEPTOR GENE EXPRESSION
1998 StandoutNobel
Role of the α2B-Adrenergic Receptor in the Development of Salt-Induced Hypertension
1999 StandoutNobel
Effect of guanosine diphosphate on microtubule assembly and stability.
1980
Gene Profile of Electroconvulsive Seizures: Induction of Neurotrophic and Angiogenic Factors
2003
Works of Ewen MacDonald being referenced
Central α1-adrenoceptors
1999
Evaluation of the effects of a specific α2-adrenoceptor antagonist, atipamezole, on α1- and α2-adrenoceptor subtype binding, brain neurochemistry and behaviour in comparison with yohimbine
1997
Behavioural and neurochemical effects of medetomidine, a novel veterinary sedative
1988
Behavioural and neurochemical effects of antipamezole, a novel α2-adrenoceptor antagonist
1988
Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines
2005
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel
The effects of alpha-2 adrenoceptor antagonist, atipamezole, on spatial learning in scopolamine-treated and aged rats
1992
Behavioral and neurochemical characterization of α2A-adrenergic receptor knockout mice
2002 StandoutNobel
Genetic alteration of the α2-adrenoceptor subtype c in mice affects the development of behavioral despair and stress-induced increases in plasma corticosterone levels
1999 StandoutNobel
Medetomidine — a novel α2-adrenoceptor agonist: A review of its pharmacodynamic effects
1989
Genetic Alteration of α2C-Adrenoceptor Expression in Mice: Influence on Locomotor, Hypothermic, and Neurochemical Effects of Dexmedetomidine, a Subtype-Nonselective α2-Adrenoceptor Agonist
1997 StandoutNobel
Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects
2003
Inhibition of catalase in vitro and in vivo by 4‐hydroxypyrazole, a metabolite of pyrazole
1980
Behavioural and neurochemical effects of atipamezole, a novel α2-adreneceptor antagonist
1988
Comparison of the effects of detomidine and xylazine on some α2-adrenoceptor-mediated responses in the central and peripheral nervous systems
1985
Comparison of the behavioral and neurochemical effects of the two optical enantiomers of medetomidine, a selective alpha-2-adrenoceptor agonist.
1991
Distribution and pharmacology of alpha 2-adrenoceptors in the central nervous system.
1995
Role of nucleotides in tubulin polymerization: effect of guanylyl 5'-methylenediphosphonate.
1977
Gene targeting — homing in on α2-adrenoceptor-subtype function
1997 StandoutNobel