Standout Papers
Citation Impact
Citing Papers
High-Resolution Crystal Structure of an Engineered Human β 2 -Adrenergic G Protein–Coupled Receptor
2007 StandoutScienceNobel
GPCR Engineering Yields High-Resolution Structural Insights into β 2 -Adrenergic Receptor Function
2007 StandoutScienceNobel
Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling
2001 Standout
Cardiovascular and Metabolic Alterations in Mice Lacking Both β1- and β2-Adrenergic Receptors
1999 StandoutNobel
Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A
1997 StandoutNatureNobel
Constitutive mutants in the yeast pheromone response: Ordered function of the gene products
1989
Common signal transduction system shared by STE2 and STE3 in haploid cells of Saccharomyces cerevisiae : autocrine cell-cycle arrest results from forced expression of STE2
1987
Effect of Atenolol on Mortality and Cardiovascular Morbidity after Noncardiac Surgery
1996 Standout
Catecholamine Receptors: Structure, Function, and Regulation
1993 StandoutNobel
Targeted Disruption of the β2 Adrenergic Receptor Gene
1999 StandoutNobel
Right Heart Catheterization and Cardiac Complications in Patients Undergoing Noncardiac Surgery
2001
Perioperative myocardial ischemia in patients undergoing noncardiac surgery—I: Incidence and severity during the 4 Day perioperative period
1991
The STE4 and STE18 genes of yeast encode potential β and γ subunits of the mating factor receptor-coupled G protein
1989
Preoperative Optimization of Cardiovascular Hemodynamics Improves Outcome in Peripheral Vascular Surgery
1991
Crystal structure of the human β2 adrenergic G-protein-coupled receptor
2007 StandoutNatureNobel
Genetic analysis of the molecular basis for β‐adrenergic receptor subtype specificity
1989
Adrenergic Receptors From Molecular Structure to in vivo function
1997 StandoutNobel
Adrenergic Receptors as Models for G Protein-Coupled Receptors
1992 StandoutNobel
A Randomized, Controlled Trial of the Use of Pulmonary-Artery Catheters in High-Risk Surgical Patients
2003 Standout
Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors
1995 StandoutNatureNobel
Aortic dissection and aortic aneurysm surgery: Clinical observations, experimental investigations, and statistical analyses part II
1992
cDNA eloping of bovine substance-K receptor through oocyte expression system
1987 Nature
Seven transmembrane receptors: something old, something new
2007 StandoutNobel
Nonsurgical Reconstruction of Thoracic Aortic Dissection by Stent–Graft Placement
1999 Standout
Historical review: A brief history and personal retrospective of seven-transmembrane receptors
2004 StandoutNobel
Identification and sequence of a binding site peptide of the .beta.2-adrenergic receptor
1988
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Selective management of acute type B aortic dissection: Long-term follow-up
1996
Dissecting Descending Thoracic and Thoracoabdominal Aortic Aneurysms: Part II
1995
Physiological consequences of β-adrenergic receptor disruption
1998
The coming of age of de novo protein design
2016 StandoutNatureNobel
Crystal structure of the β2 adrenergic receptor–Gs protein complex
2011 StandoutNatureNobel
Correlation between Preoperative Ischemia and Major Cardiac Events after Peripheral Vascular Surgery
1989
The structure and function of G-protein-coupled receptors
2009 StandoutNatureNobel
Association of Perioperative Myocardial Ischemia with Cardiac Morbidity and Mortality in Men Undergoing Noncardiac Surgery
1990
The superfamily of heptahelical receptors
2000 StandoutNobel
Structure of a nanobody-stabilized active state of the β2 adrenoceptor
2011 StandoutNatureNobel
Structure, function, and regulation of adrenergic receptors
1993
Identification of a Gs activator region of the β2-adrenergic receptor that is autoregulated via protein kinase A-dependent phosphorylation
1991
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Phosphorylation of the β-adrenergic receptor in intact cells: Relationship to heterologous and homologous mechanisms of adenylate cyclase desensitization
1987 StandoutNobel
Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization
1988 StandoutNatureNobel
A Medical Perspective
1994
The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptor
1988 StandoutNatureNobel
Structure of a β1-adrenergic G-protein-coupled receptor
2008 StandoutNatureNobel
The mouse 5-HT1C receptor contains eight hydrophobic domains and is X-linked
1991
Preoperative Assessment of Patients with Known or Suspected Coronary Disease
1995
Seven-transmembrane receptors
2002 StandoutNobel
The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain
1988
Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c Receptor
1988 StandoutScienceNobel
Regulation of beta-adrenergic receptors by "permissive" hormones: glucocorticoids increase steady-state levels of receptor mRNA.
1988
Molecular characterization of a rat alpha 2B-adrenergic receptor.
1990
Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.
1990
Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.
1986 StandoutNobel
Stoichiometry of G protein subunits affects the Saccharomyces cerevisiae mating pheromone signal transduction pathway.
1990
Identification of a Family of Muscarinic Acetylcholine Receptor Genes
1987 Science
G Protein-coupled Receptors
1998
Conserved aspartic acid residues 79 and 113 of the beta-adrenergic receptor have different roles in receptor function.
1988
Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.
1988 StandoutNobel
Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.
1988 StandoutNobel
Identification of residues required for ligand binding to the beta-adrenergic receptor.
1987
The avian beta-adrenergic receptor: primary structure and membrane topology.
1986
G Protein–Coupled Receptor Rhodopsin
2006
Identification of Two Serine Residues Involved in Agonist Activation of the β-Adrenergic Receptor
1989
Regulation of transmembrane signaling by receptor phosphorylation
1987 StandoutNobel
Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.
1987
Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.
1992 StandoutNobel
Determining Surgical Indications for Acute Type B Dissection Based on Enlargement of Aortic Diameter During the Chronic Phase
1995
The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration
1987
Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.
1990
Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide.
1992 StandoutNobel
Preoperative Assessment of High-Risk Surgical Patients
1985
Molecular biology of the visual pigments
1986
Distinct primary structures, ligand-binding properties and tissue-specific expression of four human muscarinic acetylcholine receptors.
1987
Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells.
1988
Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor
1986 Nature
Long-term Cardiac Prognosis Following Noncardiac Surgery
1992
A family of receptors coupled to guanine nucleotide regulatory proteins
1987 StandoutNobel
Primary structure of porcine cardiac muscarinic acetylcholine receptor deduced from the cDNA sequence
1986
An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins
1987 StandoutNatureNobel
Primary Structure and Biochemical Properties of an M 2 Muscarinic Receptor
1987 Science
Cardiac Assessment for Patients Undergoing Noncardiac Surgery A Multifactorial Clinical Risk Index
1986
The peptide product of a 5' leader cistron in the beta 2 adrenergic receptor mRNA inhibits receptor synthesis.
1994 StandoutNobel
STE12, a protein involved in cell-type-specific transcription and signal transduction in yeast, is part of protein-DNA complexes.
1989
Molecular and Regulatory Properties of Adrenergic Receptors
1987 StandoutNobel
Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.
1987
The hydrophobic tryptic core of the beta-adrenergic receptor retains Gs regulatory activity in response to agonists and thiols.
1987
Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.
1987 StandoutNobel
Hydrophobic amino acid in the i2 loop plays a key role in receptor-G protein coupling.
1993
A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients
1993
The role of cytosolic and membrane factors in processing of the human beta-2 adrenergic receptor following translocation and glycosylation in a cell-free system.
1990 StandoutNobel
Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes.
1987 StandoutNobel
Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.
1988 StandoutNobel
Recent Advances in Cardiac β2-Adrenergic Signal Transduction
1999
Variations on a theme
1991 StandoutNatureNobel
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.
1990 StandoutNobel
Monitoring operative risk in the elderly
1980
Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects.
1996 StandoutNobel
Regulation of the yeast pheromone response pathway by G protein subunits.
1990
Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization
1989 StandoutNobel
Predictors of Postoperative Myocardial Ischemia in Patients Undergoing Noncardiac Surgery
1992
The family of G‐protein‐coupled receptors
1995
The Mammalian β-Adrenergic Receptor: Structural and Functional Characterization of the Carbohydrate Moiety
1987 StandoutNobel
GPA1, a haploid-specific essential gene, encodes a yeast homolog of mammalian G protein which may be involved in mating factor signal transduction
1987
Genetic regulation of β2-adrenergic receptors in 3T3-L1 fibroblasts
1989
Two distinct pathways for cAMP-mediated down-regulation of the β2-adrenergic receptor
1989 StandoutNobel
cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
1987 StandoutNobel
Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase
1986 StandoutNatureNobel
The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.
1987 StandoutNobel
Selective binding of ligands to beta 1, beta 2 or chimeric beta 1/beta 2-adrenergic receptors involves multiple subsites.
1990
Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.
1987
Cloning, Sequencing, and Expression of the Gene Coding for the Human Platelet α 2 -Adrenergic Receptor
1987 StandoutScienceNobel
Site-directed Anti-peptide Antibodies Define the Topography of the β-Adrenergic Receptor
1989
Structure and functional expression of cloned rat serotonin 5HT-2 receptor.
1988
A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists
1991 StandoutNobel
Perioperative Cardiac Morbidity
1990
cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes.
1987
Cloning and sequence analysis of the human brain β‐adrenergic receptor
1987
Ligand binding to the β-adrenergic receptor involves its rhodopsin-like core
1987 Nature
Purification and characterization of the beta-adrenergic receptor kinase.
1987
Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.
1988
Monitoring for Myocardial Ischemia During Noncardiac Surgery
1992
Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.
1988
Selective Amplification And Cloning Of Four New Members Of The G Protein-coupled Receptor Family
1989 Science
Reconstitutively active G protein-coupled receptors purified from baculovirus-infected insect cells.
1991
INSIGHTS FROM IN VIVO MODIFICATION OF ADRENERGIC RECEPTOR GENE EXPRESSION
1998 StandoutNobel
In-Hospital and Long-term Mortality in Male Veterans Following Noncardiac Surgery
1992
Order of action of components in the yeast pheromone response pathway revealed with a dominant allele of the STE11 kinase and the multiple phosphorylation of the STE7 kinase.
1992 StandoutNobel
Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.
1988 StandoutNobel
Characterization of the binding domain of the beta-adrenergic receptor with the fluorescent antagonist carazolol. Evidence for a buried ligand binding site.
1990
Acetoxymethyl esters of phosphates, enhancement of the permeability and potency of cAMP.
1993 StandoutNobel
Structural features required for ligand binding to the beta-adrenergic receptor.
1987
Why are there so many adrenoceptor subtypes?
1994
Cloning of the cDNA for the human beta 1-adrenergic receptor.
1987 StandoutNobel
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
The high affinity state of the beta 2-adrenergic receptor requires unique interaction between conserved and non-conserved extracellular loop cysteines.
1994
Works of Eve E. Slater being referenced
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells
1989
The clinical recognition of dissecting aortic aneurysm
1976
Cloning of the gene and cDNA for mammalian β-adrenergic receptor and homology with rhodopsin
1986 StandoutNatureNobel
Multifactorial Index of Cardiac Risk in Noncardiac Surgical Procedures
1977 Standout
Long-term survival of patients with treated aortic dissection
1984
CARDIAC RISK FACTORS AND COMPLICATIONS IN NON-CARDIAC SURGERY
1978
Synthetic segments of the mammalian βAR are preferentially recognized by cAMP-dependent protein kinase and protein kinase C
1987