Standout Papers
Citation Impact
Citing Papers
Sequence Variations of MicroRNAs in Human Cancer: Alterations in Predicted Secondary Structure Do Not Affect Processing
2006
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
2007 StandoutNobel
A microRNA expression signature of human solid tumors defines cancer gene targets
2006 Standout
Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening
2008 Science
miR-15 and miR-16 induce apoptosis by targeting BCL2
2005 Standout
A Polycistronic MicroRNA Cluster, miR-17-92 , Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation
2005
p53 represses c-Myc through induction of the tumor suppressor miR-145
2009
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
2005 Science
WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway
2009
Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
2011 Science
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
MicroRNA-214 Suppresses Growth and Invasiveness of Cervical Cancer Cells by Targeting UDP-N-acetyl-α-d-galactosamine:Polypeptide N-Acetylgalactosaminyltransferase 7
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
Bump-and-Hole Engineering Identifies Specific Substrates of Glycosyltransferases in Living Cells
2020 StandoutNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Systematic identification of microRNA functions by combining target prediction and expression profiling
2006
p53‐repressed miRNAs are involved with E2F in a feed‐forward loop promoting proliferation
2008
MicroRNA function in animal development
2005
MicroRNA fingerprints during human megakaryocytopoiesis
2006
Transgenic RNA interference in ES cell–derived embryos recapitulates a genetic null phenotype
2003
Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis
2009
Mammalian microRNAs: a small world for fine-tuning gene expression
2006
Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs
2006
Quantitative assessment of markers for cell senescence
2010
Senescence-messaging secretome: SMS-ing cellular stress
2009
MicroRNAs
2004 Standout
Spatial preferences of microRNA targets in 3' untranslated regions
2007
Control of the Embryonic Stem Cell State
2011
MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer
2009
Control of mucin-type O-glycosylation: A classification of the polypeptide GalNAc-transferase gene family
2011
Oncogene addiction: setting the stage for molecularly targeted cancer therapy
2007
How microRNAs control cell division, differentiation and death
2005
Tumor Self-Seeding by Circulating Cancer Cells
2009
Adenine base editing in an adult mouse model of tyrosinaemia
2019
Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death
2005
p53-Mediated Activation of miRNA34 Candidate Tumor-Suppressor Genes
2007
Cellular senescence: when bad things happen to good cells
2007 Standout
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
Targeting microRNAs in cancer: rationale, strategies and challenges
2010
Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease?
2005
Pro-senescence therapy for cancer treatment
2011
Ionizing radiation‐induced long‐term expression of senescence markers in mice is independent of p53 and immune status
2010
p53 — a Jack of all trades but master of none
2009
Cancer Metastasis: Building a Framework
2006 Standout
p38MAPK is a novel DNA damage response‐independent regulator of the senescence‐associated secretory phenotype
2011
A microRNA component of the p53 tumour suppressor network
2007 StandoutNature
Epithelial-Mesenchymal Transition Induced by Senescent Fibroblasts
2011
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
2009 Standout
Cellular Senescence in Cancer and Aging
2007 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Telomeres and telomerase in cancer
2009
Slicer function of Drosophila Argonautes and its involvement in RISC formation
2005
Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation
2009
LNA-modified oligonucleotides mediate specific inhibition of microRNA function
2006
MicroRNAs: Target Recognition and Regulatory Functions
2009 Standout
Probing tumor phenotypes using stable and regulated synthetic microRNA precursors
2005
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
2013
Short Hairpin Activated Gene Silencing in Mammalian Cells
2004
A three-dimensional view of the molecular machinery of RNA interference
2008 StandoutNatureNobel
EMT, cancer stem cells and drug resistance: an emerging axis of evil in the war on cancer
2010 Standout
Involvement of Human Micro-RNA in Growth and Response to Chemotherapy in Human Cholangiocarcinoma Cell Lines
2006
Models, mechanisms and clinical evidence for cancer dormancy
2007
Short Telomeres Limit Tumor Progression In Vivo by Inducing Senescence
2007 StandoutNobel
MicroRNAs as oncogenes
2005
Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay
2011
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice
2012
Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
2007 StandoutNature
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
Killing the messenger: short RNAs that silence gene expression
2003
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
2006
A Genetic Screen Implicates miRNA-372 and miRNA-373 As Oncogenes in Testicular Germ Cell Tumors
2006
Differential Regulation of microRNAs by p53 Revealed by Massively Parallel Sequencing: miR-34a is a p53 Target That Induces Apoptosis and G1-arrest
2007
An efficient and sensitive method for preparing cDNA libraries from scarce biological samples
2014 StandoutNobel
Restoration of p53 function leads to tumour regression in vivo
2007 Nature
Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues
2005
Stalled Fork Rescue via Dormant Replication Origins in Unchallenged S Phase Promotes Proper Chromosome Segregation and Tumor Suppression
2011
A resource for large-scale RNA-interference-based screens in mammals
2004
The essence of senescence: Figure 1.
2010 Standout
Whole Chromosome Instability Caused by Bub1 Insufficiency Drives Tumorigenesis through Tumor Suppressor Gene Loss of Heterozygosity
2009
Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning
2013
Tumor Suppressor and Aging Biomarker p16INK4a Induces Cellular Senescence without the Associated Inflammatory Secretory Phenotype
2011
Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan
2012
RNA-guided genetic silencing systems in bacteria and archaea
2012 StandoutNatureNobel
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing
2010
CRISPR-mediated direct mutation of cancer genes in the mouse liver
2014 Nature
Oncomirs — microRNAs with a role in cancer
2006 Standout
Cellular senescence: putting the paradoxes in perspective
2010
Mad2-induced chromosome instability leads to lung tumour relapse after oncogene withdrawal
2010 Nature
Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases
2012
Extensive post-transcriptional regulation of microRNAs and its implications for cancer
2006
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
2009
Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network
2008 Standout
A Genome-Wide Map of Conserved MicroRNA Targets in C. elegans
2006
The common biology of cancer and ageing
2007 Nature
Healing and Hurting: Molecular Mechanisms, Functions, and Pathologies of Cellular Senescence
2009
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi
2010
MicroRNAs in cell proliferation, cell death, and tumorigenesis
2006
Programmed Cell Senescence during Mammalian Embryonic Development
2013 Standout
The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
2008 StandoutNobel
Portrait of PTEN: Messages from mutant mice
2008 StandoutNobel
The causes and consequences of genetic heterogeneity in cancer evolution
2013 StandoutNature
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
Transactivation of miR-34a by p53 Broadly Influences Gene Expression and Promotes Apoptosis
2007 Standout
How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?
2007
DNA breaks and chromosome pulverization from errors in mitosis
2012 Nature
Oncogene-induced senescence: the bright and dark side of the response
2010
Silencing of microRNAs in vivo with ‘antagomirs’
2005 StandoutNature
Causes and consequences of aneuploidy in cancer
2012
MicroRNAs in Human Cancer
2012
Genomics of microRNA
2006
MicroRNA signatures in human cancers
2006 Standout
The PtdIns(3,4)P2 phosphatase INPP4A is a suppressor of excitotoxic neuronal death
2010 StandoutNatureNobel
Leukaemogenesis: more than mutant genes
2009
Revealing the world of RNA interference
2004 StandoutNatureNobel
miRBase: microRNA sequences, targets and gene nomenclature
2005 Standout
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
2013
Immune surveillance of senescent cells--biological significance in cancer- and non-cancer pathologies
2012
MicroRNAs in Stress Signaling and Human Disease
2012
The role of senescent cells in ageing
2014 StandoutNature
Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
2012 StandoutNatureNobel
Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
2006 Standout
The Hallmarks of Aging
2013 Standout
CRISPR-Mediated Modular RNA-Guided Regulation of Transcription in Eukaryotes
2013 StandoutNobel
The Causes and Consequences of Polyploidy in Normal Development and Cancer
2011
Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
2011 StandoutNobel
Overgrowth caused by misexpression of a microRNA with dispensable wild-type function
2006
Camels and zebrafish, viruses and cancer: a microRNA update
2005
Stem cell division is regulated by the microRNA pathway
2005 Nature
Actions of human telomerase beyond telomeres
2008
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
2009 Standout
Inflammatory networks during cellular senescence: causes and consequences
2010
Senescence in tumours: evidence from mice and humans
2009
Pten Dose Dictates Cancer Progression in the Prostate
2003
Cellular senescence: hot or what?
2009
p21 Both Attenuates and Drives Senescence and Aging in BubR1 Progeroid Mice
2013
Extensive modulation of a set of microRNAs in primary glioblastoma
2005
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
2009 Standout
MicroRNAs and cancer
2003
Feedback between p21 and reactive oxygen production is necessary for cell senescence
2010
Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
2004
Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells
2008 Science
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy
2008
Selection against PUMA Gene Expression in Myc-Driven B-Cell Lymphomagenesis
2008
Aging, Cellular Senescence, and Cancer
2012 Standout
TIMER2.0 for analysis of tumor-infiltrating immune cells
2020 Standout
MicroRNA functions in animal development and human disease
2005
The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
2010 Standout
microRNAs exhibit high frequency genomic alterations in human cancer
2006
Natural Innate and Adaptive Immunity to Cancer
2011 Standout
Cellular senescence controls fibrosis in wound healing
2010
Lysosome-mediated processing of chromatin in senescence
2013
Histone variant macroH2A confers resistance to nuclear reprogramming
2011 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
miR-34a repression of SIRT1 regulates apoptosis
2008
A role for Dicer in immune regulation
2006 StandoutNobel
The role of microRNA genes in papillary thyroid carcinoma
2005 Standout
Sizing up miRNAs as cancer genes
2005
Immune-mediated dormancy: an equilibrium with cancer
2008
Aneuploidy: Cells Losing Their Balance
2008
New Insights into the Troubles of Aneuploidy
2012
Four faces of cellular senescence
2011 Standout
Regulation of apoptosis by the circadian clock through NF-κB signaling
2011 StandoutNobel
NF-κB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
2006 StandoutNobel
MicroRNA Expression Abnormalities in Pancreatic Endocrine and Acinar Tumors Are Associated With Distinctive Pathologic Features and Clinical Behavior
2006
Emerging Challenges in Regulatory T Cell Function and Biology
2007 StandoutScienceNobel
Cell-type-specific signatures of microRNAs on target mRNA expression
2006
Distance constraints between microRNA target sites dictate efficacy and cooperativity
2007
How Do MicroRNAs Regulate Gene Expression?
2007
Suppression of tumorigenesis by the p53 target PUMA
2004
A MicroRNA Signature of Hypoxia
2006
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
2008 Standout
The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression
2010
Cellular senescence induced by CD158d reprograms natural killer cells to promote vascular remodeling
2012
Structural Basis for Double-Stranded RNA Processing by Dicer
2006 StandoutScienceNobel
MicroRNA-Cancer Connection: The Beginning of a New Tale
2006
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
2009
Lamin B1 loss is a senescence-associated biomarker
2012
Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice
2011
The Arf/p53 Pathway in Cancer and Aging
2008
Works of Eva Hernando being referenced
Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations
2007
A Leukocyte Infiltration Score Defined by a Gene Signature Predicts Melanoma Patient Prognosis
2018
The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
2007 Standout
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8
2010 Nature
Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice
2006
Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence
2008
Rb inactivation promotes genomic instability by uncoupling cell cycle progression from mitotic control
2004 Nature
An epi-allelic series of p53 hypomorphs created by stable RNAi produces distinct tumor phenotypes in vivo
2003
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
2007 StandoutNature
Tissue-specific and reversible RNA interference in transgenic mice
2007
Implications of Cellular Senescence in Tissue Damage Response, Tumor Suppression, and Stem Cell Biology
2008
A microRNA polycistron as a potential human oncogene
2005 StandoutNature
miR-30b/30d Regulation of GalNAc Transferases Enhances Invasion and Immunosuppression during Metastasis
2011
A microRNA polycistron as a potential human oncogene
2020
Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells
2004