Citation Impact

Citing Papers

Recognition of a Ubiquitous Self Antigen by Prostate Cancer-Infiltrating CD8 + T Lymphocytes
2008 StandoutScienceNobel
Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors
2009 StandoutScience
RNA-Guided Human Genome Engineering via Cas9
2013 StandoutScience
A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
2012 StandoutScienceNobel
Aire-Dependent Thymic Development of Tumor-Associated Regulatory T Cells
2013 StandoutScienceNobel
Optimized TAL effector nucleases (TALENs) for use in treatment of sickle cell disease
2012
Frequent Endonuclease Cleavage at Off-target Locations In Vivo
2010
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Autonomous zinc-finger nuclease pairs for targeted chromosomal deletion
2010
Epigenetic inheritance based on DNA methylation
1993
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Coevolution of a Homing Endonuclease and Its Host Target Sequence
2007
A guide to genome engineering with programmable nucleases
2014 Standout
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
2011
Rewiring of the Fruit Metabolome in Tomato Breeding
2018 Standout
Assessment of the optimization of affinity and specificity at protein–DNA interfaces
2009 StandoutNobel
Directed Evolution of an Enhanced and Highly Efficient FokI Cleavage Domain for Zinc Finger Nucleases
2010
A novel expression assay to study transcriptional activators
1990
High-frequency modification of plant genes using engineered zinc-finger nucleases
2009 Nature
Modular system for the construction of zinc-finger libraries and proteins
2010
Computer design of obligate heterodimer meganucleases allows efficient cutting of custom DNA sequences
2008
Multiplex CRISPR/Cas9-based genome editing for correction of dystrophin mutations that cause Duchenne muscular dystrophy
2015
Tumor Metastasis: Molecular Insights and Evolving Paradigms
2011 Standout
Enabling functional genomics with genome engineering
2015
Zinc finger protein-dependent and -independent contributions to the in vivo off-target activity of zinc finger nucleases
2010
p53 Gene Repair with Zinc Finger Nucleases Optimised by Yeast 1-Hybrid and Validated by Solexa Sequencing
2011
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes
2011
Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome
2015
Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering
2011 StandoutNobel
Massively parallel determination and modeling of endonuclease substrate specificity
2014 StandoutNobel
Meganucleases and DNA Double-Strand Break-Induced Recombination: Perspectives for Gene Therapy
2007
Transcriptional Activation by Tetracyclines in Mammalian Cells
1995 StandoutScience
Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects
2012
Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases
2007
Highly active zinc-finger nucleases by extended modular assembly
2012
Gene Silencing in Cancer in Association with Promoter Hypermethylation
2003 Standout
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
2003 Standout
GATA-3 Links Tumor Differentiation and Dissemination in a Luminal Breast Cancer Model
2008
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
2011
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
T Cell Surveillance of Oncogene-Induced Prostate Cancer Is Impeded by T Cell-Derived TGF-β1 Cytokine
2011 StandoutNobel
One-Step Generation of Mice Carrying Mutations in Multiple Genes by CRISPR/Cas-Mediated Genome Engineering
2013 Standout
A synthetic homing endonuclease-based gene drive system in the human malaria mosquito
2011 StandoutNatureNobel
Improved Modeling of Side-Chain–Base Interactions and Plasticity in Protein–DNA Interface Design
2012 StandoutNobel
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Targeted genome editing in pluripotent stem cells using zinc-finger nucleases
2010
DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei
2004 StandoutNobel
Precision genome engineering with programmable DNA-nicking enzymes
2012
Characterization of the Interaction of a Recombinant Soluble Neuroligin-1 with Neurexin-1β
2003 StandoutNobel
Engineering domain fusion chimeras from I-OnuI family LAGLIDADG homing endonucleases
2012 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Gene Targeting in Drosophila and Caenorhabditis elegans With Zinc-Finger Nucleases
2008
Computational reprogramming of homing endonuclease specificity at multiple adjacent base pairs
2010 StandoutNobel
Meganucleases and Other Tools for Targeted Genome Engineering: Perspectives and Challenges for Gene Therapy
2011
Structure-Based DNA-Binding Prediction and Design
2010
A library of TAL effector nucleases spanning the human genome
2013
Attenuation of Zinc Finger Nuclease Toxicity by Small-Molecule Regulation of Protein Levels
2009
The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA
2001
Evidence for the direct role of acetylcholinesterase in neurite outgrowth in primary dorsal root ganglion neurons
2000
Heritable targeted mutagenesis in maize using a designed endonuclease
2009
Progress and prospects: Zinc-finger nucleases as gene therapy agents
2008
Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases
2008
Engineered I-CreI Derivatives Cleaving Sequences from the Human XPC Gene can Induce Highly Efficient Gene Correction in Mammalian Cells
2007
Mining Endonuclease Cleavage Determinants in Genomic Sequence Data
2011 StandoutNobel
High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity
2013 StandoutNobel
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Mutagenesis and Oncogenesis by Chromosomal Insertion of Gene Transfer Vectors
2006
β-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
2002 Standout
Manipulation of T cell costimulatory and inhibitory signals for immunotherapy of prostate cancer
1997 StandoutNobel
Simian Virus 40 and Polyoma Virus Gene Expression Explored by the Microinjection Technique
1979
Targeted and Equally Distributed Delivery of mRNA to Organs with Pentaerythritol-Based One-Component Ionizable Amphiphilic Janus Dendrimers
2023 StandoutNobel
Breast cancer classification and prognosis based on gene expression profiles from a population-based study
2003 Standout
From Genomics to Gene Therapy: Induced Pluripotent Stem Cells Meet Genome Editing
2015 Nobel
Molecular Mechanisms of Gene Silencing Mediated by DNA Methylation
2002
Regulation of simian virus 40 gene expression in Xenopus laevis oocytes.
1985
Preferential overexpression of a 172Arg-->Leu mutant p53 in the mammary gland of transgenic mice results in altered lobuloalveolar development.
1994
Initiating oncogenic event determines gene-expression patterns of human breast cancer models
2002
Location and function of retroviral and SV40 sequences that enhance biochemical transformation after microinjection of DNA
1983 StandoutNobel
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Genome Engineering With Zinc-Finger Nucleases
2011
G Protein-Coupled Receptors: Functional and Mechanistic Insights Through Altered Gene Expression
1998 StandoutNobel
Reprogramming homing endonuclease specificity through computational design and directed evolution
2013 StandoutNobel
Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
2000 StandoutNobel
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 StandoutNobel
Prostate cancer in a transgenic mouse.
1995 Standout
Synthetic peptides as nuclear localization signals
1986 StandoutNatureNobel
megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 StandoutNobel
Acetylcholinesterase-transgenic mice display embryonic modulations in spinal cord choline acetyltransferase and neurexin Iβ gene expression followed by late-onset neuromotor deterioration
1997
Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation
2004 StandoutNobel
The Role of DNA Methylation in Mammalian Epigenetics
2001 StandoutScience
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Prostate and mammary adenocarcinoma in transgenic mice carrying a rat C3(1) simian virus 40 large tumor antigen fusion gene.
1994
Male‐sterile maize plants produced by targeted mutagenesis of the cytochrome P450‐like gene (MS26) using a re‐designed I–CreI homing endonuclease
2013
Acetylcholinesterase — new roles for an old actor
2001
Targeted Mutagenesis, Precise Gene Editing, and Site-Specific Gene Insertion in Maize Using Cas9 and Guide RNA
2015
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Functional redundancy of acetylcholinesterase and neuroligin in mammalian neuritogenesis
1998
Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.
1994
Elimination of residual metastatic prostate cancer after surgery and adjunctive cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade immunotherapy
1999 StandoutNobel

Works of Eva Guhl being referenced

The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect
2001
Custom Zinc-Finger Nucleases for Use in Human Cells
2005
Mouse DNA Methyltransferase (MTase) Deletion Mutants that Retain the Catalytic Domain Display neither De Novo nor Maintenance Methylation Activity In Vivo
1997
Overexpression of Alternative Human Acetylcholinesterase Forms Modulates Process Extensions in Cultured Glioma Cells
1996
After microinjection hemimethylated DNA is converted into symmetrically methylated DNA before DNA replication
1991
DNA-binding Specificity Is a Major Determinant of the Activity and Toxicity of Zinc-finger Nucleases
2007
Breast cancer formation in transgenic animals induced by the whey acidic protein SV40 T antigen (WAP-SV-T) hybrid gene.
1993
Quantitative correlation between simian virus 40 T-antigen synthesis and late viral gene expression in permissive and nonpermissive cells
1978
Methylation of single sites within the herpes simplex virus tk coding region and the simian virus 40 T-antigen intron causes gene inactivation.
1994
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