Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
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Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
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SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
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Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression
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2002 StandoutScienceNobel
Fat Metabolism Links Germline Stem Cells and Longevity in C. elegans
2008 StandoutScienceNobel
PDE4 cAMP-specific phosphodiesterases
2001
Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes
2004
New connections in the regulation of PEPCK gene expression by insulin
1996
Ceramides in insulin resistance and lipotoxicity
2005
Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family
2000
mTOR Signaling in Growth Control and Disease
2012 Standout
The lipolytic stimulation of 3T3-L1 adipocytes promotes the translocation of hormone-sensitive lipase to the surfaces of lipid storage droplets
2000
Phosphodiesterase-5 Inhibition: the Molecular Biology of Erectile Function and Dysfunction
2005
Delineation of RAID1, the RACK1 interaction domain located within the unique N-terminal region of the cAMP-specific phosphodiesterase, PDE4D5
2002
Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
2004
Involvement of the Pleckstrin Homology Domain in the Insulin-stimulated Activation of Protein Kinase B
1998
Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase
1996
The Molecular Biology of Cyclic Nucleotide Phosphodiesterases
1999
[16] Large-scale purification and kinetic properties of recombinant hormone-sensitive lipase from baculovirus-insect cell systems
1997
Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt
2007
Oncogenic kinase signalling
2001 StandoutNature
Prostaglandin E2 Regulates the Complement Inhibitor CD55/Decay-accelerating Factor in Colorectal Cancer
2004
Modulation of Hormone-sensitive Lipase and Protein Kinase A-mediated Lipolysis by Perilipin A in an Adenoviral Reconstituted System
2002
Mechanisms linking obesity with cardiovascular disease
2006 StandoutNature
Cyclic Nucleotide Phosphodiesterases: Molecular Regulation to Clinical Use
2006 Standout
Capturing cyclic nucleotides in action: snapshots from crystallographic studies
2006
Human fat cell lipolysis: Biochemistry, regulation and clinical role
2005
Isoforms of Cyclic Nucleotide Phosphodiesterase PDE3A in Cardiac Myocytes
2002
Identification and distribution of different mRNA variants produced by differential splicing in the human phosphodiesterase 9A gene
2003
Subcellular Localization of Cyclic Nucleotide Phosphodiesterase Type 10A Variants, and Alteration of the Localization by cAMP-dependent Protein Kinase-dependent Phosphorylation
2004
Autophagy regulates lipid metabolism
2009 StandoutNature
Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte‐macrophage differentiation of human U937 cells
2004
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
2008 Standout
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
1999 StandoutNatureNobel
Sub‐family selective actions in the ability of Erk2 MAP kinase to phosphorylate and regulate the activity of PDE4 cyclic AMP‐specific phosphodiesterases
2000
Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies
2005
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Phosphodiesterase 4B Gene Transcription Is Activated by Lipopolysaccharide and Inhibited by Interleukin-10 in Human Monocytes
1999
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases
2000
Cellular survival: a play in three Akts
1999 Standout
Dimerization of the Type 4 cAMP-specific Phosphodiesterases Is Mediated by the Upstream Conserved Regions (UCRs)
2002
Medium‐Chain Fatty Acids Attenuate Agonist‐Stimulated Lipolysis, Mimicking the Effects of Starvation
2004
Metabolism of lipids in human white adipocyte
2004
Two common structural motifs for TCR recognition by staphylococcal enterotoxins
2016 StandoutNobel
Dietary-fat-induced obesity in mice results in beta cell hyperplasia but not increased insulin release: evidence for specificity of impaired beta cell adaptation
2005
Nuclear factor-κB in cancer development and progression
2006 StandoutNature
Cyclic nucleotide phosphodiesterases: Relating structure and function
2000
A central role for JNK in obesity and insulin resistance
2002 StandoutNature
Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN
1998 StandoutNobel
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
Thematic review series: Adipocyte Biology. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis
2007 Standout
Characterization of p87PIKAP, a Novel Regulatory Subunit of Phosphoinositide 3-Kinase γ That Is Highly Expressed in Heart and Interacts with PDE3B
2006
PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects
2004
Aquaporin Adipose, a Putative Glycerol Channel in Adipocytes
2000
Insulin Regulation of Phosphoenolpyruvate Carboxykinase Gene Expression Does Not Require Activation of the Ras/Mitogen-activated Protein Kinase Signaling Pathway
1996
Mechanisms linking obesity to insulin resistance and type 2 diabetes
2006 StandoutNature
Cyclic GMP as substrate and regulator of cyclic nucleotide phosphodiesterases (PDEs)
2005
Phosphatidylinositol 3-Kinase, but Not p70/p85 Ribosomal S6 Protein Kinase, Is Required for the Regulation of Phosphoenolpyruvate Carboxykinase (PEPCK) Gene Expression by Insulin
1995
Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB
2006 Standout
Insulin signalling and the regulation of glucose and lipid metabolism
2001 StandoutNature
A PP2A Regulatory Subunit Regulates C. elegans Insulin/IGF-1 Signaling by Modulating AKT-1 Phosphorylation
2009
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
2005 StandoutNobel
The role of mouse Akt2 in insulin-dependent suppression of adipocyte lipolysis in vivo
2015
Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A‐mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)
2002
Sarcoplasmic reticulum-associated cyclic adenosine 5'-monophosphate phosphodiesterase activity in normal and failing human hearts.
1991
Obesity as a medical problem
2000 StandoutNature
Characterization of the Functional Interaction of Adipocyte Lipid-binding Protein with Hormone-sensitive Lipase
2001
Reactive oxygen species have a causal role in multiple forms of insulin resistance
2006 StandoutNature
On the Control of Lipolysis in Adipocytes
1999
Single-cell transcriptomes identify human islet cell signatures and reveal cell-type–specific expression changes in type 2 diabetes
2016
The Oligomerization State Determines Regulatory Properties and Inhibitor Sensitivity of Type 4 cAMP-specific Phosphodiesterases
2004
Mechanism of activation and function of protein kinase B
1998
Role of IRS-2 in insulin and cytokine signalling
1995 Nature
NF-κB activation by tumour necrosis factor requires the Akt serine–threonine kinase
1999 StandoutNature
Phosphoinositides in cell regulation and membrane dynamics
2006 StandoutNature
Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility
2004
AKT/PKB Signaling: Navigating the Network
2017 Standout
Tumor Necrosis Factor Promotes Phosphorylation and Binding of Insulin Receptor Substrate 1 to Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes
1996
Regulation of Protein Kinase B
1999
TAPAS-1, a Novel Microdomain within the Unique N-terminal Region of the PDE4A1 cAMP-specific Phosphodiesterase That Allows Rapid, Ca2+-triggered Membrane Association with Selectivity for Interaction with Phosphatidic Acid
2002
Protein Kinase B Stimulates the Translocation of GLUT4 but Not GLUT1 or Transferrin Receptors in 3T3-L1 Adipocytes by a Pathway Involving SNAP-23, Synaptobrevin-2, and/or Cellubrevin
1999
Lipolysis: pathway under construction
2005
Dissociation between phosphodiesterase inhibition and antiproliferative effects of phosphodiesterase inhibitors on the dami cell line
1997
Comprehensive Integration of Single-Cell Data
2019 Standout
Foxp3-dependent programme of regulatory T-cell differentiation
2007 Nature
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
2005
Endothelium‐dependent relaxation resistant to N/ω‐nitro‐L‐arginine in the rat hepatic artery and aorta
1994
Insulin signalling mechanisms for triacylglycerol storage
2013
Absence of perilipin results in leanness and reverses obesity in Leprdb/db mice
2000
GIBBERELLIN INSENSITIVE DWARF1 encodes a soluble receptor for gibberellin
2005 StandoutNature
Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
1998 StandoutNobel
Dual modulation of cell survival and cell death by β 2 -adrenergic signaling in adult mouse cardiac myocytes
2001 StandoutNobel
Phosphorylation of a cAMP-specific phosphodiesterase (HSPDE4B2B) by mitogen-activated protein kinase
1996
PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization
2003
Mechanisms of Insulin Action and Insulin Resistance
2018 Standout
Molecular Mechanisms Regulating Hormone-Sensitive Lipase and Lipolysis
2000
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B
2002
DAF-16 recruits the CREB-binding protein coactivator complex to the insulin-like growth factor binding protein 1 promoter in HepG2 cells
2000 StandoutNobel
Immuno-Navigator, a batch-corrected coexpression database, reveals cell type-specific gene networks in the immune system
2016 StandoutNobel
Protein Phosphatase 2A Negatively Regulates Insulin's Metabolic Signaling Pathway by Inhibiting Akt (Protein Kinase B) Activity in 3T3-L1 Adipocytes
2004
A MOLECULAR PERSPECTIVE OF CTLA-4 FUNCTION
2005
Are Increased Plasma Non-Esterified Fatty Acid Concentrations a Risk Marker for Coronary Heart Disease and other Chronic Diseases?
1996
Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase
1999
A-Kinase Anchoring Proteins Interact with Phosphodiesterases in T Lymphocyte Cell Lines
2004
Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes
2006 StandoutNobel
Fluorescence Resonance Energy Transfer–Based Analysis of cAMP Dynamics in Live Neonatal Rat Cardiac Myocytes Reveals Distinct Functions of Compartmentalized Phosphodiesterases
2004
PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
2006
Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms
1995 Standout
Perilipin A is essential for the translocation of hormone-sensitive lipase during lipolytic activation
2003 Standout
Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
2004
Insulin-Induced Phosphorylation and Activation of Cyclic Nucleotide Phosphodiesterase 3B by the Serine-Threonine Kinase Akt
1999
Atomic Structure of PDE4: Insights into Phosphodiesterase Mechanism and Specificity
2000 Science
The Chemistry and Biochemistry of Vanadium and the Biological Activities Exerted by Vanadium Compounds
2004 Standout
Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?
2000
Phosphodiesterase 4D is required for β 2 adrenoceptor subtype-specific signaling in cardiac myocytes
2005 StandoutNobel
Per-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IκB proteins
2004
The short-term activation of a rolipram-sensitive, cAMP-specific phosphodiesterase by thyroid-stimulating hormone in thyroid FRTL-5 cells is mediated by a cAMP-dependent phosphorylation.
1994
Cyclic nucleotide phosphodiesterase 3A–deficient mice as a model of female infertility
2004
Spatiotemporal dynamics of guanosine 3′,5′-cyclic monophosphate revealed by a genetically encoded, fluorescent indicator
2001 StandoutNobel
Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism
2010
Identification of the Insulin-Regulated Interaction of Phosphodiesterase 3B With 14-3-3 β Protein
2002
Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer
2001
Aquaglyceroporin AQP9: Solute permeation and metabolic control of expression in liver
2003 StandoutNobel
Design of vanadium compounds as insulin enhancing agents
2000
Tumor Necrosis Factor-α Decreases Akt Protein Levels in 3T3-L1 Adipocytes via the Caspase-Dependent Ubiquitination of Akt
2005
TCR- and CD28-Mediated Recruitment of Phosphodiesterase 4 to Lipid Rafts Potentiates TCR Signaling
2004
Vitamin B 2 -based blue-light photoreceptors in the retinohypothalamic tract as the photoactive pigments for setting the circadian clock in mammals
1998 StandoutNobel
Zinc interactions and conserved motifs of the cGMP-binding cGMP-specific phosphodiesterase suggest that it is a zinc hydrolase.
1994
Biochemistry and Physiology of Cyclic Nucleotide Phosphodiesterases: Essential Components in Cyclic Nucleotide Signaling
2007 Standout
Section Review: Cardiovascular & Renal: Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiovascular diseases
1995
mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3‐L1 Adipocytes
2010
The Role of PDE3B Phosphorylation in the Inhibition of Lipolysis by Insulin
2015
IRS-1-Mediated Inhibition of Insulin Receptor Tyrosine Kinase Activity in TNF-α- and Obesity-Induced Insulin Resistance
1996 StandoutScience
Regulation of Cell Death Protease Caspase-9 by Phosphorylation
1998 StandoutScience
Works of Eva Degerman being referenced
IL-3 and IL-4 Activate Cyclic Nucleotide Phosphodiesterases 3 (PDE3) and 4 (PDE4) by Different Mechanisms in FDCP2 Myeloid Cells
1999
Stimulation by Insulin of a Serine Kinase in Human Platelets That Phosphorylates and Activates the cGMP-Inhibited cAMP Phosphodiesterase
1993
Phosphorylation of PDE3B by Phosphatidylinositol 3-Kinase Associated with the Insulin Receptor
2000
Diversity in Cyclic Nucleotide Phosphodiesterase Isoenzyme Families
1995
Membrane Localization of Cyclic Nucleotide Phosphodiesterase 3 (PDE3)
2000
Phosphodiesterase 3B Is Localized in Caveolae and Smooth ER in Mouse Hepatocytes and Is Important in the Regulation of Glucose and Lipid Metabolism
2009
Alterations in regulation of energy homeostasis in cyclic nucleotide phosphodiesterase 3B–null mice
2006
Superantigen activates the gp130 receptor on adipocytes resulting in altered adipocyte metabolism
2014
Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B
2007
Various phosphodiesterase subtypes mediate the in vivo antilipolytic effect of insulin on adipose tissue and skeletal muscle in man
1998
Functions of the N-terminal Region of Cyclic Nucleotide Phosphodiesterase 3 (PDE 3) Isoforms
2000
Protein kinase B activity is required for the effects of insulin on lipid metabolism in adipocytes
2009
β-Cell-targeted Overexpression of Phosphodiesterase 3B in Mice Causes Impaired Insulin Secretion, Glucose Intolerance, and Deranged Islet Morphology
2004
Identification of Novel Phosphorylation Sites in Hormone-sensitive Lipase That Are Phosphorylated in Response to Isoproterenol and Govern Activation Properties in Vitro
1998
Selective inhibition of cGMP-inhibited and cGMP-noninhibited cyclic nucleotide phosphodiesterases and relaxation of rat aorta
1991
Insulin-Induced Translocation of Protein Kinase B to the Plasma Membrane in Rat Adipocytes
1998
Plasma membrane cyclic nucleotide phosphodiesterase 3B (PDE3B) is associated with caveolae in primary adipocytes
2006
Relaxant Effects of the Selective Phosphodiesterase Inhibitors Milrinone and OPC 3911 on Isolated Human Mesenteric Vessels
1989
Important Role of Phosphodiesterase 3B for the Stimulatory Action of cAMP on Pancreatic β-Cell Exocytosis and Release of Insulin
2002
Mechanisms Involved in the Regulation of Free Fatty Acid Release from Isolated Human Fat Cells by Acylation-stimulating Protein and Insulin
1999
Structure, Localization, and Regulation of cGMP-inhibited Phosphodiesterase (PDE3)
1997
Met hods to Study Phosphorylation and Activation of the Hormone-Sensitive Adipocyte Phosphodiesterase Type 3B in Rat Adipocytes
2003
Cyclic nucleotide phosphodiesterases (PDE) 3 and 4 in normal, malignant, and HTLV-I transformed human lymphocytes
1999
Identification of the Site in the cGMP-inhibited Phosphodiesterase Phosphorylated in Adipocytes in Response to Insulin and Isoproterenol
1996
Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes
2005
Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
2002
Reduced insulin secretion correlates with decreased expression of exocytotic genes in pancreatic islets from patients with type 2 diabetes
2012
Single-step affinity purification, partial structure and properties of human platelet cGMP inhibited cAMP phosphodiesterase
1994
Regulation of Protein Kinase B in Rat Adipocytes by Insulin, Vanadate, and Peroxovanadate
1997
Essential role of phosphatidylinositol 3‐kinase in insulin‐induced activation and phosphorylation of the cGMP‐inhibited cAMP phosphodiesterase in rat adipocytes studies using the selective inhibitor wortmannin
1994
Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin
1995
Expression and characterization of deletion recombinants of two cGMP-inhibited cyclic nucleotide phosphodiesterases (PDE-3)
1998
Molecular Mechanisms Involved in the Antilipolytic Action of Insulin: Phosphorylation and Activation of a Particulate Adipocyte cAMP Phosphodiesterase
1991
Purification and properties of the cGMP-inhibited cAMP phosphodiesterase from bovine aortic smooth muscle
1992
Growth Hormone Stimulates the Tyrosine Phosphorylation of the Insulin Receptor Substrate-1 and Its Association with Phosphatidylinositol 3-Kinase in Primary Adipocytes
1995
Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes
1999
Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase.
1994
Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes
1999
Hormone-sensitive cyclic GMP-inhibited cyclic AMP phosphodiesterase in rat adipocytes. Regulation of insulin- and cAMP-dependent activation by phosphorylation
1991
cGMP-inhibited phosphodiesterases (PDE3 gene family)
1996
Cyclic Nucleotide Phosphodiesterase 3 Signaling Complexes
2012
Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes
2000
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A
1999
Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor α and cAMP
2000
Molecular cloning and expression of human myocardial cGMP-inhibited cAMP phosphodiesterase.
1992
Purification of the putative hormone-sensitive cyclic AMP phosphodiesterase from rat adipose tissue using a derivative of cilostamide as a novel affinity ligand.
1987
Domain-structure analysis of recombinant rat hormone-sensitive lipase
1996
Insulin-induced formation of macromolecular complexes involved in activation of cyclic nucleotide phosphodiesterase 3B (PDE3B) and its interaction with PKB
2007
C2-Ceramide Influences the Expression and Insulin-Mediated Regulation of Cyclic Nucleotide Phosphodiesterase 3B and Lipolysis in 3T3-L1 Adipocytes
2002
Identification of a novel isoform of the cyclic-nucleotide phosphodiesterase PDE3A expressed in vascular smooth-muscle myocytes
2000
[48] Selective inhibitors of specific phosphodiesterases in intact adipocytes
1988
Down-regulation of cyclic-nucleotide phosphodiesterase 3B in 3T3-L1 adipocytes induced by tumour necrosis factor α and cAMP
2000
Insulin-Induced Phosphorylation and Activation of Phosphodiesterase 3B in Rat Adipocytes: Possible Role for Protein Kinase B But Not Mitogen-Activated Protein Kinase or p70 S6 Kinase*
1998
Cyclic Nucleotide Phosphodiesterases (PDEs): Diverse Regulators of Cyclic Nucleotide Signals and Inviting Molecular Targets for Novel Therapeutic Agents
1999
Characterization of Two Recombinant PDE3 (cGMP-Inhibited Cyclic Nucleotide Phosphodiesterase) Isoforms, RcGIP1 and HcGIP2, Expressed in NIH 3006 Murine Fibroblasts and Sf9 Insect Cells
1996
Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the β3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes
2009
Hormone-sensitive lipase, the rate-limiting enzyme in triglyceride hydrolysis, is expressed and active in beta-cells.
1999
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A
1999
Evidence that insulin and isoprenaline activate the cGMP-inhibited low-Km cAMP phosphodiesterase in rat fat cells by phosphorylation.
1990
Cyclic Nucleotide Phosphodiesterase 3B Is a Downstream Target of Protein Kinase B and May Be Involved in Regulation of Effects of Protein Kinase B on Thymidine Incorporation in FDCP2 Cells
2000