Standout Papers
Citation Impact
Citing Papers
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
2009
Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease
2014
Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils
2001 Science
Disruption of cellular proteostasis by H1N1 influenza A virus causes α-synuclein aggregation
2020
Selective changes of resting-state networks in individuals at risk for Alzheimer's disease
2007
A Neural Circuit for Memory Specificity and Generalization
2013 StandoutScienceNobel
A Neuroligin-3 Mutation Implicated in Autism Increases Inhibitory Synaptic Transmission in Mice
2007 StandoutScienceNobel
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
2012 StandoutScience
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Biochemical and anatomical redistribution of tau protein in Alzheimer's disease.
1993
Propagation of Tau Pathology in a Model of Early Alzheimer's Disease
2012
Early frontotemporal dementia targets neurons unique to apes and humans
2006
Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
2003
Roles of tau protein in health and disease
2017
Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
2017
Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
2008
Aminothienopyridazines and Methylene Blue Affect Tau Fibrillization via Cysteine Oxidation
2013
A novel in vivo model of tau propagation with rapid and progressive neurofibrillary tangle pathology: the pattern of spread is determined by connectivity, not proximity
2014
AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development
2019
The synaptic pathology of α-synuclein aggregation in dementia with Lewy bodies, Parkinson’s disease and Parkinson’s disease dementia
2010
Interactions between APP secretases and inflammatory mediators
2008
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
2013
Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study
2005
Transgenic mouse models of Alzheimer's disease: How useful have they been for therapeutic development?
2004
Neuroinflammation in Parkinson's disease: a target for neuroprotection?
2009 Standout
Regional Specificity of Brain Atrophy in Huntington's Disease
1998
Progression of Cerebral Amyloid Load Is Associated with the Apolipoprotein E ε4 Genotype in Alzheimer's Disease
2010
Advanced glycation endproducts and their receptor RAGE in Alzheimer's disease
2009
Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease
2010
Entorhinal cortex of the human, monkey, and rat: Metabolic map as revealed by cytochrome oxidase
1992
Cytoskeletal pathology in familial cerebral amyloid angiopathy (British type) with non-neuritic amyloid plaque formation
1999
Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease
2010
Presenilins are essential for regulating neurotransmitter release
2009 StandoutNatureNobel
The pathological process underlying Alzheimer’s disease in individuals under thirty
2010
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics
2011 Standout
Parkinson's disease
2021 Standout
Electroresponsiveness of medial entorhinal cortex layer III neurons in vitro
1997
Cortical morphology in children and adolescents with different apolipoprotein E gene polymorphisms: an observational study
2007
Changing the research criteria for the diagnosis of Parkinson's disease: obstacles and opportunities
2013
Hippocampus and entorhinal cortex in mild cognitive impairment and early AD
2003
Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism
2005
Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration
2004 Nobel
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
2005
Variant Alzheimer Disease With Spastic paraparesis: Neuropathological phenotype
2001
Anti-Tau Antibodies that Block Tau Aggregate Seeding In Vitro Markedly Decrease Pathology and Improve Cognition In Vivo
2013
From Healthy Aging to Early Alzheimer's Disease: In Vivo Detection of Entorhinal Cortex Atrophy
2000
Ca2+ and Mg2+ selectively induce aggregates of PHF-tau but not normal human tau
1999
Deciphering the Molecular Basis of Memory Failure in Alzheimer's Disease
2004
Microstructure of a spatial map in the entorhinal cortex
2005 StandoutNatureNobel
Specific Hippocampal Volume Reductions in Individuals at Risk for Alzheimer’s Disease
1997
Cortical demyelination and diffuse white matter injury in multiple sclerosis
2005
Neurodegenerative disease status and post-mortem pathology in idiopathic rapid-eye-movement sleep behaviour disorder: an observational cohort study
2013
Mechanisms Underlying Inflammation in Neurodegeneration
2010 Standout
Microglia-mediated neurotoxicity: uncovering the molecular mechanisms
2006 Standout
Cerebrospinal fluid biomarkers in Parkinson disease
2013
Tau protein pathology in neurodegenerative diseases
1998
In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
2005
Reduced O-glycosylated clathrin assembly protein AP180: implication for synaptic vesicle recycling dysfunction in Alzheimer's disease
1998
Biological and Clinical Implications of Comorbidities in Parkinson’s Disease
2017
Association Between Early-Onset Parkinson Disease and 22q11.2 Deletion Syndrome
2013
Neural Synchrony in Brain Disorders: Relevance for Cognitive Dysfunctions and Pathophysiology
2006 Standout
Parkinson’s disease: lesions in dorsal horn layer I, involvement of parasympathetic and sympathetic pre- and postganglionic neurons
2007
Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by β-amyloid fibrils
2003
Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
2012
Cerebral blood flow and metabolic abnormalities in Alzheimer’s disease
2001
Propentofylline attenuates tau hyperphosphorylation in Alzheimer's Swedish mutant model Tg2576
2004
Reciprocal Connections between the Amygdala and the Hippocampal Formation, Perirhinal Cortex, and Postrhinal Cortex in Rat: A Review
2000
Neuropathological Diagnosis of Alzheimer’s Disease: A Perspective from Longitudinal Clinicopathological Studies
1997
Traumatic brain injury and Alzheimer's disease: a review
2007
Protein aggregation and aggregate toxicity: new insights into protein folding, misfolding diseases and biological evolution
2003
Lewy body cortical involvement may not always predict dementia in Parkinson's disease
2003
Advances in the early detection of Alzheimer's disease
2004
BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
2018
Genes and pathways underlying regional and cell type changes in Alzheimer's disease
2013
The Lewy body in Parkinson's disease: Molecules implicated in the formation and degradation of α‐synuclein aggregates
2007
Classification and basic pathology of Alzheimer disease
2009
The Relationship between Lewy Body Disease, Parkinson's Disease, and Alzheimer's Disease
2003
Relationships between age and late progression of Parkinson's disease: a clinico-pathological study
2010
Tau phosphorylation and aggregation in Alzheimer's disease pathology
2006
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
2005
Comparison of different methodological implementations of voxel-based morphometry in neurodegenerative disease
2005
Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain
2018
Premotor Parkinson's disease: Concepts and definitions
2012
The patients' perception of prodromal symptoms before the initial diagnosis of Parkinson's disease
2011
Widespread and abundant α‐synuclein pathology in a neurologically unimpaired subject
2005
Topography of brain atrophy during normal aging and alzheimer's disease
1996
Incidental Lewy Body Disease and Preclinical Parkinson Disease
2008
Alzheimer's disease versus dementia with Lewy bodies: Cerebral metabolic distinction with autopsy confirmation
2001
The Relationship of Parkinson Disease With Aging
2007
Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies
1998
Neuropathologic Substrate of Mild Cognitive Impairment
2006
Molecular pathology of amyloidogenic proteins and the role of vascular amyloidosis in Alzheimer's disease
1989
Neuroimaging Findings in Twins Discordant for Alzheimer’s Disease
1998
Ischemic stress induces deposition of amyloid ? immunoreactivity in human brain
1995
Alpha-synuclein and transgenic mouse models
2004
Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model
2010
Coordination of entorhinal–hippocampal ensemble activity during associative learning
2014 StandoutNatureNobel
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
1999
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
2015
Neurodegenerative Diseases Target Large-Scale Human Brain Networks
2009 Standout
Cognitive status correlates with neuropathologic stage in Parkinson disease
2005
The Endosomal-Lysosomal System of Neurons in Alzheimer's Disease Pathogenesis: A Review
2000
Morphological and electrophysiological characteristics of layer V neurons of the rat lateral entorhinal cortex
2002
Voxel-wise analysis of diffusion weighted imaging reveals disruption of the olfactory tract in Parkinson's disease
2005
Network Analysis of Intrinsic Functional Brain Connectivity in Alzheimer's Disease
2008
Adult mouse astrocytes degrade amyloid-β in vitro and in situ
2003
Phosphorylation of Neuronal Cytoskeletal Proteins in Alzheimer's Disease and Lewy Body Dementiasa
1994
Decision Rules Guiding the Clinical Diagnosis of Alzheimer’s Disease in Two Community-Based Cohort Studies Compared to Standard Practice in a Clinic-Based Cohort Study
2006
Variable phenotype of Alzheimer's disease with spastic paraparesis
2001
Role of the Toll-Like Receptor 4 in Neuroinflammation in Alzheimer’s Disease
2007
Rivastigmine for Dementia Associated with Parkinson's Disease
2004
Gastric α-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
2005
Differential regional dysfunction of the hippocampal formation among elderly with memory decline and Alzheimer's disease
1999
A Plasticity‐Based Theory of the Pathogenesis of Alzheimer's Disease
2000
Clinical criteria for subtyping Parkinson’s disease: biomarkers and longitudinal progression
2017
Imaging of onset and progression of Alzheimer's disease with voxel-compression mapping of serial magnetic resonance images
2001
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
2011
Evolution, development, and plasticity of the human brain: from molecules to bones
2013
Development of α-synuclein immunoreactive astrocytes in the forebrain parallels stages of intraneuronal pathology in sporadic Parkinson’s disease
2007
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria
2009
Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?
2011
Glycosylation of microtubule–associated protein tau: An abnormal posttranslational modification in Alzheimer's disease
1996
Metabolism of amyloid-β peptide and Alzheimer's disease
2005
Immune System Response in Alzheimer'sDisease
1989
Adult hippocampal neurogenesis and its role in Alzheimer's disease
2011
Parkinson's disease
2009 Standout
The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
1991
Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism
2005
Preclinical Evidence of Alzheimer's Disease in Persons Homozygous for the ε4 Allele for Apolipoprotein E
1996
Neurotoxic lesions of the thalamic reuniens or mediodorsal nucleus in rats affect non-mnemonic aspects of watermaze learning
2009
The prion hypothesis in Parkinson's disease: Braak to the future
2013
100 years of Lewy pathology
2012
Applicability of current staging/categorization of α-synuclein pathology and their clinical relevance
2008
Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts
1997
Presenilins and APP in Neuritic and Synaptic Plasticity: Implications for the Pathogenesis of Alzheimer's Disease
2002
Parkin Disease
2013
Amyloid-β and tau — a toxic pas de deux in Alzheimer's disease
2010
Parkinson Disease Neuropathology
2002
Frequency of gamma oscillations routes flow of information in the hippocampus
2009 StandoutNatureNobel
Analysis of the Adrenal Gland Is Useful for Evaluating Pathology of the Peripheral Autonomic Nervous System in Lewy Body Disease
2007
Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
1997
The Cellular Phase of Alzheimer’s Disease
2016
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
2019 Standout
The case described by Alois Alzheimer in 1911
1998
Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity
2000
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
2005 Standout
Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
2008
A clinico-pathological study of subtypes in Parkinson's disease
2009
Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau
1998
Late-stage Parkinson disease
2012
ApoE genotype accounts for the vast majority of AD risk and AD pathology
2004
Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease
2012
The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease
2003
Structural Imaging in Parkinson’s Disease: New Developments
2019
Atypical form of Alzheimer's disease with prominent posterior cortical atrophy: A review of lesion distribution and circuit disconnection in cortical visual pathways
1997
Alzheimer's disease
2015
Parkinson's disease
2015 Standout
Meta‐analysis of early nonmotor features and risk factors for Parkinson disease
2012
Striatal β-Amyloid Deposition in Parkinson Disease With Dementia
2008
Morphogenesis of Lewy Bodies: Dissimilar Incorporation of α-Synuclein, Ubiquitin, and p62
2003
Is alpha‐synuclein in the colon a biomarker for premotor Parkinson's Disease? Evidence from 3 cases
2012
Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
2013
Ubiquitin–proteasome system and Parkinson's disease
2006
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
2000
A β-arrestin 2 Signaling Complex Mediates Lithium Action on Behavior
2008 StandoutNobel
α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
2014
α-Synuclein Cooperates with CSPα in Preventing Neurodegeneration
2005 StandoutNobel
A Chimpanzee Genome Project Is a Biomedical Imperative: Figure B1.
2000
Hippocampal volume discriminates between normal cognition; questionable and mild dementia in the elderly
2001
Altered brain functional connectivity and impaired short-term memory in Alzheimer's disease
2001
Parkinson's disease: a dual‐hit hypothesis
2007
Tangles and plaques in nondemented aging and ?preclinical? Alzheimer's disease
1999
Cerebral perfusion SPET correlated with Braak pathological stage in Alzheimer's disease
2002
Regional brain hypometabolism is unrelated to regional amyloid plaque burden
2015
The neuropathology of genetic Parkinson's disease
2012
Subtypes of Parkinson’s Disease: What Do They Tell Us About Disease Progression?
2017
Remembering familiar people: the posterior cingulate cortex and autobiographical memory retrieval
2001
Abnormal fronto‐parietal coupling of brain rhythms in mild Alzheimer's disease: a multicentric EEG study
2004
Patterns of levodopa response in Parkinson's disease: a clinico-pathological study
2007
The progression of pathology in longitudinally followed patients with Parkinson’s disease
2008
Senile plaque neurites fail to demonstrate anti-paired helical filament and anti-microtubule-associated protein-tau immunoreactive proteins in the absence of neurofibrillary tangles in the neocortex
1989
A Clinicopathologic Study of 100 Cases of Parkinson's Disease
1993
Trans-Synaptic Spread of Tau Pathology In Vivo
2012
Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
2013
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
2008
Accumulation of Phosphorylated α-Synuclein in Aging Human Brain
2003
Alzheimer's disease
2006 Standout
Parkinson's disease and α‐synuclein expression
2011
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
2004
No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice
2016
Effect of APOE genotype on microvascular basement membrane in Alzheimer's disease
2002
Effect of Vascular Lesions on Cognition in Alzheimer's Disease: A Community‐Based Study
2004
Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
2017
Age-Related Memory Decline
2001
Antibody Therapeutics Targeting Aβ and Tau
2017
Delayed emergence of a parkinsonian disorder or dementia in 81% of older men initially diagnosed with idiopathic rapid eye movement sleep behavior disorder: a 16-year update on a previously reported series
2013
Anti-Aβ Drug Screening Platform Using Human iPS Cell-Derived Neurons for the Treatment of Alzheimer's Disease
2011 StandoutNobel
Biomarker Modeling of Alzheimer’s Disease
2013
Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
2010
Imaging Physiologic Dysfunction of Individual Hippocampal Subregions in Humans and Genetically Modified Mice
2000 StandoutNobel
Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy
2010
The entorhinal grid map is discretized
2012 StandoutNatureNobel
The Role of Apolipoprotein E in Alzheimer's Disease
2009
Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease
2000
Memory and Executive Function in Aging and AD
2004
Parkinson's Disease
1998 Standout
DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease
2010
Overview and recent advances in neuropathology. Part 2: Neurodegeneration
2011
Microvascular injury and blood–brain barrier leakage in Alzheimer's disease
2006
Olfaction and Parkinson's syndromes: its role in differential diagnosis
2004
Neuropathologic substrates of Parkinson disease dementia
2012
Blood-Brain Barrier Breakdown in the Aging Human Hippocampus
2015 Standout
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Non-motor features of Parkinson disease
2017 Standout
Whole Brain Segmentation
2002 Standout
Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET
1999
Widespread distribution of tauopathy in preclinical Alzheimer's disease
2018
Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 Standout
Anatomical Organization of the Parahippocampal‐Hippocampal Network
2000
Prevalence of cerebrovascular lesions in Parkinson's disease. A postmortem study
2003
Prevalence and impact of vascular and Alzheimer pathologies in Lewy body disease
2008
Prion-like spreading of pathological α-synuclein in brain
2013
Herpes virus in Alzheimer's disease: relation to progression of the disease
2013
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
1994
Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation
2011 StandoutNatureNobel
Distribution of major histocompatibility complex class II-positive microglia and cytokine profile of Parkinson's disease brains
2003
Imaging biomarkers in Parkinson's disease
2011
Iron, brain ageing and neurodegenerative disorders
2004
Head direction cells and the neurophysiological basis for a sense of direction
1998
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
1997
White matter changes in mild cognitive impairment and AD: A diffusion tensor imaging study
2005
Neurodegenerative diseases and oxidative stress
2004 Standout
Apolipoprotein E as a Therapeutic Target in Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence
2016
Transmission and spreading of tauopathy in transgenic mouse brain
2009
Cortical α-synuclein load is associated with amyloid-β plaque burden in a subset of Parkinson’s disease patients
2008
Tau pathology in Alzheimer disease and other tauopathies
2004
The DIAN‐TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model
2016
Solvent exposures and parkinson disease risk in twins
2011
Evaluating the function of hippocampal subregions with high-resolution MRI in Alzheimer's disease and aging
2000
Neuropathologic Features of Amnestic Mild Cognitive Impairment
2006 Standout
Non motor subtypes and Parkinson's disease
2015
Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
2008
Axonal disruption and aberrant localization of tau protein characterize the neuropil pathology of Alzheimer's disease
1987
Are synucleinopathies prion-like disorders?
2010
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
PET imaging of amyloid in Alzheimer's disease
2004
The road to restoring neural circuits for the treatment of Alzheimer's disease
2016 Nature
MRI-derived entorhinal volume is a good predictor of conversion from MCI to AD
2004
Selective functional, regional, and neuronal vulnerability in frontotemporal dementia
2008
Dementia with Lewy bodies and Parkinson's disease with dementia: Are they different?
2005
Staging of Cytoskeletal and β-Amyloid Changes in Human Isocortex Reveals Biphasic Synaptic Protein Response during Progression of Alzheimer’s Disease
2000
Magnetic resonance imaging of the substantia nigra in Parkinson's disease
2012
Multi-organ distribution of phosphorylated α-synuclein histopathology in subjects with Lewy body disorders
2010
Factors affecting the clinical outcome after neural transplantation in Parkinson's disease
2005
Single-cell transcriptomic analysis of Alzheimer’s disease
2019 StandoutNature
Hippocampal formation glucose metabolism and volume losses in MCI and AD
2001
Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI
2006
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
The Alzheimer's Disease Centers' Uniform Data Set (UDS)
2009
Tau Kinetics in Neurons and the Human Central Nervous System
2018
Propagation of Tau Misfolding from the Outside to the Inside of a Cell
2009
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
2011
Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study
2013
Decreased EEG synchronization in Alzheimer’s disease and mild cognitive impairment
2004
Parkinson's disease subtypes: lost in translation?
2012
The molecular pathology of Alzheimer's disease
1991 Standout
Different Species of α-Synuclein Oligomers Induce Calcium Influx and Seeding
2007
Neurofibrillary tangles of the Indiana kindred of Gerstmann-Stra¨ussler-Scheinker disease share antigenic determinants with those of Alzheimer disease
1990
Reciprocal connections of the insular and piriform claustrum with limbic cortex: An anatomical study in the cat
1988
Tracking Alzheimerʼs disease in transgenic mice using fluorodeoxyglucose autoradiography
2000
The amyloid hypothesis of Alzheimer's disease at 25 years
2016 Standout
Mitochondrial Quality Control and Dynamics in Parkinson's Disease
2011
Novel nondopaminergic targets for motor features of Parkinson's disease: Review of recent trials
2012
Volume loss of the hippocampus and temporal lobe in healthy elderly persons destined to develop dementia
1997
Neurodegenerative Diseases: Expanding the Prion Concept
2015
Optogenetic Dissection of Entorhinal-Hippocampal Functional Connectivity
2013 StandoutScienceNobel
Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology
2016
Prediction of cognitive decline in normal elderly subjects with 2-[ 18 F]fluoro-2-deoxy- d -glucose/positron-emission tomography (FDG/PET)
2001
The role of neurotransmitters in the development of Parkinson's disease‐related psychosis
2017
EPIDEMIOLOGY OF NEURODEGENERATION
2003
Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging
2013
Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype
2018
APOLIPOPROTEIN E ALLELES AS RISK FACTORS IN ALZHEIMER'S DISEASE
1996
Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD
2006
Nucleus Reuniens Thalami Modulates Activity in Hippocampal Field CA1 through Excitatory and Inhibitory Mechanisms
1997
Clinical, genetic, and neuropathologic characteristics of posterior cortical atrophy
2004
Neurodegenerative Tauopathies
2001 Standout
Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
2019
Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.
1987
Accuracy of clinical diagnosis of Parkinson disease
2016
Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model
2008 StandoutNobel
Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.
2000
The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics
2002 StandoutScience
Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
2005
Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
2000
Diagnosis and Treatment of Parkinson Disease
2020 Standout
Pericapillary Haem-Rich Deposits: Evidence for Microhaemorrhages in Aging Human Cerebral Cortex
2005
MRI measures of entorhinal cortex vs hippocampus in preclinical AD
2002
Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia
2019
Dynamics of Gray Matter Loss in Alzheimer's Disease
2003
A Century of Alzheimer's Disease
2006 StandoutScience
Common Pathological Processes and Transcriptional Pathways in Alzheimer's Disease and Type 2 Diabetes
2009
[ 11 C]PIB in a nondemented population
2006
Gamma Oscillations in the Entorhinal Cortex of the Freely Behaving Rat
1998
Practice parameter: Management of dementia (an evidence-based review) [RETIRED]
2001 Standout
Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
2014 StandoutScienceNobel
Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia
2003
Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse
1997
Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy
2017
The vascular factor in Alzheimer's disease: A study in Golgi technique and electron microscopy
2012
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
2012
Copper Homeostasis and Neurodegenerative Disorders (Alzheimer's, Prion, and Parkinson's Diseases and Amyotrophic Lateral Sclerosis)
2006 Standout
Inflammation as a central mechanism in Alzheimer's disease
2018 Standout
Longitudinal tau PET in ageing and Alzheimer’s disease
2018
Enteric alpha‐synuclein expression is increased in P arkinson's disease but not A lzheimer's disease
2013
Reduced fear expression after lesions of the ventral hippocampus
2002 StandoutNobel
Localization of Neurofibrillary Tangles and Beta-Amyloid Plaques in the Brains of Living Patients With Alzheimer Disease
2002
Evolution of prodromal Parkinson’s disease and dementia with Lewy bodies: a prospective study
2019
Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease
1996
Default-mode network activity distinguishes Alzheimer's disease from healthy aging: Evidence from functional MRI
2004 Standout
Practice parameter: Diagnosis of dementia (an evidence-based review)
2001
Sexual differentiation of the human hypothalamus in relation to gender and sexual orientation
1995
Synthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents
2003
Hippocampus-independent phase precession in entorhinal grid cells
2008 StandoutNatureNobel
Neuropathology of prodromal Lewy body disease
2014
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
1999
Evidence That Synaptically Released β-Amyloid Accumulates as Extracellular Deposits in the Hippocampus of Transgenic Mice
2002
Brain Inflammation and Alzheimer's-Like Pathology in Individuals Exposed to Severe Air Pollution
2004
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
1998 Nobel
Anatomy, pigmentation, ventral and dorsal subpopulations of the substantia nigra, and differential cell death in Parkinson's disease.
1991
Alzheimer’s Disease: The Challenge of the Second Century
2011
Amyloid, hypometabolism, and cognition in Alzheimer disease
2006
Intra- and Interspecific Variation in Primate Gene Expression Patterns
2002 StandoutScienceNobel
How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes
2004
Lewy body extracts from Parkinson disease brains trigger α‐synuclein pathology and neurodegeneration in mice and monkeys
2013
Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease
1985 Science
Molecular Pathways of Neurodegeneration in Parkinson's Disease
2003 Science
Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
1999
Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.
1988 StandoutNobel
Hippocampal and entorhinal cortex atrophy in frontotemporal dementia and Alzheimer’s disease
1999
Rates of hippocampal atrophy correlate with change in clinical status in aging and AD
2000
Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease
2019
Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex
2006 StandoutScienceNobel
A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
2014
Frameshift Mutants of β Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down Patients
1998 Science
Phosphorylation that Detaches Tau Protein from Microtubules (Ser262, Ser214) Also Protects It against Aggregation into Alzheimer Paired Helical Filaments
1999
A nucleated assembly mechanism of Alzheimer paired helical filaments
1998
Comparison of different MRI brain atrophy rate measures with clinical disease progression in AD
2004
Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in alzheimer's disease
1988
Inflammatory Mechanisms in Alzheimer's Disease: Inhibition of β-Amyloid-Stimulated Proinflammatory Responses and Neurotoxicity by PPARγ Agonists
2000
Apolipoprotein E ε4 allele, AD pathology, and the clinical expression of Alzheimer’s disease
2003
Positron emission tomography and magnetic resonance imaging in the diagnosis and prediction of dementia
2006
High-Level Neuronal Expression of Aβ1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation
2000 Standout
Evaluation of Tau Imaging in Staging Alzheimer Disease and Revealing Interactions Between β-Amyloid and Tauopathy
2016
A proposed dual role of neuromelanin in the pathogenesis of Parkinson’s disease
2006
Mapping the evolution of regional atrophy in Alzheimer's disease: Unbiased analysis of fluid-registered serial MRI
2002
Deficiency in Mural Vascular Cells Coincides with Blood–Brain Barrier Disruption in A lzheimer's Disease
2012
Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer's disease
2001
Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD
2005
Alpha-synuclein cortical Lewy bodies correlate with dementia in Parkinson’s disease
2000
THE TOPOGRAPHY OF PLAQUES AND TANGLES IN DOWN'S SYNDROME PATIENTS OF DIFFERENT AGES
1986
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease
2003
A Phase II Trial of Tideglusib in Alzheimer's Disease
2015
Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
2015
Molecular Biology of Prion Diseases
1991 StandoutScienceNobel
α‐Synuclein pathology does not predict extrapyramidal symptoms or dementia
2004
Dissociation of neuropathology from severity of dementia in late-onset Alzheimer disease
2006
Hippocampal atrophy in Alzheimer disease: Age matters
2006
Functional deactivations: Change with age and dementia of the Alzheimer type
2003
Neuropathology of older persons without cognitive impairment from two community-based studies
2006 Standout
Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease
2000
Differences in neuropathologic characteristics across the Lewy body dementia spectrum
2006
Examination of phosphorylated tau protein as a PHF-precursor at early stage alzheimer's disease
1995
Neuronal activity regulates extracellular tau in vivo
2014
Spatial Representation in the Entorhinal Cortex
2004 StandoutScienceNobel
Declining brain activity in cognitively normal apolipoprotein E ɛ4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease
2001
Wnt signaling function in Alzheimer’s disease
2000
α‐Synuclein oligomers and clinical implications for Parkinson disease
2012
Works of Eva Braak being referenced
Silver Impregnation of Alzheimer's Neurofibrillary Changes Counterstained for Basophilic Material and Lipofuscin Pigment
1988
Chapter 20 Neuropathological hallmarks of Alzheimer's and Parkinson's diseases
1998
Alzheimer's disease: areal and laminar pathology in the occipital isocortex
1989
Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes
1999
Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis
1996
Demonstration of Amyloid Deposits and Neurofibrillary Changes in Whole Brain Sections
1991
Neurofibrillary changes confined to the entorhinal region and an abundance of cortical amyloid in cases of presenile and senile dementia
1990
Cognitive impairment in Parkinson's disease: amyloid plaques, neurofibrillary tangles, and neuropil threads in the cerebral cortex
1990
Alzheimer Lesions in the Entorhinal Region and Isocortex in Parkinson's and Alzheimer's Diseasesa
1991
A silver impregnation method for labeling both Alzheimer paired helical filaments and their polypeptides separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis
1991
Staging of Alzheimer-Type Pathology: An Interrater-Intrarater Study
1997
Staging of Alzheimer-Related Cortical Destruction
1993
Abnormally phosphorylated tau protein related to the formation of neurofibrillary tangles and neuropil threads in the cerebral cortex of sheep and goat
1994
Staging of brain pathology related to sporadic Parkinson’s disease
2002 Standout
α-Synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei
2001
Allocortical involvement in Huntington's disease
1992
Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder
1994
The Progression of Alzheimer’s Disease from Limbic Regions to the Neocortex: Clinical, Radiological and Pathological Relationships
1999
Sequence of Aβ-Protein Deposition in the Human Medial Temporal Lobe
2000
Neuropathological stageing of Alzheimer-related changes
1991 Standout
Evolution of the neuropathology of Alzheimer's disease
1996
Fleecy Amyloid Deposits in the Internal Layers of the Human Entorhinal Cortex are Comprised of N-terminal Truncated Fragments of Aβ
1999
Pattern of brain destruction in Parkinson's and Alzheimer's diseases
1996
Pathoanatomy of Parkinson’s disease
2000
Distribution, Levels, and Activity of Glycogen Synthase Kinase-3 in the Alzheimer Disease Brain
1997
Evolution of neuronal changes in the course of Alzheimer’s disease
1998
Relationship between Clinical and Radiological Diagnostic Criteria for Alzheimer’s Disease and the Extent of Neuropathology as Reflected by ‘Stages’: A Prospective Study
1999
CORTICAL AND SUBCORTICAL ARGYROPHILIC GRAINS CHARACTERIZE A DISEASE ASSOCIATED WITH ADULT ONSET DEMENTIA
1989
The presubicular region in Alzheimer's disease: topography of amyloid deposits and neurofibrillary changes
1989
Amyloid β-protein (Aβ)-containing astrocytes are located preferentially near N-terminal-truncated Aβ deposits in the human entorhinal cortex
2000
Diagnostic Criteria for Neuropathologic Assessment of Alzheimer’s Disease
1997
High Frequency of Apolipoprotein E ϵ4 Allele in Young Individuals with Very Mild Alzheimer's Disease-Related Neurofibrillary Changes
1998
Evolution of Alzheimer’s disease related cortical lesions
1998
Alzheimer's disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon's horn
1997
Staging of alzheimer's disease-related neurofibrillary changes
1995 Standout
Extensive axonal Lewy neurites in Parkinson's disease: a novel pathological feature revealed by α-synuclein immunocytochemistry
1999
Amygdala pathology in Parkinson's disease
1994
Neurofibrillary pathology in the human paraventricular and supraoptic nuclei
1997
Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells
1988
Alzheimer's disease affects limbic nuclei of the thalamus
1991
Allocortical neurofibrillary changes in progressive supranuclear palsy
1992
Age, neurofibrillary changes, Aβ-amyloid and the onset of Alzheimer's disease
1996
Alpha-synuclein immunoreactive Lewy bodies and Lewy neurites in Parkinson's disease are detectable by an advanced silver-staining technique
1999
The human entorhinal cortex: normal morphology and lamina-specific pathology in various diseases
1992
Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories
1997
Parvalbumin‐immunoreactive structures of the adult human entorhinal and transentorhinal region
1993
The autonomic higher order processing nuclei of the lower brain stem are among the early targets of the Alzheimer's disease-related cytoskeletal pathology
2001
Neuropathology of Alzheimer’s disease: what is new since A. Alzheimer?
1999
Assessment of the Pathological Stages of Alzheimer’s Disease in Thin Paraffin Sections: A Comparative Study
1998
Evolution of Alzheimer's disease-related cytoskeletal changes in the basal nucleus of Meynert
2000
Gender and age modify the association between APOE and AD-related neuropathology
2001
Alzheimer's disease: striatal amyloid deposits and neurofibrillary changes.
1990
The hypothalamus of the human adult: chiasmatic region
1987
Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes
1987
Alzheimerʼs Disease
1990
Somatostatin-like immunoreactivity in non-pyramidal neurons of the human isocortex
1985
Localization of active forms of C-jun kinase (JNK) and p38 kinase in Alzheimer's disease brains at different stages of neurofibrillary degeneration
2001
Neuronal types in the striatum of man
1982
Staging of Alzheimer-Related Cortical Destruction
1997
Neuronal types in the basolateral amygdaloid nuclei of man
1983
Entorhinal—hippocampal interaction in mnestic disorders
1993
A sex difference in neurodegeneration of the human hypothalamus
1996
Entorhinal-hippocampal interaction in mnestic disorders.
1993
Neuronal types in the claustrum of man
1982
Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques
1986
A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
1994
Nuclear configuration and neuronal types of the nucleus niger in the brain of the human adult.
1986
On areas of transition between entorhinal allocortex and temporal isocortex in the human brain. Normal morphology and lamina-specific pathology in Alzheimer's disease
1985