Standout Papers
Citation Impact
Citing Papers
An enumerative algorithm for de novo design of proteins with diverse pocket structures
2020 StandoutNobel
Olefin Cyclopropanation via Carbene Transfer Catalyzed by Engineered Cytochrome P450 Enzymes
2012 StandoutScienceNobel
The Genetic Basis for Bacterial Mercury Methylation
2013 StandoutScience
Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/Condensation
2009 StandoutScience
Single molecules of the bacterial actin MreB undergo directed treadmilling motion in Caulobacter crescentus
2006 StandoutNobel
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins
2019 StandoutNobel
Actin retrograde flow actively aligns and orients ligand-engaged integrins in focal adhesions
2017 StandoutNobel
Origins of catalysis by computationally designed retroaldolase enzymes
2010 StandoutNobel
Computational Thermostabilization of an Enzyme
2005 StandoutScienceNobel
T Cell Ig and Mucin Domain Proteins and Immunity
2010
Structural and Kinetic Evidence for an Extended Hydrogen-bonding Network in Catalysis of Methyl Group Transfer
2006
Three-dimensional tracking of single mRNA particles in Saccharomyces cerevisiae using a double-helix point spread function
2010 StandoutNobel
Cell mechanics and the cytoskeleton
2010 StandoutNature
Purine nucleoside phosphorylase from Cellulomonas sp.: physicochemical properties and binding of substrates determined by ligand-dependent enhancement of enzyme intrinsic fluorescence, and by protective effects of ligands on thermal inactivation of the enzyme
2002
Dynamic personalities of proteins
2007 StandoutNature
Structures of T Cell Immunoglobulin Mucin Protein 4 Show a Metal-Ion-Dependent Ligand Binding Site where Phosphatidylserine Binds
2007
Crystal Structure of Calf Spleen Purine Nucleoside Phosphorylase with Two Full Trimers in the Asymmetric Unit: Important Implications for the Mechanism of Catalysis
2004 StandoutNobel
Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1
2012
Evolution of atrazine-degrading capabilities in the environment
2012
Cell Signaling by Receptor Tyrosine Kinases
2010 Standout
Identification of endoribonuclease specific cleavage positions reveals novel targets of RNase III inStreptococcus pyogenes
2017 StandoutNobel
Enzymatic transition states: thermodynamics, dynamics and analogue design
2004
A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization
2000
Structure of the ERM Protein Moesin Reveals the FERM Domain Fold Masked by an Extended Actin Binding Tail Domain
2000
The Cryo-EM Structure of a Translation Initiation Complex from Escherichia coli
2005 StandoutNobel
The road to fully programmable protein catalysis
2022 StandoutNatureNobel
Calf spleen purine nucleoside phosphorylase: complex kinetic mechanism, hydrolysis of 7-methylguanosine, and oligomeric state in solution
2002
Expanding the Enzyme Universe: Accessing Non‐Natural Reactions by Mechanism‐Guided Directed Evolution
2015 StandoutNobel
Static and Dynamic Errors in Particle Tracking Microrheology
2004
Catalysis by hen egg-white lysozyme proceeds via a covalent intermediate
2001 Nature
UCSF Chimera—A visualization system for exploratory research and analysis
2004 Standout
The cell as a material
2006
High-resolution structure prediction and the crystallographic phase problem
2007 StandoutNatureNobel
Strain Hardening of Actin Filament Networks
2000
Enzyme promiscuity: evolutionary and mechanistic aspects
2006
Opportunities and challenges for a sustainable energy future
2012 StandoutNatureNobel
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
2012
A Measure of the Promiscuity of Proteins and Characteristics of Residues in the Vicinity of the Catalytic Site That Regulate Promiscuity
2012
Nonlinear elasticity in biological gels
2005 StandoutNature
From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites
2016 Standout
A Novel SNARE N-terminal Domain Revealed by the Crystal Structure of Sec22b
2001
Conformational strictness required for maximum activity and stability of bovine pancreatic ribonuclease A as revealed by crystallographic study of three Phe120 mutants at 1.4 Å resolution
2002
Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1
2012
Enzymatic functionalization of carbon–hydrogen bonds
2010 StandoutNobel
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
2016 Standout
Open and closed conformation of the E. coli purine nucleoside phosphorylase active center and implications for the catalytic mechanism
2002
The Assembly of MreB, a Prokaryotic Homolog of Actin
2004
Directed evolution drives the next generation of biocatalysts
2009
Optimal Germinal Center Responses Require a Multistage T Cell:B Cell Adhesion Process Involving Integrins, SLAM-Associated Protein, and CD84
2010
Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization
2001
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
2016
Integrins
2002 Standout
Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation
2008 Standout
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Ribosome Structure and the Mechanism of Translation
2002 StandoutNobel
ModBase, a database of annotated comparative protein structure models, and associated resources
2010
Obstructive sleep apnoea and its cardiovascular consequences
2008 Standout
Engineering the third wave of biocatalysis
2012 StandoutNature
Exploitation of binding energy for catalysis and design
2009 StandoutNatureNobel
Aczonin, a 550-Kd Putative Scaffolding Protein of Presynaptic Active Zones, Shares Homology Regions with Rim and Bassoon and Binds Profilin
1999
Atomic Dissection of the Hydrogen Bond Network for Transition-State Analogue Binding to Purine Nucleoside Phosphorylase
2002
Dynamical Contributions to Enzyme Catalysis: Critical Tests of A Popular Hypothesis
2006 StandoutNobel
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
Steric and Dynamic Parameters Influencing In Situ Cycloadditions to Form Triazole Inhibitors with Crystalline Acetylcholinesterase
2016 StandoutNobel
Bioactivity-Guided Navigation of Chemical Space
2010
Promoting Vibrations in Human Purine Nucleoside Phosphorylase. A Molecular Dynamics and Hybrid Quantum Mechanical/Molecular Mechanical Study
2004
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
2011
In the light of directed evolution: Pathways of adaptive protein evolution
2009 StandoutNobel
T Cell/Transmembrane, Ig, and Mucin-3 Allelic Variants Differentially Recognize Phosphatidylserine and Mediate Phagocytosis of Apoptotic Cells
2010
Cytoskeletal polymer networks: The molecular structure of cross-linkers determines macroscopic properties
2006
Signal-dependent membrane targeting by pleckstrin homology (PH) domains
2000
Follicular Helper CD4 T Cells (TFH)
2011 Standout
Specificity and versatility of SH3 and other proline-recognition domains: structural basis and implications for cellular signal transduction
2005
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
Ligand-Binding Proteins: Their Potential for Application in Systems for Controlled Delivery and Uptake of Ligands
2000
Molecular Mechanisms Controlling Actin Filament Dynamics in Nonmuscle Cells
2000
Protein Pockets: Inventory, Shape, and Comparison
2010
Absence of YbeY RNase compromises the growth and enhances the virulence plasmid gene expression of Yersinia enterocolitica O:3
2014
Insights into the serine protease mechanism from atomic resolution structures of trypsin reaction intermediates
2006
Tim-3 mediates phagocytosis of apoptotic cells and cross-presentation
2009
The specificity of SNARE-dependent fusion is encoded in the SNARE motif
2004 StandoutNobel
GTPase Activity, Structure, and Mechanical Properties of Filaments Assembled from Bacterial Cytoskeleton Protein MreB
2006
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Challenges in Enzyme Mechanism and Energetics
2003
On Catalytic Preorganization in Oxyanion Holes: Highlighting the Problems with the Gas-Phase Modeling of Oxyanion Holes and Illustrating the Need for Complete Enzyme Models
2010 StandoutNobel
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Architecture and function of metallopeptidase catalytic domains
2013
Actin Binding Proteins: Regulation of Cytoskeletal Microfilaments
2003
SLAM Family Receptors and SAP Adaptors in Immunity
2011
Tim-3 is an inducible human natural killer cell receptor that enhances interferon gamma production in response to galectin-9
2012
Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template
2013
Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate
2013 StandoutNobel
Electrostatic Basis for Enzyme Catalysis
2006 StandoutNobel
Chemomimetic Biocatalysis: Exploiting the Synthetic Potential of Cofactor-Dependent Enzymes To Create New Catalysts
2015 StandoutNobel
Differential Transition-State Stabilization in Enzyme Catalysis: Quantum Chemical Analysis of Interactions in the Chorismate Mutase Reaction and Prediction of the Optimal Catalytic Field
2004
Asymmetric Catalysis of the Carbonyl-Amine Condensation: Kinetic Resolution of Primary Amines
2017 StandoutNobel
Treg-expressed CTLA-4 depletes CD80/CD86 by trogocytosis, releasing free PD-L1 on antigen-presenting cells
2021 StandoutNobel
De Novo Computational Design of Retro-Aldol Enzymes
2008 StandoutScienceNobel
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
2012
Piccolo and bassoon maintain synaptic vesicle clustering without directly participating in vesicle exocytosis
2010 StandoutNobel
Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
2011
A Perspective on Enzyme Catalysis
2003 Science
High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate
2002 StandoutNobel
Germinal Center T Follicular Helper Cell IL-4 Production Is Dependent on Signaling Lymphocytic Activation Molecule Receptor (CD150)
2010
Enantioselective Total Synthesis of Nigelladine A via Late-Stage C–H Oxidation Enabled by an Engineered P450 Enzyme
2017 StandoutNobel
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Works of E.V. Fedorov being referenced
X-ray Structure and Mutational Analysis of the Atrazine Chlorohydrolase TrzN
2010
Micromechanics and ultrastructure of actin filament networks crosslinked by human fascin: A comparison with α-actinin
2001
The ybeY protein fromEscherichia coliis a metalloprotein
2005
Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function.
1999
Prediction and assignment of function for a divergent N-succinyl amino acid racemase
2007
How actin crosslinking and bundling proteins cooperate to generate an enhanced cell mechanical response
2005
Multiple-Particle Tracking Measurements of Heterogeneities in Solutions of Actin Filaments and Actin Bundles
2000
NTB-A Receptor Crystal Structure: Insights into Homophilic Interactions in the Signaling Lymphocytic Activation Molecule Receptor Family
2006
T Cell Immunoglobulin Mucin-3 Crystal Structure Reveals a Galectin-9-Independent Ligand-Binding Surface
2007 StandoutNobel
Profilin binds proline-rich ligands in two distinct amide backbone orientations.
1999
Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex
2020
Structure-based activity prediction for an enzyme of unknown function
2007 Nature
Structure of CD84 provides insight into SLAM family function
2007
Structure-Based Function Discovery of an Enzyme for the Hydrolysis of Phosphorylated Sugar Lactones
2012
Evolution of Enzymatic Activities in the Enolase Superfamily: Stereochemically Distinct Mechanisms in Two Families of cis,cis-Muconate Lactonizing Enzymes
2009
Ionic Interactions in Crystalline Bovine Pancreatic Ribonuclease A,
1996
Mapping the Functional Surface of Domain 2 in the Gelsolin Superfamily,
2000
Structural Diversity within the Mononuclear and Binuclear Active Sites of N-Acetyl-d -glucosamine-6-phosphate Deacetylase,
2007
Transition State Structure of Purine Nucleoside Phosphorylase and Principles of Atomic Motion in Enzymatic Catalysis,
2000
Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization,
2009