Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
Differential Antigen Processing by Dendritic Cell Subsets in Vivo
2007 StandoutScienceNobel
Directed evolution of cytochrome c for carbon–silicon bond formation: Bringing silicon to life
2016 StandoutScienceNobel
Identification and Characterization of Ich-3, a Member of the Interleukin-1β Converting Enzyme (ICE)/Ced-3 Family and an Upstream Regulator of ICE
1996
Functional Characterization of the Prodomain of Interleukin1β-converting Enzyme
1996
The mystery of nonclassical protein secretion
2003
A conformational switch controls hepatitis delta virus ribozyme catalysis
2004 StandoutNatureNobel
Crystal Structure of a Purple Acid Phosphatase Containing a Dinuclear Fe(III)-Zn(II) Active Site
1995 Science
Characterization of the S1 binding site of the glutamic acid‐specific protease from Streptomyces griseus
1996
Zinc coordination, function, and structure of zinc enzymes and other proteins
1990
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 Standout
Evidence for the role of solvated metal hydroxide in the hammerhead cleavage mechanism
1993
Crystal Structure of a pol α Family Replication DNA Polymerase from Bacteriophage RB69
1997 StandoutNobel
Metal ion catalysis in the Tetrahymena ribozyme reaction
1993 NatureNobel
Crystal structures of phosphate, iodide and iodate-inhibited phospholipase C from Bacillus cereus and structural investigations of the binding of reaction products and a substrate analogue
1992
Casper Is a FADD- and Caspase-Related Inducer of Apoptosis
1997
Making and Breaking Nucleic Acids: Two-Mg2+-Ion Catalysis and Substrate Specificity
2006
Structural Basis for the Inhibition of Caspase-3 by XIAP
2001
ICE-LAP3, a Novel Mammalian Homologue of the Caenorhabditis elegans Cell Death Protein Ced-3 Is Activated during Fas- and Tumor Necrosis Factor-induced Apoptosis
1996
Caspase-8 specificity probed at subsite S 4 :crystal structure of the caspase-8-Z-DEVD-cho complex 1 1Edited by R. Huber
2000
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Substrate Specificities of Caspase Family Proteases
1997
Predicted secondary and supersecondary structure for the serine–threonine‐specific protein phosphatase family
1995
Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro
1995
ERICE, a Novel FLICE-activatable Caspase
1998
The Hallmarks of Cancer
2000 Standout
Positional Information within the Mu Transposase Tetramer: Catalytic Contributions of Individual Monomers
1996
Protease Activity of in Vitro Transcribed and Translated Caenorhabditis elegans Cell Death Gene (ced-3) Product
1996
Structure of Recombinant Human CPP32 in Complex with the Tetrapeptide Acetyl-Asp-Val-Ala-Asp Fluoromethyl Ketone
1997
Crystal structure of Thermus aquaticus DNA polymerase
1995 StandoutNatureNobel
ICE-LAP6, a Novel Member of the ICE/Ced-3 Gene Family, Is Activated by the Cytotoxic T Cell Protease Granzyme B
1996
The biochemistry of apoptosis
2000 StandoutNature
A theoretical study of the active sites of papain and S195C rat trypsin: Implications for the low reactivity of mutant serine proteinases
1996
Inhibition of Human Caspases by Peptide-based and Macromolecular Inhibitors
1998
The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.
1996 StandoutNobel
The C. elegans Protein EGL-1 Is Required for Programmed Cell Death and Interacts with the Bcl-2–like Protein CED-9
1998 StandoutNobel
A new metal ion interaction in the Tetrahymena ribozyme reaction revealed by double sulfur substitution.
1999
Identification and Characterization of CPP32/Mch2 Homolog 1, a Novel Cysteine Protease Similar to CPP32
1996
Hydrolysis of phosphate monoesters: a biological problem with multiple chemical solutions
1992
Biochemical Characteristics of Caspases-3, -6, -7, and -8
1997
Substrate and Inhibitor Specificity of Interleukin-1β-converting Enzyme and Related Caspases
1997
Structure of Taq polymerase with DNA at the polymerase active site
1996 StandoutNatureNobel
Checkpoints of dueling dimers foil death wishes
1994
Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis
1995 StandoutNature
Ligation of CD40 Activates Interleukin 1β-converting Enzyme (Caspase-1) Activity in Vascular Smooth Muscle and Endothelial Cells and Promotes Elaboration of Active Interleukin 1β
1997
Proteases to die for
1998
Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor
1997 StandoutNatureNobel
A DNA metalloenzyme with DNA ligase activity
1995 StandoutNatureNobel
Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase
1995 Standout
Structural principles for the inhibition of the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates
1998 StandoutNobel
FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex
1996 Standout
Characterization of seven murine caspase family members
1997
Caspases: killer proteases
1997 Standout
Atherosclerosis — An Inflammatory Disease
1999 Standout
ICE/CED3-like Proteases as Therapeutic Targets for the Control of Inappropriate Apoptosis
1996
Structural Basis for Proofreading during Replication of the Escherichia coli Chromosome
2002
The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity
2000
Expression, Refolding, and Autocatalytic Proteolytic Processing of the Interleukin-1β-converting Enzyme Precursor
1995
The atomic-resolution structure of human caspase-8, a key activator of apoptosis
1999
The Ced-3/Interleukin 1β Converting Enzyme-like Homolog Mch6 and the Lamin-cleaving Enzyme Mch2α Are Substrates for the Apoptotic Mediator CPP32
1996
In vitro evolution of new ribozymes with polynucleotide kinase activity
1994 StandoutNatureNobel
Activation of the Native 45-kDa Precursor Form of Interleukin-1-converting Enzyme
1996
Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase
2005 StandoutNatureNobel
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Analysis of zinc binding sites in protein crystal structures
1998
The chemical repertoire of natural ribozymes
2002 StandoutNatureNobel
Catalytic promiscuity and the evolution of new enzymatic activities
1999
Purification and catalytic properties of human caspase family members
1999
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis
1996
Fas-associated Death Domain Protein Interleukin-1β-converting Enzyme 2 (FLICE2), an ICE/Ced-3 Homologue, Is Proximally Involved in CD95- and p55-mediated Death Signaling
1997
Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock
1995
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1
1995 StandoutNature
Structural Biology of Zinc
1991
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase
1993 StandoutNobel
Inhibition of death receptor signals by cellular FLIP
1997 StandoutNature
Caspase Activation Involves the Formation of the Aposome, a Large (∼700 kDa) Caspase-activating Complex
1999
Mutational Analysis of the Caenorhabditis elegans Cell-Death Gene ced-3
1999 StandoutNobel
Nucleases: diversity of structure, function and mechanism
2010
Up-Regulation of the Nedd2 Gene Encoding an ICE/Ced-3-Like Cysteine Protease in the Gerbil Brain after Transient Global Ischemia
1997
The three-dimensional structure of caspase-8: an initiator enzyme in apoptosis
1999
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Caspases: key mediators of apoptosis
1998
Crystal Structure of a Procaspase-7 Zymogen
2001
Suicidal Tendencies: Apoptotic Cell Death by Caspase Family Proteinases
1999
Identification and Characterization of ICH-2, a Novel Member of the Interleukin-1β-converting Enzyme Family of Cysteine Proteases
1995
A combinatorial approach for determining protease specificities: application to interleukin-1β converting enzyme (ICE)
1997
CPP32/Apopain Is a Key Interleukin 1β Converting Enzyme-like Protease Involved in Fas-mediated Apoptosis
1996
Involvement of an ICE-like protease in Fas-mediated apoptosis
1995 Nature
Structure and Mechanism of Bovine Lens Leucine Aminopeptidase
1994
Conservation analysis and structure prediction of the protein serine/threonine phosphatases
1994
Molecular Cloning and Pro-apoptotic Activity of ICErelII and ICErelIII, Members of the ICE/CED-3 Family of Cysteine Proteases
1995
The Tumor Necrosis Factor Ligand and Receptor Families
1996 StandoutNobel
Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein
1995 StandoutNatureNobel
Interleukin‐1βconverting enzyme: A novel cysteine protease required for IL‐1β production and implicated in programmed cell death
1995
Fas- and Tumor Necrosis Factor-induced Apoptosis Is Inhibited by the Poxvirus crmA Gene Product
1995
Altered Cytokine Export and Apoptosis in Mice Deficient in Interleukin-1β Converting Enzyme
1995 Science
Life, death, and the pursuit of apoptosis.
1996
Molecular Recognition of Protein−Ligand Complexes: Applications to Drug Design
1997 Standout
Serpin Structure, Mechanism, and Function
2002 Standout
Crystal Structure of a Group I Ribozyme Domain: Principles of RNA Packing
1996 StandoutScienceNobel
A general two-metal-ion mechanism for catalytic RNA.
1993 StandoutNobel
Caspase-1 (interleukin-1β-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9
1999
Differential Lysosomal Proteolysis in Antigen-Presenting Cells Determines Antigen Fate
2005 Science
Structural and Functional Aspects of Metal Sites in Biology
1996 Standout
Tripeptide Aldehyde Inhibitors of Human Rhinovirus 3C Protease: Design, Synthesis, Biological Evaluation, and Cocrystal Structure Solution of P1 Glutamine Isosteric Replacements
1998
Inhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35
1995 Science
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
DCP-1, a Drosophila Cell Death Protease Essential for Development
1997 Science
The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.
1994
Insights into Editing from an Ile-tRNA Synthetase Structure with tRNA Ile and Mupirocin
1999 StandoutScienceNobel
How many catalytic RNAs? Ions and the Cheshire cat conjecture.
1993
Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia
1996
Structural basis for the activation of human procaspase-7
2001 Nobel
Recent Advances in Zinc Enzymology
1996 Nobel
The role of proteases during apoptosis
1996
Dimer formation drives the activation of the cell death protease caspase 9
2001
A novel human protease similar to the interleukin-1 beta converting enzyme induces apoptosis in transfected cells.
1995
Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations
2000 StandoutScienceNobel
Ischemic Cell Death in Brain Neurons
1999 Standout
Structure of DNA Polymerase I Klenow Fragment Bound to Duplex DNA
1993 StandoutScienceNobel
Potassium Deprivation-Induced Apoptosis of Cerebellar Granule Neurons: A Sequential Requirement for New mRNA and Protein Synthesis, ICE-Like Protease Activity, and Reactive Oxygen Species
1996
Mammalian Caspases: Structure, Activation, Substrates, and Functions During Apoptosis
1999 Standout
Dalton perspectives. The emergence of trinuclear constellations at metallobiosites
1993
Ribozyme Structures and Mechanisms
2000 StandoutNobel
Ab Initio Evaluation of the Free Energy Surfaces for the General Base/Acid Catalyzed Thiolysis of Formamide and the Hydrolysis of Methyl Thiolformate: A Reference Solution Reaction for Studies of Cysteine Proteases
2001 StandoutNobel
Side chains involved in catalysis of the polymerase reaction of DNA polymerase I from Escherichia coli.
1992
Architecture of RNA Polymerase II and Implications for the Transcription Mechanism
2000 StandoutScienceNobel
Site-specific cleavage by metal ion cofactors and inhibitors of M1 RNA, the catalytic subunit of RNase P from Escherichia coli.
1991 Nobel
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
1994
Two-Metal-Ion Catalysis in Adenylyl Cyclase
1999 ScienceNobel
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis
1997
Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.
1994
Metalloenzymes, Structural Motifs, and Inorganic Models
1993 Science
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
On the Interpretation of the Observed Linear Free Energy Relationship in Phosphate Hydrolysis: A Thorough Computational Study of Phosphate Diester Hydrolysis in Solution
2008 StandoutNobel
Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein
1997
Internally quenched fluorescent peptide substrates disclose the subsite preferences of human caspases 1, 3, 6, 7 and 8
2000 StandoutNobel
Caspases: Enemies Within
1998 StandoutScience
Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.
1995
Roles of caspases in apoptosis, development, and cytokine maturation revealed by homozygous gene deficiencies
2000
Protein-tyrosine phosphatases.
1994
Works of Eunice E. Kim being referenced
Refinement of the crystal structure of ribonuclease S. Comparison with and between the various ribonuclease A structures
1992
Structure and mechanism of interleukin-lβ converting enzyme
1994 Nature
Reaction mechanism of alkaline phosphatase based on crystal structures
1991 Standout
Structure of alkaline phosphatases
1990
Crystal structures of bis(urea)bis(dihydrogenphosphato)calcium-bis(urea) and its isomorphous magnesium analog, M[OC(NH2)2]2(H2PO4)2.2CO(NH2)2 (M = Ca, Mg)
1982