Citation Impact
Citing Papers
Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase
2004 StandoutScience
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α
2007 Standout
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
2009 StandoutScience
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
2004 Science
Metabolic enzymes and coenzymes in transcription – a direct link between metabolism and transcription?
2004
Functional Proteomics Establishes the Interaction of SIRT7 with Chromatin Remodeling Complexes and Expands Its Role in Regulation of RNA Polymerase I Transcription
2012
Regulation of Insulin Secretion by SIRT4, a Mitochondrial ADP-ribosyltransferase
2007
Sirtuins as regulators of metabolism and healthspan
2012 Standout
Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1
2004 Standout
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
2009 StandoutNature
NAD+-dependent deacetylation of H4 lysine 16 by class III HDACs
2007
Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants
2007 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
Calorie restriction reduces rDNA recombination independently of rDNA silencing
2009
SIRT6 protects against pathological damage caused by diet‐induced obesity
2009
SIRT1 Deacetylates and Positively Regulates the Nuclear Receptor LXR
2007
Hepatic-Specific Disruption of SIRT6 in Mice Results in Fatty Liver Formation Due to Enhanced Glycolysis and Triglyceride Synthesis
2010
Mechanism of Human SIRT1 Activation by Resveratrol
2005
Mammalian single-strand break repair: Mechanisms and links with chromatin
2006
SNAPc: a core promoter factor with a built-in DNA-binding damper that is deactivated by the Oct-1 POU domain
1999
Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
2015
Editing the epigenome: technologies for programmable transcription and epigenetic modulation
2016
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
2008 StandoutNature
Calorie Restriction— the SIR2 Connection
2005
A systematic RNAi screen for longevity genes in C. elegans
2005 StandoutNobel
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
2006 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
Chromatin Modifications and Their Function
2007 Standout
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
The Sir2 family of protein deacetylases
2005
The genetics of ageing
2010 StandoutNature
Chromatin regulation at the frontier of synthetic biology
2015
Increased dosage of mammalian Sir2 in pancreatic β cells enhances glucose-stimulated insulin secretion in mice
2005
Fundamental Cellular Processes Do Not Require Vertebrate-specific Sequences within the TATA-binding Protein
2003 StandoutNobel
SIRT1 Functionally Interacts with the Metabolic Regulator and Transcriptional Coactivator PGC-1α
2005
Hallmarks of aging: An expanding universe
2023 Standout
Calorie restriction effects on silencing and recombination at the yeast rDNA
2009
Epigenetic Control of rDNA Loci in Response to Intracellular Energy Status
2008
A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology
2008 Standout
Calorie restriction (CR) and CR mimetics for the prevention and treatment of age-related eye disorders
2013
Adipocytes as regulators of energy balance and glucose homeostasis
2006 StandoutNature
NAD+ as a Signaling Molecule Modulating Metabolism
2011
Conserved Metabolic Regulatory Functions of Sirtuins
2008
Enabling functional genomics with genome engineering
2015
Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions
2012
Regulation of gene expression by TBP-associated proteins
1998
MicroRNA-92a is a circadian modulator of neuronal excitability in Drosophila
2017 StandoutNobel
Glucose Restriction Inhibits Skeletal Myoblast Differentiation by Activating SIRT1 through AMPK-Mediated Regulation of Nampt
2008
Transcriptional targets of sirtuins in the coordination of mammalian physiology
2008
Mitochondrial longevity pathways
2010
SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation
2007
S Phase Activation of the Histone H2B Promoter by OCA-S, a Coactivator Complex that Contains GAPDH as a Key Component
2003
Quantitation of the RNA Polymerase II Transcription Machinery in Yeast
2001 StandoutNobel
Tissue-specific regulation of SIRT1 by calorie restriction
2008
Coevolution of HMG domains and homeodomains and the generation of transcriptional regulation by Sox/POU complexes
2001
Nampt/PBEF/Visfatin: A regulator of mammalian health and longevity?
2006
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
2015
The NAD Biosynthesis Pathway Mediated by Nicotinamide Phosphoribosyltransferase Regulates Sir2 Activity in Mammalian Cells
2004
Mechanisms and Molecular Probes of Sirtuins
2008
Cardiac glycosides are potent inhibitors of interferon-β gene expression
2010
Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC‐1α
2007
A Role for SIR-2.1 Regulation of ER Stress Response Genes in Determining C. elegans Life Span
2005
Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells
2005
Fasting promotes the expression of SIRT1, an NAD+-dependent protein deacetylase, via activation of PPARα in mice
2010
Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells
2005 Standout
The transcription factor code in iPSC reprogramming
2021
Aging networks in Caenorhabditis elegans: AMP‐activated protein kinase (aak‐2) links multiple aging and metabolism pathways
2006
Autophagy and Aging
2011 Standout
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Sir2 and calorie restriction in yeast: A skeptical perspective
2007
Calorie restriction extends the chronological lifespan of Saccharomyces cerevisiae independently of the Sirtuins
2007
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ
2004 StandoutNature
Mitochondrial sirtuins
2010
Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
2010
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
2015 Standout
Targeting Sirtuin 1 to Improve Metabolism: All You Need Is NAD+?
2011
Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α
2006 Standout
The Hallmarks of Aging
2013 Standout
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
2005 StandoutNature
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose
2010
SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
2006
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation
2012 Nature
Reactive oxygen species, cellular redox systems, and apoptosis
2010 Standout
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
2008
NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity
2010
Aspirin extends the lifespan of Caenorhabditis elegans via AMPK and DAF-16/FOXO in dietary restriction pathway
2013
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
Dissecting the Regulatory Circuitry of a Eukaryotic Genome
1998 Standout
PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure
2009
SIRT6 in DNA repair, metabolism and ageing
2008
SIRT1 transgenic mice show phenotypes resembling calorie restriction
2007
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5
2008
Mammalian SIRT1 Represses Forkhead Transcription Factors
2004
SIRT1 and SIRT2: emerging targets in neurodegeneration
2013
NAD + /NADH and NADP + /NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences
2007 Standout
Click Chemistry for Drug Development and Diverse Chemical–Biology Applications
2013 Standout
Nuclear ADP-Ribosylation Reactions in Mammalian Cells: Where Are We Today and Where Are We Going?
2006
A Mitochondrial Paradigm of Metabolic and Degenerative Diseases, Aging, and Cancer: A Dawn for Evolutionary Medicine
2005 Standout
Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice
2008
Explorative Study on Isoform-Selective Histone Deacetylase Inhibitors
2009
The Biochemistry of Sirtuins
2006
Sirtuin 1 and Sirtuin 3: Physiological Modulators of Metabolism
2012
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
2005 StandoutScience
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
2011 Science
Fluorescence Lifetime Measurements and Biological Imaging
2010 Standout
Sirtuins, a key regulator of ageing and age-related neurodegenerative diseases
2022
Mammalian Sirtuins: Biological Insights and Disease Relevance
2010 Standout
Spermidine in health and disease
2018 StandoutScience
SIRT6, a Mammalian Deacylase with Multitasking Abilities
2019
Differential regulation of S-region hypermutation and class-switch recombination by noncanonical functions of uracil DNA glycosylase
2014 StandoutNobel
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis
2009
Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity
2010
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Sirtuin Functions in Health and Disease
2007
Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2
2006
Nuclear Import of the TATA-binding Protein: Mediation by the Karyopherin Kap114p and a Possible Mechanism for Intranuclear Targeting
1999 StandoutNobel
Sirtuins — novel therapeutic targets to treat age-associated diseases
2008
Extending Healthy Life Span—From Yeast to Humans
2010 StandoutScience
The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways
2010
ATP-sensitive potassium channel (K ATP )–dependent regulation of cardiotropic viral infections
2011 StandoutNobel
Works of Ethan Ford being referenced
Characterization of a Trimeric Complex Containing Oct-1, SNAPc, and DNA
1997
Analysis of an artificial zinc finger epigenetic modulator: widespread binding but limited regulation
2014
Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming
2017
Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase
2005
The Oct-1 POU domain activates snRNA gene transcription by contacting a region in the SNAPc largest subunit that bears sequence similarities to the Oct-1 coactivator OBF-1
1998
The transcriptional code of human IFN-β gene expression
2010
Calorie restriction extends yeast life span by lowering the level of NADH
2004
Crossing the Line between RNA Polymerases: Transcription of Human snRNA Genes by RNA Polymerases II and III
1998
Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
2006