Standout Papers
Citation Impact
Citing Papers
The Mechanism of Endogenous Receptor Activation Functionally Distinguishes Prototype Canonical and Noncanonical Wnts
2005
Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency
2007
Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea
2012
Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
2012 Science
An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
2014 Science
The Soluble Wnt Receptor Frizzled8CRD-hFc Inhibits the Growth of Teratocarcinomas In vivo
2007
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility
2011
Defining the Epithelial Stem Cell Niche in Skin
2003 StandoutScience
Bcl9/Bcl9l Are Critical for Wnt-Mediated Regulation of Stem Cell Traits in Colon Epithelium and Adenocarcinomas
2010
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C. elegans
2006
β-Catenin Is Dispensable for Hematopoiesis and Lymphopoiesis
2004
A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
2013
Single-Molecule Genomic Data Delineate Patient-Specific Tumor Profiles and Cancer Stem Cell Organization
2012
LGR5-Targeted Antibody–Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence
2016
In vivo role of lipid adducts on Wingless
2008
Artificial three-dimensional niches deconstruct pancreas development in vitro
2013
Structural Basis of Wnt Recognition by Frizzled
2012 Science
Instructive Role of Wnt/ß-Catenin in Sensory Fate Specification in Neural Crest Stem Cells
2004 Science
2012
Complex interplay between -catenin signalling and Notch effectors in intestinal tumorigenesis
2011 StandoutNobel
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1)
2012
Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea
2012
The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
2011
Cellular Heterogeneity in the Mouse Esophagus Implicates the Presence of a Nonquiescent Epithelial Stem Cell Population
2014
DKK1 Antagonizes Wnt Signaling without Promotion of LRP6 Internalization and Degradation
2008
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Lgr5+ Gastric Stem Cells Divide Symmetrically to Effect Epithelial Homeostasis in the Pylorus
2013
Stearoyl CoA Desaturase Is Required to Produce Active, Lipid-Modified Wnt Proteins
2013
The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
2015
A genome editing approach to study cancer stem cells in human tumors
2017
Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
2017
The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network
2007
WNT5A mutations in patients with autosomal dominant Robinow syndrome
2009
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
2013
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny
2013
A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer
2017 Nature
Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex
2008
Wnt signaling in the stem cell niche
2004
Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
2015
TBL1–TBLR1 and β-catenin recruit each other to Wnt target-gene promoter for transcription activation and oncogenesis
2008
Inflammation and Cancer: Triggers, Mechanisms, and Consequences
2019 Standout
Lgr5+ve Stem/Progenitor Cells Contribute to Nephron Formation during Kidney Development
2012
Porcupine homolog is required for canonical Wnt signaling and gastrulation in mouse embryos
2011
Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
2014
The complex world of WNT receptor signalling
2012
The microenvironment of the embryonic neural stem cell: Lessons from adult niches?
2007
Differentiation of the brain vasculature: the answer came blowing by the Wnt
2010
Noninvasive Imaging beyond the Diffraction Limit of 3D Dynamics in Thickly Fluorescent Specimens
2012 StandoutNobel
Applying the principles of stem-cell biology to cancer
2003
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
2007
Chronic myeloid leukaemia as a model of disease evolution in human cancer
2007
Sequential cancer mutations in cultured human intestinal stem cells
2015 Nature
Isolation and in vitro expansion of human colonic stem cells
2011
Drosophila Wnt-1 Undergoes a Hydrophobic Modification and Is Targeted to Lipid Rafts, a Process That Requires Porcupine
2004
Interactions between cancer stem cells and their niche govern metastatic colonization
2011 Nature
Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors
2006 StandoutNobel
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
2010
Notum deacylates Wnt proteins to suppress signalling activity
2015 Nature
Wnt signaling: is the party in the nucleus?
2006
WNT signalling pathways as therapeutic targets in cancer
2012 Standout
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells
2011
WNT and β-catenin signalling: diseases and therapies
2004 Standout
Transcriptional Networks and Signaling Pathways that Govern Vertebrate Intestinal Development
2010
Leucine-Rich Repeat-Containing G-Protein-Coupled Receptors as Markers of Adult Stem Cells
2010
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
2011 Standout
The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
2014
Trafficking and signaling by fatty-acylated and prenylated proteins
2006
Socializing with the Neighbors
2004 Standout
Lipid-independent Secretion of a Drosophila Wnt Protein
2008
Organoids: Modeling Development and the Stem Cell Niche in a Dish
2016
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
WNT10B mutations in human obesity
2006
Active Wnt proteins are secreted on exosomes
2012
Lgr5-Expressing Cells Are Sufficient and Necessary for Postnatal Mammary Gland Organogenesis
2013
Inflammation and colorectal cancer: colitis-associated neoplasia
2012
Intestinal Inflammation and Cancer
2011
Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update
2015
In vitro and in vivo expansion of hematopoietic stem cells
2004
Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
2013
Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury
2016
Wnt Proteins Are Self-Renewal Factors for Mammary Stem Cells and Promote Their Long-Term Expansion in Culture
2010
Cancer stem cells revisited
2017 Standout
Identification of Key Residues and Regions Important for Porcupine-mediated Wnt Acylation
2014
Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
2012
Notum Is Required for Neural and Head Induction via Wnt Deacylation, Oxidation, and Inactivation
2015
Wnt signaling in the intestinal epithelium: from endoderm to cancer
2005
Interleukin-22 protects intestinal stem cells against genotoxic stress
2019 Nature
Casein Kinase 2 Is Activated and Essential for Wnt/β-Catenin Signaling
2006
Wntless, a Conserved Membrane Protein Dedicated to the Secretion of Wnt Proteins from Signaling Cells
2006
Glycosylation and palmitoylation of Wnt‐3a are coupled to produce an active form of Wnt‐3a
2007
Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells
2005
Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6
2007
Organoid culture systems for prostate epithelial and cancer tissue
2016
Therapeutic implications of cancer stem cells
2003
Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless
2009
The organoid-initiating cells in mouse pancreas and liver are phenotypically and functionally similar
2014
Lipoprotein particles are required for Hedgehog and Wingless signalling
2005 Nature
Inflammation and Colon Cancer
2010 Standout
Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals
2015
Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In Vivo
2007
Monounsaturated Fatty Acid Modification of Wnt Protein: Its Role in Wnt Secretion
2006
Sox2+ Adult Stem and Progenitor Cells Are Important for Tissue Regeneration and Survival of Mice
2011
C‐terminal‐binding protein directly activates and represses Wnt transcriptional targets in Drosophila
2006
Wnt/β-Catenin Signaling and Disease
2012 Standout
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
Asymmetric cell division: recent developments and their implications for tumour biology
2010
Synthetic Par polarity induces cytoskeleton asymmetry in unpolarized mammalian cells
2023 StandoutNobel
Development, maintenance and disruption of the blood-brain barrier
2013 Standout
Porcupine-mediated lipidation is required for Wnt recognition by Wls
2011
Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals
2016
A role for Wnt signalling in self-renewal of haematopoietic stem cells
2003 StandoutNature
Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
2016
Replacement of Lost Lgr5-Positive Stem Cells through Plasticity of Their Enterocyte-Lineage Daughters
2016
Uncertainty in the niches that maintain haematopoietic stem cells
2008
Modelling human development and disease in pluripotent stem-cell-derived gastric organoids
2014 Nature
Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
2011 Nature
Secretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
2006
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
2012
Systematic Mapping of WNT-FZD Protein Interactions Reveals Functional Selectivity by Distinct WNT-FZD Pairs
2015
Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer
2009
Stems Cells and the Pathways to Aging and Cancer
2008
Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
2014
Helping Wingless take flight: how WNT proteins are secreted
2007
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context
2006
Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
2013
Deficiency of PORCN, a regulator of Wnt signaling, is associated with focal dermal hypoplasia
2007
-Catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells
2004
Assaying β-Catenin/TCF Transcription with β-Catenin/TCF Transcription-Based Reporter Constructs
2008
Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
2018 StandoutNobel
Wnt/β-Catenin Signaling in Development and Disease
2006 Standout
The Tortoise and the Hair: Slow-Cycling Cells in the Stem Cell Race
2009
Structure and function of Norrin in assembly and activation of a Frizzled 4–Lrp5/6 complex
2013
Mouse Cristin/R-spondin Family Proteins Are Novel Ligands for the Frizzled 8 and LRP6 Receptors and Activate β-Catenin-dependent Gene Expression
2006
AWNT4Mutation Associated with Müllerian-Duct Regression and Virilization in a 46,XX Woman
2004
A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities
2012
Role of shelterin in cancer and aging
2010
Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling
2017 StandoutNatureNobel
Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells
2007
The Hallmarks of Aging
2013 Standout
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
2005
TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth
2006 Standout
Reconstitution of a Frizzled8·Wnt3a·LRP6 Signaling Complex Reveals Multiple Wnt and Dkk1 Binding Sites on LRP6
2010
Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
2010
Rapid, Wnt-Induced Changes in GSK3β Associations that Regulate β-Catenin Stabilization Are Mediated by Gα Proteins
2005
Identification of human brain tumour initiating cells
2004 StandoutNature
Cell plasticity in epithelial homeostasis and tumorigenesis
2017
Wnt signalling in stem cells and cancer
2005 StandoutNature
Wingless secretion promotes and requires retromer-dependent cycling of Wntless
2008
The role of telomeres and telomerase in stem cell aging
2010
Fatty acylation of Wnt proteins
2016
Liposomal Packaging Generates Wnt Protein with In Vivo Biological Activity
2008
In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
2014
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
2009 StandoutNature
Single luminal epithelial progenitors can generate prostate organoids in culture
2014
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
2012
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
2013 Nature
Identification of stem cells in small intestine and colon by marker gene Lgr5
2007 StandoutNature
Long-term single-cell imaging of mammalian stem cells
2011
Granulocyte–Macrophage Progenitors as Candidate Leukemic Stem Cells in Blast-Crisis CML
2004
R-spondin1 Is a High Affinity Ligand for LRP6 and Induces LRP6 Phosphorylation and β-Catenin Signaling
2007
Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
2017 Standout
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
2003 Standout
Structural Studies of Wnts and Identification of an LRP6 Binding Site
2013
Modeling Development and Disease with Organoids
2016 Standout
Cancer stem cells: an evolving concept
2012
Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila
2008
Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes
2010
Type 2 alveolar cells are stem cells in adult lung
2013 Standout
Genetic reconstitution of tumorigenesis in primary intestinal cells
2013
Convergence of Wnt, ß-Catenin, and Cadherin Pathways
2004 StandoutScience
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Cancer Stem Cells: Basic Concepts and Therapeutic Implications
2016
Isolating gene-corrected stem cells without drug selection
2005 StandoutNobel
An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/ wingless signaling pathway
2011
Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue
2013
Activation of Wnt signalling in acute myeloid leukemia by induction of Frizzled-4
1992
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
2004
Hematopoietic Stem and Progenitor Cells: Clinical and Preclinical Regeneration of the Hematolymphoid System
2002
Programmed assembly of 3-dimensional microtissues with defined cellular connectivity
2009 StandoutNobel
Wnt signals across the plasma membrane to activate the β-catenin pathway by forming oligomers containing its receptors, Frizzled and LRP
2004
Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells
2003
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Developmental stage‐specific contribution of LGR5 + cells to basal and luminal epithelial lineages in the postnatal mammary gland
2012
Wnt/β-catenin signaling controls development of the blood–brain barrier
2008
Quiescent gastric stem cells maintain the adult Drosophila stomach
2011
Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids
2017
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Organogenesis in a dish: Modeling development and disease using organoid technologies
2014 StandoutScience
LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
2004
The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways
2022 StandoutNobel
Towards an integrated view of Wnt signaling in development
2009
Post-translational palmitoylation and glycosylation of Wnt-5a are necessary for its signalling
2007
Wnt signaling orients the proximal-distal axis of kidney nephrons
2015
Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan
2015
Porcupine-mediated lipid-modification regulates the activity and distribution of Wnt proteins in the chick neural tube
2007
Control of stem cell self-renewal and differentiation by the heterochronic genes and the cellular asymmetry machinery in Caenorhabditis elegans
2015 StandoutNobel
Cancer Genome Landscapes
2013 StandoutScience
THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE
2004 Standout
Targeting LGR5 + cells with an antibody-drug conjugate for the treatment of colon cancer
2015
Normal and leukemic hematopoiesis: Are leukemias a stem cell disorder or a reacquisition of stem cell characteristics?
2003
A Localized Wnt Signal Orients Asymmetric Stem Cell Division in Vitro
2013 StandoutScienceNobel
Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1
2003
Wnt3a Growth Factor Induces Androgen Receptor-Mediated Transcription and Enhances Cell Growth in Human Prostate Cancer Cells
2004
Transcriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal
2012 StandoutNobel
Signaling in stem cell niches: lessons from theDrosophilagermline
2005
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Tracking adult stem cells
2011
Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice
2008 StandoutNobel
Deletion of mouse Porcn blocks Wnt ligand secretion and reveals an ectodermal etiology of human focal dermal hypoplasia/Goltz syndrome
2011
Sprinter: a novel transmembrane protein required for Wg secretion and signaling
2006
Works of Esther Danenberg being referenced
Wnt proteins are lipid-modified and can act as stem cell growth factors
2003 StandoutNature
Phosphatidylinositol 3-Kinase Signaling Does Not Activate the Wnt Cascade
2009
p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice
2009
Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
2010
Crypt stem cells as the cells-of-origin of intestinal cancer
2008 StandoutNature