Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Induction of interferon-stimulated gene expression and antiviral responses require protein deacetylase activity
2004 StandoutNobel
The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency
2008 StandoutScienceNobel
Feedback Circuit among INK4 Tumor Suppressors Constrains Human Glioblastoma Development
2008
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
2008 StandoutNature
Serine Phosphorylation, Chromosomal Localization, and Transforming Growth Factor-β Signal Transduction by Human
1996
Identification of Two Smad4 Proteins in Xenopus
1999
Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
1997 Nature
Genetic and biochemical analysis of TGFβ signal transduction
1997
TGF-β and cancer
1999
Novel Markers of Pancreatic Adenocarcinoma in Fine-Needle Aspiration: Mesothelin and Prostate Stem Cell Antigen Labeling Increases Accuracy in Cytologically Borderline Cases
2003
A human Mad protein acting as a BMP-regulated transcriptional activator
1996 Nature
MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling
1996
Pancreatic cancer
2004 Standout
Inflammation and cancer
2002 StandoutNature
Role of Ras and Mapks in TGFβ signaling
2000
TGF-β signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
1999
SIP1, a Novel Zinc Finger/Homeodomain Repressor, Interacts with Smad Proteins and Binds to 5′-CACCT Sequences in Candidate Target Genes
1999
TGF-β signaling, Smads, and tumor suppressors
1998
Critical Role of Smads and AP-1 Complex in Transforming Growth Factor-β-dependent Apoptosis
2000
Targeted Disruption in Murine Cells Reveals Variable Requirement for Smad4 in Transforming Growth Factor β-related Signaling
2000
Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
1998
Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily
1996
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15Ink4B transcription in response to TGF-β
2000
Role of Transforming Growth Factor β in Human Disease
2000 Standout
Transforming growth factor-β1 is a new form of tumor suppressor with true haploid insufficiency
1998
Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
1997
MAD-related proteins in TGF-β signalling
1996
Cells’ Perception of Position in a Concentration Gradient
1998 StandoutNobel
Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling
1997
The TGF-β signaling inhibitor Smad7 enhances tumorigenicity in pancreatic cancer
1999
A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes
1996 Standout
Role of TAK1 and TAB1 in BMP signaling in early Xenopus development
1998
Tumor Suppressing Pathways
1998
TGF-β signaling in tumor suppression and cancer progression
2001 Standout
TGF-β signalling from cell membrane to nucleus through SMAD proteins
1997 StandoutNature
Elite and stochastic models for induced pluripotent stem cell generation
2009 StandoutNatureNobel
Genetic instabilities in human cancers
1998 StandoutNature
MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways
1996
Breast and Ovarian Cancer
2003
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
2005 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling
1997
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
2005 Standout
Oncoprotein Networks
1997
Smad6 inhibits signalling by the TGF-β superfamily
1997 Nature
Mutational profiling of cancer candidate genes in glioblastoma, melanoma and pancreatic carcinoma reveals a snapshot of their genomic landscapes
2008
A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF‐β signals
1998
Importance of Age of Onset in Pancreatic Cancer Kindreds
2010
Smad2 and Smad4 gene mutations in hepatocellular carcinoma
1999
The Hallmarks of Cancer
2000 Standout
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
Lessons from Hereditary Colorectal Cancer
1996 Standout
Molecular Biology of Pancreatic Cancer
2001
Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes
1999
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
2001
The tumor suppressor Smad4/DPC 4 as a central mediator of Smad function
1997
Telomere Dysfunction Increases Mutation Rate and Genomic Instability
2001 StandoutNobel
Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
2000
TGF-β singaling and cancer: structural and functional consequences of mutations in Smads
1998
Food and metabolic signalling defects in a Caenorhabditis elegans serotonin-synthesis mutant
2000 StandoutNatureNobel
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
2005
KLF4, p21 and context-dependent opposing forces in cancer
2005
Screening for Early Pancreatic Neoplasia in High-Risk Individuals: A Prospective Controlled Study
2006
BRCA2 Germline Mutations in Familial Pancreatic Carcinoma
2003
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
1996
Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kγ
2000 StandoutNatureNobel
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
1996 Nature
Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways
1996 StandoutNature
TGF-β receptor signaling
1997
Integrated genomic characterization of endometrial carcinoma
2013 StandoutNature
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
1998
Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
1996 Standout
Cloning and Characterization of a Novel Member of the Human Mad Gene Family (MADH6)
1997
Induction of Apoptosis by DPC4, a Transcriptional Factor Regulated by Transforming Growth Factor-β through Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) Signaling Pathway
1997
Characterization of the Interaction of FKBP12 with the Transforming Growth Factor-β Type I Receptor in Vivo
1996
TGFβ Signaling: Receptors, Transducers, and Mad Proteins
1996
Cytogenetic Analysis of Colorectal Adenomas
1998
TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
1997
Germline and Somatic Mutations of the STK11/LKB1 Peutz-Jeghers Gene in Pancreatic and Biliary Cancers
1999
Allelic Loss Is Often the First Hit in the Biallelic Inactivation of the p53 and DPC4 Genes During Pancreatic Carcinogenesis
2001
Signaling of transforming growth factor‐β family members through Smad proteins
2000
Inflammation and the development of pancreatic cancer
2002
A structural basis for mutational inactivation of the tumour suppressor Smad4
1997 Nature
The DAF-3 Smad protein antagonizes TGF-β-related receptor signaling in the Caenorhabditis elegansdauer pathway
1997 StandoutNobel
TGF-β Family Signal Transduction in Drosophila Development: From Mad to Smads
1999
Control of Male Sexual Behavior and Sexual Orientation in Drosophila by the fruitless Gene
1996 StandoutNobel
Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes
1998
Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis
1999
K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis
1999
Nucleocytoplasmic Shuttling of Smads 2, 3, and 4 Permits Sensing of TGF-β Receptor Activity
2002
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta
1999
A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras
1999
Determinants of specificity in TGF-β signal transduction
1998
How cells read TGF-β signals
2000 Standout
MADR2 Maps to 18q21 and Encodes a TGFβ–Regulated MAD–Related Protein That Is Functionally Mutated in Colorectal Carcinoma
1996
Functional mapping of the MH1 DNA-binding domain of DPC4/SMAD4
2000
The molecular genetics of pancreatic ductal carcinoma:
2000
Direct Interaction of c-Myc with Smad2 and Smad3 to Inhibit TGF-β-Mediated Induction of the CDK Inhibitor p15Ink4B
2002
SMADs: mediators and regulators of TGF-β signaling
1998
Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4
2000
Identification and mapping of human cDNAs homologous to Drosophila mutant genes through EST database searching
1996
Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers
1998
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Mads and Smads in TGFβ signalling
1998
TGF-β-stimulated cooperation of Smad proteins with the coactivators CBP/p300
1998
The C-terminal domain of Mad-like signal transducers is sufficient for biological activity in the Xenopus embryo and transcriptional activation
1997
Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion
1998
Cancer-related inflammation
2008 StandoutNature
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
2010 StandoutNature
Somatic alterations of the SMAD-2 gene in human colorectal cancers
1998
Crystal Structure of a Phosphorylated Smad2
2001
A Smad Transcriptional Corepressor
1999
lin-35 and lin-53, Two Genes that Antagonize a C. elegans Ras Pathway, Encode Proteins Similar to Rb and Its Binding Protein RbAp48
1998 StandoutNobel
TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling
1997
TGF-β signaling by Smad proteins
2000
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
2016 StandoutNobel
Novel Human and Mouse Homologs of Saccharomyces cerevisiae DNA Polymerase η
1999
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
1997 Nature
Conservation of dorsal-ventral patterning in arthropods and chordates
1996
The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
1997
TGF-β signaling by Smad proteins
2000
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
1997 Nature
Pancreatic cancer
2011 Standout
Evidence That Smad2 Is a Tumor Suppressor Implicated in the Control of Cellular Invasion
1999
Tumor suppressor activity of the TGF-β pathway in human cancers
1996
Screening for pancreatic neoplasia in high-risk individuals: an EUS-based approach
2004
Characterization of Functional Domains within Smad4/DPC4
1997
Interferon γ inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis
2001
Genetics of Pancreatic Cancer
1998
Autocrine Motility Factor Signaling Enhances Pancreatic Cancer Metastasis
2004
Analysis of specific gene mutations in the transforming growth factor-beta signal transduction pathway in human ovarian cancer.
2000
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor β signaling by targeting Smads to the ubiquitin–proteasome pathway
2000
Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium
1997
Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5
1999
TGF-β SIGNAL TRANSDUCTION
1998 Standout
Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth.
1996
G 1 cell cycle arrest and apoptosis induction by nuclear Smad4/Dpc4: Phenotypes reversed by a tumorigenic mutation
1999
Abrogation of the Rb/p16 tumor-suppressive pathway in virtually all pancreatic carcinomas.
1997
Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis
2000
Role of Growth Factors in Pancreatic Cancer
1998
Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4
1997
Transgenic mice overexpressing a dominant-negative mutant type II transforming growth factor beta receptor show enhanced tumorigenesis in the mammary gland and lung in response to the carcinogen 7,12-dimethylbenz-[a]-anthracene.
1997
Transforming growth factor-beta-induced growth inhibition in a Smad4 mutant colon adenoma cell line.
2001
Quality Control by DNA Repair
1999 StandoutScienceNobel
A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum
2000 StandoutNobel
Specificity, diversity, and regulation in TGF-beta superfamily signaling.
1999
Mad acts downstream of Dpp receptors, revealing a differential requirement for dpp signaling in initiation and propagation of morphogenesis in the Drosophila eye
1996
Memory Suppressor Genes: Inhibitory Constraints on the Storage of Long-Term Memory
1998 StandoutScienceNobel
Genes and pathways downstream of telomerase in melanoma metastasis
2006 StandoutNobel
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library.
2000
Lack of a role for transforming growth factor-β in cytotoxic T lymphocyte antigen-4-mediated inhibition of T cell activation
2001 StandoutNobel
The L3 loop: a structural motif determining specific interactions between SMAD proteins and TGF-beta receptors
1998
Update on pancreatic intraepithelial neoplasia.
2008
A quantitative analysis of signal transduction from activin receptor to nucleus and its relevance to morphogen gradient interpretation
1999 StandoutNobel
Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins
1996
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
1997 Nature
Defective repression of c- myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
2001
Regulation of intracellular dynamics of Smad4 by its leucine‐rich nuclear export signal
2000
TGF-β–induced Phosphorylation of Smad3 Regulates Its Interaction with Coactivator p300/CREB-binding Protein
1998
Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1–1.5 Mb and preparation of a PAC-based physical map
1997
Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis
2010
Transforming growth factor-? responsiveness inDPC4/SMAD4-null cancer cells
1999
The Taxonomy of Developmental Control in Caenorhabditis elegans
1998 StandoutScienceNobel
Smad4/DPC4 Silencing and Hyperactive Ras Jointly Disrupt Transforming Growth Factor-β Antiproliferative Responses in Colon Cancer Cells
1999
Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice.
1999
Cooperation between the activin and Wnt pathways in the spatial control of organizer gene expression
1998 StandoutNobel
Evaluation of candidate genes MAP2K4, MADH4, ACVR1B, and BRCA2 in familial pancreatic cancer: deleterious BRCA2 mutations in 17%.
2002
Surfing the p53 network
2000 StandoutNature
Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-β responsive cells
1996
Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.
1998
Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade
1997
Targeted Disruption of Smad3 Reveals an Essential Role in Transforming Growth Factor β-Mediated Signal Transduction
1999
Cancer Genome Landscapes
2013 StandoutScience
HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition
2006
Tumor Suppressor Smad4 Is a Transforming Growth Factor β-Inducible DNA Binding Protein
1997
The S387Y mutations of the transforming growth factor-beta receptor type I gene is uncommon in metastases of breast cancer and other common types of adenocarcinoma.
1999
The SMAD4 protein and prognosis of pancreatic ductal adenocarcinoma.
2001
TGF-β signalling through the Smad pathway
1997
Discovery of novel targets for aberrant methylation in pancreatic carcinoma using high-throughput microarrays.
2003
Smad8 mediates the signaling of the receptor serine kinase
1997
Mechanism for Mutational Inactivation of the Tumor Suppressor Smad2
2001
DPC4 Gene Status of the Primary Carcinoma Correlates With Patterns of Failure in Patients With Pancreatic Cancer
2009
Xenopus mothers against decapentaplegic is an embryonic ventralizing agent that acts downstream of the BMP-2/4 receptor
1996
A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.
1996
Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas.
1996
PancPRO: Risk Assessment for Individuals With a Family History of Pancreatic Cancer
2007
A Deletion in the Gene for Transforming Growth Factor β Type I Receptor Abolishes Growth Regulation by Transforming Growth Factor β in a Cutaneous T-Cell Lymphoma
1999
Multifocal neoplastic precursor lesions associated with lobular atrophy of the pancreas in patients having a strong family history of pancreatic cancer.
2006
Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers
1998 StandoutNobel
Integrative clustering of multiple genomic data types using a joint latent variable model with application to breast and lung cancer subtype analysis
2009
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
2004
Human Homolog of patched , a Candidate Gene for the Basal Cell Nevus Syndrome
1996 StandoutScience
Mechanisms underlying losses of heterozygosity in human colorectal cancers
2001
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Frequency of Smad gene mutations in human cancers.
1997
TbetaR-I(6A) is a candidate tumor susceptibility allele.
1999
Specificity, diversity, and regulation in TGF‐β superfamily signaling
1999
Transforming growth factor-beta receptor type I gene is frequently mutated in ovarian carcinomas.
2001
DPC4, a candidate tumor suppressor gene, is altered infrequently in head and neck squamous cell carcinoma.
1996
TGF-β and cancer
2005
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
2000
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
ß-Arrestin 2 Mediates Endocytosis of Type III TGF-ß Receptor and Down-Regulation of Its Signaling
2003 StandoutScienceNobel
Morphogen gradient interpretation
2001 StandoutNatureNobel
Mutations in the SMAD4/DPC4 Gene in Juvenile Polyposis
1998 Science
Somatic in vivo alterations of the DPC4 gene at 18q21 in human lung cancers.
1996
Works of Ester Rozenblum being referenced
Mad-related genes in the human
1996
Impact of DNA amplification on gene expression patterns in breast cancer.
2002
An integrated high-resolution physical map of the DPC/BRCA2 region at chromosome 13q12.
1995
Homozygous deletion map at 18q21.1 in pancreatic cancer.
1996
Tumor-suppressive pathways in pancreatic carcinoma.
1997
INK4 genes in pancreatic carcinoma
1996
Identification by representational difference analysis of a homozygous deletion in pancreatic carcinoma that lies within the BRCA2 region.
1995
Increased risk of incident pancreatic cancer among first-degree relatives of patients with familial pancreatic cancer.
2001
DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1
1996 StandoutScience