Citation Impact
Citing Papers
Endogenous MHC Class II Processing of a Viral Nuclear Antigen After Autophagy
2004 Science
Disruption of Autophagy at the Maturation Step by the Carcinogen Lindane Is Associated with the Sustained Mitogen-Activated Protein Kinase/Extracellular Signal–Regulated Kinase Activity
2006
Sensitization to the Lysosomal Cell Death Pathway by Oncogene-Induced Down-regulation of Lysosome-Associated Membrane Proteins 1 and 2
2008
X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C
2011 StandoutNobel
Consequences of the selective blockage of chaperone-mediated autophagy
2006
Cargo sorting into multivesicular bodies in vitro
2009 StandoutNobel
Chaperone‐Mediated Autophagy in Aging and Disease
2006
Lysosomes, a meeting point of proteins, chaperones, and proteases
1997
Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinases
2014
Autophagy and NF-κB: Fight for fate
2007
Age-related Decline in Chaperone-mediated Autophagy
2000
Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination
2006
Import of a Cytosolic Protein into Lysosomes by Chaperone-Mediated Autophagy depends on its Folding State
2000
Role of mitochondrial permeability transition pores in mitochondrial autophagy
2004
Selective Uptake of Cytosolic, Peroxisomal, and Plasma Membrane Proteins into the Yeast Lysosome for Degradation
1996 StandoutNobel
Molecular and cellular basis of lysosomal transmembrane protein dysfunction
2008
Sphingolipid Storage Affects Autophagic Metabolism of the Amyloid Precursor Protein and Promotes Aβ Generation
2011
Autophagy: in sickness and in health
2004
Ubiquitin, cellular inclusions and their role in neurodegeneration
1998
Localization of the 26S proteasome during mitosis and meiosis in fission yeast
1998
AMPK: guardian of metabolism and mitochondrial homeostasis
2017 Standout
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
2003 StandoutNobel
Firefly luciferase mutants as sensors of proteome stress
2011
The role of autophagy in neurodegenerative disease
2013 Standout
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function
2009 Standout
AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes
2016
At the acidic edge: emerging functions for lysosomal membrane proteins
2003
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits
2010
Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression
2003 Standout
Autophagy regulates lipid metabolism
2009 StandoutNature
Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation
1999
Autophagy as a cell death and tumor suppressor mechanism
2004 Standout
Autophagy fights disease through cellular self-digestion
2008 StandoutNature
Loss of Macroautophagy Promotes or Prevents Fibroblast Apoptosis Depending on the Death Stimulus
2007
Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance
2015
Lysosome membrane lipid microdomains: novel regulators of chaperone‐mediated autophagy
2006
Mitochondrial Dysfunction and Neurodegeneration in Lysosomal Storage Disorders
2017
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing
2009
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function
2008
Autophagy and neurodegeneration: when the cleaning crew goes on strike
2007
Myocyte aging and mitochondrial turnover
2004
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
2010
The Nuclear Ubiquitin-Proteasome System Degrades MyoD
2001 StandoutNobel
A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1
2011 StandoutNatureNobel
Activity and Regulation of the Centrosome-associated Proteasome
2000
Innate and Adaptive Immunity through Autophagy
2007
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
2006 StandoutNature
Roles of LAMP-1 and LAMP-2 in lysosome biogenesis and autophagy
2006
Degradation of 3-Hydroxy-3-methylglutaryl-CoA Reductase in Endoplasmic Reticulum Membranes Is Accelerated as a Result of Increased Susceptibility to Proteolysis
1996 StandoutNobel
Autophagy: a barrier or an adaptive response to cancer
2003
FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells
2007
The Proteasome: Paradigm of a Self-Compartmentalizing Protease
1998
Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)
2005
Autophagy Signaling and the Cogwheels of Cancer
2006
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1996 StandoutNature
STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy
2013
Subcellular Localization, Stoichiometry, and Protein Levels of 26 S Proteasome Subunits in Yeast
1999
Sensitivity to Lysosome-Dependent Cell Death Is Directly Regulated by Lysosomal Cholesterol Content
2012
The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation
2012
Induction of autophagy and inhibition of tumorigenesis by beclin 1
1999 StandoutNature
An intact HDM2 RING-finger domain is required for nuclear exclusion of p53
2000
Autophagy and Aging: The Importance of Maintaining "Clean" Cells
2005
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
2015
Dynamics of proteasome distribution in living cells
1997
Translocation of a long amino‐terminal domain through ER membrane by following signal‐anchor sequence
2005
[24] Multicatalytic endopeptidase complex: Proteasome
1994
AMPK activation: a therapeutic target for type 2 diabetes?
2014
Autophagic proteolysis: control and specificity
1997
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
2010
Autophagy modulation as a potential therapeutic target for diverse diseases
2012 Standout
Cerebral Ischemia-Hypoxia Induces Intravascular Coagulation and Autophagy
2006
The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14
2016
Familial intrahepatic cholestasis 1: Studies of localization and function
2001
Methods for monitoring autophagy
2004
Molecular chaperones in cellular protein folding
1996 StandoutNature
ROS, mitochondria and the regulation of autophagy
2007
Proteolytic and lipolytic responses to starvation
2006
Autophagy and Human Disease
2007
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
1995 StandoutNobel
Chaperone-mediated autophagy: a unique way to enter the lysosome world
2012
Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion
2007 StandoutNobel
Arrested maturation ofNeisseria-containing phagosomes in the absence of the lysosome-associated membrane proteins, LAMP-1 and LAMP-2
2007
The autophagic response to nutrient deprivation in the hl‐1 cardiac myocyte is modulated by Bcl‐2 and sarco/endoplasmic reticulum calcium stores
2007
The role of autophagy during the early neonatal starvation period
2004 StandoutNatureNobel
Interplay of LRRK2 with chaperone-mediated autophagy
2013
The Hallmarks of Aging
2013 Standout
Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
2007
Ordered Organelle Degradation during Starvation-induced Autophagy
2008
Gold nanoparticles in biomedical applications: recent advances and perspectives
2011 Standout
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Protein homeostasis and aging: The importance of exquisite quality control
2010
LAMP proteins are required for fusion of lysosomes with phagosomes
2007
Early cellular changes after blockage of chaperone-mediated autophagy
2008
Aggresomes, inclusion bodies and protein aggregation
2000 Standout
Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation
2014
A novel direct activator of AMPK inhibits prostate cancer growth by blocking lipogenesis
2014
Regulation of Autophagy by Reactive Oxygen Species (ROS): Implications for Cancer Progression and Treatment
2008
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
2019
The mouse and human genes encoding the recognition component of the N-end rule pathway
1998 StandoutNobel
Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification
2013
A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes
1996 Science
Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis.
1994
The 26S Proteasome: A Molecular Machine Designed for Controlled Proteolysis
1999 Standout
Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-Arrestin
2001 StandoutScienceNobel
Nonselective autophagy of cytosolic enzymes by isolated rat hepatocytes.
1990
Role for Rab7 in maturation of late autophagic vacuoles
2004
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression
2014 StandoutNobel
Autophagy in chronically ischemic myocardium
2005
Immunoelectron microscopic localization of the ubiquitin-activating enzyme E1 in HepG2 cells.
1992 StandoutNobel
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
2022 StandoutNobel
Membrane proteomics of phagosomes suggests a connection to autophagy
2008 StandoutNobel
Liver mitochondria contain an ATP-dependent, vanadate-sensitive pathway for the degradation of proteins.
1982
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
2008 Standout
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
2000
ATP-dependent degradation of ubiquitin-protein conjugates.
1984 StandoutNobel
Homotypic Lysosome Fusion in Macrophages: Analysis Using an In Vitro Assay
1997
Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome
2002
Site of catabolite inactivation
1994 StandoutNatureNobel
Altered lipid content inhibits autophagic vesicular fusion
2010
Roles of molecular chaperones in protein degradation.
1996
Novel Aspects of Degradation of T Cell Receptor Subunits from the Endoplasmic Reticulum (ER) in T Cells: Importance of Oligosaccharide Processing, Ubiquitination, and Proteasome-dependent Removal from ER Membranes
1998 StandoutNobel
Chaperone-Mediated Autophagy Is Required for Tumor Growth
2011
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Subcellular distribution of proteasomes implicates a major location of protein degradation in the nuclear envelope-ER network in yeast
1998
Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.
1994
Release of iron from ferritin requires lysosomal activity
2006
Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells.
1994
Impaired Phagosomal Maturation in Neutrophils Leads to Periodontitis in Lysosomal-Associated Membrane Protein-2 Knockout Mice
2008
A complex between peptide: N -glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins
2004
UBIQUITIN AND THE CONTROL OF PROTEIN FATE IN THE SECRETORY AND ENDOCYTIC PATHWAYS
1998
Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age
2007
The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis
1997 StandoutScience
Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease
2005
Gold nanoparticles: preparation, functionalisation and applications in biochemistry and immunochemistry
2007
Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy
2008
Role of Cue1p in Ubiquitination and Degradation at the ER Surface
1997 Science
IκB Is a Substrate for a Selective Pathway of Lysosomal Proteolysis
1998
Endosomal sorting of readily releasable synaptic vesicles
2010 StandoutNobel
In mouse myoblasts nuclear prosomes are associated with the nuclear matrix and accumulate preferentially in the perinucleolar areas
2000
Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6
1998
HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53
2003 StandoutNobel
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
2004 StandoutScience
Protein Turnover Via Autophagy: Implications for Metabolism
2007
Degradation of Ornithine Decarboxylase by the Mammalian and Yeast 26S Proteasome Complexes Requires all the Components of the Protease
1995 StandoutNobel
In Vitro Budding of Intralumenal Vesicles into Late Endosomes Is Regulated by Alix and Tsg101
2008
The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
2002 StandoutNobel
Autophagy in neurons: a review.
2002
Unconventional Secretion, Unconventional Solutions
2013 StandoutScienceNobel
THE UBIQUITIN SYSTEM
1998 StandoutNobel
Demonstration of an ATP-dependent, vanadate-sensitive endoprotease in the matrix of rat liver mitochondria.
1982
Scanning the human proteome for calmodulin-binding proteins
2005 StandoutNobel
Molecular Characterization of Dendritic Cell-Derived Exosomes
1999
Thimet Oligopeptidase (EC 3.4.24.15), a Novel Protein on the Route of MHC Class I Antigen Presentation
1999
Repair of DNA–polypeptide crosslinks by human excision nuclease
2006 StandoutNobel
Biosynthesis and Degradation of CFTR
1999
ER Degradation of a Misfolded Luminal Protein by the Cytosolic Ubiquitin-Proteasome Pathway
1996 Science
Degradation of Oxidized Proteins by Autophagy during Oxidative Stress in Arabidopsis
2006
Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
2009 Science
Regulation of Mammalian Autophagy in Physiology and Pathophysiology
2010 Standout
Modulating Macroautophagy: A Neuronal Perspective
2012
Protein Translocation Across Biological Membranes
2005 StandoutScienceNobel
Neuronal pigmented autophagic vacuoles: lipofuscin, neuromelanin, and ceroid as macroautophagic responses during aging and disease
2008
Proteasomes: multicatalytic proteinase complexes
1993
Autophagy in Health and Disease: A Double-Edged Sword
2004 StandoutScience
Works of Erwin Knecht being referenced
Activation of Chaperone-mediated Autophagy during Oxidative Stress
2004
Withdrawal of Essential Amino Acids Increases Autophagy by a Pathway Involving Ca2+/Calmodulin-dependent Kinase Kinase-β (CaMKK-β)
2012
Autophagy of mitochondria in rat liver assessed by immunogold procedures.
1988
Laforin, the most common protein mutated in Lafora disease, regulates autophagy
2010
Degradation of Proteasomes by Lysosomes in Rat Liver
1995
Acidic cytosolic proteins are preferentially imported into rat liver lysosomes
1997
Electron microscopic localization of the multicatalytic proteinase complex in rat liver and in cultured cells.
1992
Proteasome location
1993
Selective uptake and degradation of c‐Fos and v‐Fos by rat liver lysosomes
1996
Alterations in ROS Activity and Lysosomal pH Account for Distinct Patterns of Macroautophagy in LINCL and JNCL Fibroblasts
2013
Differences in the half‐lives of some mitochondrial rat liver enzymes may derive partially from hepatocyte heterogeneity
1987
Role of proteasomes in the degradation of short-lived proteins in human fibroblasts under various growth conditions
2003
A769662, a novel activator of AMP‐activated protein kinase, inhibits non‐proteolytic components of the 26S proteasome by an AMPK‐independent mechanism
2008
A Population of Rat Liver Lysosomes Responsible for the Selective Uptake and Degradation of Cytosolic Proteins
1997
Degradation of Proteasomes by Lysosomes in Rat Liver
1995
Subpopulations of proteasomes in rat liver nuclei, microsomes and cytosol
1996
The Laforin–Malin Complex, Involved in Lafora Disease, Promotes the Incorporation of K63-linked Ubiquitin Chains into AMP-activated Protein Kinase β Subunits
2010
Glucose induces autophagy under starvation conditions by a p38 MAPK-dependent pathway
2012
Autophagy of ferritin incorporated into the cytosol of HeLa cells by liposomes
1980
Import of a Cytosolic Protein into Lysosomes by Chaperone-mediated Autophagy Depends on Its Folding State
2000
Regulation of lysosomal autophagy in transformed and non-transformed mouse fibroblasts under several growth conditions*1
1984
Vanadate inhibits degradation of short-lived, but not of long-lived, proteins in L-132 human cells
1989
Selective binding and uptake of ribonuclease A and glyceraldehyde-3-phosphate dehydrogenase by isolated rat liver lysosomes
1994
Use of Inductively Coupled Plasma–Mass Spectrometry for the Quantitation of the Binding and Uptake of Colloidal Gold–Low-Density Lipoprotein Conjugates by Cultured Cells
1996
Subcellular localization of proteasomes and their regulatory complexes in mammalian cells
2000
Fate of proteins synthesized in mitochondria of cultured mammalian cells revealed by electron microscope radioautography
1980
Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation
1995
Uptake and degradation of glyceraldehyde-3-phosphate dehydrogenase by rat liver lysosomes
1993
A Rapid Procedure Suitable to Assess Quantitatively the Endocytosis of Colloidal Gold and Its Conjugates in Cultured Cells
1998
Disturbed Cholesterol Traffic but Normal Proteolytic Function in LAMP-1/LAMP-2 Double-deficient Fibroblasts
2004
Changes in proteasome localization during the cell cycle.
1994
Changes in the proteolytic activities of proteasomes and lysosomes in human fibroblasts produced by serum withdrawal, amino-acid deprivation and confluent conditions
2003