Standout Papers
Citation Impact
Citing Papers
Preferential Generation of Follicular B Helper T Cells from Foxp3 + T Cells in Gut Peyer's Patches
2009 StandoutScienceNobel
Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists
2010 StandoutScience
IL-23 plays a key role in Helicobacter hepaticus –induced T cell–dependent colitis
2006
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
Immune-Related Gene Expression Profiling After PD-1 Blockade in Non–Small Cell Lung Carcinoma, Head and Neck Squamous Cell Carcinoma, and Melanoma
2017
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category
2008
IL-23 Is Required for Neutrophil Homeostasis in Normal and Neutrophilic Mice
2007
Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells
2010
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
The role of CXCR4 receptor expression in breast cancer: a large tissue microarray study
2005
Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α
2005
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Heparin-Protein Interactions
2002 Standout
Regulation of cancer cell migration and bone metastasis by RANKL
2006 Nature
Chemokine Networks and Breast Cancer Metastasis
2007
Functional diversity of helper T lymphocytes
1996 StandoutNature
The alarmin IL-33 promotes regulatory T-cell function in the intestine
2014 Nature
Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4
2009
Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
1998 Standout
How chemokines organize the tumour microenvironment
2023
Tumor-Cell Homing to Lymph Nodes and Bone Marrow and CXCR4 Expression in Esophageal Cancer
2005
The role of chemoattraction in cancer metastases
2001
IL23 differentially regulates the Th1/Th17 balance in ulcerative colitis and Crohn’s disease
2008
Inflammation and cancer
2002 StandoutNature
Dependence of intestinal granuloma formation on unique myeloid DC-like cells
2007
The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells
2006 Standout
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
2006
Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
1994
Altered macrophage differentiation and immune dysfunction in tumor development
2007
Immunosuppressive networks in the tumour environment and their therapeutic relevance
2005 Standout
Role of tumor-associated macrophages in tumor progression and invasion
2006
Cancer to bone: a fatal attraction
2011 Standout
Chemokines: multiple levels of leukocyte migration control☆
2004
Pathogenesis and clinical features of psoriasis
2007 Standout
Lymphocyte-Dependent and Th2 Cytokine-Associated Colitis in Mice Deficient in Wiskott-Aldrich Syndrome Protein
2007
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
2002 Standout
Matrix Metalloproteinase Activity Inactivates the CXC Chemokine Stromal Cell-derived Factor-1
2001
Chemokines: agents for the immunotherapy of cancer?
2002
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
New insights on the role of CXCR4 in cancer metastasis
2008
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 76-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 1)
2008 Standout
IL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
2009
Interleukin 17–producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
2005 Standout
Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism
1998
Regulatory T Cells
2000 StandoutNobel
High-resolution crystal structure of human protease-activated receptor 1
2012 StandoutNatureNobel
Cancer Metastasis: Building a Framework
2006 Standout
The lineage decisions of helper T cells
2002
Intravital imaging of cell movement in tumours
2003
WHIM syndromes with different genetic anomalies are accounted for by impaired CXCR4 desensitization to CXCL12
2004
Imaging in the era of molecular oncology
2008 StandoutNature
Dissemination and growth of cancer cells in metastatic sites
2002 Standout
A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis
2012
A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment
2000 Standout
Regulatory T Cells and Immune Tolerance
2008 StandoutNobel
Cytokine regulation of granuloma formation in schistosomiasis
1995
Monoclonal Anti–Interleukin 23 Reverses Active Colitis in a T Cell–Mediated Model in Mice
2007
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
2009 Standout
Interleukin-18
1999
MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis
2002
Development, cytokine profile and function of human interleukin 17–producing helper T cells
2007 Standout
The transcription factor IFN regulatory factor–4 controls experimental colitis in mice via T cell–derived IL-6
2008
IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells
2007 StandoutNature
Pericytes: gatekeepers in tumour cell metastasis?
2007
Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets
1998
Inflammatory Bowel Disease
2009 Standout
T140 analogs as CXCR4 antagonists identified as anti‐metastatic agents in the treatment of breast cancer
2003
Interleukin-23 Restrains Regulatory T Cell Activity to Drive T Cell-Dependent Colitis
2008
A multigenic program mediating breast cancer metastasis to bone
2003 Standout
IL-12–induced IFN-γ is dependent on caspase-1 processing of the IL-18 precursor
1999
Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival Signals
2009
Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers
2006
Ligand-independent Dimerization of CXCR4, a Principal HIV-1 Coreceptor
2003
A Randomized Trial of Ustekinumab, a Human Interleukin-12/23 Monoclonal Antibody, in Patients With Moderate-to-Severe Crohn's Disease
2008
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist
2012 StandoutNatureNobel
Human prostate cancer metastases target the hematopoietic stem cell niche to establish footholds in mouse bone marrow
2011
Dimerization of chemokine receptors in living cells: key to receptor function and novel targets for therapy
2008
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
2004 Standout
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation
2002
Ubiquitin-dependent regulation of COPII coat size and function
2012 StandoutNatureNobel
Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties
2006
The microenvironment of the tumour–host interface
2001 StandoutNature
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
1997 StandoutNature
Autologous Chemotaxis as a Mechanism of Tumor Cell Homing to Lymphatics via Interstitial Flow and Autocrine CCR7 Signaling
2007
Efficacy and safety of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)
2008
GATA-3 Significantly Downregulates IFN-γ Production from Developing Th1 Cells in Addition to Inducing IL-4 and IL-5 Levels
1999
Moving in the right direction—Nanoimaging in cancer cell motility and metastasis
2007
IL‐1, IL‐18, and IL‐33 families of cytokines
2008
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Interleukin 27 negatively regulates the development of interleukin 17–producing T helper cells during chronic inflammation of the central nervous system
2006
Ligand stabilization of CXCR4/δ‐opioid receptor heterodimers reveals a mechanism for immune response regulation
2008
Current and emerging concepts in tumour metastasis
2010
Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice
2003
Cytokines in cancer pathogenesis and cancer therapy
2004
Hypoxic gene expression and metastasis
2004
A Large-Scale Genetic Association Study Confirms IL12B and Leads to the Identification of IL23R as Psoriasis-Risk Genes
2007
Chemokines in cancer
2002
Allosteric Transinhibition by Specific Antagonists in CCR2/CXCR4 Heterodimers
2007
Interleukin-33 – cytokine of dual function or novel alarmin?
2009
The chemokine receptors CXCR4 and CXCR3 in cancer
2009
Twist, a Master Regulator of Morphogenesis, Plays an Essential Role in Tumor Metastasis
2004 Standout
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
RORγ-Expressing Th17 Cells Induce Murine Chronic Intestinal Inflammation via Redundant Effects of IL-17A and IL-17F
2008
Microenvironmental regulation of metastasis
2008 Standout
Crystal structure of the µ-opioid receptor bound to a morphinan antagonist
2012 StandoutNatureNobel
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
2012
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
2009 StandoutNature
Th17 Cell Differentiation: The Long and Winding Road
2008
Revealing the world of RNA interference
2004 StandoutNatureNobel
Metadherin, a cell surface protein in breast tumors that mediates lung metastasis
2004
The Genetics of Inflammatory Bowel Disease
2007
Hypoxia, gene expression, and metastasis
2007
In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
2003 Standout
let-7 Regulates Self Renewal and Tumorigenicity of Breast Cancer Cells
2007 Standout
Modulation of Chromatin Structure Regulates Cytokine Gene Expression during T Cell Differentiation
1998
The IL-23/IL-17 axis in inflammation
2006
Cancer and the chemokine network
2004 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Metastatic colonization by circulating tumour cells
2016 StandoutNature
The significance of cancer cell expression of the chemokine receptor CXCR4
2004
Cancer-related inflammation
2008 StandoutNature
Chapter 5 Emergence of the Th17 Pathway and Its Role in Host Defense
2008
Chemokine receptor CXCR4 downregulated by von Hippel–Lindau tumour suppressor pVHL
2003 Nature
Co-evolution of tumor cells and their microenvironment
2008
The link between IL-23 and Th17 cell-mediated immune pathologies
2007
Innate immune signaling and regulation in cancer immunotherapy
2016
Validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy
2006
Cancer Dissemination—Lessons from Leukocytes
2010
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
2008 Standout
New functions for the matrix metalloproteinases in cancer progression
2002 Standout
MyD88 Is an Adaptor Protein in the hToll/IL-1 Receptor Family Signaling Pathways
1998
Defective NK Cell Activity and Th1 Response in IL-18–Deficient Mice
1998
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
2006
Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs
2011
Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
2006 StandoutNature
Molecular characterization of the tumor microenvironment in breast cancer
2004
Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response
2018 Standout
Tumors and inflammatory infiltrates: Friends or foes?
2002
Interleukin-23 drives innate and T cell–mediated intestinal inflammation
2006
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans
2007
Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4
2004
Imaging chemokine receptor dimerization with firefly luciferase complementation
2008
CX3CR1-Fractalkine Expression Regulates Cellular Mechanisms Involved in Adhesion, Migration, and Survival of Human Prostate Cancer Cells
2004
Life with Oxygen
2007 StandoutScienceNobel
Cracking the cytokine code in psoriasis
2007
The Inflammatory Cytokine Tumor Necrosis Factor-α Regulates Chemokine Receptor Expression on Ovarian Cancer Cells
2005
Epithelial cancer cell migration: a role for chemokine receptors?
2001
IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
2008
Differentiation and stability of T helper 1 and 2 cells derived from naive human neonatal CD4+ T cells, analyzed at the single-cell level.
1996
IL-1α and TNF-α Are Required for IL-12-Induced Development of Th1 Cells Producing High Levels of IFN-γ in BALB/c But Not C57BL/6 Mice
1998
IL-17 and Th17 Cells
2009 Standout
Cutting Edge: Priming of NK Cells by IL-18
2008 StandoutNobel
IL-17 Family Cytokines and the Expanding Diversity of Effector T Cell Lineages
2007 Standout
Synergy of IL-12 and IL-18 for IFN-γ Gene Expression: IL-12-Induced STAT4 Contributes to IFN-γ Promoter Activation by Up-Regulating the Binding Activity of IL-18-Induced Activator Protein 1
2002
High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells.
1994
Chemokine Receptor CCR6 Expression Level and Liver Metastases in Colorectal Cancer
2006
The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway
1999
Microbial Lipopeptides Induce the Production of IL-17 in Th Cells
2000
CXC chemokines in angiogenesis
2000
Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication
2002
Distinct dendritic cell subsets differentially regulate the class of immune responseinvivo
1999
IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
2004
IL-1 Receptor-Associated Kinase 4 Is Essential for IL-18-Mediated NK and Th1 Cell Responses
2003
The commensal microbiome is associated with anti–PD-1 efficacy in metastatic melanoma patients
2018 StandoutScience
B7 and interleukin 12 cooperate for proliferation and interferon gamma production by mouse T helper clones that are unresponsive to B7 costimulation.
1994
Regulation of the Chemokine Receptor CXCR4 by Hypoxia
2003
AACR Centennial Series: The Biology of Cancer Metastasis: Historical Perspective
2010
A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
2006
Dimerization of CXCR4 in living malignant cells: control of cell migration by a synthetic peptide that reduces homologous CXCR4 interactions
2006
IL-1 alpha and TNF-alpha are required for IL-12-induced development of Th1 cells producing high levels of IFN-gamma in BALB/c but not C57BL/6 mice.
1998
Chemokine ReceptorCXCR4Expression in Colorectal Cancer Patients Increases the Risk for Recurrence and for Poor Survival
2005
Severe Mycobacterial and Salmonella Infections in Interleukin-12 Receptor-Deficient Patients
1998 Science
Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon γ Production from CD4+ Versus CD8+ T Cells
1999
Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells
1997
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment
2005
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORγt+ T cells
2008
Structural Basis of CXCR4 Sulfotyrosine Recognition by the Chemokine SDF-1/CXCL12
2008
Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes
2004
IL-18 and IL-33 elicit Th2 cytokines from basophils via a MyD88- and p38α-dependent pathway
2009
GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large
2006 StandoutNobel
A phase 1, double-blind, placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12/23 monoclonal antibody in subjects with plaque psoriasis
2007
Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer.
2002
Discovery and Biology of IL-23 and IL-27: Related but Functionally Distinct Regulators of Inflammation
2006
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Adjuvant-Enhanced Antibody Responses in the Absence of Toll-Like Receptor Signaling
2006 StandoutScienceNobel
Lineage commitment in the immune system: the T helper lymphocyte grows up
2000
Differentiation of Effector CD4 T Cell Populations
2010 Standout
Immune recognition and tumor protection
2002
Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer
2007
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Erin Murphy being referenced
IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis
2006
Involvement of chemokine receptors in breast cancer metastasis
2001 StandoutNature
Detection of in vivo expression of interleukin-10 using a semi-quantitative polymerase chain reaction method in Schistosoma mansoni infected mice
1993
Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization
2004
IGIF Does Not Drive Th1 Development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB
1997
IL-33, an Interleukin-1-like Cytokine that Signals via the IL-1 Receptor-Related Protein ST2 and Induces T Helper Type 2-Associated Cytokines
2005 Standout
Association of response to programmed death receptor 1 (PD-1) blockade with pembrolizumab (MK-3475) with an interferon-inflammatory immune gene signature.
2015
Anti–Interleukin 10 Receptor Monoclonal Antibody Is an Adjuvant for T Helper Cell Type 1 Responses to Soluble Antigen Only in the Presence of Lipopolysaccharide
2000
Reversibility of T helper 1 and 2 populations is lost after long-term stimulation.
1996
Relationship between immune gene signatures and clinical response to PD-1 blockade with pembrolizumab (MK-3475) in patients with advanced solid tumors
2015
Inflamed-phenotype gene expression signatures to predict benefit from the anti-PD-1 antibody pembrolizumab in PD-L1+ head and neck cancer patients.
2015
IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade
2017 Standout
IL-23 is essential for T cell–mediated colitis and promotes inflammation via IL-17 and IL-6
2006