Citation Impact
Citing Papers
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
2012 StandoutScience
Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA
2012 StandoutScience
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7
2021 StandoutNobel
Trained immunity: A program of innate immune memory in health and disease
2016 StandoutScience
K+ Efflux Agonists Induce NLRP3 Inflammasome Activation Independently of Ca2+ Signaling
2015
Structure of the Absent in Melanoma 2 (AIM2) Pyrin Domain Provides Insights into the Mechanisms of AIM2 Autoinhibition and Inflammasome Assembly
2013
UV Light Potentiates STING (Stimulator of Interferon Genes)-dependent Innate Immune Signaling through Deregulation of ULK1 (Unc51-like Kinase 1)
2015 StandoutNobel
Inflammasomes in cancer: a double-edged sword
2014
Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2′,3′ cGAMP Signaling
2015 StandoutNobel
Viral tricks to grid-lock the type I interferon system
2010
Ischemia and reperfusion—from mechanism to translation
2011 Standout
The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells
2011
Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence
2019 StandoutNobel
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC
2013
Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor
2012
Necroptosis and its role in inflammation
2015 StandoutNature
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
2010 Standout
Emerging inflammasome effector mechanisms
2011
Converging roles of caspases in inflammasome activation, cell death and innate immunity
2015
Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer
2015
Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity
2012 StandoutNature
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
2017 StandoutNobel
Activation and regulation of the inflammasomes
2013 Standout
Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity
2011 Standout
Type I interferons in infectious disease
2015 Standout
The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection
2018
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
2015
An NLRP7-Containing Inflammasome Mediates Recognition of Microbial Lipopeptides in Human Macrophages
2012
Phosphorylation of NLRC4 is critical for inflammasome activation
2012 Nature
The molecular machinery of regulated cell death
2019 Standout
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
2017
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
2012
Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium
2015
Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes
2014 Standout
Pathogen Recognition by the Innate Immune System
2011 Standout
Sensing Cytoplasmic Danger Signals by the Inflammasome
2010
IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes
2016
Central roles of NLRs and inflammasomes in viral infection
2010
Mechanisms of inflammasome activation: recent advances and novel insights
2015
Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
2012
Differential roles of caspase-1 and caspase-11 in infection and inflammation
2017
A long-awaited merger of the pathways mediating host defence and programmed cell death
2014
Pyroptosis: mechanisms and diseases
2021 Standout
Multiple Interferon Stimulated Genes Synergize with the Zinc Finger Antiviral Protein to Mediate Anti-Alphavirus Activity
2012 StandoutNobel
Functional interactions between the gut microbiota and host metabolism
2012 StandoutNature
Regulation of inflammasome signaling
2012
Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling
2019
Caspase Functions in Cell Death and Disease
2013 Standout
K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter
2013 Standout
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
2010 Standout
Autophagy in Human Health and Disease
2013 Standout
Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes
2010
The PYRIN domain–only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses
2014
Immune Sensing of DNA
2013
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
2015 StandoutNature
Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium
2015
Inflammasomes: mechanism of assembly, regulation and signalling
2016 Standout
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
2016 StandoutNature
Autophagy and Aging
2011 Standout
Inflammatory caspases are innate immune receptors for intracellular LPS
2014 StandoutNature
The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors
2013
Inflammasome-Independent NLRP3 Restriction of a Protective Early Neutrophil Response to Pulmonary Tularemia
2016
Sterile inflammation: sensing and reacting to damage
2010 Standout
Sensing and reacting to microbes through the inflammasomes
2012
Mechanisms and Functions of Inflammasomes
2014 Standout
Immunomodulatory functions of type I interferons
2012
Phosphorylation of the adaptor ASC acts as a molecular switch that controls the formation of speck-like aggregates and inflammasome activity
2013
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Listeria monocytogenes Triggers AIM2-Mediated Pyroptosis upon Infrequent Bacteriolysis in the Macrophage Cytosol
2010
Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy
2017 Standout
OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids
2014
Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
2010
Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling
2011
Inflammation, metaflammation and immunometabolic disorders
2017 StandoutNature
Inflammasomes: mechanism of action, role in disease, and therapeutics
2015 Standout
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
NLRP3 Controls Trypanosoma cruzi Infection through a Caspase-1-Dependent IL-1R-Independent NO Production
2013
Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing
2010
Inflammasomes in health and disease
2012 StandoutNature
Regulation of the Antimicrobial Response by NLR Proteins
2011
An Update on PYRIN Domain-Containing Pattern Recognition Receptors: From Immunity to Pathology
2013
DNA Repair Synthesis and Ligation Affect the Processing of Excised Oligonucleotides Generated by Human Nucleotide Excision Repair
2014 StandoutNobel
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
2017 StandoutNature
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida
2015
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
2011
Phagosomal Neutralization by the Fungal Pathogen Candida albicans Induces Macrophage Pyroptosis
2016
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
2017 Standout
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses
2011 StandoutNobel
Differential Requirements for NAIP5 in Activation of the NLRC4 Inflammasome
2011
Cytosolic DNA sensors regulating type I interferon induction
2011
Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids
2014
Pyroptotic cell death defends against intracellular pathogens
2015
Pore-forming activity and structural autoinhibition of the gasdermin family
2016 StandoutNature
Cutting Edge: TLR Signaling Licenses IRAK1 for Rapid Activation of the NLRP3 Inflammasome
2013
Aggregation-Induced Emission: Together We Shine, United We Soar!
2015 Standout
Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans
2011 StandoutNobel
Modulation of Inflammasome Pathways by Bacterial and Viral Pathogens
2011
Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response
2012 StandoutNobel
Nucleic Acid Recognition by the Innate Immune System
2011
Intracellular sensing of microbes and danger signals by the inflammasomes
2011
Interferon-Stimulated Genes: A Complex Web of Host Defenses
2014 StandoutNobel
Brucella abortus Triggers a cGAS-Independent STING Pathway To Induce Host Protection That Involves Guanylate-Binding Proteins and Inflammasome Activation
2017
Type I interferon: friend or foe?
2010
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
The biology , function , and biomedical applications of exosomes
2020 StandoutScience
Activation of the Pyrin Inflammasome by Intracellular Burkholderia cenocepacia
2012
Inflammasomes and Their Roles in Health and Disease
2012
AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity
2015
Recognition of Bacteria by Inflammasomes
2012
MPYS Is Required for IFN Response Factor 3 Activation and Type I IFN Production in the Response of Cultured Phagocytes to Bacterial Second Messengers Cyclic-di-AMP and Cyclic-di-GMP
2011
A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion
2014
Regulation of inflammasome activation
2015
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation
2016
Critical role for the AIM 2 inflammasome during acute CNS bacterial infection
2014
Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
2012
Cutting Edge: Cytosolic Bacterial DNA Activates the Inflammasome via Aim2
2010
Works of Erin McDermott being referenced
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
2010