Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Programmed cell death 1 inhibits inflammatory helper T-cell development through controlling the innate immune response
2013 StandoutNobel
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
2016 Science
Progressive Loss of Memory T Cell Potential and Commitment to Exhaustion during Chronic Viral Infection
2012
The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain
2008 Science
A sex-biased imbalance between Tfr, Tph, and atypical B cells determines antibody responses in COVID-19 patients
2023 StandoutNobel
Mouse models of acute and chronic hepacivirus infection
2017 StandoutScienceNobel
PIEZOs mediate neuronal sensing of blood pressure and the baroreceptor reflex
2018 StandoutScienceNobel
The microbiota regulates type 2 immunity through RORγt + T cells
2015 StandoutScienceNobel
Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)
2013 StandoutNobel
PIEZO ion channel is required for root mechanotransduction in Arabidopsis thaliana
2021 StandoutNobel
PD-1 + regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer
2019 StandoutNobel
A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1
2015
Reversal of NK-Cell Exhaustion in Advanced Melanoma by Tim-3 Blockade
2014
Regulation of Virus-Specific CD4+ T Cell Function by Multiple Costimulatory Receptors during Chronic HIV Infection
2010
CD4 T Cells Promote Rather than Control Tuberculosis in the Absence of PD-1–Mediated Inhibition
2010
TGF-β Blockade Does Not Improve Control of an Established Persistent Viral Infection
2012
T-cell exhaustion in the tumor microenvironment
2015
Tim-3 expression on peripheral T cell subsets correlates with disease progression in hepatitis B infection
2011
Glycogen Synthase Kinase 3 Inactivation Drives T-bet-Mediated Downregulation of Co-receptor PD-1 to Enhance CD8+ Cytolytic T Cell Responses
2016
Confusing signals: Recent progress in CTLA-4 biology
2015
PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity
2017 StandoutNature
Hypoxia-inducible factors enhance the effector responses of CD8+ T cells to persistent antigen
2013
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction
2015
T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
2013
T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?
2014
PD-1 modulates regulatory T-cell homeostasis during low-dose interleukin-2 therapy
2017
The development and in vivo function of T helper 9 cells
2015
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion
2012
Epigenetic Manipulation Restores Functions of Defective CD8+ T Cells From Chronic Viral Infection
2014
Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection
2011
Elements of cancer immunity and the cancer–immune set point
2017 StandoutNature
De Novo Epigenetic Programs Inhibit PD-1 Blockade-Mediated T Cell Rejuvenation
2017
Extended Co-Expression of Inhibitory Receptors by Human CD8 T-Cells Depending on Differentiation, Antigen-Specificity and Anatomical Localization
2012
Tolerance and exhaustion: defining mechanisms of T cell dysfunction
2013
Oncology Meets Immunology: The Cancer-Immunity Cycle
2013 Standout
Combination cancer immunotherapy and new immunomodulatory targets
2015
T cell exhaustion
2011 Standout
Networking at the Level of Host Immunity: Immune Cell Interactions during Persistent Viral Infections
2013
The biology and management of non-small cell lung cancer
2018 StandoutNature
Prospects for prophylactic and therapeutic vaccines against the hepatitis C viruses
2010 StandoutNobel
Hypoxia and Inflammation
2011 Standout
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4
2017 StandoutNobel
The promise of low-dose interleukin-2 therapy for autoimmune and inflammatory diseases
2015
Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing
2014 Nature
Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy
2016 Nature
The Transcription Factor FoxO1 Sustains Expression of the Inhibitory Receptor PD-1 and Survival of Antiviral CD8+ T Cells during Chronic Infection
2014
PD-1 and BTLA and CD8+T-cell “exhaustion” in cancer
2012
MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer
2014 StandoutNature
TCF1 in T cell immunity: a broadened frontier
2021
Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity
2010
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain
2011 StandoutNatureNobel
Type I Interferons Regulate Immune Responses in Humans with Blood-Stage Plasmodium falciparum Infection
2016
The role of the capsaicin receptor TRPV1 and acid-sensing ion channels (ASICS) in proton sensitivity of subpopulations of primary nociceptive neurons in rats and mice
2006
Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential
2015 StandoutNobel
Complex-trait genetics: emergence of multivariate strategies
2002
Piezo2 is the major transducer of mechanical forces for touch sensation in mice
2014 StandoutNatureNobel
T cell exhaustion during persistent viral infections
2015
Allograft rejection is restrained by short-lived TIM-3+PD-1+Foxp3+ Tregs
2012
Structure of the mechanically activated ion channel Piezo1
2017 StandoutNatureNobel
Overcoming T cell exhaustion in infection and cancer
2015
A Distinct Function of Regulatory T Cells in Tissue Protection
2015
Tim-3 Negatively Regulates Cytotoxicity in Exhausted CD8+ T Cells in HIV Infection
2012
Upregulation of the Tim-3/Galectin-9 Pathway of T Cell Exhaustion in Chronic Hepatitis B Virus Infection
2012
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression
2015 Standout
Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors
2010
Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
2013
IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma
2012
The Immunoreceptor TIGIT Regulates Antitumor and Antiviral CD8 + T Cell Effector Function
2014
Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
2016 Standout
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
2016
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
2016
Interferon-β Suppresses Murine Th1 Cell Function in the Absence of Antigen-Presenting Cells
2015
Coinhibitory Receptor Expression and Immune Checkpoint Blockade: Maintaining a Balance in CD8+ T Cell Responses to Chronic Viral Infections and Cancer
2017 StandoutNobel
PIEZO2 in sensory neurons and urothelial cells coordinates urination
2020 StandoutNatureNobel
Animal models for viral infection and cell exhaustion
2014
CD160 and PD-1 Co-Expression on HIV-Specific CD8 T Cells Defines a Subset with Advanced Dysfunction
2012
Distinct Cellular Mechanisms Underlie Anti-CTLA-4 and Anti-PD-1 Checkpoint Blockade
2017 StandoutNobel
Immune escape to PD-L1/PD-1 blockade: seven steps to success (or failure)
2016
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
TIM3+FOXP3+regulatory T cells are tissue-specific promoters of T-cell dysfunction in cancer
2013
BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination
2010
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Molecular and cellular insights into T cell exhaustion
2015 Standout
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
2016
The acute respiratory distress syndrome
2012 Standout
Clinical blockade of PD1 and LAG3 — potential mechanisms of action
2014
The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection
2017
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
2013 StandoutNobel
Host protective roles of type 2 immunity: Parasite killing and tissue repair, flip sides of the same coin
2014
The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
2015
Defining and using immune archetypes to classify and treat cancer
2023
Molecular regulation of effector and memory T cell differentiation
2014
Blockade of T im‐3 signaling restores the virus‐specific CD 8+T ‐cell response in patients with chronic hepatitis B
2012
NF-κB Regulates PD-1 Expression in Macrophages
2015
RTP4 inhibits IFN-I response and enhances experimental cerebral malaria and neuropathology
2020 StandoutNobel
Detection of self-reactive CD8 + T cells with an anergic phenotype in healthy individuals
2014 StandoutScienceNobel
Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia
2011
T Cell Ig and Mucin Domain–Containing Protein 3 Is Recruited to the Immune Synapse, Disrupts Stable Synapse Formation, and Associates with Receptor Phosphatases
2013
Coinhibitory Pathways in Immunotherapy for Cancer
2016
Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1
2014
Programmed Cell Death 1-Directed Immunotherapy for Enhancing T-Cell Function
2013
The Influence of T Cell Ig Mucin-3 Signaling on Central Nervous System Autoimmune Disease Is Determined by the Effector Function of the Pathogenic T Cells
2013
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
2013
Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model
2016 StandoutNobel
Exhaustion of tumor-specific CD8+ T cells in metastases from melanoma patients
2011
Toward an understanding of regulatory T cells in COVID‐19: A systematic review
2021
Inhibitory Receptors on Lymphocytes: Insights from Infections
2012
Sprouty-2 regulates HIV-specific T cell polyfunctionality
2013
Functional mapping of disease susceptibility loci using cell biology
2006 StandoutNobel
Immunotherapeutic effects of IL-7 during a chronic viral infection in mice
2011
4-1BB Signaling Synergizes with Programmed Death Ligand 1 Blockade To Augment CD8 T Cell Responses during Chronic Viral Infection
2011
PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
2014 Standout
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
2016
Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood
2016 StandoutNobel
Chemotherapy induces enrichment of CD47 + /CD73 + /PDL1 + immune evasive triple-negative breast cancer cells
2018 StandoutNobel
Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection
2012 Science
The future of immune checkpoint therapy
2015 StandoutScienceNobel
PD-1 Upregulated on Regulatory T Cells during Chronic Virus Infection Enhances the Suppression of CD8+ T Cell Immune Response via the Interaction with PD-L1 Expressed on CD8+ T Cells
2015
Characteristics of splenic CD8+ T cell exhaustion in patients with hepatitis C
2013
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation
2018 StandoutNobel
Cutting Edge: Prolonged Exposure to HIV Reinforces a Poised Epigenetic Program for PD-1 Expression in Virus-Specific CD8 T Cells
2013
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Genetic and Epigenetic Regulation of PD-1 Expression
2016
Neoantigens in cancer immunotherapy
2015 StandoutScience
Expansion of Dysfunctional Tim-3–Expressing Effector Memory CD8+ T Cells during Simian Immunodeficiency Virus Infection in Rhesus Macaques
2014
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity
2012
PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors
2014
Phosphotyrosine-Dependent Coupling of Tim-3 to T-Cell Receptor Signaling Pathways
2011
Cancer immunotherapy using checkpoint blockade
2018 StandoutScience
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Therapeutic Blockade of Transforming Growth Factor Beta Fails To Promote Clearance of a Persistent Viral Infection
2012
Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype
2011 StandoutNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
The Yin and Yang of regulatory T cells in infectious diseases and avenues to target them
2017
Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection
2015 Science
Works of Erin E. West being referenced
Opposing actions of IL-2 and IL-21 on Th9 differentiation correlate with their differential regulation of BCL6 expression
2014
Chronic Virus Infection Enforces Demethylation of the Locus that Encodes PD-1 in Antigen-Specific CD8+ T Cells
2011
Identification of quantitative trait loci for chemical/inflammatory nociception in mice
2002
Heritability of nociception. III. Genetic relationships among commonly used assays of nociception and hypersensitivity
2002
Thymic stromal lymphopoietin and interleukin-4 mediate the pathogenesis of halothane-induced liver injury in mice
2014
Effector CD8 T cells dedifferentiate into long-lived memory cells
2017 Nature
PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice
2010
PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells
2013
Tight Regulation of Memory CD8+ T Cells Limits Their Effectiveness during Sustained High Viral Load
2011
Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections
2008
Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection
2014
CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury
2009
Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection
2010