Citation Impact
Citing Papers
Prospective identification of tumorigenic breast cancer cells
2003 Standout
C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion
2014 StandoutNobel
A Conserved Family of Prolyl-4-Hydroxylases That Modify HIF
2001 StandoutScience
Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis
2012 StandoutNobel
Histone deacetylase inhibitors prevent oxidative neuronal death independent of expanded polyglutamine repeats via an Sp1-dependent pathway
2003
Hallmarks of Cancer: The Next Generation
2011 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
Transcriptional Regulation and Its Misregulation in Disease
2013
Bioluminescent imaging of Cdk2 inhibition in vivo
2004 StandoutNobel
C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation
2001 StandoutNobel
p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism
2002
The Ubiquitin Proteasome System in Neurodegenerative Diseases
2003 StandoutNobel
GSK3 takes centre stage more than 20 years after its discovery
2001
Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions
2003
AKT/PKB Signaling: Navigating Downstream
2007 Standout
Mechanism of Action of Camptothecin
2000
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
2002 Standout
Telomerase protects developing neurons against DNA damage-induced cell death
2001
Fundamental Cellular Processes Do Not Require Vertebrate-specific Sequences within the TATA-binding Protein
2003 StandoutNobel
The Mediator complex: a central integrator of transcription
2015
Novel 7-Alkyl Methylenedioxy-Camptothecin Derivatives Exhibit Increased Cytotoxicity and Induce Persistent Cleavable Complexes Both with Purified Mammalian Topoisomerase I and in Human Colon Carcinoma SW620 Cells
1997 StandoutNobel
Cell division in the CNS: Protective response or lethal event in post-mitotic neurons?
2006
Function and regulation of the Mediator complex
2011
Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer
2004 Standout
Oxygen sensing by HIF hydroxylases
2004 StandoutNobel
β‐Site APP cleaving enzyme up‐regulation induced by 4‐hydroxynonenal is mediated by stress‐activated protein kinases pathways
2005
NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis
2000
SM-20 Is a Novel Mitochondrial Protein That Causes Caspase-dependent Cell Death in Nerve Growth Factor-dependent Neurons
2001
The biochemistry of apoptosis
2000 StandoutNature
Super-Enhancers in the Control of Cell Identity and Disease
2013 Standout
Binding of pRB to the PHD Protein RBP2 Promotes Cellular Differentiation
2005 StandoutNobel
Mitochondrial fragmentation in neurodegeneration
2008
Blinded by the Light: The Growing Complexity of p53
2009 Standout
Wnt/β-Catenin Signaling and Disease
2012 Standout
Processing of topoisomerase I cleavable complexes into DNA damage by transcription
1997
Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
2009 Standout
SCAN1 mutant Tdp1 accumulates the enzyme–DNA intermediate and causes camptothecin hypersensitivity
2005
Gene expression profiling of choline-deprived neural precursor cells isolated from mouse brain
2004
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants
2005 StandoutNatureNobel
Irinotecan: mechanisms of tumor resistance and novel strategies for modulating its activity
2002
Expression of the SM‐20 Gene Promotes Death in Nerve Growth Factor‐Dependent Sympathetic Neurons
1999
Chondroitinase ABC promotes functional recovery after spinal cord injury
2002 StandoutNature
Inhibition of mitochondrial permeability transition and release of cytochrome c by anti-apoptotic nucleoside analogues
2002
Methods in Mammalian Autophagy Research
2010 Standout
Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate
2010
Cellular mechanisms of tumour suppression by the retinoblastoma gene
2008
Mammalian Cells Cycle without the D-Type Cyclin-Dependent Kinases Cdk4 and Cdk6
2004
Apoptosis without caspases: an inefficient molecular guillotine?
1999
Alzheimer's Disease
2010 Standout
Alzheimer's disease and Aβ toxicity: from top to bottom
2001
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
2006 StandoutNature
Defective DNA Repair and Neurodegenerative Disease
2007
Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: a critical examination of telomere length maintenance-independent roles of telomerase
2009 StandoutNobel
Parkin Is a Component of an SCF-like Ubiquitin Ligase Complex and Protects Postmitotic Neurons from Kainate Excitotoxicity
2003
Cell cycle, CDKs and cancer: a changing paradigm
2009 Standout
The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
2010
Clonal evolution in cancer
2012 StandoutNature
To cycle or not to cycle: a critical decision in cancer
2001
Cyclin-dependent kinases as new targets for the prevention and treatment of cancer
2002
Mechanism of Action of Camptothecin
1996
Ras, PI(3)K and mTOR signalling controls tumour cell growth
2006 StandoutNature
The TNF and TNF Receptor Superfamilies
2001 Standout
The Retinoblastoma Binding Protein RBP2 Is an H3K4 Demethylase
2007 StandoutNobel
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex
2004
Cell Cycle Activation Linked to Neuronal Cell Death Initiated by DNA Damage
2004
Topoisomerase I inhibitors: camptothecins and beyond
2006 Standout
Pathways towards and away from Alzheimer's disease
2004 StandoutNature
Repair of and checkpoint response to topoisomerase I-mediated DNA damage
2003
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
2013 Standout
Abortive oncogeny and cell cycle-mediated events in Alzheimer disease
2000
Repair of Topoisomerase I‐Mediated DNA Damage
2006
Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase
2018 StandoutNobel
Chemical Topology: Complex Molecular Knots, Links, and Entanglements
2011 StandoutNobel
Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons
1997
Comparing Astrocytic Cell Lines that Are Inhibitory or Permissive for Axon Growth: the Major Axon-Inhibitory Proteoglycan Is NG2
1999
Neuronal Cell Death Is Preceded by Cell Cycle Events at All Stages of Alzheimer's Disease
2003
Lysosomal activity regulatesCaenorhabditis elegansmitochondrial dynamics through vitamin B12 metabolism
2020 StandoutNobel
Decrease in topoisomerase I is responsible for activation-induced cytidine deaminase (AID)-dependent somatic hypermutation
2011 StandoutNobel
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
2002 StandoutNobel
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
2004
Tumor Cell Death Induced by Topoisomerase-Targeting Drugs
2001
AID-induced decrease in topoisomerase 1 induces DNA structural alteration and DNA cleavage for class switch recombination
2009 StandoutNobel
Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells.
2001
Alzheimer's Disease Is a Synaptic Failure
2002 StandoutScience
Ischemic Cell Death in Brain Neurons
1999 Standout
Heterozygous Disruption of the TATA-Binding Protein Gene in DT40 Cells Causes Reduced cdc25B Phosphatase Expression and Delayed Mitosis
2001
Protection from Oxidative Stress–Induced Apoptosis in Cortical Neuronal Cultures by Iron Chelators Is Associated with Enhanced DNA Binding of Hypoxia-Inducible Factor-1 and ATF-1/CREB and Increased Expression of Glycolytic Enzymes, p21waf1/cip1, and Erythropoietin
1999 StandoutNobel
Topoisomerase I inhibitors: selectivity and cellular resistance
1999
Staurosporine-Induced Apoptosis of Cultured Rat Hippocampal Neurons Involves Caspase-1-Like Proteases as Upstream Initiators and Increased Production of Superoxide as a Main Downstream Effector
1998
Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity
2000
Nitric oxide prevents axonal degeneration by inducing HIF-1–dependent expression of erythropoietin
2011 StandoutNobel
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation
2012 StandoutNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
2005
Impairment of the Ubiquitin-Proteasome System by Protein Aggregation
2001 StandoutScience
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
2005
Works of Erick J. Morris being referenced
E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3
2000
Drosophila E2F1 Has Context-Specific Pro- and Antiapoptotic Properties during Development
2005
G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression
2003
Oxidative stress mediates neuronal DNA damage and apoptosis in response to cytosine arabinoside
2001
Retinoblastoma protein partners
2001
Induction and Modulation of Cerebellar Granule Neuron Death by E2F-1
2000
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
2008 Nature
G1/S Cell Cycle Blockers and Inhibitors of Cyclin-Dependent Kinases Suppress Camptothecin-Induced Neuronal Apoptosis
1997
Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage
2001
Optimization of Single-Cell Gel Electrophoresis (SCGE) for Quantitative Analysis of Neuronal DNA Damage
1999
Induction of neuronal apoptosis by camptothecin, an inhibitor of DNA topoisomerase-I: evidence for cell cycle-independent toxicity.
1996
Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents
1998
Multiple Pathways of Neuronal Death Induced by DNA-Damaging Agents, NGF Deprivation, and Oxidative Stress
1998