Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Activity-Dependent Internalization of Smoothened Mediated by ß-Arrestin 2 and GRK2
2004 StandoutScienceNobel
IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8 + T Cells
2004
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis
2019 StandoutScienceNobel
Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling
2004
1 Developmental roles and clinical significance of Hedgehog signaling
2003
Basal Cell Carcinomas in Mice Overexpressing Sonic Hedgehog
1997 StandoutScience
Comprehensive molecular portraits of human breast tumours
2012 StandoutNature
Engineered receptors for soluble cellular communication and disease sensing
2024 StandoutNatureNobel
Platelet factor 4–induced T H 1-T reg polarization suppresses antitumor immunity
2024 StandoutScienceNobel
Mammalian Suppressor-of-Fused modulates nuclear–cytoplasmic shuttling of GLI-1
1999
Hedgehog: functions and mechanisms
2008 Standout
Shadow enhancers: Frequently asked questions about distributed cis‐regulatory information and enhancer redundancy
2011
Large-scale analysis of the regulatory architecture of the mouse genome with a transposon-associated sensor
2011
The mechanisms of Hedgehog signalling and its roles in development and disease
2013 Standout
Phenotypic robustness conferred by apparently redundant transcriptional enhancers
2010 Nature
Some distal limb structures develop in mice lacking Sonic hedgehog signaling
2001
Sonic hedgehog is essential to foregut development
1998
Biological functions of fucose in mammals
2017
A direct requirement for Hedgehog signaling for normal specification of all ventral progenitor domains in the presumptive mammalian spinal cord
2002
Cross-talk between skeletal muscle and adipose tissue: A link with obesity?
2004
IL-15: targeting CD8+T cells for immunotherapy
2005
A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis
2012 StandoutNature
Inhibition of Sonic hedgehog signaling in vivo results in craniofacial neural crest cell death
1999
Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription
2008
Smad transcription factors
2005 Standout
Accelerated Evolution of Nervous System Genes in the Origin of Homo sapiens
2004
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
The Hedgehog's tale: developing strategies for targeting cancer
2011
UNC-39, the C. elegans homolog of the human myotonic dystrophy-associated homeodomain protein Six5, regulates cell motility and differentiation
2004 StandoutNobel
Recognition of microorganisms and activation of the immune response
2007 StandoutNature
Temporal and Spatial Effects of Sonic Hedgehog Signaling in Chick Eye Morphogenesis
2001
Proliferation, cell cycle and apoptosis in cancer
2001 StandoutNature
Smad-dependent and Smad-independent pathways in TGF-β family signalling
2003 StandoutNature
The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla
2008 Nature
Sinistral Snails and Gentlemen Scientists
2005 StandoutNobel
A microduplication of the long range SHH limb regulator (ZRS) is associated with triphalangeal thumb-polysyndactyly syndrome
2008
The hedgehog signaling network
2003
Neural-Tube Defects
1999 Standout
Sonic hedgehog in CNS development: one signal, multiple outputs
2002
The Interpretation of Position in a Morphogen Gradient as Revealed by Occupancy of Activin Receptors
1998 StandoutNobel
The role of Sonic hedgehog in neural tube patterning
2000
Effective targeted gene ‘knockdown’ in zebrafish
2000 Standout
Left–right asymmetry in embryonic development: a comprehensive review
2004
The single-cell transcriptional landscape of mammalian organogenesis
2019 StandoutNature
Interleukin-2 receptor α chain regulates the size and content of the peripheral lymphoid compartment
1995
The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design
2006
Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia
2004
The seven-transmembrane receptor Smoothened cell-autonomously induces multiple ventral cell types
2000
Hhat Is a Palmitoylacyltransferase with Specificity for N-Palmitoylation of Sonic Hedgehog
2008
Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control
2001
The Sonic Hedgehog–Patched–Gli Pathway in Human Development and Disease
2000
Identification of Sonic hedgehog as a candidate gene responsible for the polydactylous mouse mutant Sasquatch
1999
LRP2 Is an Auxiliary SHH Receptor Required to Condition the Forebrain Ventral Midline for Inductive Signals
2012
Holt-Oram syndrome is caused by mutations in TBX5, a member of the Brachyury (T) gene family
1997 Standout
IL-15Rα Recycles and Presents IL-15 In trans to Neighboring Cells
2002
Hedgehog-Mediated Patterning of the Mammalian Embryo Requires Transporter-like Function of Dispatched
2002
New players and puzzles in the Hedgehog signaling pathway
1998
Gli and hedgehog in cancer: tumours, embryos and stem cells
2002
Sonic hedgehogParticipates in Craniofacial Morphogenesis and Is Down-regulated by Teratogenic Doses of Retinoic Acid
1997
Hedgehog signaling in animal development: paradigms and principles
2001 Standout
Genetics of ventral forebrain development and holoprosencephaly
2000
Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
1997 Nature
Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain
1995
Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model
2000
Mechanisms of Hedgehog gradient formation and interpretation
2005
Immunotherapy: past, present and future
2003
Interleukin-2 and interleukin-15: immunotherapy for cancer
2002
Neurogenesis and the Cell Cycle
2003
Co-localization of Patched and activated Sonic hedgehog to lysosomes in neurons
2000
Transcription factors: from enhancer binding to developmental control
2012 Standout
Cyclopamine Inhibition of Sonic Hedgehog Signal Transduction Is Not Mediated through Effects on Cholesterol Transport
2000
IL-15 Receptor Maintains Lymphoid Homeostasis by Supporting Lymphocyte Homing and Proliferation
1998
Expression of the Sonic hedgehog (SHH) Gene during Early Human Development and Phenotypic Expression of New Mutations Causing Holoprosencephaly
1999
Chapter 13 Long‐Range Gene Control and Genetic Disease
2008
How cells read TGF-β signals
2000 Standout
Points of control in inflammation
2002 StandoutNature
TGFβ Signaling in Growth Control, Cancer, and Heritable Disorders
2000 Standout
Pax6 Controls Progenitor Cell Identity and Neuronal Fate in Response to Graded Shh Signaling
1997
The TRA-1A Sex Determination Protein of C. elegans Regulates Sexually Dimorphic Cell Deaths by Repressing the egl-1 Cell Death Activator Gene
1999 StandoutNobel
Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6
2008 Standout
The patched gene in development and cancer
1998
Role of cholesterol in germ‐line development of Caenorhabditis elegans*
2002
Mice cloned from olfactory sensory neurons
2004 StandoutNatureNobel
Spatial partitioning of the regulatory landscape of the X-inactivation centre
2012 StandoutNature
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
2002 Standout
Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
1997
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
Cytokines in clinical cancer immunotherapy
2018
A Novel Mutation of desert hedgehog in a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Dual Roles of Cripto as a Ligand and Coreceptor in the Nodal Signaling Pathway
2002
β-Arrestin2 mediates the initiation and progression of myeloid leukemia
2012 StandoutNobel
Cell Migration: Integrating Signals from Front to Back
2003 StandoutScience
β-Arrestin–Mediated Localization of Smoothened to the Primary Cilium
2008 StandoutScienceNobel
Parallel Patterns of Evolution in the Genomes and Transcriptomes of Humans and Chimpanzees
2005 StandoutScienceNobel
Lymphocyte Homing and Homeostasis
1996 StandoutScience
Reversible Defects in Natural Killer and Memory Cd8 T Cell Lineages in Interleukin 15–Deficient Mice
2000
Characterization of two patched receptors for the vertebrate hedgehog protein family
1998
Simple and efficient CRISPR/Cas9‐mediated targeted mutagenesis in Xenopus tropicalis
2013
Sonic hedgehog regulates the growth and patterning of the cerebellum
1999
The biological roles of exercise-induced cytokines: IL-6, IL-8, and IL-15
2007
Pancreas development is promoted by cyclopamine, a Hedgehog signaling inhibitor
1998
Missense Mutations and Gene Interruption in PROSIT240 , a Novel TRAP240 -Like Gene, in Patients With Congenital Heart Defect (Transposition of the Great Arteries)
2003
Augmented IL-15Rα Expression by CD40 Activation Is Critical in Synergistic CD8 T Cell-Mediated Antitumor Activity of Anti-CD40 Antibody with IL-15 in TRAMP-C2 Tumors in Mice
2012 StandoutNobel
Regulation of Actin Filament Network Formation Through ARP2/3 Complex: Activation by a Diverse Array of Proteins
2001
Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms
1999
Flt3 permits survival during infection by rendering dendritic cells competent to activate NK cells
2010 StandoutNobel
Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
1998 StandoutScience
The Shh signalling pathway in tooth development: defects in Gli2 and Gli3 mutants
1998
Regulation of retinal ganglion cell production by Sonic hedgehog
2001
Novel Lipid Modifications of Secreted Protein Signals
2004
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Interleukin (IL)-15Rα–deficient Natural Killer Cells Survive in Normal but Not IL-15Rα–deficient Mice
2003
Expression of the Sonic Hedgehog gene in human embryos with neural tube defects
2000
Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes Implications for Immunotherapy
2001
Gli Proteins in Development and Disease
2011
Simultaneous inhibition of two regulatory T-cell subsets enhanced Interleukin-15 efficacy in a prostate tumor model
2012 StandoutNobel
IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice
2000
Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly
2005
Site-specific chemical modification of recombinant proteins produced in mammalian cells by using the genetically encoded aldehyde tag
2009 StandoutNobel
ß-Arrestin 2 Regulates Zebrafish Development Through the Hedgehog Signaling Pathway
2004 Science
Zic2 regulates the kinetics of neurulation
2000
Processing and turnover of the Hedgehog protein in the endoplasmic reticulum
2011
Cellular Control of Actin Nucleation
2002
Cerebellar proteoglycans regulate sonic hedgehog responses during development
2002
A Novel Mutation ofdesert hedgehogin a Patient with 46,XY Partial Gonadal Dysgenesis Accompanied by Minifascicular Neuropathy
2000
Morphogen to mitogen: the multiple roles of hedgehog signalling in vertebrate neural development
2006
Regulation of pancreas development by hedgehog signaling
2000
Hedgehog signals regulate multiple aspects of gastrointestinal development
2000
THE MULTIFACETED REGULATION OF INTERLEUKIN-15 EXPRESSION AND THE ROLE OF THIS CYTOKINE IN NK CELL DIFFERENTIATION AND HOST RESPONSE TO INTRACELLULAR PATHOGENS
1999
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
2011 StandoutNobel
Immunotherapy: Bewitched, Bothered, and Bewildered No More
2004 StandoutScienceNobel
The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins
2004 StandoutNobel
Role of myokines in exercise and metabolism
2007
Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor.
1995
Patched2 Modulates Tumorigenesis in Patched1 Heterozygous Mice
2006
Contrasting Roles of IL-2 and IL-15 in the Life and Death of Lymphocytes
2001
Interleukin-15 combined with an anti-CD40 antibody provides enhanced therapeutic efficacy for murine models of colon cancer
2009
IL-15: targeting CD8+ T cells for immunotherapy
2005
Cutting Edge: Murine Dendritic Cells Require IL-15Rα to Prime NK Cells
2004
DIVERSE FUNCTIONS OF IL-2, IL-15, AND IL-7 IN LYMPHOID HOMEOSTASIS
2006
Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
2002 StandoutNobel
Defective Lymphoid Development in Mice Lacking Jak3
1995 StandoutScienceNobel
Shadow Enhancers as a Source of Evolutionary Novelty
2008 Science
Transduction of Receptor Signals by ß-Arrestins
2005 StandoutScienceNobel
Works of Erich Roessler being referenced
A functional screen for sonic hedgehog regulatory elements across a 1 Mb interval identifies long-range ventral forebrain enhancers
2006
Regulation of a remote Shh forebrain enhancer by the Six3 homeoprotein
2008
Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects
2000
Midline and laterality defects: Left and right meet in the middle†
2001
CFC1 Mutations in Patients with Transposition of the Great Arteries and Double-Outlet Right Ventricle
2002
Mutations in the C-Terminal Domain of Sonic Hedgehog Cause Holoprosencephaly
1997
SONIC HEDGEHOG mutations causing human holoprosencephaly impair neural patterning activity
2003
Human developmental disorders and the Sonic hedgehog pathway
1998
The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly
2002
The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly
1999
Mutations in PATCHED-1, the receptor for SONIC HEDGEHOG, are associated with holoprosencephaly
2002
A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2
2005
A loss-of-function mutation in the CFC domain of TDGF1 is associated with human forebrain defects
2002
Holoprosencephaly in RSH/Smith-Lemli-Opitz syndrome: Does abnormal cholesterol metabolism affect the function ofsonic hedgehog?
1996
ARP3β, the gene encoding a new human actin‐related protein, is alternatively spliced and predominantly expressed in brain neuronal cells
2000
The molecular genetics of holoprosencephaly
2010
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
1996 Standout
Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly
1998
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination
2000
How a Hedgehog might see holoprosencephaly
2003
Cytogenetic rearrangements involving the loss of the Sonic Hedgehog gene at 7q36 cause holoprosencephaly
1997
Mutations in the homeodomain of the human SIX3 gene cause holoprosencephaly
1999
Mutations in the human Sonic Hedgehog gene cause holoprosencephaly
1996 Standout
The mutational spectrum of holoprosencephaly-associated changes within theSHHgene in humans predicts loss-of-function through either key structural alterations of the ligand or its altered synthesis
2009
Holoprosencephaly: A paradigm for the complex genetics of brain development
1998
A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
1994
Cooperative interactions between the interleukin 2 receptor alpha and beta chains alter the interleukin 2-binding affinity of the receptor subunits.
1994
The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia
1993
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features
2003
The interleukin (IL) 2 receptor beta chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells.
1994
The interleukin 2 receptor (IL-2R): the IL-2R alpha subunit alters the function of the IL-2R beta subunit to enhance IL-2 binding and signaling by mechanisms that do not require binding of IL-2 to IL-2R alpha subunit.
1992