Standout Papers
Citation Impact
Citing Papers
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 StandoutScienceNobel
Potent CRISPR-Cas9 inhibitors from Staphylococcus genomes
2020 StandoutNobel
MYC Drives Pten/Trp53 -Deficient Proliferation and Metastasis due to IL6 Secretion and AKT Suppression via PHLPP2
2015
Phthalimide conjugation as a strategy for in vivo target protein degradation
2015 Science
CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells
2016 Science
The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins
2013 StandoutScienceNobel
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
2020 Science
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Acute B lymphoblastic leukaemia‐propagating cells are present at high frequency in diverse lymphoblast populations
2012
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
RNAi screening comes of age: improved techniques and complementary approaches
2014
Chromatin Reader Brd4 Functions in Ig Class Switching as a Repair Complex Adaptor of Nonhomologous End-Joining
2014 StandoutNobel
Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
2016 StandoutNature
DNA Sequencing versus Standard Prenatal Aneuploidy Screening
2014 Standout
A view on drug resistance in cancer
2019 StandoutNature
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Three-dimensional genome architecture: players and mechanisms
2015
Histone methylation: a dynamic mark in health, disease and inheritance
2012 Standout
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Systematic comparison of CRISPR/Cas9 and RNAi screens for essential genes
2016
Cancer Epigenetics: From Mechanism to Therapy
2012 Standout
Functional Classification and Experimental Dissection of Long Noncoding RNAs
2018 Standout
Enabling functional genomics with genome engineering
2015
Cell-free DNA Analysis for Noninvasive Examination of Trisomy
2015 Standout
An Optimized microRNA Backbone for Effective Single-Copy RNAi
2013
An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries
2017
Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes
2015 StandoutNobel
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
H2A.Z Maintenance during Mitosis Reveals Nucleosome Shifting on Mitotically Silenced Genes
2010
Targeting apoptosis in cancer therapy
2020 Standout
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation
2011
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy
2015
Tumour heterogeneity and cancer cell plasticity
2013 StandoutNature
TET enzymes, TDG and the dynamics of DNA demethylation
2013 StandoutNature
CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer
2015
EMT: 2016
2016 Standout
BET domain co-regulators in obesity, inflammation and cancer
2012
Applications of CRISPR technologies in research and beyond
2016 StandoutNobel
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Epigenetic expansion of VHL-HIF signal output drives multiorgan metastasis in renal cancer
2012
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
TGF-β Tumor Suppression through a Lethal EMT
2016
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia
2012
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
2019 StandoutNature
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes
2016 Standout
The PI3K Pathway in Human Disease
2017 Standout
Cornerstones of CRISPR–Cas in drug discovery and therapy
2016 StandoutNobel
A decade of exploring the cancer epigenome — biological and translational implications
2011 Standout
Metastatic colonization by circulating tumour cells
2016 StandoutNature
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
MLL3 Is a Haploinsufficient 7q Tumor Suppressor in Acute Myeloid Leukemia
2014
Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting
2013
CRISPR/Cas9-Mediated Genome Editing of Epigenetic Factors for Cancer Therapy
2015
A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes
2014 Science
B7x in the Periphery Abrogates Pancreas-Specific Damage Mediated by Self-reactive CD8 T Cells
2012 StandoutNobel
Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma
2014
CRISPRi and CRISPRa Screens in Mammalian Cells for Precision Biology and Medicine
2017
Identification of DNA cleavage- and recombination-specific hnRNP cofactors for activation-induced cytidine deaminase
2015 StandoutNobel
Systematic discovery of natural CRISPR-Cas12a inhibitors
2018 StandoutScienceNobel
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
2012
Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis
2013
Epigenetic plasticity: A central regulator of epithelial-to-mesenchymal transition in cancer
2014
Copper induces cell death by targeting lipoylated TCA cycle proteins
2022 StandoutScience
Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers
2014
Evaluating and Enhancing Target Specificity of Gene-Editing Nucleases and Deaminases
2019
Multiplexed genetic engineering of human hematopoietic stem and progenitor cells using CRISPR/Cas9 and AAV6
2017
BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation
2018 StandoutNobel
Fluorosulfuryl Isocyanate Enabled SuFEx Ligation of Alcohols and Amines
2021 StandoutNobel
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
2018 StandoutNobel
Targeted gene knock-in by homology-directed genome editing using Cas9 ribonucleoprotein and AAV donor delivery
2017 StandoutNobel
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia
2021 StandoutNobel
Genetics and biology of pancreatic ductal adenocarcinoma
2016
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
APE1 is dispensable for S-region cleavage but required for its repair in class switch recombination
2014 StandoutNobel
Liquid phase condensation in cell physiology and disease
2017 StandoutScience
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
2018 Science
Nontoxic nanopore electroporation for effective intracellular delivery of biological macromolecules
2019 StandoutNobel
Works of Eric Wang being referenced
Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment
2019
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
2011 StandoutNature
The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;NrasG12D acute myeloid leukemia
2012
Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains
2015
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome‐wide association analysis
2008
A Reconfigured Pattern of MLL Occupancy within Mitotic Chromatin Promotes Rapid Transcriptional Reactivation Following Mitotic Exit
2009
An integrated approach to dissecting oncogene addiction implicates a Myb-coordinated self-renewal program as essential for leukemia maintenance
2011
Gestational age and maternal weight effects on fetal cell‐free DNA in maternal plasma
2013