Standout Papers
Citation Impact
Citing Papers
SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase
2019 StandoutNobel
Global analysis of protein folding using massively parallel design, synthesis, and testing
2017 StandoutScienceNobel
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors
2022 StandoutNobel
Copper-free click chemistry in living animals
2010 StandoutNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Cell-penetrating peptides
2000
Protein transduction: unrestricted delivery into all cells?
2000
Synthesis and characterization of guanidinylated poly(propylene imine) dendrimers as gene transfection agents
2006
Bioorthogonal Chemistry: Fishing for Selectivity in a Sea of Functionality
2009 StandoutNobel
Human immunodeficiency virus type 1–infected monocytic cells can destroy human neural cells after cell‐to‐cell adhesion
1992 StandoutNobel
Uptake of analogs of penetratin, Tat(48–60) and oligoarginine in live cells
2003
Arginine-rich Peptides
2001
Oligomers of the Arginine-rich Motif of the HIV-1 TAT Protein Are Capable of Transferring Plasmid DNA into Cells
2003
A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
2003
Intracellular delivery of large molecules and small particles by cell-penetrating proteins and peptides
2004
An endosomolytic Tat peptide produced by incorporation of histidine and cysteine residues as a nonviral vector for DNA transfection
2008
Arginine Topology Controls Escape of Minimally Cationic Proteins from Early Endosomes to the Cytoplasm
2012
Repair of a minimal DNA double-strand break by NHEJ requires DNA-PKcs and is controlled by the ATM/ATR checkpoint
2003
Twenty years of cell‐penetrating peptides: from molecular mechanisms to therapeutics
2009
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
2020 StandoutNatureNobel
The cellular delivery of antisense oligonucleotides and ribozymes
2001
Novel Polyaminolipids Enhance the Cellular Uptake of Oligonucleotides
1995
Super pH-sensitive multifunctional polymeric micelle for tumor pHe specific TAT exposure and multidrug resistance
2008
Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid
2006
DNA-based therapeutics and DNA delivery systems: A comprehensive review
2005
Cellular uptake of Antennapedia Penetratin peptides is a two-step process in which phase transfer precedes a tryptophan-dependent translocation
2003
Conjugates of Antisense Oligonucleotides with the Tat and Antennapedia Cell-Penetrating Peptides: Effects on Cellular Uptake, Binding to Target Sequences, and Biologic Actions
2002
Branching Out of Single‐Molecule Fluorescence Spectroscopy: Challenges for Chemistry and Influence on Biology
2005
Cell surface adherence and endocytosis of protein transduction domains
2003
Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor
2006
Mammalian display screening of diverse cystine-dense peptides for difficult to drug targets
2017 StandoutNobel
Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells
2003
Synthetic mimics of mammalian cell surface receptors: prosthetic molecules that augment living cells
2005
Antisense oligonucleotides: towards clinical trials
1996
Membrane-permeable arginine-rich peptides and the translocation mechanisms
2004
Plasticity in Fast Synaptic Inhibition of Adult Oxytocin Neurons Caused by Switch in GABAA Receptor Subunit Expression
1997
Mechanism Matters: A Taxonomy of Cell Penetrating Peptides
2015
Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
2005 Standout
Transduction peptides: from technology to physiology
2004
On the mechanism of non-endosomial peptide-mediated cellular delivery of nucleic acids
2004
A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain
2019 StandoutNobel
Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes
2009
Cell-Penetrating Peptides: From Basic Research to Clinics
2017
Evaluation of transportan 10 in PEI mediated plasmid delivery assay
2005
Vectorial delivery of macromolecules into cells using peptide-based vehicles
2001
Scorpion venom components that affect ion-channels function
2013
Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
1998
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality
2021 StandoutNobel
HIV as the cause of AIDS
1996 StandoutNobel
Inverse‐electron‐demand Diels‐Alder reaction as a highly efficient chemoselective ligation procedure: Synthesis and function of a BioShuttle for temozolomide transport into prostate cancer cells
2009
Cu-free click cycloaddition reactions in chemical biology
2010 StandoutNobel
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis
2004
Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
1994 StandoutNatureNobel
Arginine-conjugated polypropylenimine dendrimer as a non-toxic and efficient gene delivery carrier
2006
Complexes of Plasmid DNA with Basic Domain 47-57 of the HIV-1 Tat Protein Are Transferred to Mammalian Cells by Endocytosis-mediated Pathways
2003
Structural requirements for cellular uptake of α-helical amphipathic peptides
1999
Gold Nanoparticles for Biology and Medicine
2010 Standout
A common E2F-1 and p73 pathway mediates cell death induced by TCR activation
2000 StandoutNatureNobel
Antisense inhibition of P-glycoprotein expression using peptide–oligonucleotide conjugates
2000
Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells
2004
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
Evaluation of Generation 2 and 3 Poly(Propylenimine) Dendrimers for the Potential Cellular Delivery of Antisense Oligonucleotides Targeting the Epidermal Growth Factor Receptor
2004
Site of Docking and Fusion of Insulin Secretory Granules in Live MIN6 β Cells Analyzed by TAT-conjugated Anti-syntaxin 1 Antibody and Total Internal Reflection Fluorescence Microscopy
2004
Oligonucleotide conjugation to a cell-penetrating (TAT) peptide by Diels–Alder cycloaddition
2008
Fusion of HIV-1 Tat protein transduction domain to poly-lysine as a new DNA delivery tool
2004
Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation
2014
Delivery of 2-5A cargo into living cells using the Tat cell penetrating peptide: 2-5A-tat
2006
Cytoplasmic and Nuclear Delivery of a TAT-derived Peptide and a β-Peptide after Endocytic Uptake into HeLa Cells
2003
Click Chemistry in Peptide-Based Drug Design
2013
Trojan peptides: the penetratin system for intracellular delivery
1998
Chemoselective Tyrosine Bioconjugation through Sulfate Click Reaction
2018
SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization
2018 StandoutNobel
Cell‐penetrating peptides: 20 years later, where do we stand?
2013
Novel Tat-Peptide Chelates for Direct Transduction of Technetium-99m and Rhenium into Human Cells for Imaging and Radiotherapy
2000
Intracellular Delivery of Molecular Cargo Using Cell-Penetrating Peptides and the Combination Strategies
2015
Well-Ordered Mesoporous Silica Nanoparticles as Cell Markers
2005
Photoexpulsion of Surface-Grafted Ruthenium Complexes and Subsequent Release of Cytotoxic Cargos to Cancer Cells from Mesoporous Silica Nanoparticles
2013 StandoutNobel
Attachment of Peptide Building Blocks to Proteins Through Tyrosine Bioconjugation
2007
Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists
1999 StandoutNobel
Quantitative Analysis of Permeation Peptide Complexes Labeled with Technetium-99m: Chiral and Sequence-Specific Effects on Net Cell Uptake
2003
The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters
2000
Synthesis of an Artificial Cell Surface Receptor that Enables Oligohistidine Affinity Tags to Function as Metal-Dependent Cell-Penetrating Peptides
2005
Modulation of Anxiety and Neuropeptide Y-Y1 Receptors by Antisense Oligodeoxynucleotides
1993 Science
Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo.
2001
Synthesis and Characterization of a Novel Arginine-Grafted Dendritic Block Copolymer for Gene Delivery and Study of Its Cellular Uptake Pathway Leading to Transfection
2007
The State of Nanoparticle-Based Nanoscience and Biotechnology: Progress, Promises, and Challenges
2012
Translocation of the pAntp Peptide and Its Amphipathic Analogue AP-2AL
2001
One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA
2021 StandoutNobel
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
2005 StandoutScience
Cell Transduction Pathways of Transportans
2005
Recent advances in bone-targeting nanoparticles for biomedical applications
2021
Autonomous in Vitro Anticancer Drug Release from Mesoporous Silica Nanoparticles by pH-Sensitive Nanovalves
2010 StandoutNobel
Nonviral Vectors for Gene Delivery
2008 Standout
A Peptide-Based Dendrimer That Enhances the Splice-Redirecting Activity of PNA Conjugates in Cells
2009
Marked decrease of neuropeptide Y Y2 receptor binding sites in the hippocampus in murine prion disease
1997 StandoutNobel
Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy
2003
Recent Advances in the Synthesis of Peptoid Macrocycles
2018
Macrocyclic Chelators with Paramagnetic Cations Are Internalized into Mammalian Cells via a HIV-Tat Derived Membrane Translocation Peptide
2000
Molecular Engineering of Dendritic Polymers and Their Application as Drug and Gene Delivery Systems
2007
DNA origami protection and molecular interfacing through engineered sequence-defined peptoids
2020 StandoutNobel
Pathogenesis of human immunodeficiency virus infection
1993
Reversible Photocontrol of Biological Systems by the Incorporation of Molecular Photoswitches
2013 StandoutNobel
Recent Developments in Peptide-Based Nucleic Acid Delivery
2008
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
Cellular Trajectories of Peptide-Modified Gold Particle Complexes: Comparison of Nuclear Localization Signals and Peptide Transduction Domains
2004
Poly(3-guanidinopropyl methacrylate): A Novel Cationic Polymer for Gene Delivery
2004
Enzymatic synthesis of DNA on glycerol nucleic acid templates without stable duplex formation between product and template
2007 StandoutNobel
New directions in single-molecule imaging and analysis
2007 StandoutNobel
Peptide blockade of HIFα degradation modulates cellular metabolism and angiogenesis
2002 StandoutNobel
Imperatoxin A, a Cell-Penetrating Peptide from Scorpion Venom, as a Probe of Ca2+-Release Channels/Ryanodine Receptors
2010
TAPping into mRNA Export
2001 StandoutScienceNobel
Characterization of Novel Histidine-Tagged Tat-Peptide Complexes Dual-Labeled with 99mTc-Tricarbonyl and Fluorescein for Scintigraphy and Fluorescence Microscopy
2002
DNA cleavage in immunoglobulin somatic hypermutation depends onde novoprotein synthesis but not on uracil DNA glycosylase
2005 StandoutNobel
Fluorescence Correlation Spectroscopy Reveals Highly Efficient Cytosolic Delivery of Certain Penta-Arg Proteins and Stapled Peptides
2015
Noninvasive Remote-Controlled Release of Drug Molecules in Vitro Using Magnetic Actuation of Mechanized Nanoparticles
2010 StandoutNobel
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Dendrimers Designed for Functions: From Physical, Photophysical, and Supramolecular Properties to Applications in Sensing, Catalysis, Molecular Electronics, Photonics, and Nanomedicine
2010 Standout
Cell transfection in vitro and in vivo with nontoxic TAT peptide-liposome–DNA complexes
2003
Breaching Biological Barriers: Protein Translocation Domains as Tools for Molecular Imaging and Therapy
2003
Integrating Genetic Approaches into the Discovery of Anticancer Drugs
1997 StandoutScienceNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Single-Molecule Motions of Oligoarginine Transporter Conjugates on the Plasma Membrane of Chinese Hamster Ovary Cells
2008 StandoutNobel
Noncovalent Cell Surface Engineering: Incorporation of Bioactive Synthetic Glycopolymers into Cellular Membranes
2008 StandoutNobel
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
DNA Transfer into Human Lung Cells Is Improved with Tat−RGD Peptide by Caveoli-Mediated Endocytosis
2006
Cyclic Tetrapeptides from Nature and Design: A Review of Synthetic Methodologies, Structure, and Function
2019
Peptoidic Amino- and Guanidinium-Carrier Systems: Targeted Drug Delivery into the Cell Cytosol or the Nucleus
2008
The Role of Ganglioside GM1 in Cellular Internalization Mechanisms of Poly(amidoamine) Dendrimers
2009
Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear
1993 StandoutNobel
JNK1 controls mast cell degranulation and IL-1β production in inflammatory arthritis
2010 StandoutNobel
Dendritic Molecular Transporters Provide Control of Delivery to Intracellular Compartments
2007
In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
1999 StandoutScience
De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination
2004 StandoutNobel
Fluorescent Labeling of Biomolecules with Organic Probes
2008
Works of Éric Vivès being referenced
A Truncated HIV-1 Tat Protein Basic Domain Rapidly Translocates through the Plasma Membrane and Accumulates in the Cell Nucleus
1997 Standout
Cell-penetrating Peptides
2002
Activating region of HIV-1 Tat protein: vacuum UV circular dichroism and energy minimization
1991
Tat peptide-mediated cellular delivery: back to basics
2005
Different mechanisms for cellular internalization of the HIV‐1 Tat‐derived cell penetrating peptide and recombinant proteins
fused to Tat
2002
Lethal neurotoxicity in mice of the basic domains of HIV and SIV Rev proteins Study of these regions by circular dichroism
1991
Present and future of cell-penetrating peptide mediated delivery systems: “Is the Trojan horse too wild to go only to Troy?”
2005
All-L-Leu-Pro-Leu-Pro: a challenging cyclization
2000
Cell-penetrating and cell-targeting peptides in drug delivery
2008
Cellular utake of the Tat peptide: an endocytosis mechanism following ionic interactions
2003
Cellular uptake and intracellular fate of antisense oligonucleotides
1992
TAT Peptide Internalization: Seeking the Mechanism of Entry
2003
Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation
2005
Selective coupling of a highly basic peptide to an oligonucleotide
1997
One-pot labeling and purification of peptides and proteins with fluorescein maleimide
2003
1997
Cellular uptake and intracellular fate of antisense oligonucleotides.
2003
Effects of the Tat basic domain on human immunodeficiency virus type 1 transactivation, using chemically synthesized Tat protein and Tat peptides
1994
Evidence for neurotoxic activity of tat from human immunodeficiency virus type 1
1991