Citation Impact
Citing Papers
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
2019 StandoutScienceNobel
Cells Silenced for SDHB Expression Display Characteristic Features of the Tumor Phenotype
2008
Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension
2010
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
2013
Targetable Signaling Pathway Mutations Are Associated with Malignant Phenotype in IDH -Mutant Gliomas
2014
NAD + repletion improves mitochondrial and stem cell function and enhances life span in mice
2016 Science
In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter
2010 StandoutNobel
Conserved N-terminal cysteine dioxygenases transduce responses to hypoxia in animals and plants
2019 StandoutScienceNobel
Response of mitochondrial reactive oxygen species generation to steady-state oxygen tension: implications for hypoxic cell signaling
2006
Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression
2010 StandoutNobel
Elevated Mitochondrial Reactive Oxygen Species Generation Affects the Immune Response via Hypoxia-Inducible Factor-1α in Long-Lived Mclk1 +/− Mouse Mutants
2009
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
2014 StandoutNobel
Mitochondrial reactive oxygen species regulate hypoxic signaling
2009
Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
2012
Hallmarks of Cancer: The Next Generation
2011 Standout
Induction of HIF-2α is dependent on mitochondrial O2 consumption in an O2-sensitive adrenomedullary chromaffin cell line
2008
Hypoxia and intra-complex genetic suppressors rescue complex I mutants by a shared mechanism
2024 StandoutNobel
The interplay between MYC and HIF in cancer
2007
The role of hypoxia-inducible factors in tumorigenesis
2008
Redox regulation of the hypoxia-inducible factor
2006
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
2011
Hypoxia-Inducible Factors in Physiology and Medicine
2012 StandoutNobel
Cancer Cell Metabolism
2011
Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism
2010 StandoutNobel
Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues
2013 Standout
Hypoxia, DNA repair and genetic instability
2008
Mitochondrial Complex III ROS Regulate Adipocyte Differentiation
2011
Reductive carboxylation supports growth in tumour cells with defective mitochondria
2011 Nature
The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
2007
Stabilization of Hypoxia-inducible Factor-1α Protein in Hypoxia Occurs Independently of Mitochondrial Reactive Oxygen Species Production
2010
Hypoxia, HIF1 and glucose metabolism in the solid tumour
2008
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
2006 Standout
Influence of Metabolism on Epigenetics and Disease
2013 StandoutNobel
The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
2012
Metabolic Regulation of Epigenetics
2012
HIF-Dependent Antitumorigenic Effect of Antioxidants In Vivo
2007 StandoutNobel
Sirtuin-7 Inhibits the Activity of Hypoxia-inducible Factors
2013 StandoutNobel
Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells
2015
S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate
2016 Nature
Mitochondria in cancer: Not just innocent bystanders
2008
Effects of hypoxia on tumor metabolism
2007
Spermidine/Spermine-N1-Acetyltransferase 2 Is an Essential Component of the Ubiquitin Ligase Complex That Regulates Hypoxia-inducible Factor 1α
2007 StandoutNobel
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
2008 Standout
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
2013
Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
2005 StandoutNobel
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
2013 StandoutNobel
AMP‐activated protein kinase and cancer
2009
Acetate Dependence of Tumors
2014
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
2008
Metabolic Control of Longevity
2016
A Unifying Mechanism for Mitochondrial Superoxide Production during Ischemia-Reperfusion Injury
2016
Modulation of oxidative stress as an anticancer strategy
2013 Standout
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
2013 Nature
The multifaceted roles of fatty acid synthesis in cancer
2016
Sirtuins, Aging, and Medicine
2011
Links between metabolism and cancer
2012
SDH5 Mutations and Familial Paraganglioma: Somewhere Warburg is Smiling
2009 StandoutNobel
Sirtuins, Aging, and Metabolism
2011
Acetyl Coenzyme A: A Central Metabolite and Second Messenger
2015
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
2006 StandoutNobel
Neonatal Intermittent Hypoxia Leads to Long-Lasting Facilitation of Acute Hypoxia-Evoked Catecholamine Secretion From Rat Chromaffin Cells
2009
Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia
2006
A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans
2010
ROS Function in Redox Signaling and Oxidative Stress
2014 Standout
The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology
2007 Standout
What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer
2013 StandoutNobel
Mitochondrial reactive oxygen species and cancer
2014
Control of glutamine metabolism by the tumor suppressor Rb
2013
The Proto-oncometabolite Fumarate Binds Glutathione to Amplify ROS-Dependent Signaling
2013
Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer
2013 StandoutNobel
Post-transcriptional regulation of the mitochondrial H+-ATP synthase: A key regulator of the metabolic phenotype in cancer
2010
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Regulation of cancer cell metabolism
2011 Standout
Tumor suppressors and cell metabolism: a recipe for cancer growth
2009
L-2-Hydroxyglutarate production arises from noncanonical enzyme function at acidic pH
2017
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
2016 StandoutNobel
Direct Visualization of De novo Lipogenesis in Single Living Cells
2014
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
2005
Nox proteins in signal transduction
2009
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
2005
CRISPR-mediated direct mutation of cancer genes in the mouse liver
2014 Nature
MicroRNA-210 Regulates Mitochondrial Free Radical Response to Hypoxia and Krebs Cycle in Cancer Cells by Targeting Iron Sulfur Cluster Protein ISCU
2010
Mitochondrial dysfunction in COPD patients with low body mass index
2006
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
2010
The Emerging Hallmarks of Cancer Metabolism
2016 Standout
Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
2011 StandoutNobel
HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells
2007 StandoutNobel
Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis
2013 Standout
Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism☆
2009
The von Hippel–Lindau protein, HIF hydroxylation, and oxygen sensing
2005 StandoutNobel
Signalling hypoxia by HIF hydroxylases
2005 StandoutNobel
An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis
2015
The Mitochondrial Respiratory Chain Is Required for Organismal Adaptation to Hypoxia
2016
Chromatin as an oxygen sensor and active player in the hypoxia response
2011
Redox stress is not essential for the pseudo-hypoxic phenotype of succinate dehydrogenase deficient cells
2006
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma
2013
Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway
2008 StandoutNobel
Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling
2013
Hypoxia Induces Production of L-2-Hydroxyglutarate
2015
Mitochondria and cancer
2012 Standout
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
2016 StandoutNobel
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
2010
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer
2012
Mitochondrial Diseases: Hope for the Future
2020
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
2016
Mitochondria as Oxidative Signaling Organelles in T-cell Activation: Physiological Role and Pathological Implications
2013
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
2016 Standout
Reverse TCA cycle flux through isocitrate dehydrogenases 1 and 2 is required for lipogenesis in hypoxic melanoma cells
2012
Prolyl Hydroxylase Domain Inhibitors: A Route to HIF Activation and Neuroprotection
2009
Novel Role of NADPH Oxidase in Angiogenesis and Stem/Progenitor Cell Function
2009
Metabolic switching and fuel choice during T‐cell differentiation and memory development
2012
Reprogramming of proline and glutamine metabolism contributes to the proliferative and metabolic responses regulated by oncogenic transcription factor c-MYC
2012
Clues from cell metabolism
2010 StandoutNatureNobel
Life with Oxygen
2007 StandoutScienceNobel
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Hypoxia-Inducible Factor 1 (HIF-1) Pathway
2007 StandoutNobel
Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation
2011 Standout
Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
2010
Hypoxia-inducible Factor-1α Stabilization in Nonhypoxic Conditions: Role of Oxidation and Intracellular Ascorbate Depletion
2007
The FIH hydroxylase is a cellular peroxide sensor that modulates HIF transcriptional activity
2012 StandoutNobel
von Hippel-Lindau Disease
2006 StandoutNobel
How mitochondria produce reactive oxygen species
2008 Standout
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Signal transduction by reactive oxygen species
2011 Standout
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Pyruvate carboxylase is critical for non–small-cell lung cancer proliferation
2015
Fumarate Hydratase Deficiency in Renal Cancer Induces Glycolytic Addiction and Hypoxia-Inducible Transcription Factor 1α Stabilization by Glucose-Dependent Generation of Reactive Oxygen Species
2009
Spermidine in health and disease
2018 StandoutScience
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
2022 StandoutScienceNobel
Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss
2010 StandoutScienceNobel
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
2016 StandoutScienceNobel
Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development
2013
Reactive Oxygen Species: A Breath of Life or Death?
2007
Hypoxia. 2. Hypoxia regulates cellular metabolism
2010
A key role for transketolase-like 1 in tumor metabolic reprogramming
2016
Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses
2011 Science
Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity
2017 StandoutNobel
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
2009 StandoutScience
Perinuclear Mitochondrial Clustering Creates an Oxidant-Rich Nuclear Domain Required for Hypoxia-Induced Transcription
2012
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
2010
Multiple Factors Affecting Cellular Redox Status and Energy Metabolism Modulate Hypoxia-Inducible Factor Prolyl Hydroxylase Activity In Vivo and In Vitro
2006
Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?
2012 Standout
Works of Eric L. Bell being referenced
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
2011
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
2011 Nature
The SirT3 Divining Rod Points to Oxidative Stress
2011
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
2005
Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging
2013
Global microRNA depletion suppresses tumor angiogenesis
2014
Mitochondrial regulation of oxygen sensing
2005
Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
2013
Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
2007
The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production
2007
SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production
2013
Loss of the SdhB, but Not the SdhA, Subunit of Complex II Triggers Reactive Oxygen Species-Dependent Hypoxia-Inducible Factor Activation and Tumorigenesis
2007
Mitochondrial Reactive Oxygen Species Trigger Hypoxia-Inducible Factor-Dependent Extension of the Replicative Life Span during Hypoxia
2007