Citation Impact
Citing Papers
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
2005 Standout
Hypothalamic mTOR Signaling Regulates Food Intake
2006 Science
Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
2010 StandoutScienceNobel
ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones
2002 Science
Regulation of adult erythropoiesis by prolyl hydroxylase domain proteins
2007
ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 Phosphorylation
2005
Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains
2001
TOR Signaling in Growth and Metabolism
2006 Standout
Immunological aspects of cancer chemotherapy
2007
The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α
2007
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
von Hippel–Lindau mutation in mice recapitulates Chuvash polycythemia via hypoxia-inducible factor-2α signaling and splenic erythropoiesis
2007
Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis
2009 StandoutNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism
1998
The Hypoxia-Associated Factor Switches Cells from HIF-1α- to HIF-2α-Dependent Signaling Promoting Stem Cell Characteristics, Aggressive Tumor Growth and Invasion
2011
HIF-2α, but not HIF-1α, promotes iron absorption in mice
2009
Endothelial deletion of hypoxia-inducible factor–2α (HIF-2α) alters vascular function and tumor angiogenesis
2009
Hif-2α is not essential for cell-autonomous hematopoietic stem cell maintenance
2013 StandoutNobel
Biology of hypoxia-inducible factor-2α in development and disease
2008
A Gain-of-Function Mutation in the HIF2A Gene in Familial Erythrocytosis
2008
The many substrates and functions of ATM
2000
Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k
1997
The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO
2012
Neutrophil activation on biological surfaces. Massive secretion of hydrogen peroxide in response to products of macrophages and lymphocytes.
1987
The p70 S6 Kinase Integrates Nutrient and Growth Signals to Control Translational Capacity
2001
Responses to DNA damage and regulation of cell cycle checkpoints by the ATM protein kinase family
1997
Structure and Function of Leukocyte Integrins
1990
Osmotic Stress Inhibits p70/85 S6 Kinase through Activation of a Protein Phosphatase
1999
Cutaneous Wound Healing
1999 Standout
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
2010 StandoutNobel
Distinct cellular functions mediated by different VLA integrin α subunit cytoplasmic domains
1992
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
2003
Signal Regulatory Proteins Negatively Regulate Immunoreceptor-dependent Cell Activation
1999
Predominance of null mutations in ataxia-telangiectasia
1996
The 14-3-3 proteins positively regulate rapamycin-sensitive signaling
1998
Distinct regulatory mechanism for p70 S6 kinase β from that for p70 S6 kinase α
2001
The role of DNA damage and repair in aging through the prism of Koch-like criteria
2012
mTOR Signaling in Growth Control and Disease
2012 Standout
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
2007
"ATR activation in response to ionizing radiation: still ATM territory"
2006
mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway
2011
The Mammalian Target of Rapamycin (mTOR) Partner, Raptor, Binds the mTOR Substrates p70 S6 Kinase and 4E-BP1 through Their TOR Signaling (TOS) Motif
2003
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E
2002
Cancer Immunosurveillance and Immunoediting: The Roles of Immunity in Suppressing Tumor Development and Shaping Tumor Immunogenicity
2006
ATR Regulates Fragile Site Stability
2002
Complementation of dominant suppression implicates CD98 in integrin activation
1997 Nature
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1997 StandoutNatureNobel
Cell cycle checkpoint signaling through the ATM and ATR kinases
2001 Standout
S6K1 Plays a Critical Role in Early Adipocyte Differentiation
2010
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism
1999
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
2000
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
2011 StandoutNobel
The expanding TOR signaling network
2005
HIF-1 and ventilatory acclimatization to chronic hypoxia
2008
FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions
2000
Cell-cycle checkpoints and cancer
2004 StandoutNature
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
2002 Standout
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
2009 Standout
Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling
2004
Regulation of translation initiation by FRAP/mTOR
2001
The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling
1995
Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation
1999
ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background
2004
Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche
2011 StandoutNobel
TOR2 Is Part of Two Related Signaling Pathways Coordinating Cell Growth in Saccharomyces cerevisiae
1998
Are changes in integrin affinity and conformation overemphasized?
1998
Histone H2AX
2003
A reevaluation of integrins as regulators of angiogenesis
2002
The TOR signaling cascade regulates gene expression in response to nutrients
1999
HIF2α cooperates with RAS to promote lung tumorigenesis in mice
2009 StandoutNobel
TOR, a Central Controller of Cell Growth
2000 Standout
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
2003 Standout
ATM and related protein kinases: safeguarding genome integrity
2003 Standout
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
1994
DNA damage checkpoints in mammals
2005
Telomeres and telomerase in cancer
2009
Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress
2000
ATR: an essential regulator of genome integrity
2008
GβL, a Positive Regulator of the Rapamycin-Sensitive Pathway Required for the Nutrient-Sensitive Interaction between Raptor and mTOR
2003
Integrin transmembrane signaling and cytoskeletal control
1995
A possible linkage between AMP‐activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway
2003
Global heterochromatin loss
2012
Mcm2 Is a Direct Substrate of ATM and ATR during DNA Damage and DNA Replication Checkpoint Responses
2004
A microRNA program in the C. elegans hypodermis couples to intestinal mTORC2/PQM-1 signaling to modulate fat transport
2016 StandoutNobel
Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action
2002 Standout
TOR Mutations Confer Rapamycin Resistance by Preventing Interaction with FKBP12-Rapamycin
1995
Oncogene-Induced Cell Senescence — Halting on the Road to Cancer
2006
Phorbol ester-induced differentiation of U937 cells enhances attachment to fibronectin and distinctly modulates the α5β1 and α4β1 fibronectin receptors
1991
Characterization of the Phosphoproteins and Protein Kinase Activity in mTOR Immunoprecipitates
1998
Regulation of eIF-4E BP1 Phosphorylation by mTOR
1997
Cancer immunosurveillance, immunoediting and inflammation: independent or interdependent processes?
2007
Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints
1998
DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?
2001
Acute upregulation of an NKG2D ligand promotes rapid reorganization of a local immune compartment with pleiotropic effects on carcinogenesis
2008
Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro
1999
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
2009
The Formation of Ceramide-1-phosphate during Neutrophil Phagocytosis and Its Role in Liposome Fusion
1998 StandoutNobel
Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast
1998 StandoutNobel
RPA2 Is a Direct Downstream Target for ATR to Regulate the S-phase Checkpoint
2006
How stem cells age and why this makes us grow old
2007
Upstream and downstream of mTOR
2004 Standout
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
2003 Standout
Human neutrophil granules and secretory vesicles
1993
Checking on DNA damage in S phase
2004
The modular phosphorylation and activation of p70s6k
1997
The DNA Damage Response: Making It Safe to Play with Knives
2010 Standout
Suppression of Integrin Activation: A Novel Function of a Ras/Raf-Initiated MAP Kinase Pathway
1997
Carboxyl‐terminal region conserved among phosphoinositide‐kinase‐related kinases is indispensable for mTOR function in vivo and in vitro
2000
TOR Deficiency in C. elegans Causes Developmental Arrest and Intestinal Atrophy by Inhibition of mRNA Translation
2002
Human DNA damage response and repair deficiency syndromes: Linking genomic instability and cell cycle checkpoint proficiency
2009
A splicing mutation affecting expression of ataxia–telangiectasia and Rad3–related protein (ATR) results in Seckel syndrome
2003
Claspin, a regulator of Chk1 in DNA replication stress pathway
2004
Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts
2000
The Talin Head Domain Binds to Integrin β Subunit Cytoplasmic Tails and Regulates Integrin Activation
1999
Phosphorylation of Mammalian Target of Rapamycin (mTOR) at Ser-2448 IsMediated by p70S6 Kinase
2005
Antisense-mediated reduction in insulin-like growth factor-I receptor expression suppresses the malignant phenotype of a human alveolar rhabdomyosarcoma.
1994
Immunity, Inflammation, and Cancer
2010 Standout
Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
2009 StandoutNobel
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast
1999
Genotype-Phenotype Relationships in Ataxia-Telangiectasia and Variants
1998
VLA Proteins in the Integrin Family: Structures, Functions, and Their Role on Leukocytes
1990
Stems Cells and the Pathways to Aging and Cancer
2008
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability
2004
Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways
1999
DNA double-strand breaks: signaling, repair and the cancer connection
2001 Standout
The DNA damage response, immunity and cancer
2006
Cloning and Characterization of p70S6KβDefines a Novel Family of p70 S6 Kinases
1998
Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint
2000
Networks and crosstalk: integrin signalling spreads
2002
Sensing the environment: a historical perspective on integrin signal transduction
2002
Integrin affinity modulation
1998
Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition
2010
A diverse range of gene products are effectors of the type I interferon antiviral response
2011 StandoutNatureNobel
Regulation of mammalian translation factors by nutrients
2002
ATR and ATM regulate the timing of DNA replication origin firing
2004
β1 integrins show specific association with CD98 protein in low density membranes
2001
Integrins and Actin Filaments: Reciprocal Regulation of Cell Adhesion and Signaling
2000
Role of shelterin in cancer and aging
2010
Characterization of S6K2, a novel kinase homologous to S6K1
1999
Integrin associated proteins
1998
The DNA damage response: putting checkpoints in perspective
2000 StandoutNature
Fibronectin Matrix Deposition and Fibronectin Receptor Expression in Healing and Normal Skin
1990
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer
2017 StandoutNature
Mammalian TIMELESS and Tipin are Evolutionarily Conserved Replication Fork-associated Factors
2006
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
2000
The Fission Yeast TOR Homolog,tor1 +, Is Required for the Response to Starvation and Other Stresses via a Conserved Serine
2001
A Dominant Complement Fixation Pathway for Pneumococcal Polysaccharides Initiated by SIGN-R1 Interacting with C1q
2006 StandoutNobel
The mRNA 5′ cap-binding protein eIF4E and control of cell growth
1998
Specificity and mechanism of action of some commonly used protein kinase inhibitors
2000 Standout
The Mre11 complex is required for ATM activation and the G2/M checkpoint
2003
The Hallmarks of Aging
2013 Standout
A mammalian protein targeted by G1-arresting rapamycin–receptor complex
1994 StandoutNature
Functional interaction between RAFT1/FRAP/mTOR and protein kinase Cδ in the regulation of cap-dependent initiation of translation
2000
Regulation of Protein Phosphatase 2A Catalytic Activity by alpha4 Protein and Its Yeast Homolog Tap42
1998
Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
2003
Amino Acid Signaling to mTOR Mediated by Inositol Polyphosphate Multikinase
2011
Human Claspin Is Required for Replication Checkpoint Control
2003
Mammalian G1- and S-phase checkpoints in response to DNA damage
2001
Integrins
2002 Standout
Bidirectional modulation of insulin action by amino acids.
1998
Insulin Signaling and the Control of PHAS-I Phosphorylation
2001
α4 Associates with Protein Phosphatases 2A, 4, and 6
1998
Claspin, a Novel Protein Required for the Activation of Chk1 during a DNA Replication Checkpoint Response in Xenopus Egg Extracts
2000
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
2006
Targeting the checkpoint kinases: chemosensitization versus chemoprotection
2004
A ubiquitin-like system mediates protein lipidation
2000 StandoutNatureNobel
Mammalian Target of Rapamycin-dependent Phosphorylation of PHAS-I in Four (S/T)P Sites Detected by Phospho-specific Antibodies
2000
mTOR — beyond transplantation
2005
Integrin-associated Protein Is a Ligand for the P84 Neural Adhesion Molecule
1999
Rapamycin Inhibition of the G1 to S Transition Is Mediated by Effects on Cyclin D1 mRNA and Protein Stability
1998
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
2004 Standout
Cellular senescence: hot or what?
2009
The Role of Single-stranded DNA and Polymerase α in Establishing the ATR, Hus1 DNA Replication Checkpoint
2002
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins
2004 Standout
Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation
1999 Nobel
The Role of Antibody and Complement in the Reticuloendothelial Clearance of Pneumococci from the Bloodstream
1983
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
1998
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12–rapamycinassociated protein
1999
Inactivation of mouse Hus1 results in genomic instability and impaired responses to genotoxic stress
2000
Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A
1998
The coordinate regulation of the p53 and mTOR pathways in cells
2005
mTOR Is Essential for Growth and Proliferation in Early Mouse Embryos and Embryonic Stem Cells
2004 StandoutNobel
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
1998 Standout
Functional classification of interferon-stimulated genes identified using microarrays
2001
Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint
2000
Rh-related antigen CD47 is the signal-transducer integrin-associated protein.
1994
Isolation and characterization of CD47 glycoprotein: a multispanning membrane protein which is the same as integrin-associated protein (IAP) and the ovarian tumour marker OA3
1994
Regulation of Hypoxia-Inducible Factor 1α Expression and Function by the Mammalian Target of Rapamycin
2002
Integrins: Versatility, modulation, and signaling in cell adhesion
1992 Standout
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.
2000
Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro
2000
IMPAIRED HUMAN ANTIBODY RESPONSE TO THE THYMUS-INDEPENDENT ANTIGEN, DNP-FICOLL, AFTER SPLENECTOMY
1985
Cytokine-induced respiratory burst of human neutrophils: dependence on extracellular matrix proteins and CD11/CD18 integrins.
1989
The G2-phase DNA-damage checkpoint
2000
Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120-kDa fibroblastic cell-binding fragment.
1988
Constitutive and stimulus-induced phosphorylation of CD11/CD18 leukocyte adhesion molecules.
1989
Expression and function of chicken integrin beta 1 subunit and its cytoplasmic domain mutants in mouse NIH 3T3 cells.
1990
Molecular cloning of integrin-associated protein: an immunoglobulin family member with multiple membrane-spanning domains implicated in alpha v beta 3-dependent ligand binding.
1993
Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase
2000 StandoutNobel
The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells.
1991
Studies of group B streptococcal infection in mice deficient in complement component C3 or C4 demonstrate an essential role for complement in both innate and acquired immunity.
1995
Syk Activation Initiates Downstream Signaling Events During Human Polymorphonuclear Leukocyte Phagocytosis
1999 StandoutNobel
Complementary Roles for Receptor Clustering and Conformational Change in the Adhesive and Signaling Functions of Integrin αIIbβ3
1998
Hypoxia Links ATR and p53 through Replication Arrest
2002
Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.
1996
Adaptive and Maladaptive Cardiorespiratory Responses to Continuous and Intermittent Hypoxia Mediated by Hypoxia-Inducible Factors 1 and 2
2012 StandoutNobel
Transmembrane signaling pathways involved in phagocytosis and associated activation of NADPH oxidase mediated by FcγRs in human neutrophils
1993
Rapamycin Resistance Tied to Defective Regulation of p27Kip1
1996
Bacterial phagocytosis activates extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades in human neutrophils
1998
An ATR- and Chk1-Dependent S Checkpoint Inhibits Replicon Initiation following UVC-Induced DNA Damage
2002
Structure of the FKBP12-Rapamycin Complex Interacting with Binding Domain of Human FRAP
1996 Science
ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1
2001
The classical pathway is the dominant complement pathway required for innate immunity toStreptococcus pneumoniaeinfection in mice
2002
Activation of a Plasma Membrane–Associated Neutral Sphingomyelinase and Concomitant Ceramide Accumulation During IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1998 StandoutNobel
Sphingosine Blocks Human Polymorphonuclear Leukocyte Phagocytosis Through Inhibition of Mitogen-Activated Protein Kinase Activation
1999 StandoutNobel
Role of CD47 as a Marker of Self on Red Blood Cells
2000 StandoutScience
Complete amino acid sequence of an integrin beta subunit (beta 7) identified in leukocytes
1991
Control of Nutrient-Sensitive Transcription Programs by the Unconventional Prefoldin URI
2003 Science
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
2001
MECHANISMS OF PHAGOCYTOSIS IN MACROPHAGES
1999 Standout
Elucidating TOR Signaling and Rapamycin Action: Lessons from Saccharomyces cerevisiae
2002
Aberrant cell cycle checkpoint function and early embryonic death in Chk1−/− mice
2000
Phagocytosis and inflammatory stimuli induce GM-CSF mRNA in macrophages through posttranscriptional regulation
1987
Regulation of Peroxisome Proliferator–Activated Receptor-γ Activity by Mammalian Target of Rapamycin and Amino Acids in Adipogenesis
2004
Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.
2001
cDNA cloning and gene mapping of a candidate human cell cycle checkpoint protein.
1996
Chk1 and Cds1: linchpins of the DNA damage and replication checkpoint pathways
2000
The Rh blood group system: a review
2000
Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin
1997 Science
Activation of CD4 cells by fibronectin and anti-CD3 antibody. A synergistic effect mediated by the VLA-5 fibronectin receptor complex.
1989
FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity.
1995
Ceramide Inhibits IgG-Dependent Phagocytosis in Human Polymorphonuclear Leukocytes
1997 StandoutNobel
Optical trapping and manipulation of neutral particles using lasers
1997 StandoutNobel
Regulation of polymorphonuclear leukocyte phagocytosis by myosin light chain kinase after activation of mitogen-activated protein kinase
2000 StandoutNobel
A DNA Damage-Regulated BRCT-Containing Protein, TopBP1, Is Required for Cell Survival
2002
Inhibitors of the mammalian target of rapamycin
2005
Surviving the Breakup: The DNA Damage Checkpoint
2006
Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling
2001 Science
P53 Binding Protein 1 (53bp1) Is an Early Participant in the Cellular Response to DNA Double-Strand Breaks
2000
Drosophila Target of Rapamycin Kinase Functions as a Multimer
2005
Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
2009 StandoutNobel
Toward Maintaining the Genome: DNA Damage and Replication Checkpoints
2002
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
Target of rapamycin proteins and their kinase activities are required for meiosis
1997
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.
1994
Dual roles of ATM in the cellular response to radiation and in cell growth control.
1996 Nobel
HIF-1 regulates CD47 expression in breast cancer cells to promote evasion of phagocytosis and maintenance of cancer stem cells
2015 StandoutNobel
Ig Receptor Binding Protein 1 (α4) Is Associated With a Rapamycin-Sensitive Signal Transduction in Lymphocytes Through Direct Binding to the Catalytic Subunit of Protein Phosphatase 2A
1998
ATR and ATRIP: Partners in Checkpoint Signaling
2001 Science
Structure and function of the leukocyte adhesion molecules CD11/CD18
1990
Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage
1998 StandoutScience
Phosphorylation of serines 635 and 645 of human Rad17 is cell cycle regulated and is required for G 1 /S checkpoint activation in response to DNA damage
2001
Phylogenetic Perspectives in Innate Immunity
1999 StandoutScienceNobel
Lounging in a lysosome: the intracellular lifestyle of Coxiella burnetii
2007 Standout
Isolation and characterization of gelatinase granules from human neutrophils
1994
Thrombospondin stimulates motility of human neutrophils.
1990 StandoutNobel
Fluorescence Spectroscopy of Single Biomolecules
1999 StandoutScience
Autophagy as a Regulated Pathway of Cellular Degradation
2000 StandoutScience
PIK-Related Kinases: DNA Repair, Recombination, and Cell Cycle Checkpoints
1995 Science
Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells.
1999
Control of Erythropoietin Gene Expression and its Use in Medicine
2007
Monocytes and macrophages synthesize and secrete thrombospondin
1985
Molecular Mechanisms of Mammalian DNA Repair and the DNA Damage Checkpoints
2004 StandoutNobel
Complete amino acid sequence of a novel integrin beta subunit (beta 6) identified in epithelial cells using the polymerase chain reaction.
1990
ATAXIA-TELANGIECTASIA AND THE NIJMEGEN BREAKAGE SYNDROME: Related Disorders But Genes Apart
1997
4E-BP1 and S6K1: translational integration sites for nutritional and hormonal information in muscle
2000
Phosphorylation ofXenopusRad1 and Hus1 Defines a Readout for ATR Activation That Is Independent of Claspin and the Rad9 Carboxy Terminus
2006
The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.
1996
Works of Eric J. Brown being referenced
Subversion of Monocyte Functions by Coxiella burnetii: Impairment of the Cross-Talk Between αvβ3 Integrin and CR3
1999
CD47 Deficiency Protects Mice from Lipopolysaccharide-Induced Acute Lung Injury and Escherichia coli Pneumonia
2008
Acute postnatal ablation of Hif-2 α results in anemia
2007
Integrin-associated protein (CD47) is a comitogenic molecule on CD3-activated human T cells.
1997
Complement receptors and phagocytosis
1991
Fibronectin-mediated Calmette-Guerin bacillus attachment to murine bladder mucosa. Requirement for the expression of an antitumor response.
1990
Distinct Tyrosine Kinase Activation and Triton X-100 Insolubility upon FcγRII or FcγRIIIB Ligation in Human Polymorphonuclear Leukocytes.
1995
Phagocytosis
1995
Tissue regenerative delays and synthetic lethality in adult mice after combined deletion of Atr and Trp53
2009
Adhesion-activating phorbol ester increases the mobility of leukocyte integrin LFA-1 in cultured lymphocytes.
1996
Entactin stimulates neutrophil adhesion and chemotaxis through interactions between its Arg-Gly-Asp (RGD) domain and the leukocyte response integrin.
1992
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
2003 Nobel
Replicative stress, stem cells and aging
2008
Control of p70 S6 kinase by kinase activity of FRAP in vivo
1995 Nature
Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis
2007
Studies on the molecular mechanisms of human Fc receptor-mediated phagocytosis. Amplification of ingestion is dependent on the generation of reactive oxygen metabolites and is deficient in polymorphonuclear leukocytes from patients with chronic granulomatous disease.
1988
The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor
2005 Nature
Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss
2007
Mechanism of inhibition of immunoglobulin G-mediated phagocytosis by monoclonal antibodies that recognize the Mac-1 antigen.
1988
Integrin-associated protein (CD47) and its ligands
2001
Regulation of insulin-like growth factor (IGF) I receptor expression during muscle cell differentiation. Potential autocrine role of IGF-II.
1991
Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.
1995
Immunoglobulin-mediated phagocytosis by human monocytes requires protein kinase C activation. Evidence for protein kinase C translocation to phagosomes.
1992
A quantitative analysis of the interactions of antipneumococcal antibody and complement in experimental pneumococcal bacteremia.
1982
Ligand binding specificity of the leukocyte response integrin expressed by human neutrophils.
1992
Mechanism of fibronectin enhancement of group B streptococcal phagocytosis by human neutrophils and culture-derived macrophages
1993
CR3 (Mac-1, alpha M beta 2, CD11b/CD18) and Fc gamma RIII cooperate in generation of a neutrophil respiratory burst: requirement for Fc gamma RIII and tyrosine phosphorylation.
1994
Expression of the 50-kDa integrin-associated protein on myeloid cells and erythrocytes
1992
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.
1994
Fibronectin receptors of phagocytes. Characterization of the Arg-Gly-Asp binding proteins of human monocytes and polymorphonuclear leukocytes.
1988
Transendothelial migration of neutrophils involves integrin-associated protein (CD47).
1995
The Role of Extracellular Matrix Proteins in the Control of Phagocytosis
1986
Role of Cholesterol in Formation and Function of a Signaling Complex Involving αvβ3, Integrin-Associated Protein (Cd47), and Heterotrimeric G Proteins
1999
Decreased Resistance to Bacterial Infection and Granulocyte Defects in IAP-Deficient Mice
1996 Science
In vivo expression of alternatively spliced forms of integrin-associated protein (cd47)
1995
Human Signal-Regulatory Protein Is Expressed on Normal, But Not on Subsets of Leukemic Myeloid Cells and Mediates Cellular Adhesion Involving Its Counterreceptor CD47
1999
Human neutrophils increase expression of C3bi as well as C3b receptors upon activation.
1984
Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development
2004
Opsonic Requirements for Intravascular Clearance after Splenectomy
1981
Signal transduction by neutrophil immunoglobulin G Fc receptors. Dissociation of intracytoplasmic calcium concentration rise from inositol 1,4,5-trisphosphate.
1992
Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins.
1990
Subversion of monocyte functions by coxiella burnetii: impairment of the cross-talk between alphavbeta3 integrin and CR3.
1999
ATR disruption leads to chromosomal fragmentation and early embryonic lethality
2000 Nobel
Studies on the fibronectin receptors of human peripheral blood leukocytes. Morphologic and functional characterization.
1984
Tim–Tipin dysfunction creates an indispensible reliance on the ATR–Chk1 pathway for continued DNA synthesis
2009
Coxiella burnetii Avoids Macrophage Phagocytosis by Interfering with Spatial Distribution of Complement Receptor 3
2003
Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein.
1995
A Molecular Mechanism of Integrin Crosstalk: αvβ3 Suppression of Calcium/Calmodulin-dependent Protein Kinase II Regulates α5β1 Function
1999
Studies on the molecular mechanisms of human neutrophil Fc receptor-mediated phagocytosis. Evidence that a distinct pathway for activation of the respiratory burst results in reactive oxygen metabolite-dependent amplification of ingestion.
1990
A novel member of the integrin receptor family mediates Arg-Gly-Asp-stimulated neutrophil phagocytosis.
1989
The Critical Role of Complement in Experimental Pneumococcal Sepsis
1980
Costimulation of T Cell Activation by Integrin-associated Protein (CD47) Is an Adhesion-dependent, CD28-independent Signaling Pathway
1997
Thrombospondin modulates alpha v beta 3 function through integrin-associated protein.
1996
Plasma fibronectin enhances phagocytosis of opsonized particles by human peripheral blood monocytes.
1983
An immobile subset of plasma membrane CD11b/CD18 (Mac-1) is involved in phagocytosis of targets recognized by multiple receptors.
1989
FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line.
1993
The ATR-Independent DNA Replication Checkpoint
2003