Citation Impact
Citing Papers
The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways
2007
Targeting both HIF-1 and HIF-2 in human colon cancer cells improves tumor response to sunitinib treatment
2009
Tumor imaging by means of proteolytic activation of cell-penetrating peptides
2004 StandoutNobel
Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress
2011
Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis
2014 StandoutNobel
Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice
2011
On-target efficacy of a HIF-2α antagonist in preclinical kidney cancer models
2016 StandoutNatureNobel
Hallmarks of Cancer: The Next Generation
2011 Standout
HIFing the Brakes: Therapeutic Opportunities for Treatment of Human Malignancies
2006
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m 6 A-demethylation of NANOG mRNA
2016 StandoutNobel
Inactivating mutation of the pro‐apoptotic gene BID in gastric cancer
2004
Hypoxia — a key regulatory factor in tumour growth
2002 Standout
The DNA-damage response in human biology and disease
2009 StandoutNature
Evolutionary Genetics of Fish
1991
Targeting HIF-1 for cancer therapy
2003 StandoutNobel
Cell-cell adhesion mediated by CD8 and MHC class I molecules
1988 Nature
Targeting hypoxia cell signaling for cancer therapy
2007
EMT and Dissemination Precede Pancreatic Tumor Formation
2012 Standout
Effects of hypoxia on tumor metabolism
2007
Dissemination and growth of cancer cells in metastatic sites
2002 Standout
LRP: a multifunctional scavenger and signaling receptor
2001
Insights into the Mitochondrial Signaling Pathway: What Lessons for Chemotherapy?
2003
Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck
2006 Standout
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
1998 StandoutNatureNobel
Metastatic Stem Cells: Sources, Niches, and Vital Pathways
2014
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
2015 Standout
p21-activated Kinase 1 (Pak1)-dependent Phosphorylation of Raf-1 Regulates Its Mitochondrial Localization, Phosphorylation of BAD, and Bcl-2 Association
2005
Beyond natural antibodies: the power of in vitro display technologies
2011
Metastasis suppressor pathways—an evolving paradigm
2003
Angiogenesis in cancer and other diseases
2000 StandoutNature
The Hallmarks of Cancer
2000 Standout
Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
2005 Nature
Intravascular Location of Breast Cancer Cells after Spontaneous Metastasis to the Lung
2002
Apoptotic cell death in mammary adenocarcinoma cells is prevented by soluble factors present in the target organ of metastasis
2001
The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck
2004
Eater, a Transmembrane Protein Mediating Phagocytosis of Bacterial Pathogens in Drosophila
2005 StandoutNobel
Metastasis suppressors alter the signal transduction of cancer cells
2003
CD4: Collaborator in immune recognition and HIV infection
1990 StandoutNobel
The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation
2003
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Natural RNA circles function as efficient microRNA sponges
2013 StandoutNature
Intravascular origin of metastasis from the proliferation of endothelium-attached tumor cells: a new model for metastasis
2000
Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3
2005
Adhesion receptors of the immune system
1990 StandoutNature
Links between Innate Immunity and Normal Tissue Radiobiology
2010
Mitochondrial Membrane Permeabilization in Cell Death
2007 Standout
Matrix metalloproteinase-2 (MMP-2) is associated with survival in breast carcinoma
2003
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
2006
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
1991 StandoutNobel
In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy
2001
Tumor metastasis: mechanistic insights and clinical challenges
2006 Standout
Identification of hypoxia in cells and tissues of epigastric 9L rat glioma using EF5 [2-(2-nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-pentafluoropropyl) acetamide]
1995
The Hallmarks of Aging
2013 Standout
The Causes and Consequences of Polyploidy in Normal Development and Cancer
2011
The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis
2004 Standout
Oxygen Sensing, Homeostasis, and Disease
2011 StandoutNobel
The role of the bcl-2/ced-9 gene family in cancer and general implications of defects in cell death control for tumourigenesis and resistance to chemotherapy
1997
Metastatic colonization by circulating tumour cells
2016 StandoutNature
ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model
2005
Cancer-related inflammation
2008 StandoutNature
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution
1992 StandoutNobel
Control of apoptosis by p53
2003
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
2011 StandoutNobel
p53 alterations in human cancer: more questions than answers
2007
Strategies to improve radiotherapy with targeted drugs
2011
Changing views of the role of matrix metalloproteinases in metastasis
1997
Macrophage Binding to Receptor VCAM-1 Transmits Survival Signals in Breast Cancer Cells that Invade the Lungs
2011
Trex1 Exonuclease Degrades ssDNA to Prevent Chronic Checkpoint Activation and Autoimmune Disease
2007 StandoutNobel
Regulation of Proliferation-Survival Decisions during Tumor Cell Hypoxia
1998
Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis
2011 StandoutNobel
The Bcl-2 Protein Family: Arbiters of Cell Survival
1998 StandoutScience
Digoxin and other cardiac glycosides inhibit HIF-1α synthesis and block tumor growth
2008 StandoutNobel
Detecting conserved regulatory elements with the model genome of the Japanese puffer fish, Fugu rubripes.
1995 StandoutNobel
Expression of CD4 in transgenic mice alters the specificity of CD8 cells for allogeneic major histocompatibility complex.
1991 StandoutNobel
Normalization of the Vasculature for Treatment of Cancer and Other Diseases
2011
G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently.
1993 StandoutNobel
Physiology meets biophysics: Visualizing the interaction of hypoxia-inducible factor 1α with p300 and CBP
2002 StandoutNobel
Hypoxic stress proteins: Survival of the fittest
1996
Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD
2005
HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses
2009
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Microenvironment and Radiation Therapy
2012
M(r) 92,000 type IV collagenase is increased in plasma of patients with colon cancer and breast cancer.
1993
microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma
2008
Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion
2005
Blockade of Paracrine Supply of Insulin-Like Growth Factors Using Neutralizing Antibodies Suppresses the Liver Metastasis of Human Colorectal Cancers
2005
β1 Integrin Inhibition Dramatically Enhances Radiotherapy Efficacy in Human Breast Cancer Xenografts
2008
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
1995 StandoutNobel
EGFR Activation Results in Enhanced Cyclooxygenase-2 Expression through p38 Mitogen-Activated Protein Kinase–Dependent Activation of the Sp1/Sp3 Transcription Factors in Human Gliomas
2007
PUMA Couples the Nuclear and Cytoplasmic Proapoptotic Function of p53
2005 Science
Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment
2018 StandoutNobel
Transcriptional control of human p53-regulated genes
2008 Standout
p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site
2004
Metabolic reprogramming and cancer progression
2020 StandoutScience
Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota
2008
Multistage nanoparticle delivery system for deep penetration into tumor tissue
2011 StandoutNobel
Hypoxia-Mediated Down-Regulation of Bid and Bax in Tumors Occurs via Hypoxia-Inducible Factor 1-Dependent and -Independent Mechanisms and Contributes to Drug Resistance
2004
Apoptosis - the p53 network
2003
LRP: a multifunctional scavenger and signaling receptor
2001
Hypoxic retinal Müller cells promote vascular permeability by HIF-1–dependent up-regulation of angiopoietin-like 4
2013 StandoutNobel
Quantum dot/antibody conjugates for in vivo cytometric imaging in mice
2015 StandoutNobel
Angiogenesis in Endocrine Tumors
2003
Chemotherapy triggers HIF-1–dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype
2015 StandoutNobel
Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment
2014 StandoutNobel
Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
2005
BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma
2005
Persistence of solitary mammary carcinoma cells in a secondary site: a possible contributor to dormancy.
2002
Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells
2003
An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
1994
Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard.
1994 StandoutNobel
Works of Eric J. Bernhard being referenced
Dual Inhibition of the PI3K/mTOR Pathway Increases Tumor Radiosensitivity by Normalizing Tumor Vasculature
2011
Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy
2006
Class I PI3 Kinase Inhibition by the Pyridinylfuranopyrimidine Inhibitor PI-103 Enhances Tumor Radiosensitivity
2008
Tumor Vascular Changes Mediated by Inhibition of Oncogenic Signaling
2009
A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
2010
Induction of apoptosis at different oxygen tensions: evidence that oxygen radicals do not mediate apoptotic signaling.
1995
NVP-BEZ235 and NVP-BGT226, dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitors, enhance tumor and endothelial cell radiosensitivity
2012
Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells
2007
Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo
2001
Mutant epidermal growth factor receptor displays increased signaling through the phosphatidylinositol-3 kinase/AKT pathway and promotes radioresistance in cells of astrocytic origin
2004
BID regulation by p53 contributes to chemosensitivity
2002
The RAS signal transduction pathway and its role in radiation sensitivity
2003
Successful growth and characterization of mouse pancreatic ductal cells: functional properties of the Ki-RASG12V oncogene
2004
Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth
2004
The effect of E1A transfection on MMP‐9 expression and metastatic potential
1995
Akt1 Activation Can Augment Hypoxia-Inducible Factor-1α Expression by Increasing Protein Translation through a Mammalian Target of Rapamycin–Independent Pathway
2006
Sp1 Is Involved in Akt-mediated Induction of VEGF Expression through an HIF-1–independent Mechanism
2004
Selective Inhibition of Ras, Phosphoinositide 3 Kinase, and Akt Isoforms Increases the Radiosensitivity of Human Carcinoma Cell Lines
2005
Identification by site-directed mutagenesis of amino acid residues contributing to serologic and CTL-defined epitope differences between HLA-A2.1 and HLA-A2.3.
1988
Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells.
1994
Direct evidence for the contribution of activated N-ras and K-ras oncogenes to increased intrinsic radiation resistance in human tumor cell lines.
2000
Apoptosis: an early event in metastatic inefficiency.
2001
The Ras radiation resistance pathway.
2001
The farnesyltransferase inhibitor L744,832 reduces hypoxia in tumors expressing activated H-ras.
2001
Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction.
2002
Neutralization of tetanus toxin by distinct monoclonal antibodies binding to multiple epitopes on the toxin molecule
1984
Tissue-specific induction of p53 targets in vivo.
2002
Cytotoxic T cell responses in HLA-A2.1 transgenic mice. Recognition of HLA alloantigens and utilization of HLA-A2.1 as a restriction element.
1989
Mr 92,000 gelatinase release correlates with the metastatic phenotype in transformed rat embryo cells.
1990
DR5 Knockout Mice Are Compromised in Radiation-Induced Apoptosis
2005
Increased G 2 Delay in Radiation-Resistant Cells Obtained by Transformation of Primary Rat Embryo Cells with the Oncogenes H-ras and v-myc
1991