Citation Impact
Citing Papers
The Sec1p/Munc18 protein Vps45p binds its cognate SNARE proteins via two distinct modes
2006
Sec1p directly stimulates SNARE-mediated membrane fusion in vitro
2004
Ultrahigh-resolution imaging reveals formation of neuronal SNARE/Munc18 complexes in situ
2013 StandoutNobel
Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion
2009 StandoutScienceNobel
Single Reconstituted Neuronal SNARE Complexes Zipper in Three Distinct Stages
2012 StandoutScienceNobel
SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice
2001 StandoutScienceNobel
SNARE-complex disassembly by NSF follows synaptic-vesicle fusion
2001
Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion
2008 StandoutScienceNobel
α-Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
2010 StandoutScienceNobel
Munc18-1 binds directly to the neuronal SNARE complex
2007 StandoutNobel
Reconstitution of the Vital Functions of Munc18 and Munc13 in Neurotransmitter Release
2012 Science
Functionally and Spatially Distinct Modes of munc18-Syntaxin 1 Interaction
2007
Resolving the Function of Distinct Munc18-1/SNARE Protein Interaction Modes in a Reconstituted Membrane Fusion Assay
2011
Functional architecture of an intracellular membrane t-SNARE
2000 StandoutNatureNobel
Sec1/Munc18 Proteins
2000
The riddle of the Sec1/Munc-18 proteins – new twists added to their interactions with SNAREs
2003
Sec18p and Vam7p remodel trans‐SNARE complexes to permit a lipid‐anchored R‐SNARE to support yeast vacuole fusion
2007
Synaptic vesicle fusion complex contains unc-18 homologue bound to syntaxin
1993 StandoutNatureNobel
Identification and characterization of the vesicular GABA transporter
1997 Nature
Direct Interaction of the Rab3 Effector RIM with Ca2+Channels, SNAP-25, and Synaptotagmin
2001
SNAREs and SNARE regulators in membrane fusion and exocytosis
1999
The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis
1994
Regulated exocytosis: merging ideas on fusing membranes
2007
Vesicle trafficking: pleasure and pain from SM genes
2003
Unraveling the mechanisms of synaptotagmin and SNARE function in neurotransmitter release
2006
Synaptophysin is sorted from endocytotic markers in neuroendocrine PC12 cells but not transfected fibroblasts
1991
Membrane Tethering and Fusion in the Secretory and Endocytic Pathways
2000
Unravelling hepatitis C virus replication from genome to function
2005 StandoutNatureNobel
The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts
1993 Nature
Conserved α-Helical Segments on Yeast Homologs of the Synaptobrevin/VAMP Family of v-SNAREs Mediate Exocytic Function
1997
Munc18-1 Promotes Large Dense-Core Vesicle Docking
2001 StandoutNobel
Munc18–1 stabilizes syntaxin 1, but is not essential for syntaxin 1 targeting and SNARE complex formation
2005 StandoutNobel
Mechanisms of pH Regulation in the Regulated Secretory Pathway
2001 StandoutNobel
The Vesicle- and Target-SNARE Proteins That Mediate Glut4 Vesicle Fusion Are Localized in Detergent-insoluble Lipid Rafts Present on Distinct Intracellular Membranes
2002
Molecular Dissection of the Munc18c/Syntaxin4 Interaction: Implications for Regulation of Membrane Trafficking
2006
Vam3p structure reveals conserved and divergent properties of syntaxins.
2001
Multiple SNARE interactions of an SM protein: Sed5p/Sly1p binding is dispensable for transport
2004
Neurotransmitter Release: The Last Millisecond in the Life of a Synaptic Vesicle
2013 StandoutNobel
Rab proteins as membrane organizers
2001 Standout
Snares and munc18 in synaptic vesicle fusion
2002 StandoutNobel
Self-interaction of a SNARE Transmembrane Domain Promotes the Hemifusion-to-fusion Transition
2006
Conformational Regulation of SNARE Assembly and Disassembly in Vivo
2002
Exocytotic and endocytotic membrane traffic in neurons
1991
Structure and function of SNARE and SNARE-interacting proteins
2005
Assembly of a Ternary Complex by the Predicted Minimal Coiled-coil-forming Domains of Syntaxin, SNAP-25, and Synaptobrevin
1998
Structural insights into the molecular mechanism of Ca2+-dependent exocytosis
2000
Membrane fusion
2002
Botulinum neurotoxin A selectively cleaves the synaptic protein SNAP-25
1993 StandoutNatureNobel
SNAREs Contribute to the Specificity of Membrane Fusion
2000
SNARE Complex Structure and Function
2001
How Tlg2p/syntaxin 16 'snares' Vps45
2002
Energetics and dynamics of SNAREpin folding across lipid bilayers
2007 StandoutNobel
Synaptic vesicle fusion
2008
Membrane protein sequestering by ionic protein–lipid interactions
2011 StandoutNatureNobel
Lipid-Anchored SNAREs Lacking Transmembrane Regions Fully Support Membrane Fusion during Neurotransmitter Release
2013 StandoutNobel
Determinants for Membrane Association of the Hepatitis C Virus RNA-dependent RNA Polymerase
2001 StandoutNobel
Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7
2008 StandoutNatureNobel
The N-terminal Domains of Syntaxin 7 and vti1b Form Three-helix Bundles That Differ in Their Ability to Regulate SNARE Complex Assembly
2002
SNAREs — engines for membrane fusion
2006 Standout
Munc18-Bound Syntaxin Readily Forms SNARE Complexes with Synaptobrevin in Native Plasma Membranes
2006
Membrane Fusion
2003 StandoutNobel
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
Protein traffic in the yeast endocytic and vacuolar protein sorting pathways
1998
Defects in synaptic vesicle docking in unc-18 mutants
2003
Ca2+-dependent and -independent activities of neural and non-neural synaptotagmins
1995 StandoutNatureNobel
Membrane fusion: a structural perspective on the interplay of lipids and proteins
2003
Mechanisms of membrane fusion: disparate players and common principles
2008
Computational redesign of endonuclease DNA binding and cleavage specificity
2006 StandoutNatureNobel
Sec17p and HOPS, in distinct SNARE complexes, mediate SNARE complex disruption or assembly for fusion
2005
Control of eukaryotic membrane fusion by N-terminal domains of SNARE proteins
2003
Crystal structures of neuronal squid Sec1 implicate inter-domain hinge movement in the release of t-SNAREs11Edited by R. Huber
2001
SNAREs and the Secretory Pathway—Lessons from Yeast
1999
Three-dimensional structure of the neuronal-Sec1–syntaxin 1a complex
2000 Nature
Functional Analysis of Conserved Structural Elements in Yeast Syntaxin Vam3p
2001 StandoutNobel
Cytoplasm to vacuole trafficking of aminopeptidase I requires a t-SNARE-Sec1p complex composed of Tlg2p and Vps45p
1999
SNARE-Mediated Lipid Mixing Depends on the Physical State of the Vesicles
2005
Purification of active HOPS complex reveals its affinities for phosphoinositides and the SNARE Vam7p
2006
A dual function for Munc‐18 in exocytosis of PC12 cells
2005
Three-dimensional Structure of the rSly1 N-terminal Domain Reveals a Conformational Change Induced by Binding to Syntaxin 5
2004
Stable SNARE Complex Prior to Evoked Synaptic Vesicle Fusion Revealed by Fluorescence Resonance Energy Transfer
2001
The Transmembrane Domain of Vam3 Affects the Composition ofcis- and trans-SNARE Complexes to Promote Homotypic Vacuole Fusion
2003
Sly1 Binds to Golgi and ER Syntaxins via a Conserved N-Terminal Peptide Motif
2002 StandoutNobel
Interactions within the yeast t-SNARE Sso1p that control SNARE complex assembly.
2000
Hemifusion in SNARE-mediated membrane fusion
2005
The syntaxin family of vesicular transport receptors
1993
NMR analysis of the closed conformation of syntaxin-1
2008
Systematic analysis of genes required for synapse structure and function
2005 StandoutNatureNobel
Synaptic Vesicle Traffic: Rush Hour in the Nerve Terminal
1993
Cellubrevin is a ubiquitous tetanus-toxin substrate homologous to a putative synaptic vesicle fusion protein
1993 StandoutNatureNobel
Lysosome-targeting chimaeras for degradation of extracellular proteins
2020 StandoutNatureNobel
A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
2004 StandoutNatureNobel
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
1998 StandoutNatureNobel
The role of Rab3A in neurotransmitter release
1994 StandoutNatureNobel
Membrane fusion
2008 StandoutNobel
Dual Modes of Munc18-1/SNARE Interactions Are Coupled by Functionally Critical Binding to Syntaxin-1 N Terminus
2007 StandoutNobel
Mechanisms of intracellular protein transport
1994 StandoutNatureNobel
Tissue-specific alternative RNA splicing of rat vesicle-associated membrane protein-1 (VAMP-1)
1997
Selective Activation of Cognate SNAREpins by Sec1/Munc18 Proteins
2007 StandoutNobel
α-Neurexins couple Ca2+ channels to synaptic vesicle exocytosis
2003 StandoutNatureNobel
Vps45p stabilizes the syntaxin homologue Tlg2p and positively regulates SNARE complex formation
2001
Localization Versus Function of Rab3 Proteins
2002 StandoutNobel
STED microscopy reveals that synaptotagmin remains clustered after synaptic vesicle exocytosis
2006 StandoutNatureNobel
RIM1α forms a protein scaffold for regulating neurotransmitter release at the active zone
2002 StandoutNatureNobel
Synaptic vesicle membrane proteins interact to form a multimeric complex.
1992
Exorcising the Exocyst Complex
2012
Comparative studies of Munc18c and Munc18-1 reveal conserved and divergent mechanisms of Sec1/Munc18 proteins
2013
Testing the 3Q:1R “Rule”: Mutational Analysis of the Ionic “Zero” Layer in the Yeast Exocytic SNARE Complex Reveals No Requirement for Arginine
2000
Munc18a Scaffolds SNARE Assembly to Promote Membrane Fusion
2008
Serotonin-Mediated Endocytosis of apCAM: an Early Step of Learning-Related Synaptic Growth in Aplysia
1992 StandoutScienceNobel
The Tlg SNARE complex is required for TGN homotypic fusion
2001
The synaptic vesicle proteins SV2, synaptotagmin and synaptophysin are sorted to separate cellular compartments in CHO fibroblasts.
1993
HOPS Proofreads thetrans-SNARE Complex for Yeast Vacuole Fusion
2008
SCAMP 37, a new marker within the general cell surface recycling system.
1993
Colocalization of synaptophysin with transferrin receptors: implications for synaptic vesicle biogenesis.
1991
Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans
2008
Targeting of the Synaptic Vesicle Protein Synaptobrevin in the Axon of Cultured Hippocampal Neurons: Evidence for Two Distinct Sorting Steps
1997
Specific SNARE complex binding mode of the Sec1/Munc-18 protein, Sec1p
2006
Nsec1 Binds a Closed Conformation of Syntaxin1a
2000
A t-SNARE of the endocytic pathway must be activated for fusion
2001 StandoutNobel
Effect of Mutations in Vesicle-Associated Membrane Protein (VAMP) on the Assembly of Multimeric Protein Complexes
1997
The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae
2012
ENDOCYTOSIS AND MOLECULAR SORTING
1996
Sly1 protein bound to Golgi syntaxin Sed5p allows assembly and contributes to specificity of SNARE fusion complexes
2002
The Docking Stage of Yeast Vacuole Fusion Requires the Transfer of Proteins from a Cis-Snare Complex to a Rab/Ypt Protein
2000
Structure of the Munc18c/Syntaxin4 N-peptide complex defines universal features of the N-peptide binding mode of Sec1/Munc18 proteins
2007
Munc18-1 binding to the neuronal SNARE complex controls synaptic vesicle priming
2009 StandoutNobel
The Role of Syntaxins in the Specificity of Vesicle Targeting in Polarized Epithelial Cells
2005
The specificity of SNARE-dependent fusion is encoded in the SNARE motif
2004 StandoutNobel
Structural basis for the Golgi membrane recruitment of Sly1p by Sed5p
2002
Membrane Fusion and Exocytosis
1999 StandoutNobel
Control of Fusion Pore Dynamics During Exocytosis by Munc18
2001 Science
Transmembrane-domain determinants for SNARE-mediated membrane fusion
2010
Anatomy and Dynamics of a Supramolecular Membrane Protein Cluster
2007 StandoutScienceNobel
A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion
2000
Protein Sorting by Transport Vesicles
1996 StandoutScienceNobel
rsly1 Binding to Syntaxin 5 Is Required for Endoplasmic Reticulum-to-Golgi Transport but Does Not Promote SNARE Motif Accessibility
2003
Newly synthesized synaptophysin is transported to synaptic-like microvesicles via constitutive secretory vesicles and the plasma membrane.
1991
Binding of Munc18-1 to Synaptobrevin and to the SNARE Four-Helix Bundle
2010
FUSION PORES AND FUSION MACHINES IN CA2+-TRIGGERED EXOCYTOSIS
2006
Association of Rab3A with synaptic vesicles at late stages of the secretory pathway.
1991
Post-Transcriptional Regulation of Synaptic Vesicle Protein Expression and the Developmental Control of Synaptic Vesicle Formation
1997
Specific Retrieval of the Exocytic SNARE Snc1p from Early Yeast Endosomes
2000
Conflicting Views on the Membrane Fusion Machinery and the Fusion Pore
2009
Yeast Exocytic v-SNAREs Confer Endocytosis
2000
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
A Yeast t-SNARE Involved in Endocytosis
1998
SNAREs can promote complete fusion and hemifusion as alternative outcomes
2005 StandoutNobel
Patterns of synaptic activity in neural networks recorded by light emission from synaptolucins
1997
Ras family therapy: Rab, Rho and Ral talk to the exocyst
2002
Decoding the Interactions of SM Proteins with SNAREs
2005
The Syntaxin Tlg1p Mediates Trafficking of Chitin Synthase III to Polarized Growth Sites in Yeast
1998
TheSaccharomyces cerevisiaev-SNARE Vti1p Is Required for Multiple Membrane Transport Pathways to the Vacuole
1999
Synaptic Assembly of the Brain in the Absence of Neurotransmitter Secretion
2000 StandoutScienceNobel
Structure of synaptogyrin (p29) defines novel synaptic vesicle protein.
1995 StandoutNobel
A Role for Tlg1p in the Transport of Proteins within the Golgi Apparatus ofSaccharomyces cerevisiae
1999
A lipid-anchored SNARE supports membrane fusion
2011
SNARE Protein Structure and Function
2003
What is the role of SNARE proteins in membrane fusion?
2003
Secretory carrier membrane proteins 31-35 define a common protein composition among secretory carrier membranes.
1991
Munc18-1 Regulates Early and Late Stages of Exocytosis via Syntaxin-independent Protein Interactions
2004
Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia
1992 StandoutScienceNobel
Works of Eric Grote being referenced
A targeting signal in VAMP regulating transport to synaptic vesicles
1995
Protein Targeting in the Neuron
1993
Tlg2p, a Yeast Syntaxin Homolog That Resides on the Golgi and Endocytic Structures
1998
Cell–cell fusion
2007
Secretion is required for late events in the cell-fusion pathway of mating yeast
2010
Ordering the Final Events in Yeast Exocytosis
2000
Endocytosis of VAMP is facilitated by a synaptic vesicle targeting signal.
1996
Sec1p Binds to SNARE Complexes and Concentrates at Sites of Secretion
1999
Asnc1Endocytosis Mutant: Phenotypic Analysis and Suppression by Overproduction of Dihydrosphingosine Phosphate Lyase
2000
Geranylgeranylated Snares Are Dominant Inhibitors of Membrane Fusion
2000 StandoutNobel
Biogenesis of synaptic vesicle-like structures in a pheochromocytoma cell line PC-12.
1990
Promiscuity in Rab–SNARE Interactions
1999
Biogenesis of synaptic vesicles
1993
Prm1 Prevents Contact-Dependent Lysis of Yeast Mating Pairs
2004