Citation Impact
Citing Papers
On the relationship between folding and chemical landscapes in enzyme catalysis
2008 StandoutNobel
Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors
2012 Standout
Structural Basis for DNA Damage–Dependent Poly(ADP-ribosyl)ation by Human PARP-1
2012 Science
A Dynamic Knockout Reveals That Conformational Fluctuations Influence the Chemical Step of Enzyme Catalysis
2011 Science
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Conformational dynamics of a G-protein α subunit is tightly regulated by nucleotide binding
2016
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, and Escherichia coli Exists Predominantly as Disordered Monomer
2012
Probabilistic human health risk assessment of perfluorooctane sulfonate (PFOS) by integrating in vitro, in vivo toxicity, and human epidemiological studies using a Bayesian-based dose-response assessment coupled with physiologically based pharmacokinetic (PBPK) modeling approach
2020
Accessing ns–μs side chain dynamics in ubiquitin with methyl RDCs
2009
The role of dynamic conformational ensembles in biomolecular recognition
2009 Standout
Visualizing spatially correlated dynamics that directs RNA conformational transitions
2007 Nature
Dynamic personalities of proteins
2007 StandoutNature
The nature of chemical innovation: new enzymes by evolution
2015 StandoutNobel
An introduction to NMR-based approaches for measuring protein dynamics
2010
Measurement of signs of chemical shift differences between ground and excited protein states: a comparison between H(S/M)QC and R 1ρ methods
2009
Isotope labeling methods for studies of excited protein states by relaxation dispersion NMR spectroscopy
2009
Measurement of carbonyl chemical shifts of excited protein states by relaxation dispersion NMR spectroscopy: comparison between uniformly and selectively 13C labeled samples
2008
Cellular structural biology
2010
Computational Enzyme Design
2013 StandoutNobel
Protein dynamics and conformational disorder in molecular recognition
2009
Artificial enzymes based on supramolecular scaffolds
2012
Multiscale simulations of protein landscapes: Using coarse‐grained models as reference potentials to full explicit models
2009 StandoutNobel
NMR spectroscopy brings invisible protein states into focus
2009
Multiscale modeling of biological functions
2011 StandoutNobel
Molecular Dynamics Simulation for All
2018 Standout
An exciting but challenging road ahead for computational enzyme design
2010 StandoutNobel
Key role of the REC lobe during CRISPR–Cas9 activation by ‘sensing’, ‘regulating’, and ‘locking’ the catalytic HNH domain
2018 StandoutNobel
CPMG relaxation dispersion NMR experiments measuring glycine 1Hα and 13Cα chemical shifts in the ‘invisible’ excited states of proteins
2009
The EVB as a quantitative tool for formulating simulations and analyzing biological and chemical reactions
2009 StandoutNobel
Differential Responses of the Backbone and Side-Chain Conformational Dynamics in FKBP12 upon Binding the Transition-State Analog FK506: Implications for Transition-State Stabilization and Target Protein Recognition
2009
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
Unwinding RNA's secrets: advances in the biology, physics, and modeling of complex RNAs
2008
Oncogenic Mutations Counteract Intrinsic Disorder in the EGFR Kinase and Promote Receptor Dimerization
2012 StandoutNobel
Structural Determinants and Mechanism of HIV-1 Genome Packaging
2011
Intrinsically disordered proteins in cellular signalling and regulation
2014 Standout
Alternate States of Proteins Revealed by Detailed Energy Landscape Mapping
2010 StandoutNobel
A 15N CPMG relaxation dispersion experiment more resistant to resonance offset and pulse imperfection
2015
Design of activated serine–containing catalytic triads with atomic-level accuracy
2014 StandoutNobel
Molecular mechanism of Thioflavin-T binding to amyloid fibrils
2010 Standout
De Novo Enzyme Design Using Rosetta3
2011 StandoutNobel
Mutations in adenine-binding pockets enhance catalytic properties of NAD(P)H-dependent enzymes
2015 StandoutNobel
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
2007 Nature
Design of amyloidogenic peptide traps
2024 StandoutNobel
Observing biological dynamics at atomic resolution using NMR
2009
Using relaxation dispersion NMR spectroscopy to determine structures of excited, invisible protein states
2008
Allosteric regulation and catalysis emerge via a common route
2008
At the dawn of the 21st century: Is dynamics the missing link for understanding enzyme catalysis?
2009 StandoutNobel
Why nature really chose phosphate
2013 StandoutNobel
Dynamic Dysfunction in Dihydrofolate Reductase Results from Antifolate Drug Binding: Modulation of Dynamics within a Structural State
2009
A Hydrogen Bond Regulates Slow Motions in Ubiquitin by Modulating a β-Turn Flip
2011
Structure and Dynamics of a Processive Brownian Motor: The Translating Ribosome
2010 StandoutNobel
Accurate Measurement of Alpha Proton Chemical Shifts of Excited Protein States by Relaxation Dispersion NMR Spectroscopy
2009
Native α-synuclein induces clustering of synaptic-vesicle mimics via binding to phospholipids and synaptobrevin-2/VAMP2
2013 StandoutNobel
Nanozymes: Classification, Catalytic Mechanisms, Activity Regulation, and Applications
2019 Standout
Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers
2017 StandoutNobel
Pillar[5]arene as a Co-Factor in Templating Rotaxane Formation
2013 StandoutNobel
Bidirectional Photomodulation of Surface Tension in Langmuir Films
2016 StandoutNobel
Connecting Protein Conformational Dynamics with Catalytic Function As Illustrated in Dihydrofolate Reductase
2013
Prechemistry barriers and checkpoints do not contribute to fidelity and catalysis as long as they are not rate limiting
2012 StandoutNobel
Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)
2014
Free-Energy Landscape of Enzyme Catalysis
2008
The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness
2015
Flexibility and Reactivity in Promiscuous Enzymes
2013
A Chemical Category-Based Prioritization Approach for Selecting 75 Per- and Polyfluoroalkyl Substances (PFAS) for Tiered Toxicity and Toxicokinetic Testing
2019
Redox-Controlled Selective Docking in a [2]Catenane Host
2013 StandoutNobel
New Application of Proton Nuclear Spin Relaxation Unraveling the Intermolecular Structural Features of Low-Molecular-Weight Organogel Fibers
2012
Conformational photoswitching of a synthetic peptide foldamer bound within a phospholipid bilayer
2016 Science
Clustering to identify RNA conformations constrained by secondary structure
2011 StandoutNobel
Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research
2020 Standout
In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation
2019 Standout
Classification of Intrinsically Disordered Regions and Proteins
2014 Standout
RNA Structural Dynamics As Captured by Molecular Simulations: A Comprehensive Overview
2018
Functional π-Gelators and Their Applications
2014 Standout
Engineering Biomolecular Self‐Assembly at Solid–Liquid Interfaces
2020 StandoutNobel
CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data
2013 Standout
PLUMED 2: New feathers for an old bird
2013 Standout
Energy Landscapes as a Tool to Integrate GPCR Structure, Dynamics, and Function
2010 StandoutNobel
Reconstitution of selective HIV-1 RNA packaging in vitro by membrane-bound Gag assemblies
2016 StandoutNobel
The empirical valence bond model: theory and applications
2011 StandoutNobel
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
2017
Quantifying the Mechanism of Phosphate Monoester Hydrolysis in Aqueous Solution by Evaluating the Relevant Ab Initio QM/MM Free-Energy Surfaces
2013 StandoutNobel
Conformational Relaxation following Hydride Transfer Plays a Limiting Role in Dihydrofolate Reductase Catalysis
2008
Characterization of the Conformational Equilibrium between the Two Major Substates of RNase A Using NMR Chemical Shifts
2012
Enzyme millisecond conformational dynamics do not catalyze the chemical step
2009 StandoutNobel
On the Mechanism of Nonspecific Inhibitors of Protein Aggregation: Dissecting the Interactions of α-Synuclein with Congo Red and Lacmoid
2009
Redox Control of the Binding Modes of an Organic Receptor
2015 StandoutNobel
Story in a sample—the potential (and limitations) of cryo‐electron microscopy applied to molecular machines
2013 StandoutNobel
Structural Reorganization and Preorganization in Enzyme Active Sites: Comparisons of Experimental and Theoretically Ideal Active Site Geometries in the Multistep Serine Esterase Reaction Cycle
2008
Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study
2011 StandoutNobel
Works of Eric D. Watt being referenced
The mechanism of rate-limiting motions in enzyme function
2007
Hydrogen exchange of monomeric α‐synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding in Escherichia coli
2008
Uncertainty quantification in ToxCast high throughput screening
2018
Characterizing Complex Dynamics in the Transactivation Response Element Apical Loop and Motional Correlations with the Bulge by NMR, Molecular Dynamics, and Mutagenesis
2008
Recent Advances in Solid-State Nuclear Magnetic Resonance Techniques to Quantify Biomolecular Dynamics
2013
Resolving the Motional Modes That Code for RNA Adaptation
2006 Science
The Flexibility of a Distant Loop Modulates Active Site Motion and Product Release in Ribonuclease A
2009
Development and Validation of a Computational Model for Androgen Receptor Activity
2016
Characterization of Enzyme Motions by Solution NMR Relaxation Dispersion
2008