Standout Papers
Citation Impact
Citing Papers
Cryo‐electron microscopy reveals native polymeric cell wall structure in Bacillus subtilis 168 and the existence of a periplasmic space
2005
Ranking essential bacterial processes by speed of mutant death
2020
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Subpolar addition of new cell wall is directed by DivIVA in mycobacteria
2014 StandoutNobel
Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors
2020 StandoutScience
Genetic manipulation of Patescibacteria provides mechanistic insights into microbial dark matter and the epibiotic lifestyle
2023 StandoutNobel
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Expansive discovery of chemically diverse structured macrocyclic oligoamides
2024 StandoutScienceNobel
Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions
2021 StandoutNobel
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
A Eukaryotic-like Ser/Thr Kinase Signals Bacteria to Exit Dormancy in Response to Peptidoglycan Fragments
2008
Evolutionary Convergence of Pathway-Specific Enzyme Expression Stoichiometry
2018
Innovative lead discovery strategies for tropical diseases
2006
A CRISPR–dCas Toolbox for Genetic Engineering and Synthetic Biology
2018
Partial Restoration of Mutant Enzyme Homeostasis in Three Distinct Lysosomal Storage Disease Cell Lines by Altering Calcium Homeostasis
2008
Phylogenetic distribution of translational GTPases in bacteria
2007
AI in health and medicine
2022 Standout
A CRISPR toolbox to study virus–host interactions
2017
CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III
2011 StandoutNatureNobel
A Novel Sensor Platform Based on Aptamer‐Conjugated Polypyrrole Nanotubes for Label‐Free Electrochemical Protein Detection
2008
A decade of discovery: CRISPR functions and applications
2017
The cullin protein family
2011
The Science of Antibiotic Discovery
2020 Standout
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization
2018 StandoutNatureNobel
Designing antimicrobial peptides: form follows function
2011 Standout
Gramicidin S identified as a potent inhibitor for cytochrome bd‐type quinol oxidase
2008 StandoutNobel
Regulation of Ferroptotic Cancer Cell Death by GPX4
2014 Standout
Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series
2012
Phenotypic Variation in Molecular Mimicry betweenHelicobacter pylori Lipopolysaccharides and Human Gastric Epithelial Cell Surface Glycoforms
2002
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 Standout
Production of Authentic SARS-CoV Mpro with Enhanced Activity: Application as a Novel Tag-cleavage Endopeptidase for Protein Overproduction
2006
A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase
2017
Complex phenotypic assays in high-throughput screening
2004
Engineered riboswitches: Expanding researchers' toolbox with synthetic RNA regulators
2012
The primary transcriptome of the major human pathogen Helicobacter pylori
2010 StandoutNature
Phosphorylation of CpgA Protein Enhances Both Its GTPase Activity and Its Affinity for Ribosome and Is Crucial for Bacillus subtilis Growth and Morphology
2012
Glycosylation in health and disease
2019
Protein tyrosine O-glycosylation--A rather unexplored prokaryotic glycosylation system
2010
A revised annotation and comparative analysis of Helicobacter pylori genomes
2003
De novo design of bioactive protein switches
2019 StandoutNatureNobel
The catalysis of the SARS 3C‐like protease is under extensive regulation by its extra domain
2006
Genome-Scale Identification of SARS-CoV-2 and Pan-coronavirus Host Factor Networks
2020 StandoutNobel
Interaction between casein kinase II and the 90-kDa stress protein, HSP90
1995
Drug Targets in Mycobacterial Sulfur Metabolism
2007
Characterization and Repurposing of Type I and Type II CRISPR–Cas Systems in Bacteria
2018
Cyclophilin 40 (CyP-40), Mapping of Its hsp90 Binding Domain and Evidence That FKBP52 Competes with CyP-40 for hsp90 Binding
1996
Probing the Mycobacterial Trehalome with Bioorthogonal Chemistry
2012 StandoutNobel
Regulation of transcription in Helicobacter pylori: simple systems or complex circuits?
2001
Small RNAs are modified with N-glycans and displayed on the surface of living cells
2021 StandoutNobel
The physiology and metabolism of Campylobacter jejuni and Helicobacter pylori
2001
Trends in peptide drug discovery
2021
Redox Control of Protein Conformation in Flavoproteins
2009
Peptidic degron in EID1 is recognized by an SCF E3 ligase complex containing the orphan F-box protein FBXO21
2015 StandoutNobel
In vivo 3′-to-5′ exoribonuclease targetomes of Streptococcus pyogenes
2018 StandoutNobel
Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains
2013 StandoutNobel
The structure of LepA, the ribosomal back translocase
2008 StandoutNobel
Phosphorylation of IκBα in the C-Terminal PEST Domain by Casein Kinase II Affects Intrinsic Protein Stability
1996
Functional Nucleic Acid Sensors
2009 Standout
Steroid Receptor Interactions with Heat Shock Protein and Immunophilin Chaperones*
1997 Standout
Helicobacter pylori Growth and Urease Detection in the Chemically Defined Medium Ham's F-12 Nutrient Mixture
2001
Wall Teichoic Acids of Gram-Positive Bacteria
2013
Cytoprotective metal-organic frameworks for anaerobic bacteria
2018 StandoutNobel
Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques
2004
Ramshackle (Brwd3) promotes light-induced ubiquitylation of Drosophila Cryptochrome by DDB1-CUL4-ROC1 E3 ligase complex
2013 StandoutNobel
Stereospecific Radical-Mediated B12-Dependent Methyl Transfer by the Fosfomycin Biosynthesis Enzyme Fom3
2018
Visualization of mycobacterial membrane dynamics in live cells
2017 StandoutNobel
Modulatory profiling identifies mechanisms of small molecule-induced cell death
2011
Molecular Evolution of Antifungal Drug Resistance
2017
Oxidative-Stress Resistance Mutants ofHelicobacter pylori
2002
Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization
1997
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
2000 Standout
Assessment of the ATP Binding Properties of Hsp90
1996
Protein epitope mimetics as anti-infectives
2011
Reaction mechanism of Drosophila cryptochrome
2010 StandoutNobel
Osmosensory signaling in Mycobacterium tuberculosis mediated by a eukaryotic-like Ser/Thr protein kinase
2013 StandoutNobel
Pathogenesis ofHelicobacter pyloriInfection
2006 Standout
Building and remodelling Cullin–RING E3 ubiquitin ligases
2013
Enzymatic Chemistry of Cyclopropane, Epoxide, and Aziridine Biosynthesis
2011
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Enzymatic construction of highly strained carbocycles
2018 StandoutScienceNobel
Maturation of the 5′ end of Bacillus subtilis 16S rRNA by the essential ribonuclease YkqC/RNase J1
2006
Overcoming Resistance to β-Lactam Antibiotics
2013
Computationally designed peptide macrocycle inhibitors of New Delhi metallo-β-lactamase 1
2021 StandoutNobel
Distribution of Open Reading Frames of Plasticity Region of Strain J99 in Helicobacter pylori Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica
2000
Emergence of DiverseHelicobacterSpecies in the Pathogenesis of Gastric and Enterohepatic Diseases
2001
Worldwide emergence of resistance to antifungal drugs challenges human health and food security
2018 StandoutScience
Adapting Proteostasis for Disease Intervention
2008 StandoutScience
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
2021 StandoutNobel
Composition and Gene Expression of the cag Pathogenicity Island in Helicobacter pylori Strains Isolated from Gastric Carcinoma and Gastritis Patients in Costa Rica
2001
Functional Aptamers and Aptazymes in Biotechnology, Diagnostics, and Therapy
2007
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Bacterial Growth and Cell Division: a Mycobacterial Perspective
2008
The Fluorescent Toolbox for Assessing Protein Location and Function
2006 StandoutScienceNobel
A Fluorogenic Trehalose Probe for Tracking Phagocytosed Mycobacterium tuberculosis
2020 StandoutNobel
Fresh Approaches to Anti-Infective Therapies
2012
Comparative Genomics ofHelicobacter pylori: Analysis of the Outer Membrane Protein Families
2000
motility
2000
Suppression of TNF-α-Induced Apoptosis by NF-κB
1996 StandoutScience
Reconfigurable asymmetric protein assemblies through implicit negative design
2022 StandoutScienceNobel
Identification of strain-specific genes located outside the plasticity zone in nine clinical isolates of Helicobacter pylori b bThe GenBank accession numbers for the H. pylori sequences reported in this paper are AF326599–AF326607 for region A, AF326608–AF326616 for region B, AF326617–AF326625 for region C, AF326626–AF326634 for region D, AF327212–AF327220 for region E, AF328909–AF328916 and AF328924 for region F, and AF32917–AF32923 for region G.
2002
Chemical Glycoproteomics
2016 StandoutNobel
Superoxide Dismutase-Deficient Mutants of Helicobacter pylori Are Hypersensitive to Oxidative Stress and Defective in Host Colonization
2001
Generation of Anti-trypanosomal Agents through Concise Synthesis and Structural Diversification of Sesquiterpene Analogues
2011 StandoutNobel
Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
2015 StandoutScienceNobel
Iron acquisition and virulence in Helicobacter pylori: a major role for FeoB, a high‐affinity ferrous iron transporter
2000
Works of Eric D. Brown being referenced
Lesions in Teichoic Acid Biosynthesis in Staphylococcus aureus Lead to a Lethal Gain of Function in the Otherwise Dispensable Pathway
2006
Teichoic Acid Is an Essential Polymer in Bacillus subtilis That Is Functionally Distinct from Teichuronic Acid
2004
The Wall Teichoic Acid Polymerase TagF Is Non-processive in Vitro and Amenable to Study Using Steady State Kinetic Analysis
2009
Antibiotics as probes of biological complexity
2011
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
2016
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy
2011
Kinetics, Stoichiometry, and Identification of the Reactive Thiolate in the Inactivation of UDP-GlcNAc Enolpyruvoyl Transferase by the Antibiotic Fosfomycin
1994
Purified, Recombinant TagF Protein from Bacillus subtilis 168 Catalyzes the Polymerization of Glycerol Phosphate onto a Membrane Acceptor in Vitro
2003
Invited Perspective: Screening in Academe: A Perspective on Implementation of University-Based Small Molecule Screening
2003
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis
2010
New screens and targets in antibacterial drug discovery
2009
The Wall Teichoic Acid Polymerase TagF Efficiently Synthesizes Poly(glycerol phosphate) on the TagB Product Lipid III
2008
The TagB Protein in Bacillus subtilis 168 Is an Intracellular Peripheral Membrane Protein That Can Incorporate Glycerol Phosphate onto a Membrane-bound Acceptor in Vitro
2005
High-Throughput Screening for Human Lysosomal β-N-Acetyl Hexosaminidase Inhibitors Acting as Pharmacological Chaperones
2007
Probing Teichoic Acid Genetics with Bioactive Molecules Reveals New Interactions among Diverse Processes in Bacterial Cell Wall Biogenesis
2009
A FACS‐Based Approach to Engineering Artificial Riboswitches
2008
An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase
2010
High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase
2004
Small‐Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity
2006
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi–Bi reaction mechanism with micromolar Km values
2003
Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor
2011
A Deep Learning Approach to Antibiotic Discovery
2020
Studies of the Genetics, Function, and Kinetic Mechanism of TagE, the Wall Teichoic Acid Glycosyltransferase in Bacillus subtilis 168
2011
Identification of Pharmacological Chaperones for Gaucher Disease and Characterization of Their Effects on β‐Glucocerebrosidase by Hydrogen/Deuterium Exchange Mass Spectrometry
2008
Antibacterial drug discovery in the resistance era
2016 StandoutNature
Chemical Probes of Escherichia coli Uncovered through Chemical-Chemical Interaction Profiling with Compounds of Known Biological Activity
2010
Inhibition of WTA Synthesis Blocks the Cooperative Action of PBPs and Sensitizes MRSA to β-Lactams
2012
Small‐Molecule Screening Made Simple for a Difficult Target with a Signaling Nucleic Acid Aptamer that Reports on Deaminase Activity
2006
Precise Deletion of tagD and Controlled Depletion of Its Product, Glycerol 3-Phosphate Cytidylyltransferase, Leads to Irregular Morphology and Lysis of Bacillus subtilis Grown at Physiological Temperature
2001
Bifunctional Catalysis by CDP-ribitol Synthase: Convergent Recruitment of Reductase and Cytidylyltransferase Activities in Haemophilus influenzae and Staphylococcus aureus
2004
Wall Teichoic Acid Polymers Are Dispensable for Cell Viability in Bacillus subtilis
2006
Duplication of Teichoic Acid Biosynthetic Genes in Staphylococcus aureus Leads to Functionally Redundant Poly(Ribitol Phosphate) Polymerases
2008
Studies of the Interaction of Escherichia coli YjeQ with the Ribosome In Vitro
2004
Expression of recombinant human casein kinase II and recombinant heat shock protein 90 in Escherichia coli and characterization of their interactions.
1994
Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function
2005
Development and Characterization of a Xylose-Dependent System for Expression of Cloned Genes in Bacillus subtilis : Conditional Complementation of a Teichoic Acid Mutant
2001
Helicobacter pyloriPhysiology Predicted from Genomic Comparison of Two Strains
1999
Conformational change and membrane association of the PutA protein are coincident with reduction of its FAD cofactor by proline.
1993
Inhibitors of Bacterial Cystathionine β-Lyase: Leads for New Antimicrobial Agents and Probes of Enzyme Structure and Function
2007
New Targets and Screening Approaches in Antimicrobial Drug Discovery
2005
The N -Acetylmannosamine Transferase Catalyzes the First Committed Step of Teichoic Acid Assembly in Bacillus subtilis and Staphylococcus aureus
2009
Are essential genes really essential?
2009
MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli
1995
Unconventional screening approaches for antibiotic discovery
2015
Cross‐species discovery of syncretic drug combinations that potentiate the antifungal fluconazole
2011
Use of CDP-Glycerol as an Alternate Acceptor for the Teichoic Acid Polymerase Reveals that Membrane Association Regulates Polymer Length
2008
Reduction Precedes Cytidylyl Transfer without Substrate Channeling in Distinct Active Sites of the Bifunctional CDP-Ribitol Synthase from Haemophilus influenzae
2001
High-Throughput Screening Identifies Novel Inhibitors of the Acetyltransferase Activity of Escherichia coli GlmU
2009