Citation Impact
Citing Papers
Maturation-Dependent HIV-1 Surface Protein Redistribution Revealed by Fluorescence Nanoscopy
2012 StandoutScienceNobel
SNARE Proteins: One to Fuse and Three to Keep the Nascent Fusion Pore Open
2012 StandoutScienceNobel
Fusion of Cells by Flipped SNAREs
2003 StandoutScienceNobel
The ectodomain of HIV-1 env subunit gp41 forms a soluble, alpha-helical, rod-like oligomer in the absence of gp120 and the N-terminal fusion peptide.
1996
Genetic analysis of monoclonal antibody and HIV binding sites on the human lymphocyte antigen CD4
1988
Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients
1986 StandoutNobel
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
1996 Standout
Morphometric Analysis of Recombinant Soluble CD4-Mediated Release of the Envelope Glycoprotein gp120 from HIV-1
1990
Alteration of HIV-1 Infectivity and Neutralization by a Single Amino Acid Replacement in the V3 Loop Domain
1991
Crystallization of a soluble form of the rat T-cell surface glycoprotein CD4 complexed with Fab from the W3/25 monoclonal antibody
1990
Chemokines and HIV–1 second receptors
1996
A trimeric structural domain of the HIV-1 transmembrane glycoprotein
1995
Identification of the residues in human CD4 critical for the binding of HIV
1989 StandoutNobel
An internal deletion within an 11p13 zinc finger gene contributes to the development of Wilms' tumor
1990
Envelope glycoprotein of HIV induces interference and cytolysis resistance in CD4+ cells: Mechanism for persistence in AIDS
1988
Tumor suppressor genes
1991 Standout
Most CD4+ T cells from human immunodeficiency virus-1 infected patients can undergo prolonged clonal expansion.
1989 StandoutNobel
Immunohistochemical Study of Normal Skin of HIV-1—Infected Patients Shows No Evidence of Infection of Epidermal Langerhans Cells by HIV
1989
Structural Clues to Prion Replication
1994 StandoutScienceNobel
Characteristics of a Neutralizing Monoclonal Antibody to the HIV Envelope Glycoprotein
1988
Compartmental specificity of cellular membrane fusion encoded in SNARE proteins
2000 StandoutNatureNobel
HIV infection: facts and hypotheses
1986
Patterning of the Caenorhabditis elegans head region by the Pax-6 family member vab-3
1995 StandoutNatureNobel
A CD4 domain important for HIV-mediated syncytium formation lies outside the virus binding site
1990
The effects of human immunodeficiency virus recombinant envelope glycoprotein on immune cell functions in vitro
1987
Crystal structure of an HIV-binding recombinant fragment of human CD4
1990 StandoutNatureNobel
HIV infection does not require endocytosis of its receptor, CD4
1988 StandoutNobel
Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus
1991
Designing CD4 immunoadhesins for AIDS therapy
1989 Nature
Revealing the world of RNA interference
2004 StandoutNatureNobel
Single amino-acid changes in HIV envelope affect viral tropism and receptor binding
1989 StandoutNatureNobel
Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene
1992
Enzymic cleavage of a CD4 immunoadhesin generates crystallizable, biologically active Fd-like fragments
1990
Dendritic cells and the control of immunity
1998 StandoutNatureNobel
Macrophage-tropic HIV and SIV envelope proteins induce a signal through the CCR5 chemokine receptor
1997 StandoutNatureNobel
siRNA-directed inhibition of HIV-1 infection
2002
HIV infection is blocked in vitro by recombinant soluble CD4
1988 Nature
Soluble CD4 molecules neutralize human immunodeficiency virus type 1
1988 Nature
Cyclin A and the retinoblastoma gene product complex with a common transcription factor
1991 StandoutNatureNobel
soluble form of CD4 (T4) protein inhibits AIDS virus infection
1988 StandoutNatureNobel
The immunopathogenesis of sepsis
2002 StandoutNature
The Structure, Function, and Molecular Genetics of the gamma/delta T Cell Receptor
1989
Effects of anti-gp120 monoclonal antibodies on CD4 receptor binding by the env protein of human immunodeficiency virus type 1
1988
Amino acid substitutions in the human immunodeficiency virus type 1 gp120 V3 loop that change viral tropism also alter physical and functional properties of the virion envelope
1994
Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals.
1990 StandoutNobel
Neutralization of human T-lymphotropic virus type III by sera of AIDS and AIDS-risk patients
1985 Nature
T cell target 1 (TCT.1): a novel target molecule for human non-major histocompatibility complex-restricted T lymphocytes.
1990
Susceptibility to infection by the human immunodeficiency virus (HIV) correlates with T4 expression in a parental monocytoid cell line and its subclones
1987
Blocking of HIV-1 Infectivity by a Soluble, Secreted Form of the CD4 Antigen
1987 Science
Induction of HTLV-III/LAV from a Nonvirus-Producing T-Cell Line: Implications for Latency
1986 Science
High concentrations of recombinant soluble CD4 are required to neutralize primary human immunodeficiency virus type 1 isolates.
1990
Susceptibility of Human Peripheral Blood Dendritic Cells to Infection by Human Immunodeficiency Virus
1987
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain
1986 StandoutNobel
Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein
1995
HTLV-III expression in infected lymph nodes and relevance to pathogenesis of lymphadenopathy.
1986
Close Is Not Enough
2000 StandoutNobel
Truncated variants of gp120 bind CD4 with high affinity and suggest a minimum CD4 binding region.
1992
Genome organization and transactivation of the human immunodeficiency virus type 2
1987 StandoutNatureNobel
Human immunodeficiency virus type 1 gp120 envelope glycoprotein regions important for association with the gp41 transmembrane glycoprotein
1991
Loss of CD4 membrane expression and CD4 mRNA during acute human immunodeficiency virus replication.
1988 StandoutNobel
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family
1985 StandoutNobel
Human Immunodeficiency Viruses
1986 StandoutScienceNobel
Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus
1990 Standout
Immunopathogenesis of the Acquired Immunodeficiency Syndrome
1985
A History of HIV Discovery
2002 StandoutScienceNobel
Interaction between the human T-cell lymphotropic virus type IIIB envelope glycoprotein gp120 and the surface antigen CD4: role of carbohydrate in binding and cell fusion.
1987
Rapid phosphorylation and modulation of the T4 antigen on cloned helper T cells induced by phorbol myristate acetate or antigen.
1986
Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding.
1990
Protein and carbohydrate structural analysis of a recombinant soluble CD4 receptor by mass spectrometry
1989
Qualitative Analysis of Immune Function in Patients with the Acquired Immunodeficiency Syndrome
1985
Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production
1997
Persistent Noncytopathic Infection of Normal Human T Lymphocytes with AIDS-Associated Retrovirus
1985 Science
Isolation of a New Human Retrovirus from West African Patients with AIDS
1986 StandoutScienceNobel
The Human Immunodeficiency Virus: Infectivity and Mechanisms of Pathogenesis
1988 StandoutScience
Clonal Deletion Versus Clonal Anergy: The Role of the Thymus in Inducing Self Tolerance
1990 StandoutScienceNobel
Dissociation of gp120 from HIV-1 Virions Induced by Soluble CD4
1990 Science
Delineation of a region of the human immunodeficiency virus type 1 gp120 glycoprotein critical for interaction with the CD4 receptor
1987
Immunology: Approaches to AIDS therapy
1986 StandoutNatureNobel
A molecular clone of HTLV-III with biological activity
1985 Nature
Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity
1986 Nature
The cellular receptor (CD4) of the human immunodeficiency virus is expressed on neurons and glial cells in human brain.
1987
Location of the Trans -Activating Region on the Genome of Human T-Cell Lymphotropic Virus Type III
1985 Science
Human immunodeficiency virus type 1 expression in the central nervous system correlates directly with extent of disease.
1990
A Quantitative Bioassay for HIV-1 Based on Trans-Activation
1988 Science
A soluble recombinant polypeptide comprising the amino-terminal half of the extracellular region of the CD4 molecule contains an active binding site for human immunodeficiency virus.
1988
Isolation and Sequence of L3T4 Complementary DNA Clones: Expression in T Cells and Brain
1986 Science
Cytopathic effect of human immunodeficiency virus in T4 cells is linked to the last stage of virus infection.
1988
The MHC-Binding and gp120-Binding Functions of CD4 Are Separable
1989 Science
Identification of Envelope V3 Loop as the Major Determinant of CD4 Neutralization Sensitivity of HIV-1
1992 Science
Human immunodeficiency virus infection of monocytic and T-lymphocytic cells: Receptor modulation and differentiation induced by phorbol ester
1987
Persistent infection of macaques with simian-human immunodeficiency viruses
1995
The chronology of AIDS research
1987 StandoutNatureNobel
Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone
1986 Standout
Location and Chemical Synthesis of a Binding Site for HIV-1 on the CD4 Protein
1988 Science
Immunohistochemical identification of HTLV‐III antigen in brains of patients with AIDS
1986
Human immunodeficiency virus infection of CD4-bearing cells occurs by a pH-independent mechanism.
1988
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding
1995
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions
1993
Alterations in T4 (CD4) Protein and mRNA Synthesis in Cells Infected with HIV
1986 Science
Endocytosis of glycophospholipid-anchored and transmembrane forms of CD4 by different endocytic pathways.
1992
High prevalence of antibodies to acquired immune deficiency syndrome (AIDS)-associated retrovirus (ARV) in AIDS and related conditions but not in other disease states.
1985
Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid
1996 StandoutScienceNobel
Human T-cell lymphotropic virus IIIB glycoprotein (gp120) bound to CD4 determinants on normal lymphocytes and expressed by infected cells serves as target for immune attack.
1987
Synthetic CD4 Peptide Derivatives That Inhibit HIV Infection and Cytopathicity
1988 Science
Downregulation of cell surface molecules during noncytopathic infection of T cells with human immunodeficiency virus
1987
Induction of CD4-dependent cell fusion by the HTLV-III/LAV envelope glycoprotein
1986 Nature
pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
1987
Characterization of gp41 as the Transmembrane Protein Coded by the HTLV-III/LAV Envelope Gene
1985 Science
The gene encoding the T-cell surface protein T4 is located on human chromosome 12.
1986 StandoutNobel
Differential response to the cytopathic effects of human T-cell lymphotropic virus type III (HTLV-III) superinfection in T4+ (helper) and T8+ (suppressor) T-cell clones transformed by HTLV-I.
1986
Epitope mapping of the human immunodeficiency virus type 1 gp120 with monoclonal antibodies
1988
The trans-activator gene of the human T cell lymphotropic virus type III is required for replication
1986
The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
1984 StandoutNature
Identification and antigenicity of the major envelope glycoprotein of of lymphadenopathy-associated virus
1985 StandoutNobel
Binding of HTLV-III/LAV to T4 + T Cells by a Complex of the 110K Viral Protein and the T4 Molecule
1986 Science
Structure and expression of the human and mouse T4 genes.
1987 StandoutNobel
Analysis of the interaction of the human immunodeficiency virus type 1 gp120 envelope glycoprotein with the gp41 transmembrane glycoprotein
1997
Complementation of murine cells for human immunodeficiency virus envelope/CD4-mediated fusion in human/murine heterokaryons
1992
Maintenance of in Vivo Tolerance by Persistence of Antigen
1992 StandoutScienceNobel
Cloning of HTLV-4 and its relation to simian and human immunodeficiency viruses
1987 Nature
Carbohydrate structures of the human-immunodeficiency-virus (HIV) recombinant envelope glycoprotein gp120 produced in Chinese-hamster ovary cells
1988
Target cell-specific determinants of membrane fusion within the human immunodeficiency virus type 1 gp120 third variable region and gp41 amino terminus
1992
Role of N-linked glycans in the interaction between the envelope glycoprotein of human immunodeficiency virus and its CD4 cellular receptor. Structural enzymatic analysis.
1989 StandoutNobel
AIDS Retrovirus Induced Cytopathology: Giant Cell Formation and Involvement of CD4 antigen
1986 Science
Membrane Fusion: Grappling with SNARE and SM Proteins
2009 StandoutScienceNobel
Pathogenesis of Infection with Human Immunodeficiency Virus
1987
The Reservoir for HIV-1 in Human Peripheral Blood Is a T Cell That Maintains Expression of CD4
1989 Science
The HIV-1 Envelope Glycoproteins: Fusogens, Antigens, and Immunogens
1998 StandoutScience
Lymphadenopathy-Associated Virus: From Molecular Biology to Pathogenicity
1985 StandoutNobel
The Bacterial Superantigen Streptococcal Mitogenic Exotoxin Z Is the Major Immunoactive Agent ofStreptococcus pyogenes
2002
Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells
1990
Stimulatory and inhibitory influences of human immunodeficiency virus on normal B lymphocytes.
1986
Unusual intron in the immunoglobulin domain of the newly isolated murine CD4 (L3T4) gene
1987 Nature
Functional Regions of the Envelope Glycoprotein of Human Immunodeficiency Virus Type 1
1987 Science
Structural analysis of the human immunodeficiency virus-binding domain of CD4. Epitope mapping with site-directed mutants and anti-idiotypes.
1989
Binding region for human immunodeficiency virus (HIV) and epitopes for HIV-blocking monoclonal antibodies of the CD4 molecule defined by site-directed mutagenesis.
1988
Dendritic Cells Exposed to Human Immunodeficiency Virus Type-1 Transmit a Vigorous Cytopathic Infection to CD4 + T Cells
1992 StandoutScienceNobel
Epitopes of the CD4 Antigen and HIV Infection
1986 Science
Infection of HTLV-III/LAV in HTLV-I-Carrying Cells MT-2 and MT-4 and Application in a Plaque Assay
1985 Science
Apoptosis in AIDS
1993 StandoutScienceNobel
AIDS-associated retroviruses (ARV) can productively infect other cells besides human T helper cells
1985
Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis.
1992
Utilization of C-C chemokine receptor 5 by the envelope glycoproteins of a pathogenic simian immunodeficiency virus, SIVmac239
1997
Molecular cloning and polymorphism of the human immune deficiency virus type 2
1986 StandoutNatureNobel
Rapid complementation assays measuring replicative potential of human immunodeficiency virus type 1 envelope glycoprotein mutants
1990
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat
1985
Prevention of HIV-1 Infection and Preservation of CD4 Function by the Binding of CPFs to gp120
1990 Science
Increased envelope spike density and stability are not required for the neutralization resistance of primary human immunodeficiency viruses
1996
Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.
1990
Characterization of conserved human immunodeficiency virus type 1 gp120 neutralization epitopes exposed upon gp120-CD4 binding
1993
Works of Éric Champagne being referenced
Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene
1990
CD28/CTLA4‐B7 interaction is dispensable for T cell stimulation by mouse mammary tumor virus superantigen but not for B cell differentiation and virus dissemination
1996
Sequence and organization of the diversity, joining, and constant region genes of the human T-cell delta-chain locus.
1988
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
1984 StandoutNatureNobel
Pyrogenicity and Cytokine-Inducing Properties ofStreptococcus pyogenesSuperantigens: Comparative Study of Streptococcal Mitogenic Exotoxin Z and Pyrogenic Exotoxin A
2001