Standout Papers
Citation Impact
Citing Papers
Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation
2014 StandoutScienceNobel
DNA capture by a CRISPR-Cas9–guided adenine base editor
2020 StandoutScienceNobel
CRISPR/Cas9 in Genome Editing and Beyond
2016
CRISPR Immunity Drives Rapid Phage Genome Evolution in Streptococcus thermophilus
2015
MutL traps MutS at a DNA mismatch
2015 StandoutNobel
High-throughput biochemical profiling reveals sequence determinants of dCas9 off-target binding and unbinding
2017 StandoutNobel
A conformational checkpoint between DNA binding and cleavage by CRISPR-Cas9
2017 StandoutNobel
Rationally engineered Cas9 nucleases with improved specificity
2015 StandoutScience
Cas3/I-C mediated target DNA recognition and cleavage during CRISPR interference are independent of the composition and architecture of Cascade surveillance complex
2020
Unconstrained genome targeting with near-PAMless engineered CRISPR-Cas9 variants
2020 Science
Probing the target search of DNA-binding proteins in mammalian cells using TetR as model searcher
2015
CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity
2018 StandoutScienceNobel
Genome-scale measurement of off-target activity using Cas9 toxicity in high-throughput screens
2017
How specific is CRISPR/Cas9 really?
2015
Directional R-Loop Formation by the CRISPR-Cas Surveillance Complex Cascade Provides Efficient Off-Target Site Rejection
2015
The promise and challenge of therapeutic genome editing
2020 StandoutNatureNobel
Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs
2019 StandoutNobel
The role of dynamic conformational ensembles in biomolecular recognition
2009 Standout
Assembly and regulation of telomerase
1999
Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus
2014
Multiplex Engineering of Industrial Yeast Genomes Using CRISPRm
2014
Three telomerases with completely non-telomeric template replacements are catalytically active
2000
CRISPR/Cas9-mediated gene knockout is insensitive to target copy number but is dependent on guide RNA potency and Cas9/sgRNA threshold expression level
2017
Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli
2016 Nature
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
2016 StandoutNature
CRISPR-Cas3 induces broad and unidirectional genome editing in human cells
2019
PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing
2015
Two Distinct DNA Binding Modes Guide Dual Roles of a CRISPR-Cas Protein Complex
2015
Adding to the ends: what makes telomerase processive and how important is it?
2004
Single molecule studies of DNA mismatch repair
2014
Landscape of target:guide homology effects on Cas9-mediated cleavage
2014 Nobel
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
2014 Standout
The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro
2004 Nobel
CD22 blockade restores homeostatic microglial phagocytosis in ageing brains
2019 StandoutNatureNobel
Expanding the Biologist’s Toolkit with CRISPR-Cas9
2015 StandoutNobel
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators
2015
A novel specificity for the primer-template pairing requirement in Tetrahymena telomerase
1998
Processive Utilization of the Human Telomerase Template
2004 StandoutNobel
Sequence determinants of improved CRISPR sgRNA design
2015
RNA-based recognition and targeting: sowing the seeds of specificity
2017 StandoutNobel
Developmentally Programmed Gene Elimination in Euplotes crassus Facilitates a Switch in the Telomerase Catalytic Subunit
2003
The end of the (DNA) line.
2000 StandoutNobel
Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition
2015
Expanding the CRISPR imaging toolset withStaphylococcus aureusCas9 for simultaneous imaging of multiple genomic loci
2016
Programmable RNA Tracking in Live Cells with CRISPR/Cas9
2016 StandoutNobel
Methods for Optimizing CRISPR-Cas9 Genome Editing Specificity
2016
New CRISPR–Cas systems from uncultivated microbes
2016 StandoutNatureNobel
CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity
2014
Haloarcula hispanica CRISPR authenticates PAM of a target sequence to prime discriminative adaptation
2014
Telomere states and cell fates
2000 StandoutNatureNobel
Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease
2014 Nature
Functionally interacting telomerase RNAs in the yeast telomerase complex
1997 StandoutNobel
An Efficient Genotyping Method for Genome-modified Animals and Human Cells Generated with CRISPR/Cas9 System
2014
Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition
2016
CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool
2015
A Dynamic Search Process Underlies MicroRNA Targeting
2015
A decade of discovery: CRISPR functions and applications
2017
Defining and improving the genome-wide specificities of CRISPR–Cas9 nucleases
2016
MutS switches between two fundamentally distinct clamps during mismatch repair
2011
Minimum length requirement of the alignment domain of human telomerase RNA to sustain catalytic activity in vitro
2002
Planting the seed: target recognition of short guide RNAs
2014
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy
2017 StandoutNatureNobel
The CRISPR-associated DNA-cleaving enzyme Cpf1 also processes precursor CRISPR RNA
2016 StandoutNatureNobel
CRISPR-Cas immunity in prokaryotes
2015 Nature
CRISPR interference-based specific and efficient gene inactivation in the brain
2018
The structural biology of CRISPR-Cas systems
2015 StandoutNobel
Single-Stranded DNA Cleavage by Divergent CRISPR-Cas9 Enzymes
2015 StandoutNobel
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9
2016 Standout
Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design
2015
A Biophysical Model of CRISPR/Cas9 Activity for Rational Design of Genome Editing and Gene Regulation
2016
Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements
2015
Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates
1998
Cas9 specifies functional viral targets during CRISPR–Cas adaptation
2015 Nature
Crystal Structure of Staphylococcus aureus Cas9
2015
Oligomerization of the telomerase reverse transcriptase from Euplotes crassus
2002
Programmable RNA recognition and cleavage by CRISPR/Cas9
2014 StandoutNatureNobel
Unravelling the structural and mechanistic basis of CRISPR–Cas systems
2014
A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
2015
DNA and RNA interference mechanisms by CRISPR-Cas surveillance complexes
2015 StandoutNobel
Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9
2017
Real-Time Observation of Strand Exchange Reaction with High Spatiotemporal Resolution
2011
Dynamics of MutS–Mismatched DNA Complexes Are Predictive of Their Repair Phenotypes
2014
Cas9 Functionally Opens Chromatin
2016
The mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome
2013
Bacterial CRISPR: accomplishments and prospects
2015
Development and Applications of CRISPR-Cas9 for Genome Engineering
2014 Standout
Conformational control of DNA target cleavage by CRISPR–Cas9
2015 StandoutNatureNobel
Introducing a Spectrum of Long-Range Genomic Deletions in Human Embryonic Stem Cells Using Type I CRISPR-Cas
2019
Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling
2012
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
2015 Nature
De novo telomere addition by Tetrahymena telomerase invitro
1997
Mechanism of CRISPR-RNA guided recognition of DNA targets inEscherichia coli
2015
Nucleolar protein PinX1p regulates telomerase by sequestering its protein catalytic subunit in an inactive complex lacking telomerase RNA
2004 StandoutNobel
The next generation of CRISPR–Cas technologies and applications
2019
Broad-spectrum enzymatic inhibition of CRISPR-Cas12a
2019 StandoutNobel
Repetitive DNA Reeling by the Cascade-Cas3 Complex in Nucleotide Unwinding Steps
2018
Rapid upregulation of telomerase activity in human leukemia HL-60 cells treated with clinical doses of the DNA-damaging drug etoposide
2002
Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering
2016 StandoutNobel
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
2016
Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity
2015 StandoutNatureNobel
Chemistry of Class 1 CRISPR-Cas effectors: Binding, editing, and regulation
2020 StandoutNobel
Lessons from Enzyme Kinetics Reveal Specificity Principles for RNA-Guided Nucleases in RNA Interference and CRISPR-Based Genome Editing
2017
The Biology of CRISPR-Cas: Backward and Forward
2018 StandoutNobel
Crystal Structure of Cpf1 in Complex with Guide RNA and Target DNA
2016
Adaptation in CRISPR-Cas Systems
2016 StandoutNobel
CRISPR RNA-guided integrases for high-efficiency, multiplexed bacterial genome engineering
2020
CasX enzymes comprise a distinct family of RNA-guided genome editors
2019 StandoutNatureNobel
Structure Basis for Directional R-loop Formation and Substrate Handover Mechanisms in Type I CRISPR-Cas System
2017
Type III CRISPR-Cas systems: when DNA cleavage just isn’t enough
2017
The Revolution Continues: Newly Discovered Systems Expand the CRISPR-Cas Toolkit
2017
Computational design of ligand-binding proteins with high affinity and selectivity
2013 StandoutNatureNobel
Protein Engineering of Cas9 for Enhanced Function
2014
Refined sgRNA efficacy prediction improves large- and small-scale CRISPR–Cas9 applications
2017 StandoutNobel
DNA mismatch repair: Molecular mechanism, cancer, and ageing
2008
Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection
2016 StandoutNatureNobel
Structural basis of DNA targeting by a transposon-encoded CRISPR–Cas system
2019 Nature
DNase H Activity of Neisseria meningitidis Cas9
2015
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a
2019
Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
2016 StandoutNobel
The telomerase reverse transcriptase: components and regulation
1998
Telomerase RNA function in recombinant Tetrahymena telomerase
1999
Structure and specificity of the RNA-guided endonuclease Cas9 during DNA interrogation, target binding and cleavage
2015
Guide RNA Functional Modules Direct Cas9 Activity and Orthogonality
2014
Massively parallel kinetic profiling of natural and engineered CRISPR nucleases
2020 StandoutNobel
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
2014
Protospacer Adjacent Motif (PAM)-Distal Sequences Engage CRISPR Cas9 DNA Target Cleavage
2014
A novel mechanism for telomere size control in Saccharomyces cerevisiae.
1996
Tetrahymena proteins p80 and p95 are not core telomerase components
2001 StandoutNobel
Direct observation of R-loop formation by single RNA-guided Cas9 and Cascade effector complexes
2014
A Cas9–guide RNA complex preorganized for target DNA recognition
2015 StandoutScienceNobel
Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems
2016 Science
Dynamics of CRISPR-Cas9 genome interrogation in living cells
2015 StandoutScienceNobel
Functional Multimerization of the Human Telomerase Reverse Transcriptase
2001
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
2015
Characterization and developmental patterns of telomerase expression in plants
1996
Genomes in Focus: Development and Applications of CRISPR‐Cas9 Imaging Technologies
2017 StandoutNobel
The chemistry of Cas9 and its CRISPR colleagues
2017 StandoutNobel
The new frontier of genome engineering with CRISPR-Cas9
2014 StandoutScienceNobel
Identification of Two RNA-binding Proteins Associated with Human Telomerase RNA
2000 StandoutNobel
CRISPR-Cas9 nuclear dynamics and target recognition in living cells
2016
ATP-independent diffusion of double-stranded RNA binding proteins
2012 StandoutNobel
Imaging Specific Genomic DNA in Living Cells
2016
Programmed DNA destruction by miniature CRISPR-Cas14 enzymes
2018 StandoutScienceNobel
Mechanism of foreign DNA recognition by a CRISPR RNA-guided surveillance complex from Pseudomonas aeruginosa
2015
Ciliate Telomerase Biochemistry
1999
RNA-dependent RNA targeting by CRISPR-Cas9
2018 StandoutNobel
Nucleosome breathing and remodeling constrain CRISPR-Cas9 function
2016 StandoutNobel
Structure Principles of CRISPR-Cas Surveillance and Effector Complexes
2015
Structure basis for RNA-guided DNA degradation by Cascade and Cas3
2018 Science
Plasmodium falciparum Telomerase: De Novo Telomere Addition to Telomeric and Nontelomeric Sequences and Role in Chromosome Healing
1998
CRISPR-Cas9 conformational activation as elucidated from enhanced molecular simulations
2017
A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system
2019
Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression
2020
Cas9 function and host genome sampling in Type II-A CRISPR–Cas adaptation
2015
Structure Reveals a Mechanism of CRISPR-RNA-Guided Nuclease Recruitment and Anti-CRISPR Viral Mimicry
2019
Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis
2018
Cas3 Protein—A Review of a Multi-Tasking Machine
2020
RecA filament sliding on DNA facilitates homology search
2012
Telomerase in kinetoplastid parasitic protozoa
1999 StandoutNobel
Single-Molecule FRET TACKLE Reveals Highly Dynamic Mismatched DNA−MutS Complexes
2010
Cas9 interrogates DNA in discrete steps modulated by mismatches and supercoiling
2020 StandoutNobel
Regulated Expression of sgRNAs Tunes CRISPRi in E. coli
2018
The reverse transcriptase component of the Tetrahymena telomerase ribonucleoprotein complex
1998
CRISPR-Cas: Adapting to change
2017 Science
Engineering of temperature- and light-switchable Cas9 variants
2013 StandoutNobel
Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro.
1997 StandoutNobel
PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures
2018
Target specificity of the CRISPR‐Cas9 system
2014
Slow Conformational Changes in MutS and DNA Direct Ordered Transitions between Mismatch Search, Recognition and Signaling of DNA Repair
2013
Template Boundary in a Yeast Telomerase Specified by RNA Structure
2000 StandoutScienceNobel
Advances in Single-Molecule Fluorescence Methods for Molecular Biology
2008
CRISPR-Cas guides the future of genetic engineering
2018 StandoutScienceNobel
DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals
2013
Striking Plasticity of CRISPR-Cas9 and Key Role of Non-target DNA, as Revealed by Molecular Simulations
2016
CASFISH: CRISPR/Cas9-mediated in situ labeling of genomic loci in fixed cells
2015
MutS/MutL crystal structure reveals that the MutS sliding clamp loads MutL onto DNA
2015
A functional telomerase RNA swap in vivo reveals the importance of nontemplate RNA domains
1997 StandoutNobel
Nucleosomes impede Cas9 access to DNA in vivo and in vitro
2016
Molecular insights into DNA interference by CRISPR-associated nuclease-helicase Cas3
2014
How RecBCD Enzyme and Chi Promote DNA Break Repair and Recombination: a Molecular Biologist's View
2012
Works of Eric C. Greene being referenced
Sequential eviction of crowded nucleoprotein complexes by the exonuclease RecBCD molecular motor
2017
Base triplet stepping by the Rad51/RecA family of recombinases
2015 Science
Single molecule studies of homologous recombination
2008
Developmentally regulated initiation of DNA synthesis by telomerase: evidence for factor-assisted de novo telomere formation
1997
DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
2014 StandoutNatureNobel
Visualizing the Assembly of Human Rad51 Filaments on Double-stranded DNA
2006
A DNA-translocating Snf2 Molecular Motor: Saccharomyces cerevisiae Rdh54 Displays Processive Translocation and Extrudes DNA Loops
2007
Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase
2010 Nature
Visualizing one-dimensional diffusion of proteins along DNA
2008
Dynamic Basis for One-Dimensional DNA Scanning by the Mismatch Repair Complex Msh2-Msh6
2007
Direct Observation of Single MuB Polymers
2002
Developmentally programmed assembly of higher order telomerase complexes with distinct biochemical and structural properties
1998
Visualizing one-dimensional diffusion of eukaryotic DNA repair factors along a chromatin lattice
2010
Surveillance and Processing of Foreign DNA by the Escherichia coli CRISPR-Cas System
2015 StandoutNobel
Target Immunity during Mu DNA Transposition
2002
Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair
2012
Long-distance lateral diffusion of human Rad51 on double-stranded DNA
2006
Processing of Nontelomeric 3′ Ends by Telomerase: Default Template Alignment and Endonucleolytic Cleavage
1996
Organized Arrays of Individual DNA Molecules Tethered to Supported Lipid Bilayers
2005
DNA Interrogation by the CRISPR RNA-Guided Endonuclease Cas9
2014 StandoutNobel
Flexible Positioning of the Telomerase-Associated Nuclease Leads to Preferential Elimination of Nontelomeric DNA
1998