Standout Papers
Citation Impact
Citing Papers
Principles for designing proteins with cavities formed by curved β sheets
2017 StandoutScienceNobel
Atomic-Level Characterization of the Structural Dynamics of Proteins
2010 StandoutScienceNobel
Molecular Chaperone Functions in Protein Folding and Proteostasis
2013
Consistent blind protein structure generation from NMR chemical shift data
2008 StandoutNobel
Directed Evolution Mimics Allosteric Activation by Stepwise Tuning of the Conformational Ensemble
2018 StandoutNobel
Transferrin receptor targeting by de novo sheet extension
2021 StandoutNobel
Exploiting conformational dynamics to modulate the function of designed proteins
2023 StandoutNobel
Computational design of closely related proteins that adopt two well-defined but structurally divergent folds
2020 StandoutNobel
Simultaneous prediction of protein folding and docking at high resolution
2009 StandoutNobel
Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions
2011 StandoutNobel
NMR Structure Determination for Larger Proteins Using Backbone-Only Data
2010 StandoutScienceNobel
Protein structure determination from NMR chemical shifts
2007
Cotranslational structure acquisition of nascent polypeptides monitored by NMR spectroscopy
2010
Improvement of a Potential Anthrax Therapeutic by Computational Protein Design
2011 StandoutNobel
De novo design of allosterically switchable protein assemblies
2024 StandoutNatureNobel
Physicochemical Determinants of Chaperone Requirements
2010
Dynamic personalities of proteins
2007 StandoutNature
The Highly Cooperative Folding of Small Naturally Occurring Proteins Is Likely the Result of Natural Selection
2007 StandoutNobel
Expression and characterization of 15N-labeled human C-reactive protein in Escherichia coli and Pichia pastoris for use in isotope-dilution mass spectrometry
2012
Firefly luciferase mutants as sensors of proteome stress
2011
The ensemble nature of allostery
2014 Nature
NMR study of the tetrameric KcsA potassium channel in detergent micelles
2006
Structural Analysis of E. coli hsp90 Reveals Dramatic Nucleotide-Dependent Conformational Rearrangements
2006
Mutagenesis Reveals the Complex Relationships between ATPase Rate and the Chaperone Activities of Escherichia coli Heat Shock Protein 70 (Hsp70/DnaK)
2010
BPPred: A Web‐based computational tool for predicting biophysical parameters of proteins
2006
Structural insights into substrate binding by the molecular chaperone DnaK.
2000
CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification
2019 StandoutNobel
Circular permutation of polypeptide chains: Implications for protein folding and stability
1995
NMR spectroscopy captures the essential role of dynamics in regulating biomolecular function
2021
Denaturant m values and heat capacity changes: Relation to changes in accessible surface areas of protein unfolding
1995 Standout
The Hsp70 and Hsp60 Chaperone Machines
1998 Standout
Transfer of Flexibility between Ankyrin Repeats in IκBα upon Formation of the NF-κB Complex
2008
Converging concepts of protein folding in vitro and in vivo
2009
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor
2010 StandoutNatureNobel
Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor
2012 StandoutNobel
Conformational changes in the G protein Gs induced by the β2 adrenergic receptor
2011 StandoutNatureNobel
Quantitative dynamics and binding studies of the 20S proteasome by NMR
2007 Nature
Molecular chaperones in protein folding and proteostasis
2011 StandoutNature
GroEL-Mediated Protein Folding: Making the Impossible, Possible
2006
Circular permutation: a different way to engineer enzyme structure and function
2010
Solution structure of a minor and transiently formed state of a T4 lysozyme mutant
2011 StandoutNatureNobel
A transposase strategy for creating libraries of circularly permuted proteins
2012
Chaperonin-mediated protein folding: using a central cavity to kinetically assist polypeptide chain folding
2009
Hepatitis C Virus NS5B and Host Cyclophilin A Share a Common Binding Site on NS5A
2012
Protein Folding in the Cytoplasm and the Heat Shock Response
2010
From words to literature in structural proteomics
2003 Nature
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase
2010
NMR Structure of the Integral Membrane Protein OmpX
2004 Nobel
Asparagine and Aspartate Hydroxylation of the Cytoskeletal Ankyrin Family Is Catalyzed by Factor-inhibiting Hypoxia-inducible Factor
2010 StandoutNobel
Protein structure and dynamics studied by mass spectrometry: H/D exchange, hydroxyl radical labeling, and related approaches
2008
Mechanism of folding chamber closure in a group II chaperonin
2010 StandoutNatureNobel
GroEL Binds to and Unfolds Rhodanese Posttranslationally
1996
Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
2013 StandoutNobel
Monitoring Protein Conformation along the Pathway of Chaperonin-Assisted Folding
2008
Gymnastics of Molecular Chaperones
2010
Controlling protein assembly on inorganic crystals through designed protein interfaces
2019 StandoutNatureNobel
Random circular permutation leading to chain disruption within and near α helices in the catalytic chains of aspartate transcarbamoylase: Effects on assembly, stability, and function
2001
The HSP70 chaperone machinery: J proteins as drivers of functional specificity
2010
Location and Flexibility of the Unique C-Terminal Tail of Aquifex aeolicus Co-Chaperonin Protein 10 as Derived by Cryo-Electron Microscopy and Biophysical Techniques
2008
Are Neuronal SNARE Proteins Ca2+ Sensors?
2005 StandoutNobel
Protein semi-synthesis: New proteins for functional and structural studies
2005
Modeling the assembly order of multimeric heteroprotein complexes
2018
Enzyme stabilization via computationally guided protein stapling
2017
Improving Protein Expression, Stability, and Function with ProteinMPNN
2024 StandoutNobel
Circular permutation and receptor insertion within green fluorescent proteins
1999 StandoutNobel
Extreme stability in de novo-designed repeat arrays is determined by unusually stable short-range interactions
2018 StandoutNobel
Structural Features of the GroEL-GroES Nano-Cage Required for Rapid Folding of Encapsulated Protein
2006
Random circular permutation of genes and expressed polypeptide chains: application of the method to the catalytic chains of aspartate transcarbamoylase.
1996
An NMR Perspective on Enzyme Dynamics
2006
Structural and Thermodynamic Analysis of a Conformationally Strained Circular Permutant of Barnase
2009
SWISS-MODEL: homology modelling of protein structures and complexes
2018 Standout
Ile, Leu, and Val Methyl Assignments of the 723-Residue Malate Synthase G Using a New Labeling Strategy and Novel NMR Methods
2003
The Structure of a Thermophilic Kinase Shapes Fitness upon Random Circular Permutation
2016
High thermodynamic stability of parametrically designed helical bundles
2014 StandoutScienceNobel
Molecular Chaperones in the Cytosol: from Nascent Chain to Folded Protein
2002 StandoutScience
General approach to reversing ketol-acid reductoisomerase cofactor dependence from NADPH to NADH
2013 StandoutNobel
Multiscale natural moves refine macromolecules using single-particle electron microscopy projection images
2012 StandoutNobel
Long-range order in the src SH3 folding transition state
2000 StandoutNobel
Accurate protein structure modeling using sparse NMR data and homologous structure information
2012 StandoutNobel
Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
2014 StandoutNobel
Rotational dynamics and transition mechanisms of surface-adsorbed proteins
2022 StandoutNobel
The mammalian central nervous synaptic cleft contains a high density of periodically organized complexes
2005 StandoutNobel
Design of a Novel Globular Protein Fold with Atomic-Level Accuracy
2003 StandoutScienceNobel
Cross-Correlated Relaxation Enhanced 1H−13C NMR Spectroscopy of Methyl Groups in Very High Molecular Weight Proteins and Protein Complexes
2003
Networks of electrostatic and hydrophobic interactions modulate the complex folding free energy surface of a designed βα protein
2019 StandoutNobel
Principles of Allosteric Interactions in Cell Signaling
2014
New Tools Provide New Insights in NMR Studies of Protein Dynamics
2006 Science
Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples
2012 StandoutNobel
Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor
2015 StandoutNobel
Cu-Catalyzed Azide−Alkyne Cycloaddition
2008 StandoutNobel
Ultrafast Dynamics and Anionic Active States of the Flavin Cofactor in Cryptochrome and Photolyase
2008 StandoutNobel
Solid-state NMR of proteins sedimented by ultracentrifugation
2011
De novo design of protein logic gates
2020 StandoutScienceNobel
Limited internal friction in the rate-limiting step of a two-state protein folding reaction
1998 StandoutNobel
Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release
2005
Nonnative Interactions in the FF Domain Folding Pathway from an Atomic Resolution Structure of a Sparsely Populated Intermediate: An NMR Relaxation Dispersion Study
2011 StandoutNobel
Works of Eric B. Bertelsen being referenced
Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexed with ADP and substrate
2009
Direct NMR observation of a substrate protein bound to the chaperonin GroEL
2005 Nobel
Topology and dynamics of the 10 kDa C‐terminal domain of DnaK in solution
1999
Uniform and Residue-specific 15N-labeling of Proteins on a Highly Deuterated Background
2004 Nobel
Circular permutation of T4 lysozyme
1993
Allostery in the Hsp70 Chaperone Proteins
2012
Entropic effects of disulphide bonds on protein stability
1994
NMR analysis of a 900K GroEL–GroES complex
2002 StandoutNatureNobel
Allostery in Hsp70 Chaperones Is Transduced by Subdomain Rotations
2009
High-throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone DnaK
2007
Proton–proton Overhauser NMR spectroscopy with polypeptide chains in large structures
2006 Nobel
Binding of a Small Molecule at a Protein–Protein Interface Regulates the Chaperone Activity of Hsp70–Hsp40
2010
Solution NMR Techniques for Large Molecular and Supramolecular Structures
2002 StandoutNobel
Heat shock protein 70 kDa chaperone/DnaJ cochaperone complex employs an unusual dynamic interface
2011