Citation Impact
Citing Papers
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1
2008
NAD+-Dependent 15-Hydroxyprostaglandin Dehydrogenase Regulates Levels of Bioactive Lipids in Non–Small Cell Lung Cancer
2008
Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
2006
Prostaglandin F 2α elevates blood pressure and promotes atherosclerosis
2009
Mutant G-protein-coupled receptors as a cause of human diseases
2004
Photoswitchable fatty acids enable optical control of TRPV1
2015
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
2004 Standout
Specific roles of cyclooxygenase‐1 and cyclooxygenase‐2 in lipopolysaccharide‐induced fever and fos expression in rat brain
2003
Structure of the TRPA1 ion channel suggests regulatory mechanisms
2015 StandoutNatureNobel
TL1A (TNFSF15) Regulates the Development of Chronic Colitis by Modulating Both T-Helper 1 and T-Helper 17 Activation
2008
Molecular mechanisms of diverse actions of prostanoid receptors
1995
Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart
1999
Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation
2010
Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody‐driven K/BxN serum–transfer arthritis
2008
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
2007 Standout
Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta
1999
Intestinal homeostasis and its breakdown in inflammatory bowel disease
2011 StandoutNature
Insights Into Parturition Biology From Genetically Altered Mice
2008
Unravelling the pathogenesis of inflammatory bowel disease
2007 StandoutNature
TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
2009 StandoutNobel
Knockout mice lacking cPGES/p23, a constitutively expressed PGE2 synthetic enzyme, are peri-natally lethal
2007
The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure
2001
Pro-resolving lipid mediators are leads for resolution physiology
2014 StandoutNature
Roles of Prostanoids Revealed From Studies Using Mice Lacking Specific Prostanoid Receptors.
2000
Cyclooxygenase knockout mice
1999
Cough and airway disease: The role of ion channels
2017
Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
1997
The selective cyclooxygenase‐2 inhibitor rofecoxib reduces kainate‐induced cell death in the rat hippocampus
2001
Prostaglandin-Induced Activation of Nociceptive Neurons via Direct Interaction with Transient Receptor Potential A1 (TRPA1)
2007
Interpreting Neonatal Lethal Phenotypes in Mouse Mutants: Insights Into Gene Function and Human Diseases
2009
COX-2 Inhibitors and Cardiovascular Risk
2007
Pattern Recognition Receptors and Inflammation
2010 Standout
Targeting TRP channels for pain relief
2013
Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice
2010
Prostaglandin E Receptor Type 4-associated Protein Interacts Directly with NF-κB1 and Attenuates Macrophage Activation
2008
Coordinate up‐ and down‐regulation of glutathione‐dependent prostaglandin E synthase and cyclooxygenase‐2 in A549 cells
2000
TRPV1 Mediates Histamine-Induced Itching via the Activation of Phospholipase A2and 12-Lipoxygenase
2007
JAZ repressor proteins are targets of the SCFCOI1 complex during jasmonate signalling
2007 StandoutNature
Angiogenesis in cancer and other diseases
2000 StandoutNature
The vanilloid receptor TRPV1: 10 years from channel cloning to antagonist proof-of-concept
2007 Standout
Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis
2008
Expression of Vascular Endothelial Growth Factor Receptor 1 in Bone Marrow-derived Mesenchymal Cells Is Dependent on Hypoxia-inducible Factor 1
2006 StandoutNobel
Inflammatory Bowel Disease
2009 Standout
Design of selective inhibitors of cyclooxygenase-2 as nonulcerogenic anti-inflammatory agents
1998
Impaired duodenal bicarbonate secretion and mucosal integrity in mice lacking prostaglandin E–receptor subtype EP3
1999
Cyclooxygenase-2 inhibition by rofecoxib reverses naturally occurring fever in humans
1999
TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death
2004
Prostaglandins as modulators of immunity
2002
Reproductive failure and reduced blood pressure in mice lacking the EP2 prostaglandin E2 receptor
1999
Cloning, Expression, and Up-regulation of Inducible Rat Prostaglandin E Synthase during Lipopolysaccharide-induced Pyresis and Adjuvant-induced Arthritis
2001
Genetic Analysis of Fetal Development and Parturition Control in the Mouse
2000
The genetics and immunopathogenesis of inflammatory bowel disease
2008
The Rise and Fall of the Chemoattractant Receptor GPR33
2005 StandoutNobel
Prostaglandin E Receptors
2007
Targeted Reduction of Oxytocin Expression Provides Insights into its Physiological Roles
1998
Nrk, an X-linked Protein Kinase in the Germinal Center Kinase Family, Is Required for Placental Development and Fetoplacental Induction of Labor
2011 StandoutNobel
Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β
2009
Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells
2003
Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
2009
Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
2005
TRPM8 Is Required for Cold Sensation in Mice
2007 StandoutNobel
Prostaglandin F2α stimulates motility and invasion in colorectal tumor cells
2007
TRPV1 structures in distinct conformations reveal activation mechanisms
2013 StandoutNatureNobel
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
2001
Prostaglandin E synthase
2002
Prostaglandin Receptors EP2, EP3, and IP Mediate Exudate Formation in Carrageenin-Induced Mouse Pleurisy
2004
Are animal models relevant to key aspects of human parturition?
2009
Taking dendritic cells into medicine
2007 StandoutNatureNobel
Structure of the TRPV1 ion channel determined by electron cryo-microscopy
2013 StandoutNatureNobel
Regulation of Prostaglandin E2 Biosynthesis by Inducible Membrane-associated Prostaglandin E2 Synthase That Acts in Concert with Cyclooxygenase-2
2000 Standout
TREK‐1, a K+ channel involved in polymodal pain perception
2006
Thromboxane A2 and prostaglandin F2α mediate inflammatory tachycardia
2005
Reduced Pain Hypersensitivity and Inflammation in Mice Lacking Microsomal Prostaglandin E Synthase-1
2004
Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation
2000
Vascular-specific growth factors and blood vessel formation
2000 StandoutNature
Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcΔ716 knockout mice
2001
Cellular and Molecular Mechanisms of Pain
2009 StandoutNobel
RO1138452 and RO3244794: characterization of structurally distinct, potent and selective IP (prostacyclin) receptor antagonists
2005
Involvement of prostaglandin F2α receptor in ATP-induced mechanical allodynia
2009
Delayed Parturition and Altered Myometrial Progesterone Receptor Isoform A Expression in Mice Null for Krüppel-Like Factor 91
2008
Eicosanoids and cancer
2010 Standout
Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation
2000
Characterization of the LPS-Stimulated Expression of EP2 and EP4 Prostaglandin E Receptors in Mouse Macrophage-like Cell Line, J774.1
1998
Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2
1997 Nature
Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2
2008
Cox-2 Is Regulated by Toll-Like Receptor-4 (TLR4) Signaling: Role in Proliferation and Apoptosis in the Intestine
2006
Insight into prostaglandin, leukotriene, and other eicosanoid functions using mice with targeted gene disruptions☆
1999
Mechanisms of angiogenesis and arteriogenesis
2000 Standout
The role of prostaglandin E2 (PGE 2) in toll-like receptor 4 (TLR4)-mediated colitis-associated neoplasia
2010
The Genetics of Inflammatory Bowel Disease
2007
PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
2022 StandoutNobel
Novel cyclooxygenase‐catalyzed bioactive prostaglandin F2α from physiology to new principles in inflammation
2006
Genetic and pharmacological analysis of prostanoid receptor function
2001
Prostacyclin Antagonism Reduces Pain and Inflammation in Rodent Models of Hyperalgesia and Chronic Arthritis
2006
The febrile response to lipopolysaccharide is blocked in cyclooxygenase-2−/−, but not in cyclooxygenase-1−/− mice
1999
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea
2016 StandoutNatureNobel
Physiological pathways regulating the activity of magnocellular neurosecretory cells
1999
Prostanoids in health and disease
2008
Characterization of EP receptor subtypes responsible for prostaglandin E2‐induced pain responses by use of EP1 and EP3 receptor knockout mice
2001
‘Distinct Cellular Localization of the Messenger Ribonucleic Acid for Prostaglandin E Receptor Subtypes in the Mouse Uterus during Pseudopregnancy1
1997
Excitation and sensitization of nociceptors by bradykinin: what do we know?
2009
Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances
2009
PGF2α FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia
2009
Pharmacology of Vanilloid Transient Receptor Potential Cation Channels
2009
Helminths and Mucosal Immune Modulation
2006
Nociceptors: the sensors of the pain pathway
2010 StandoutNobel
Bisphosphonate conjugation for bone specific drug targeting
2018
Roles of PPARs in health and disease
2000 StandoutNature
Role of cytosolic phospholipase A2 in allergic response and parturition
1997 Nature
Genetic model of selective COX2 inhibition reveals novel heterodimer signaling
2006
Increased susceptibility to colitis and colorectal tumors in mice lacking core 3–derived O-glycans
2007
The DP receptor, allergic inflammation and asthma
2003
Prostanoid Receptors: Structures, Properties, and Functions
1999 Standout
Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
2007
Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators
2013
Cyclooxygenases: Structural, Cellular, and Molecular Biology
2000 Standout
Regulation of Parturition Update: Endocrine and Paracrine Effectors of Term and Preterm Labor
1998
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
2000 Standout
Genetic and pharmacological analysis of prostanoid receptor function
2001
Inhibition of cyclooxygenase-2 prevents inflammation-mediated preterm labor in the mouse
2000
Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase
2003
The Proinflammatory Effect of Prostaglandin E2 in Experimental Inflammatory Bowel Disease Is Mediated through the IL-23→IL-17 Axis
2007
Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells
2002
Generation and reproductive phenotypes of mice lacking estrogen receptor β
1998 StandoutNobel
Prostanoid Receptors: Subtypes and Signaling
2001
RvE1 protects from local inflammation and osteoclastmediated bone destruction in periodontitis
2005
Prostaglandin E2–prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression
2011
G Protein–Coupled Prostanoid Receptors and the Kidney
2001
Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology
2001 StandoutScience
Inflammatory Bowel Disease
2010 Standout
Host Prostaglandin E2-EP3 Signaling Regulates Tumor-Associated Angiogenesis and Tumor Growth
2003
Role of Prostacyclin in the Cardiovascular Response to Thromboxane A 2
2002 StandoutScience
Luteolysis: A Neuroendocrine-Mediated Event
1999
Cyclooxygenase in biology and disease
1998 Standout
Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1β*
1999
Inhibition of Prostaglandin Production by Nimesulide Is Accompanied by Changes in Expression of the Cassette of Uterine Labor-Related Genes in Pregnant Sheep*
1998
ERK2 mediates oxytocin-stimulated PGE2synthesis
1998
Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis.
2002
Proenkephalin+regulatory T cells expanded by ultraviolet B exposure maintain skin homeostasis with a healing function
2020 StandoutNobel
Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
2007
Preterm labor: One syndrome, many causes
2014 StandoutScience
Developmental Changes in Prostaglandin E2Receptor Subtypes in Porcine Ductus Arteriosus
1999
The Oxytocin Receptor System: Structure, Function, and Regulation
2001 Standout
Emerging Targets in Photopharmacology
2016 StandoutNobel
Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch
2018 StandoutNobel
Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion
2008
MyD88 signaling in nonhematopoietic cells protects mice against induced colitis by regulating specific EGF receptor ligands
2010 StandoutNobel
Adenoviral transfer of HIF-1α enhances vascular responses to critical limb ischemia in diabetic mice
2009 StandoutNobel
Prostaglandins and Inflammation
2011 Standout
Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment
2022 StandoutNobel
Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2
2001 StandoutNobel
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
1999
Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation
2008
Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target
1999 Nobel
Neuroendocrine Mechanisms in Pregnancy and Parturition
2010
Opposing actions of prostaglandins and oxytocin determine the onset of murine labor
1998
Expression of the prostaglandin F receptor (FP) gene along the mouse genitourinary tract
2003
Structural insights into TRPM8 inhibition and desensitization
2019 StandoutScienceNobel
De novo design of protein logic gates
2020 StandoutScienceNobel
The Parturition Defect in Steroid 5α-Reductase Type 1 Knockout Mice Is Due to Impaired Cervical Ripening
1999
Identification of a GABPα/β Binding Site Involved in the Induction of Oxytocin Receptor Gene Expression in Human Breast Cells. Potentiation by c-Fos/c-Jun*
1999
Mixed messages: modulation of inflammation and immune responses by prostaglandins and thromboxanes
2001
Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis
2006
Works of Eri Segi‐Nishida being referenced
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
2002
Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3
2005
Female Reproduction in Mice Lacking the Prostaglandin F Receptor
1998
Characterization of the mouse prostaglandin F receptor gene: a transgenic mouse study of a regulatory region that controls its expression in the stomach and kidney but not in the ovary
1997
Expression of Messenger RNA for Prostaglandin E Receptor Subtypes EP4/EP2 and Cyclooxygenase Isozymes in Mouse Periovulatory Follicles and Oviducts During Superovulation1
2003
Chronic activation of the prostaglandin receptor EP4 promotes hyaluronan-mediated neointimal formation in the ductus arteriosus
2006
Patent Ductus Arteriosus and Neonatal Death in Prostaglandin Receptor EP4-Deficient Mice
1998
Mouse Prostaglandin E Receptor EP3 Subtype Mediates Calcium Signals via Gi in cDNA-Transfected Chinese Hamster Ovary Cells
1994
Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3
1998 Nature
Stimulation of bone formation and prevention of bone loss by prostaglandin E EP4 receptor activation
2002
Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
2006
Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
2007
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
1997 Science
Characterization of the gene for the mouse prostaglandin E receptor subtype EP2: tissue-specific initiation of transcription in the macrophage and the uterus
1998
Host and Direct Antitumor Effects and Profound Reduction in Tumor Metastasis with Selective EP4 Receptor Antagonism
2006
Crucial Involvement of the EP4 Subtype of Prostaglandin E Receptor in Osteoclast Formation by Proinflammatory Cytokines and Lipopolysaccharide
2000
Sensitization of TRPV1 by EP1 and IP Reveals Peripheral Nociceptive Mechanism of Prostaglandins
2005
Dual roles of PGE 2 -EP4 signaling in mouse experimental autoimmune encephalomyelitis
2010
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
2002
The Expression of Prostaglandin E Receptors EP2 and EP4 and Their Different Regulation by Lipopolysaccharide in C3H/HeN Peritoneal Macrophages
2001
The prostaglandin receptor EP4 suppresses colitis, mucosal damage and CD4 cell activation in the gut
2002
Abortive expansion of the cumulus and impaired fertility in mice lacking the prostaglandin E receptor subtype EP 2
1999